Faculty Bibliography

OBJECTIVE:To compare association of perfluoroalkyl substances (PFASs) with metabolic syndrome (MetS) profile among firefighters (FF) at airport to suburban FF. METHODS:Cross-sectional exploratory study, 47 men FF aged 18 to 62 years were enrolled from two fire departments in Ohio. Association between MetS outcome and log transformed serum concentrations of four PFASs was evaluated using multivariable logistic regression. RESULTS:PFASs serum concentrations were 18% to 74% higher in FF than the general population, and 21% to 62% higher in airport FF than suburban FF. Compared with US general population, an elevated risk of hypertension was noted in FF, but no significant association between PFASs and MetS was found. CONCLUSIONS:Current serum PFASs in FF are not associated with MetS risk.

Approximately 200 million m³ of sediments are dredged every year in the United States. Of this amount, 2.3-9 million m³ are contaminated to the extent that they require special, and often costly, handling. Therefore, there is a pressing need to develop appropriate technology for the safe utilization of these sediments, especially in the case of the Hudson River, which is well known to demonstrate significant polychlorinated biphenyls (PCBs) contamination. Hence, the aim of the present study was to examine the influence of different doses of Hudson River sediments (10%, 25%, 50%, 75% and 100% admixtures) on soil quality and on the biochemical and growth response of cucumber (Cucumis sativus L. cv 'Wisconsin SMR 58'), used as potential phytoremediation tool for sediment-borne PCBs. A sediment/soil admixture was found to significantly decrease the nitrogen (N) content in the substratum; in addition, phosphorus (P) content was significantly increased by 50-100% sediment, while potassium (K) content was significantly increased by 10% sediment, and significantly decreased by >50% sediment. Although sediment treatment resulted in a gradual increase in PCB content in the soil-sediment substratum, exceeding the threshold effect concentration (TEC) for the ≥50% sediment admixture, the Microtox assay did not suggest toxicity to microorganisms. The results demonstrated also that admixture of 10-25% Hudson River sediment increased cucumber growth; however, higher doses led to growth inhibition, manifested as lower biomass and smaller leaves. Also, chlorophyll a and b content decreased with increasing doses of sediment. Phenylpropanoid and flavonol contents were significantly higher in plants grown in soil amended with 10% of sediment, but significantly lower in soil treated with a 100% sediment admixture. The anthocyanin content in plants was lower at admixtures of 50% and higher. The obtained results corresponded with the decreasing content of N and K.

We derive differential equations to determine the kinetics of gas/particle partitioning of semi-volatile organic compounds (SVOCs). These equations model the transient states from initiation of sorption to particles (non-steady state) through the establishment of steady state. Two hypothetical scenarios are examined: (1) exchange of SVOCs between gas- and particle-phases alone; and (2) both gas/particle partitioning and wet and dry deposition of particles. The differential equations show that, under Scenario 1, a steady state is reached as an equilibrium between gas- and particle-phases, whereas under Scenario 2, the attained steady state is not in equilibrium. Our model shows that SVOCs in atmosphere where particle deposition is occurring reach a steady non-equilibrium state sooner than they would reach equilibrium under Scenario 1. We infer that SVOCs in the atmosphere will reach steady state instead of equilibrium between gaseous and particulate phases in circumstances where wet and dry deposition of particles cannot be neglected. In addition, our study indicates that the time for SVOCs to reach steady state in the atmosphere is fast, most likely within minutes or hours, suggesting that SVOCs are in steady or quasi-steady state in the atmosphere. Our analysis also reveals that gas/particle partitioning and particle deposition of SVOCs are dependent on each other.

Melamine-based resins are used extensively in fabrics to impart fire and heat resistance as well as wrinkle-free properties. Little is known, however, regarding the occurrence of melamine and its derivatives in textiles. In this study, concentrations of melamine, ammeline, ammelide, and cyanuric acid were determined in 77 textile samples and infant clothing purchased from Albany, New York, USA. All textile samples contained one or more target analytes, at concentration ranges of 1.19-81,800, 3.21-17,800, <1.20-25,700, and <0.50-550 ng/g for melamine, cyanuric acid, ammeline, and ammelide, respectively. Melamine was the predominant compound, accounting for 52% of the total concentrations of four analytes (i.e., ∑melamines). Significant positive correlations were found between the concentrations of melamine and its three derivatives (0.347 < r < 0.862, p < .01). The concentrations of ∑melamines were significantly higher in cotton fabrics (mean: 10,500 ng/g) and cotton clothes (10,200 ng/g) than in synthetic fabrics (1,380 ng/g) and socks (40.0 ng/g) (p < .01). Simulated laundry experiments suggested that a single round of washing with water removed 76-90% of melamine from clothing. The calculated dermal exposure doses of melamine and cyanuric acid were three to four orders of magnitude below the reference value. This study provides the first evidence of the occurrence of melamine derivatives in textiles and clothing purchased in the United States. CAPSULE: Melamine and cyanuric acid are widely distributed in textiles and infant clothing collected from the United States.

BACKGROUND:Insufficient or excessive gestational weight gain are associated with increased risks of adverse birth and childhood outcomes. Increasing evidence suggests that exposure to bisphenols and phthalates may disrupt hormonal pathways and thereby influence gestational weight gain. OBJECTIVE:To examine the associations of early and mid-pregnancy bisphenol and phthalate urine concentrations with gestational weight gain. METHODS:In a population-based prospective cohort study among 1,213 pregnant women, we measured early and mid-pregnancy bisphenol and phthalate urine concentrations. Maternal anthropometrics before pregnancy were obtained by questionnaire and repeatedly measured at our research center during pregnancy. We used linear and logistic regressions to evaluate the associations of bisphenols and phthalates with total and period-specific gestational weight gain. RESULTS:Higher maternal total bisphenols and bisphenol S were associated with a lower total gestational weight gain at nominal level. Stratification by body mass index group showed that higher total bisphenols and bisphenol S were associated with lower total gestational weight gain specifically in normal weight women (respectively -509 g [95% CI -819, -198] and -398 g [95% CI -627, -169]). Each log unit increase in early pregnancy total bisphenol and bisphenol A urine concentrations were associated with lower mid- to late pregnancy gestational weight gain in the whole group (effect estimates -218 g/log unit increase [95% CI -334, -102] and -132 g/log unit increase [95% CI -231, -34], respectively). These associations were independent of mid-pregnancy compounds. Mid-pregnancy bisphenols and phthalates concentrations were not associated with gestational weight gain. DISCUSSION/CONCLUSIONS:Higher maternal bisphenol urine concentrations in early pregnancy may lead to reduced gestational weight in second half of pregnancy. Further research is needed to assess the effects of maternal bisphenols and phthalates urine concentrations on placental and fetal growth and development.

Temporal trends in plasma concentrations of per- and polyfluoroalkyl substances (PFAS) in free-ranging bottlenose dolphins (Tursiops truncatus) inhabiting two geographic areas: Indian River Lagoon, Florida over the years 2003-2015 and the waters surrounding Charleston, South Carolina over 2003-2013, were examined. Nine PFAS met the inclusion criteria for analysis based on percent of values below level of detection and sampling years. Proportionate percentiles parametric quantile regression assuming lognormal distributions was used to estimate the average ratio of PFAS concentrations per year for each chemical. Plasma concentrations decreased over time for perfluorodecanoate (PFDA), perfluorohexane sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and perfluoroundecanoate (PFUnDA) in both locations. Perfluorononanoate (PFNA) decreased with time in Indian River Lagoon dolphins. Perfluorododecanoate (PFDoDA) concentrations significantly increased over time among female Indian River Lagoon dolphins. Regulation and phaseout of specific PFAS groups may have led to the decreasing levels of those PFAS and increasing levels of other replacement PFAS.

The extensive use of melamine and its three derivatives (i.e., ammeline, ammelide, and cyanuric acid) resulted in their widespread occurrence in the environment. Nevertheless, limited information is available on their distribution in the aquatic environment. In this study, concentrations and profiles of melamine and its derivatives were determined in 223 water samples, comprising river water, lake water, seawater, tap water, bottled water, rain water, wastewater, and swimming pool water, collected from New York State, USA. The sum concentrations of melamine and its derivatives (∑₄MELs) decreased in the following order: swimming pool water (median: 1.5 × 10⁷ ng/L) ≫ wastewater (1240) > precipitation (739) > tap water (512) > river water (370) > lake water (347) > seawater (186) > bottled water (98). Cyanuric acid was the major compound, accounting for 60-100% of ∑₄MELs concentrations in swimming pool water, wastewater, precipitation, tap water, seawater, and bottled water, whereas melamine dominated in river and lake water (54-64% of ∑₄MELs). Significant positive correlations (0.499 < R < 0.703, p < 0.002) were found between the concentrations of melamine and atrazine (a triazine herbicide) in surface waters. The geographic distribution in the concentrations of ∑₄MELs in river, lake, and tap water corresponded with the degree of urbanization, suggesting that human activities contribute to the sources melamine and cyanuric acid in the aquatic environments. A preliminary hazard assessment of melamine and cyanuric acid in waters suggested that their ecological or human health risks were minimal. This is the first study to document the occurrence and spatial distribution of melamine and its derivatives in waters from the United States.

A total of 20 organophosphate triesters (OPEs), including seven alkyl-OPEs, three chlorinated (Cl)-OPEs, seven aryl-OPEs, and three oligomeric-OPEs were measured in 341 house dust samples collected from 12 countries during the period 2010-2014. OPEs were ubiquitous in indoor dust, and the total concentrations of OPEs (∑OPEs; sum of 20 OPEs) ranged from 49.4 to 249,000 ng/g dry weight (dw). Generally, Cl-OPEs were the predominant compounds (51% of total) in indoor dust samples, with a median concentration of 800 ng/g, followed by alkyl-OPEs (31%), aryl-OPEs (17%), and oligomeric-OPEs (1%), with median concentrations of 480, 270, and 21.9 ng/g, respectively. ∑OPE concentrations in indoor dust from more industrialized countries (South Korea: median, 31,300; Japan: 29,800; and the United States: 26,500 ng/g dw) were one or two orders of magnitude higher than those from less industrialized countries (Greece: 7140, Saudi Arabia: 5310, Kuwait: 4420, Romania: 4110, Vietnam: 1190, China: 1120, Colombia: 374, India: 276, and Pakistan: 138 ng/g dw). Statistically significant positive correlations (0.114 < r < 0.748, p < 0.05) were found among the concentrations of 16 OPEs in dust samples, indicating similar sources of these compounds. The median estimated daily intakes of ΣOPEs via dust ingestion for children and adults were in the ranges of 0.29-64.8 and 0.07-14.9 ng/kg bw/day, respectively.