Faculty Bibliography

Try a new search

Format these results:

Searched for:

in-biosketch:yes

person:naiks06

Total Results:

68

Arthritis & rheumatology. 2022:74(SI):2271-2274.DOI:

Spatial Transcriptomics Stratifies Health and Psoriatic Disease Severity by Emergent Cellular Ecosystems [Meeting Abstract]

Castillo, Rochelle; Sidhu, Ikjot; Dolgalev, Igor; Subudhi, Ipsita; Yan, Di; Konieczny, Piotr; Hsieh, Brandon; Chu, Tinyi; Haberman, Rebecca; Selvaraj, Shanmugapriya; Shiomi, Tomoe; Medina, Rhina; Girija, Parvathy Vasudevanpillai; Heguy, Adriana; Loomis, Cynthia; Chiriboga, Luis; Meehan, Shane; Ritchlin, Christopher; Garcia-Hernandez, Maria de la Luz; Carucci, John; Neimann, Andrea; Naik, Shruti; Scher, Jose
ISI:000877386502162
ISSN: 2326-5191
CID: 5525672
Journal of investigative dermatology. 2021:141(10):2325-2327.DOI: 10.1016/j.jid.2021.04.006

Fanning the Flames: IRAK2 Signaling in Differentiated Epithelium Potentiates Skin Inflammation [Comment]

Castillo, Rochelle; Subudhi, Ipsita; Naik, Shruti
Aberrant epidermal differentiation is a hallmark of inflammatory skin diseases, including psoriasis and atopic dermatitis. If and how differentiated epidermal cells contribute to inflammatory pathology is unclear. In their new article in the Journal of Investigative Dermatology, Shao et al. (2021) report that IRAK2 signaling downstream of IL-1 and IL-36 links epidermal differentiation and skin inflammation.
PMID: 34560916
ISSN: 1523-1747
CID: 5063102
Nature immunology. 2021:22(7).DOI: 10.1038/s41590-021-00960-y

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Divangahi, Maziar; Aaby, Peter; Khader, Shabaana Abdul; Barreiro, Luis B; Bekkering, Siroon; Chavakis, Triantafyllos; van Crevel, Reinout; Curtis, Nigel; DiNardo, Andrew R; Dominguez-Andres, Jorge; Duivenvoorden, Raphael; Fanucchi, Stephanie; Fayad, Zahi; Fuchs, Elaine; Hamon, Melanie; Jeffrey, Kate L; Khan, Nargis; Joosten, Leo A B; Kaufmann, Eva; Latz, Eicke; Matarese, Giuseppe; van der Meer, Jos W M; Mhlanga, Musa; Moorlag, Simone J C F M; Mulder, Willem J M; Naik, Shruti; Novakovic, Boris; O'Neill, Luke; Ochando, Jordi; Ozato, Keiko; Riksen, Niels P; Sauerwein, Robert; Sherwood, Edward R; Schlitzer, Andreas; Schultze, Joachim L; Sieweke, Michael H; Benn, Christine Stabell; Stunnenberg, Henk; Sun, Joseph; van de Veerdonk, Frank L; Weis, Sebastian; Williams, David L; Xavier, Ramnik; Netea, Mihai G
PMID: 34017127
ISSN: 1529-2916
CID: 4898122
Science. 2021:372(6540):346-347.DOI: 10.1126/science.abi5770

Healing without scarring [Comment]

Konieczny, Piotr; Naik, Shruti
PMID: 33888629
ISSN: 1095-9203
CID: 4889132
Cell. 2021:184(8):1968-1970.DOI: 10.1016/j.cell.2021.03.040

Neu(ronal) custodians of cutaneous immunity

Mansfield, Kody Paul; Naik, Shruti
Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD+ nonpeptidergic neurons that restrain MC activation via glutamate secretion.
PMID: 33861962
ISSN: 1097-4172
CID: 4862572
Cell stem cell. 2021:28(4):592-594.DOI: 10.1016/j.stem.2021.03.007

New dog, old tricks: Developmental programs resurface in inflammation

Rosenblum, Daniel; Naik, Shruti
Cellular cartography of human tissues has provided unprecedented insight into health and disease. In a recent issue of Science, Reynolds et al. (2021) use single-cell transcriptomics to define cell states and gene programs in human skin and uncover fetal programs in dermatological diseases that may fuel inflammatory pathology.
PMID: 33798418
ISSN: 1875-9777
CID: 4858452
Immunity. 2021:54(3):404-406.DOI: 10.1016/j.immuni.2021.02.016

A neu(ronal) player joins the T regulatory game

Larsen, Samantha B; Naik, Shruti
The enteric nervous system is surfacing as a key regulator of intestinal immunity and a liaison of host-commensal interactions. In this issue, Yan et al. identify neuronal interleukin-6 as a potent modulator of regulatory T (Treg) cells in the intestine. This neuroimmune dialog is further refined by commensal microbiota, which impact the enteric nervous system and consequently the intestinal Treg cell pool.
PMID: 33691130
ISSN: 1097-4180
CID: 4835912
Nature immunology. 2021:22(1):2-6.DOI: 10.1038/s41590-020-00845-6

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

Divangahi, Maziar; Aaby, Peter; Khader, Shabaana Abdul; Barreiro, Luis B; Bekkering, Siroon; Chavakis, Triantafyllos; van Crevel, Reinout; Curtis, Nigel; DiNardo, Andrew R; Dominguez-Andres, Jorge; Duivenwoorden, Raphael; Fanucchi, Stephanie; Fayad, Zahi; Fuchs, Elaine; Hamon, Melanie; Jeffrey, Kate L; Khan, Nargis; Joosten, Leo A B; Kaufmann, Eva; Latz, Eicke; Matarese, Giuseppe; van der Meer, Jos W M; Mhlanga, Musa; Moorlag, Simone J C F M; Mulder, Willem J M; Naik, Shruti; Novakovic, Boris; O'Neill, Luke; Ochando, Jordi; Ozato, Keiko; Riksen, Niels P; Sauerwein, Robert; Sherwood, Edward R; Schlitzer, Andreas; Schultze, Joachim L; Sieweke, Michael H; Benn, Christine Stabell; Stunnenberg, Henk; Sun, Joseph; van de Veerdonk, Frank L; Weis, Sebastian; Williams, David L; Xavier, Ramnik; Netea, Mihai G
PMID: 33293712
ISSN: 1529-2916
CID: 4730572
Journal of investigative dermatology. 2021:141(1):15-18.DOI: 10.1016/j.jid.2020.05.084

Warp Speed Ahead! Technology-driven Breakthroughs in Skin Immunity and Inflammatory Disease

Konieczny, Piotr; Naik, Shruti
The skin's physical barrier is reinforced by an arsenal of immune cells that actively patrol the tissue and respond swiftly to penetrating microbes, noxious agents, and injurious stimuli. When unchecked, these same immune cells drive diseases such as psoriasis, atopic dermatitis, and alopecia. Rapidly-advancing microscopy, animal modeling, genomic, and computational technologies have illuminated the complexity of the cutaneous immune cells and their functions in maintaining skin health and driving disease. Here we discuss the recent technology-driven breakthroughs that have transformed our understanding of skin immunity and highlight burgeoning areas that hold great promise for future discoveries.
PMID: 32533963
ISSN: 1523-1747
CID: 4496592
Current opinion in cell biology. 2020:67:64-70.DOI: 10.1016/j.ceb.2020.08.009

Under pressure: Stem cell-niche interactions coordinate tissue adaptation to inflammation

Xing, Yue; Naik, Shruti
Stem and progenitor cells (SCs) are emerging as key drivers of tissue adaptation to inflammation caused by microbes, injury, noxious agents, and other onslaughts. These pressures are most acutely experienced in epithelial tissues such as the skin and gut that interface with the external environment. Thus, here we review how epithelial SCs of the skin and intestine, along with their supportive niches, sense and respond to inflammation for the sake of preserving tissue integrity. We highlight inflammation-induced plasticity in SCs and their progeny and the lasting memory that forms thereafter. The burgeoning area of SC responses to inflammatory stressors may expand therapeutic perspectives in epithelial inflammatory conditions, wound repair, cancers, and aging.
PMID: 32916449
ISSN: 1879-0410
CID: 4593862