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Morbidity and mortality of emergency surgery in octogenarian patient
Morales-GarcÃa, Dieter; Rabanal-Llevot, José M; GarcÃa-Diez, VÃctor; Colsa-Gutiérrez, Pablo; Rica, Alejandro Suárez-de la; Maseda-Garrido, Emilio; Lage-Sánchez, José M; Marini, Corrado P; Petrone, Patrizio
OBJECTIVE:To evaluate the health outcomes (postoperative morbidity and mortality) and the functional status at discharge of elderly patients older than 80 years who underwent emergency surgery. METHOD/METHODS:Patients > 80 years of age who underwent emergency surgery during one year at the Marqués de Valdecilla University Hospital, Santander, Spain. Preoperative data (age, sex, type of surgery, comorbidity) and postoperative data (complications) were evaluated, as well as in-hospital mortality, at 30 days and 6 months after surgery. RESULTS:Five-hundred-sixty-eight patients underwent emergency surgery between 2018 and 2019. After the review, 407 patients were included in the study. Average age: 86.9 years. Women 61.7%. Mean hospital stay: 10.4 days. Traumatic interventions 41.3%, vascular surgery 19.7%, general-digestive surgery 25.3%. Medium ASA risk: 2.88. Functional status at discharge: 3.15. Postoperative complications: Clavien-Dindo I 40.8%, II 40.3%, IIIA 3.4%, IIIB 2.5%, IVA 3.9%, IVB 2.0% and V 7.1%. Hospital mortality 7.1%, 30-day mortality 10.3%, mortality at 6 months 24.6%. CONCLUSIONS:Patients > 80 years of age undergoing urgent surgery have high preoperative comorbidity, postoperative complications, and high mortality at 30 days and 6 months after surgery. This mortality is more significant in those ASA IV, nonagenarians and those undergoing high-risk surgery.
PMID: 39079252
ISSN: 2444-054x
CID: 5696362
Predictors of Length of Hospital Stay After Reduction of Internal Hernia in Patients With a History of Roux-en-Y Gastric Bypass
Sohail, Amir H; Hurwitz, Joshua C; Silverstein, Jeffrey; Hakmi, Hazim; Sajan, Abin; Ye, Ivan B; Pacheco, Tulio Brasileiro Silva; Zielinski, Gregory R; Gangwani, Manesh Kumar; Petrone, Patrizio; Levine, Jun; Kella, Venkata; Brathwaite, Collin E M; Goparaju, Anirudha
BACKGROUND:Postoperative internal hernias after Roux-en-Y gastric bypass (RYGB) have an incidence of 2%-9% and are a surgical emergency. Evidence on factors associated with length of stay (LOS) after emergent internal hernia reduction in RYGB patients is limited. METHODS:This is a retrospective review of patients who underwent internal hernia reduction after RYGB at our tertiary care center over a 5 year period from 2015 to 2020. Demographics, comorbidities, and intra- and postoperative hospital course were collected. Univariate and multivariate linear regressions were used to investigate factors associated with LOS. RESULTS:< .001) were independent risk factors for increased LOS. CONCLUSION/CONCLUSIONS:The most common location of IH after RYGB is Petersen's defect, followed by jejuno-jejunal mesenteric defect. LOS was significantly associated with male sex, exploratory laparotomy, and resection of small bowel.
PMID: 38227350
ISSN: 1555-9823
CID: 5655492
Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle
Sartelli, Massimo; Coccolini, Federico; Labricciosa, Francesco M; Al Omari, AbdelKarim H; Bains, Lovenish; Baraket, Oussama; Catarci, Marco; Cui, Yunfeng; Ferreres, Alberto R; Gkiokas, George; Gomes, Carlos Augusto; Hodonou, Adrien M; Isik, Arda; Litvin, Andrey; Lohsiriwat, Varut; Kotecha, Vihar; Khokha, Vladimir; Kryvoruchko, Igor A; Machain, Gustavo M; O'Connor, Donal B; Olaoye, Iyiade; Al-Omari, Jamal A K; Pasculli, Alessandro; Petrone, Patrizio; Rickard, Jennifer; Sall, Ibrahima; Sawyer, Robert G; Téllez-Almenares, Orlando; Catena, Fausto; Siquini, Walter
In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of the most commonly used methods to adapt guidelines in the local context and transfer best practices into routine clinical care. One of the most important measures to prevent surgical site infections is surgical antibiotic prophylaxis (SAP). This narrative review aims to present a bundle for the correct SAP administration and evaluate the evidence supporting it. Surgical site infection (SSI) prevention guidelines published by the WHO, CDC, NICE, and SHEA/IDSA/APIC/AHA, and the clinical practice guidelines for SAP by ASHP/IDSA/SIS/SHEA, were reviewed. Subsequently, comprehensive searches were also conducted using the PubMed®/MEDLINE and Google Scholar databases, in order to identify further supporting evidence-based documentation. The bundle includes five different measures that may affect proper SAP administration. The measures included may be easily implemented in all hospitals worldwide and are based on minimal drug pharmacokinetics and pharmacodynamics knowledge, which all surgeons should know. Antibiotics for SAP should be prescribed for surgical procedures at high risk for SSIs, such as clean-contaminated and contaminated surgical procedures or for clean surgical procedures where SSIs, even if unlikely, may have devastating consequences, such as in procedures with prosthetic implants. SAP should generally be administered within 60 min before the surgical incision for most antibiotics (including cefazolin). SAP redosing is indicated for surgical procedures exceeding two antibiotic half-lives or for procedures significantly associated with blood loss. In principle, SAP should be discontinued after the surgical procedure. Hospital-based antimicrobial stewardship programmes can optimise the treatment of infections and reduce adverse events associated with antibiotics. In the context of a collaborative and interdisciplinary approach, it is essential to encourage an institutional safety culture in which surgeons are persuaded, rather than compelled, to respect antibiotic prescribing practices. In that context, the proposed bundle contains a set of evidence-based interventions for SAP administration. It is easy to apply, promotes collaboration, and includes measures that can be adequately followed and evaluated in all hospitals worldwide.
PMCID:10812782
PMID: 38275329
ISSN: 2079-6382
CID: 5625362
Acute Care Surgery in Geriatric Patients
Petrone, Patrizio; Brathwaite, Collin E.M.
[S.l.] : Springer International Publishing, 2023
Extent: 1 v.
ISBN: 9783031306501
CID: 5717992
Injury Due to Extremes of Temperature
Chapter by: Petrone, Patrizio
in: Acute Care Surgery in Geriatric Patients by
[S.l.] : Springer International Publishing, 2023
pp. 311-319
ISBN: 9783031306501
CID: 5717952
Nutritional Assessment and Therapy
Chapter by: Petrone, Patrizio; Marini, Corrado P.
in: Acute Care Surgery in Geriatric Patients by
[S.l.] : Springer International Publishing, 2023
pp. 483-487
ISBN: 9783031306501
CID: 5717892
Gynecologic injuries: Trauma to uterus, ovaries, and female genitalia
Chapter by: Petrone, Patrizio; Marini, Corrado P.; Tillou, Areti
in: Current Therapy of Trauma and Surgical Critical Care by
[S.l.] : Elsevier, 2023
pp. 431-438.e1
ISBN: 9780323697873
CID: 5615692
Sepsis, septic shock, and its treatment
Chapter by: Liveris, Anna; McNelis, John; Petrone, Patrizio; Marini, Corrado P.
in: Current Therapy of Trauma and Surgical Critical Care by
[S.l.] : Elsevier, 2023
pp. 770-783.e2
ISBN: 9780323697873
CID: 5615802
Impact of Enhanced Recovery After Surgery (ERAS) Combined with Bariatric Surgery Targeting Opioid Prescriptions (BSTOP) Protocol on Patient Outcomes, Length of Stay and Opioid Prescription After Bariatric Surgery
Silverstein, Jeffrey; Sohail, Amir H; Silva-Pacheco, Tulio B; Khayat, Adam; Amodu, Leo; Cherasard, Patricia; Levine, Jun; Goparaju, Anirudha; Kella, Venkata; Shahidul, Islam; Petrone, Patrizio; Brathwaite, Collin E M
BACKGROUND:Evidence shows that 14.2% of opioid-naive patients have long-term opioid dependence after bariatric surgery. Enhanced recovery after surgery (ERAS) protocols are widely used in bariatric surgery, while bariatric surgery targeting opioid prescriptions (BSTOP) protocols were recently introduced. We will investigate the combined impact of ERAS and BSTOP protocols after bariatric surgery. METHODS:We conducted a retrospective review for patients who underwent either a sleeve gastrectomy or Roux-en-Y gastric bypass at a tertiary care center. Pre-intervention and post-intervention data were compared. Primary outcomes were length of stay (LOS), 30-day readmission, 30-day complications, and discharge on opioids. Multivariate Poisson regression with robust standard error was used to analyze LOS. RESULTS:There was no significant difference in 30-day emergency room visits (3.3% vs. 4.0%; p value = 0.631), 30-day readmission (4.4% vs. 5.4%; p value = 0.577) or 30-day complication rate (4.2% vs. 6.4%; p value = 0.199). LOS was significantly lower in the post-intervention group; mean (interquartile range) 2 (1-2) days vs. 1 (1-2) day, p value < 0.001. On multivariate analysis, the post-intervention group had 0.74 (95% confidence interval 0.65-0.85; p value < 0.001) times lower LOS as compared to pre-intervention group. Patients with DM had a significantly longer LOS (relative risk: 1.22; p = 0.018). No other covariates were associated with LOS (p value < 0.05 for all). BSTOP analysis found a significant difference between the two groups. Discharge on opioids decreased from 40.6% pre-intervention to 7.1% post-intervention. CONCLUSION:ERAS and BSTOP protocols reduced length of stay and opioid need at discharge without an increase in complication or readmission rates.
PMID: 37653212
ISSN: 1708-0428
CID: 5618242
Robotic-assisted completion cholecystectomy with repair of cholecystoduodenal fistula [Case Report]
Hurwitz, Joshua C; Kolwitz, Christine E; Kim, David Y; Petrone, Patrizio; Halpern, David K
Post-cholecystectomy syndrome (PCS) is a well-documented complication of incomplete cholecystectomy. The etiology is often post-surgical chronic inflammation from unresolved cholelithiasis, which is secondary to anatomical abnormalities, including a retained gallbladder or a large cystic duct remnant (CDR). An exceedingly rare consequence is retained gallstone fistulization into the gastrointestinal tract. We present a case of a 70-year-old female with multiple comorbidities 4 years status-post incomplete cholecystectomy, who developed PCS with cholecystoduodenal fistula secondary to retained gallstone in the remnant gallbladder, with CDR involvement, treated via robotic-assisted surgery. Reoperation in PCS has been traditionally performed via laparoscopic approach with recent advances made in robotic-assisted surgery. However, we report the first documented case of PCS complicated by bilioenteric fistula repaired with robotic-assisted surgery. This highlights the value of robotic-assisted surgery in complicated cases, where one must contend with post-surgical anatomic abnormalities and visualization difficulties. Subsequent investigation is necessary to objectively quantify the safety and reproducibility of our approach.
PMCID:10187471
PMID: 37201105
ISSN: 2042-8812
CID: 5544312