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85


Flexible optical imaging band system for the assessment of arthritis in patients with systemic lupus erythematosus

Kim, Youngwan; Marone, Alessandro; Tang, Wei; Gartshteyn, Yevgeniya; Kim, Hyun K; Askanase, Anca D; Kymissis, Ioannis; Hielscher, Andreas H
We have developed a flexible optical imaging system (FOIS) to assess systemic lupus erythematosus (SLE) arthritis in the finger joints. While any part of the body can be affected, arthritis in the finger joints is one of the most common SLE manifestations. There is an unmet need for accurate, low-cost assessment of lupus arthritis that can be easily performed at every clinic visit. Current imaging methods are imprecise, expensive, and time consuming to allow for frequent monitoring. Our FOIS can be wrapped around joints, and multiple light sources and detectors gather reflected and transmitted light intensities. Using data from two SLE patients and two healthy volunteers, we demonstrate the potential of this FOIS for assessment of arthritis in SLE patients.
PMCID:7984785
PMID: 33796379
ISSN: 2156-7085
CID: 5389872

Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography

Altoe, Mirella L; Kalinsky, Kevin; Marone, Alessandro; Kim, Hyun K; Guo, Hua; Hibshoosh, Hanina; Tejada, Mariella; Crew, Katherine D; Accordino, Melissa K; Trivedi, Meghna S; Hershman, Dawn L; Hielscher, Andreas H
BACKGROUND:The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR). METHODS:Hb changes across chemotherapy when corrected for pCR status, age, and BMI. RESULTS:Hb levels with BMI and age. CONCLUSIONS:This study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2-3 weeks of chemotherapy.
PMCID:7849076
PMID: 33517909
ISSN: 1465-542x
CID: 5389842

Monitoring neoadjuvant chemotherapy using diffuse optical tomography breast imaging system [Meeting Abstract]

Altoe, Mirella L.; Kalinsky, Kevin; Guo, Hua; Hibshoosh, Hanina; Tejada, Mariella; Crew, Katherine D.; Accordino, Melissa K.; Trivedi, Meghna; Marone, Alessandro; Kim, Hyun K.; Hielscher, Andreas H.; Hershman, Dawn L.
ISI:000618737700735
ISSN: 0008-5472
CID: 5390472

Early changes in diffuse optical tomography predicts pathologic complete response to neoadjuvant chemotherapy in triple-negative breast cancer [Meeting Abstract]

Altoe, Mirella L.; Kalinsky, Kevin; Guo, Hua; Hibshoosh, Hanina; Tejada, Mariella; Crew, Katherine D.; Accordino, Melissa K.; Trivedi, Meghna S.; Marone, Alessandro; Kim, Hyun K.; Hielscher, Andreas H.; Hershman, Dawn L.
ISI:000527012500171
ISSN: 0008-5472
CID: 5390452

A Novel Intraoperative Method to Optically Assess Perfusion During Percutaneous Interventions of the Lower Extremity [Meeting Abstract]

Smith, Matthew C.; Marone, Alessandro; Kim, Youngwan; Kim, Hyun K.; Hielscher, Andreas H.; Bajakian, Danielle
ISI:000544100700334
ISSN: 0741-5214
CID: 5390462

Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy

Altoe, Mirella L; Marone, Alessandro; Kim, Hyun K; Kalinsky, Kevin; Hershman, Dawn L; Hielscher, Andreas H; Ha, Richard S
The purpose of this study is to evaluate whether a diffuse optical tomography breast imaging system (DOTBIS) can provide a comparable optical-based image index of mammographic breast density, an established biomarker of breast cancer risk. Oxyhemoglobin concentration (ctO2Hb) measured by DOTBIS was collected from 40 patients with stage II-III breast cancer. The tumor-free contralateral breast was used for this evaluation. We observed a moderate positive correlation between the patient's mammogram density classification and ctO2Hb, rs = 0.486 (p = 0.001). In addition, significant reduction in ctO2Hb levels were noted during neoadjuvant chemotherapy treatment (p = 0.017). This observation indicates that ctO2Hb levels measured by DOTBIS could be a novel modifiable imaging biomarker of breast cancer risk and warrants further investigation.
PMCID:6701514
PMID: 31453012
ISSN: 2156-7085
CID: 5389822

Modeling of the hemodynamics in the feet of patients with peripheral artery disease

Marone, A; Hoi, J W; Khalil, M A; Kim, H K; Shrikhande, G; Dayal, R; Bajakian, D R; Hielscher, A H
To simulate the hemodynamic effects in the feet in response to a thigh cuff occlusion, we have developed a multi-compartmental model in which the circulatory system for the leg is represented by its electrical equivalents. Dynamic vascular optical tomographic imaging data previously obtained from 20 patients with peripheral artery disease (PAD) and 20 healthy subjects is used to test the model. Analyzing the clinical data with the support of the model yields diagnostic specificity and sensitivity in the 90-95% range, significantly higher than previously reported.
PMCID:6377885
PMID: 30800506
ISSN: 2156-7085
CID: 5389862

Spatial-temporal constraints guided dynamic fluorescence tomographic model for enhanced imaging of organs and functional structures in small animals [Meeting Abstract]

Kim, Hyun K.; Lee, Jong H.; Kim, Dongkyu; Hielscher, Andreas H.
ISI:000473403500033
ISSN: 0277-786x
CID: 5390432

Using dynamic vascular optical spectroscopy to evaluate peripheral arterial disease (PAD) in patients who undergo a vascular intervention [Meeting Abstract]

Marone, A.; Hoi, J. W.; Fong, C. J.; Kim, Y.; Kim, H. K.; Bajakian, D. R.; Hielscher, A. H.
ISI:000473403500007
ISSN: 0277-786x
CID: 5390412

Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with Diffuse Optical Tomography [Meeting Abstract]

Altoe, Mirella L.; Marone, Alessandro; Kim, Hyun K.; Tejada, Mariella; Hibshoosh, Hanina; Crew, Katherine; Kalinsky, Kevin; Hershman, Dawn L.; Hielscher, Andreas H.
ISI:000473403500025
ISSN: 0277-786x
CID: 5390422