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409


Collagen crimp waviness, tortuosity and period have different patterns around the eye [Meeting Abstract]

Hu, Danielle; Jan, Ning-Jiun; Iasella, Michael; Huong Tran; Ling, Yun; Schuman, Joel S.; Judisch, Alexandra; Voorhees, Andrew P.; Wollstein, Gadi; Sigal, Ian A.
ISI:000394210202365
ISSN: 0146-0404
CID: 4365102

Axonal pore paths get closer to the optic nerve center with increased depth through the lamina cribrosa [Meeting Abstract]

Dong, Zachary M.; Wang, Bo; Schuman, Joel S.; Lucy, Katie; Bilonick, Richard Anthony; Lu, Chen D.; Sigal, Ian A.; Kagemann, Larry; Fujimoto, James G.; Ishikawa, Hiroshi; Wollstein, Gadi
ISI:000394210204094
ISSN: 0146-0404
CID: 4365112

Age-related changes in anterograde transport, axonal integrity and visuomotor function in DBA/2J and C57BL/6J mice [Meeting Abstract]

Yang, Xiaolin; van der Merwe, Yolandi; Ho, Leon C.; Conner, Ian P.; Lathrop, Kira L.; Wollstein, Gadi; Schuman, Joel S.; Chan, Kevin C.
ISI:000394210600049
ISSN: 0146-0404
CID: 4365132

Studies of Structure and Function in Whole Eye Transplantation [Meeting Abstract]

Washington, Kia M.; Li, Yang; Komatsu, Chiaki; Miller, Maxine R.; van der Merwe, Yolandi; Wollstein, Gadi; Fu, Valeria L. N.; Gorantla, Vijay S.; Chan, Kevin C.; Schuman, Joel S.
ISI:000394210603340
ISSN: 0146-0404
CID: 4365152

Schlemm Canal (SC) Response to Elevated Intraocular Pressure (IOP) Varies with Morphologic Phenotype [Meeting Abstract]

Kagemann, Larry; Wollstein, Gadi; Ishikawa, Hiroshi; Sigal, Ian A.; Schuman, Joel S.
ISI:000394210603375
ISSN: 0146-0404
CID: 4365162

Glaucoma Progression Detection at the Preperimetric Stage Through the Combination of Structural and Functional Information [Meeting Abstract]

Lucy, Katie; Wollstein, Gadi; Ishikawa, Hiroshi; Kagemann, Larry; Schuman, Joel S.
ISI:000394210603386
ISSN: 0146-0404
CID: 4365172

High-resolution mapping of in-vivo stretch and compression of the lamina cribrosa in response to acute changes in intraocular and/or intracranial pressures [Meeting Abstract]

Sigal, Ian A.; Judisch, Alexandra; Huong Tran; Wang, Bo; Smith, Matthew A.; Kagemann, Larry; Ishikawa, Hiroshi; Tyler-Kabara, Elizabeth; Schuman, Joel S.; Wollstein, Gadi
ISI:000394210603402
ISSN: 0146-0404
CID: 4365182

Citicoline preserves optic nerve integrity and visuomotor function following chronic intraocular pressure elevation [Meeting Abstract]

van der Merwe, Yolandi; Yang, Xiaoling; Ho, Leon C.; Yu, Yu; Chau, Ying; Leung, Christopher Kai-Shun; Conner, Ian P.; Steketee, Michael B.; Wollstein, Gadi; Schuman, Joel S.; Chan, Kevin C.
ISI:000394210604028
ISSN: 0146-0404
CID: 4365192

Lamina cribrosa pore tortuosity in healthy and glaucomatous eyes [Meeting Abstract]

Wang, Bo; Lucy, Katie; Schuman, Joel S.; Sigal, Ian A.; Bilonick, Richard Anthony; Lu, Chen D.; Ishikawa, Hiroshi; Kagemann, Larry; Fujimoto, James G.; Wollstein, Gadi
ISI:000394210604033
ISSN: 0146-0404
CID: 4365202

Polarization microscopy for characterizing fiber orientation of ocular tissues

Jan, Ning-Jiun; Grimm, Jonathan L; Tran, Huong; Lathrop, Kira L; Wollstein, Gadi; Bilonick, Richard A; Ishikawa, Hiroshi; Kagemann, Larry; Schuman, Joel S; Sigal, Ian A
Characterizing the collagen fiber orientation and organization in the eye is necessary for a complete understanding of ocular biomechanics. In this study, we assess the performance of polarized light microscopy to determine collagen fiber orientation of ocular tissues. Our results demonstrate that the method provides objective, accurate, repeatable and robust data on fiber orientation with microm-scale resolution over a broad, cm-scale, field of view, unaffected by formalin fixation, without requiring tissue dehydration, labeling or staining. Together, this shows that polarized light microscopy is a powerful method for studying collagen architecture in the eye, with applications ranging from normal physiology and aging, to pathology and transplantation.
PMCID:4679248
PMID: 26713188
ISSN: 2156-7085
CID: 2216632