Faculty Bibliography

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350

Neuro-degenerative diseases. 2008:5(3-4):228-31.DOI: 10.1159/000113710

Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease

Counts, Scott E; He, Bin; Che, Shaoli; Ginsberg, Stephen D; Mufson, Elliott J
BACKGROUND: Fibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer's disease (AD), yet the physiological consequences of this phenomenon are unclear. OBJECTIVE: To determine whether GAL hyperinnervation of cholinergic NB neurons modulates the expression of genes critical to cholinergic transmission [e.g. acetylcholine (ACh) metabolism and ACh receptors] in AD. METHODS: Single-cell gene expression profiling was used to compare cholinergic mRNA levels in non-GAL-hyperinnervated NB neurons in tissue autopsied from cases classified as having no cognitive impairment (NCI) or late-stage AD (AD/GAL-) and in GAL-hyperinnervated (AD/GAL+) NB neurons from the same AD subjects. RESULTS: AD/GAL+ cells displayed a significant upregulation in choline acetyltransferase (ChAT) mRNA expression compared to NCI and AD/GAL- cells. CONCLUSION: GAL fiber hyperinnervation of cholinergic NB neurons upregulates the expression of ChAT, the synthetic enzyme for ACh, suggesting that GAL regulates the cholinergic tone of CBF neurons in AD
PMCID:2826456
PMID: 18322398
ISSN: 1660-2862
CID: 135335

Gene expression abnormalities mark the progression of Alzheimer's disease

Chapter by: Ginsberg, SD; Che, S; Counts, SE; Mufson, EJ
in: Research progress in Alzheimer and dementia : [Vol. 3] by Sun, Maio-Kun [Eds]
Hauppauge, N.Y. : Nova Biomedical ; Lancaster : Gazelle [distributor], 2008
pp. 25-58
ISBN: 1600219608
CID: 448582

Single and rare cell analysis-amplification methods. T7 based amplification protocols

Chapter by: Ginsberg, Stephen D
in: Microarrays in inflammation by Bosio, Andreas; Gerstmayer, Bernhard [Eds]
Basel : Birkhäuser, c2008
pp. 81-94
ISBN: 9783764383343
CID: 448572
Alzheimer research forum, 12 March 2008

Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Rogers J, Stephan DA. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4441-6.

Ginsberg, Stephen D
(Website)
CID: 453072
Alzheimer research forum, 8 Aug 2008

AD Clinical Pipeline: Immunotherapy Woes, Dimebon Boons

Ginsberg, Stephen D; Mufson, Elliot
(Website)
CID: 453062

Single cell gene expression analysis in human postmortem brain tissues and animal models of neurodegeneration

Chapter by: Ginsberg, Stephen D
in: Biomacromolecular mass spectrometry research progress by Koenig, Simone [Eds]
New York : Nova Science Publishers, c2008
pp. 109-110
ISBN: 1604564873
CID: 453022
Society for Neuroscience abstract viewer & itinerary planner. 2008:38.DOI:

Rab GTPase gene up regulation within individual cholinergic nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease and mild cognitive impairment [Meeting Abstract]

Ginsberg, S. D.; Che, S.; Counts, S. E.; Wuu, J.; Nixon, R. A.; Mufson, E. J.
BIOSIS:PREV201200148909
ISSN: 1558-3635
CID: 458922
Society for Neuroscience abstract viewer & itinerary planner. 2008:38.DOI:

Expression profile of CA1 pyramidal neurons in aged hTau mice [Meeting Abstract]

Alldred, M. J.; Duff, K. E.; Ginsberg, S. D.
BIOSIS:PREV201200148908
ISSN: 1558-3635
CID: 458982
Society for Neuroscience abstract viewer & itinerary planner. 2008:38.DOI:

Gender differences in the expression of NGF receptors in single cholinergic nucleus basalis neurons during the progression of Alzheimer's disease [Meeting Abstract]

Counts, S. E.; Che, S.; Ginsberg, S. D.; Mufson, E. J.
BIOSIS:PREV201200172882
ISSN: 1558-3635
CID: 459162
Society for Neuroscience abstract viewer & itinerary planner. 2008:38.DOI:

MicroRNA (miRNA) expression profiling using the miRNA signature sequence amplification (SSAM) technology in human postmortem brain tissues and in animal models of neurodegeneration [Meeting Abstract]

Che, S.; Ginsberg, S. D.
BIOSIS:PREV201200148907
ISSN: 1558-3635
CID: 459232