Faculty Bibliography

We examined the relative proficiency of four languages (Spanish, German, French, English) of a multilingual speaker with aphasia, JM. JM's self-rated proficiency was consistent with his naming accuracy for nouns and verbs (The Object and Action Naming Battery, Druks & Masterson, 2000) and with his performance on selected subtests of the Bilingual Aphasia Test (Paradis & Libben, 1987). Within and between-language changes were measured following two periods of language treatment, one in a highly-proficient language (Spanish) and one in a less-proficient language (English). The various outcome measures differed in their sensitivity to treatment-associated changes. Cross-language treatment effects were linked to the language of the environment at the time of testing and to relative language proficiency.

To investigate whether idiom production was vulnerable to age-related difficulties, we asked 40 younger (ages 18-30) and 40 older healthy adults (ages 60-85) to produce idiomatic expressions in a story-completion task. Younger adults produced significantly more correct idiom responses (73%) than did older adults (60%). When older adults generated partially correct responses, they were less likely than younger participants to eventually produce the complete target idiom (old: 32%; young: 70%); first-word cues after initial failure to retrieve an idiom resulted in more correct idioms for older (24%) than younger (15%) participants. Correlations between age and idiom correctness were positive for the young group and negative for the older group, suggesting mastery of familiar idioms continues into adulthood. Within each group, scores on the Boston Naming Test correlated with performance on the idiom task. Findings for retrieving idiomatic expressions are thus similar to those for retrieving lexical items.

This study evaluates the involvement of switching skills and working-memory capacity in auditory sentence processing in older adults. The authors examined 241 healthy participants, aged 55 to 88 years, who completed four neuropsychological tasks and two sentence-processing tasks. In addition to age and the expected contribution of working memory, switching ability, as measured by the number of perseverative errors on the Wisconsin Card Sorting Test, emerged as a strong predictor of performance on both sentence-processing tasks. Individuals with both low working-memory spans and more perseverative errors achieved the lowest accuracy scores. These findings are consistent with compensatory accounts of successful performance in older age.

This study documents patterns of change in speech production in a multilingual with aphasia following a cerebrovascular accident (CVA). EC, a right-handed Hebrew-English-French trilingual man, had a left fronto-temporo-parietal CVA, after which he reported that his (native) Hebrew accent became stronger in his (second language) English. Recordings of his pre- and post-CVA speech permitted an investigation of changes in his accent. In sentence- and segment-listening tasks, native American English listeners (n = 13 and 15, respectively) judged EC's pre- and post-CVA speech. EC's speech was perceived as more foreign-accented, slow, strained and hesitant, but not less intelligible, post-CVA. Acoustic analysis revealed less coarticulation and longer vowel- and word-durations post-CVA. This case extends knowledge about perceptual and acoustic changes in speech production in multilinguals following CVAs. It is suggested that EC's stronger accent post-CVA may have resulted from damage to the neuronal networks that led to impairment in his other language domains.

To determine structural brain correlates of naming abilities in older adults, we tested 24 individuals aged 56-79 on two confrontation-naming tests (the Boston Naming Test (BNT) and the Action Naming Test (ANT)), then collected from these individuals structural Magnetic-Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data. Overall, several regions showed that greater gray and white matter volume/integrity measures were associated with better task performance. Left peri-Sylvian language regions and their right-hemisphere counterparts, plus left mid-frontal gyrus correlated with accuracy and/or negatively with response time (RT) on the naming tests. Fractional anisotropy maps derived from DTI showed robust positive correlations with ANT accuracy bilaterally in the temporal lobe and in right middle frontal lobe, as well as negative correlations with BNT RT, bilaterally, in the white matter within middle and inferior temporal lobes. We conclude that those older adults with relatively better naming skills can rely on right-hemisphere peri-Sylvian and mid-frontal regions and pathways, in conjunction with left-hemisphere peri-Sylvian and mid-frontal regions, to achieve their success.

BACKGROUND: The use of constraint-induced treatment in aphasia therapy has yielded promising but mixed results. AIMS: We conducted a treatment study with an individual with chronic non-fluent aphasia. The goal of the treatment was to improve verb production in sentence- and narrative- contexts. METHODS #ENTITYSTARTX00026; PROCEDURES: We administered a modified constraint-induced aphasia treatment in a single-subject design. Treatment emphasized the production of verbs within informative exchanges. Verb production in narratives was assessed before and after the treatment. OUTCOMES #ENTITYSTARTX00026; RESULTS: Results demonstrated a significant increase in the number of verbs produced during narrative generation following treatment. Moreover, a positive change was perceived by naïve listeners who rated the social-communicative impact of the participant's narratives. CONCLUSIONS: The increase in verb production seen in the post-treatment measures is attributed to a combination of the constraints imposed on sentence production during the treatment sessions, the informative nature of the treatment exchanges, and the relative intensity of the treatment schedule.

OBJECTIVES/OBJECTIVE:To evaluate effects of health status on word-finding difficulty in aging, adjusting for the known contributors of education, sex, and ethnicity. DESIGN/METHODS:Cross-sectional. SETTING/METHODS:Community. PARTICIPANTS/METHODS:Two hundred eighty-four adults aged 55 to 85 (48.6% female) participating in an ongoing longitudinal study of language in aging. MEASUREMENTS/METHODS:Medical, neurological, and laboratory evaluations to determine health status and presence or absence of hypertension and diabetes mellitus. Lexical retrieval evaluated with the Boston Naming Test (BNT) and Action Naming Test. RESULTS:Unadjusted regression models showed that presence of diabetes mellitus was not related to naming. Presence of hypertension was associated with significantly lower accuracy on both tasks (P<.02). Adjustment for demographics attenuated the effect of hypertension (P<.08). For the BNT, a variable combining presence, treatment, and control of hypertension was marginally significant (P<.10), with subjects with uncontrolled hypertension being least accurate (91.4%). Previously observed findings regarding the effects of age, education, sex, and ethnicity were confirmed. CONCLUSION/CONCLUSIONS:In this sample of older adults, hypertension contributed to the word-finding difficulty of normal aging, but diabetes mellitus did not.