Faculty Bibliography

PURPOSE/OBJECTIVE:H coil for direct brain oximetry at 3T. METHODS:H images. RESULTS:H structural brain images demonstrated excellent quality and anatomical detail using routine clinical imaging sequence parameters and parallel acceleration. CONCLUSION/CONCLUSIONS:H imaging under standard clinical 3 T scanning conditions.

Purpose/UNASSIGNED:To revisit the "loopole," an unusual coil topology whose unbalanced current distribution captures both loop and electric dipole properties, which can be advantageous in ultra-high-field MRI. Methods/UNASSIGNED:Loopole coils were built by deliberately breaking the capacitor symmetry of traditional loop coils. The corresponding current distribution, transmit efficiency, and signal-to-noise ratio (SNR) were evaluated in simulation and experiments in comparison to those of loops and electric dipoles at 7 T (297 MHz). Results/UNASSIGNED:, the loopole demonstrated significant performance boost in either the transmit efficiency or SNR at the center of a dielectric sample when compared to a traditional loop. Modest improvements were observed when compared to an electric dipole. Conclusion/UNASSIGNED:The loopole can achieve high performance by supporting both divergence-free and curl-free current patterns, which are both significant contributors to the ultimate intrinsic performance at ultra-high field. While electric dipoles exhibit similar hybrid properties, loopoles maintain the engineering advantages of loops, such as geometric decoupling and reduced resonance frequency dependence on sample loading.

PURPOSE/OBJECTIVE:Sodium MRI has shown promise for monitoring neoadjuvant chemotherapy response in breast cancer. The purpose of this work was to build a dual-tuned bilateral proton/sodium breast coil for 7T MRI that provides sufficient SNR to enable sodium breast imaging in less than 10 minutes. METHODS:The proton/sodium coil consists of 2 shielded unilateral units: 1 for each breast. Each unit consists of 3 nested layers: (1) a 3-loop solenoid for sodium excitation, (2) a 3-loop solenoid for proton excitation and signal reception, and (3) a 4-channel receive array for sodium signal reception. Benchmark measurements were performed in phantoms with and without the sodium receive array insert. In vivo images were acquired on a healthy volunteer. RESULTS:The sodium receive array boosted 1.5 to 3 times the SNR compared with the solenoid. Proton SNR loss due to residual interaction with the sodium array was less than 10%. The coil enabled sodium imaging in vivo with 2.8-mm isotropic nominal resolution (~5-mm real resolution) in 9:36 minutes. CONCLUSION/CONCLUSIONS:The coil design that we propose addresses challenges associated with sodium's low SNR from a hardware perspective and offers the opportunity to investigate noninvasively breast tumor metabolism as a function of sodium concentration in patients undergoing neoadjuvant chemotherapy.

PURPOSE/OBJECTIVE:We present a novel, geometrically adjustable, receive coil array whose diameter can be tailored to the subject in order to maximize sensitivity for a range of body sizes. THEORY AND METHODS/UNASSIGNED:A key mechanical feature of the size-adaptable receive array is its trellis structure that was motivated by similar structures found in gardening and fencing. Our implementation is a cylindrical trellis that features encircling, diagonally interleaved slats, which are linked together at intersecting points. The ensemble allows expansion or contraction to be controlled with the angle between the slats. This mechanical frame provides a base for radiofrequency coils wherein approximately constant overlap, and therefore coupling between adjacent elements, is maintained when the trellis is expanded or contracted. We demonstrate 2 trellis coil concepts for imaging lower extremity at 3T: a single-row 8-channel array built on a trellis support structure and a multirow 24-channel array in which the coil elements themselves form the trellis structure. RESULTS:We show that the adjustable trellis array can accommodate a range of subject sizes with robust signal-to-noise ratio, loading, and coupling. CONCLUSION/CONCLUSIONS:The trellis coil concept enables an array of surface coils to expand and contract with negligible effect on tuning, matching, and decoupling. This allows an encircling array to conform closely to anatomy of various sizes, which provides significant gains in signal-to-noise ratio.

PURPOSE/OBJECTIVE:Introduce a novel coil design using an electrically long transversely oriented slot in a conductive sheet. THEORY AND METHODS/UNASSIGNED:Theoretical considerations, numerical simulations, and experimental measurements are presented for transverse slot antennas as compared with electric dipole antennas. RESULTS:Simulations show improved central and average transmit and receive efficiency, as well as larger coverage in the transverse plane, for a single slot as compared to a single dipole element. Experiments on a body phantom confirm the simulation results for a slot antenna relative to a dipole, demonstrating a large region of relatively high sensitivity and homogeneity. Images in a human subject also show a large imaging volume for a single slot and six slot antenna array. High central transmit efficiency was observed for slot arrays relative to dipole arrays. CONCLUSION/CONCLUSIONS:Transverse slots can exhibit improved sensitivity and larger field of view compared with traditional conductive dipoles. Simulations and experiments indicate high potential for slot antennas in high field MRI. Magn Reson Med, 2018. © 2018 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PURPOSE: To explore the use of polyvinylpyrrolidone (PVP) for simulated materials with tissue-equivalent dielectric properties. METHODS: PVP and salt were used to control, respectively, relative permittivity and electrical conductivity in a collection of 63 samples with a range of solute concentrations. Their dielectric properties were measured with a commercial probe and fitted to a 3D polynomial in order to establish an empirical recipe. The material's thermal properties and MR spectra were measured. RESULTS: The empirical polynomial recipe (available at https://www.amri.ninds.nih.gov/cgi-bin/phantomrecipe) provides the PVP and salt concentrations required for dielectric materials with permittivity and electrical conductivity values between approximately 45 and 78, and 0.1 to 2 siemens per meter, respectively, from 50 MHz to 4.5 GHz. The second- (solute concentrations) and seventh- (frequency) order polynomial recipe provided less than 2.5% relative error between the measured and target properties. PVP side peaks in the spectra were minor and unaffected by temperature changes. CONCLUSION: PVP-based phantoms are easy to prepare and nontoxic, and their semitransparency makes air bubbles easy to identify. The polymer can be used to create simulated material with a range of dielectric properties, negligible spectral side peaks, and long T2 relaxation time, which are favorable in many MR applications. Magn Reson Med, 2017. (c) 2017 International Society for Magnetic Resonance in Medicine.