Try a new search

Format these results:

Searched for:

in-biosketch:yes

person:jhw1

Total Results:

284


PREGNANCY IN PATIENTS WITH CEREBROSPINAL-FLUID SHUNTS - REPORT OF A SERIES AND REVIEW OF THE LITERATURE - REPLY [Letter]

WISOFF, JH
ISI:A1992HV27400033
ISSN: 0148-396x
CID: 571072

Complications of ventriculoperitoneal shunt procedures or hydrocephalus associated with vein of Galen malformations in childhood

Schneider SJ; Wisoff JS; Epstein FJ
Twenty children with vein of Galen malformations and hydrocephalus required a ventriculoperitoneal shunt. Shunt placement was associated with a 70% incidence of complications that included status epilepticus in 3 patients, intraventricular hemorrhage in 7 patients, and subdural hematoma or hygroma in 5 patients. Based upon this experience, the authors recommend the use of preoperative prophylactic anticonvulsants and the placement of medium pressure frontal ventriculoperitoneal shunts. This report will address the overall experience with and the basis on which these therapeutic recommendations were made
PMID: 1584382
ISSN: 0148-396x
CID: 13610

Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children [Case Report]

Allen J; Wisoff J; Helson L; Pearce J; Arenson E
Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required. Chemotherapy (CHT), as opposed to radiotherapy (RT), has a more desirable risk/benefit role in infants, since it is relatively sparing of late neurologic sequelae. Three young male children presented with large intraventricular CPC at 9, 18, and 27 months of age. One child had subarachnoid metastases at diagnosis and the other two had localized disease. Subtotal resections were accomplished and all three required VP shunts. Initial CHT consisted of four monthly courses of cisplatin (20 mg/m2) and etoposide (100 mg/m2), both administered intravenously, daily, for five days. After four courses, two children had complete responses and one had stable disease. Additional CHT was given but one child developed a local recurrence and another diffuse CNS metastases. Both died with intratumoral hemorrhages at 5 and 57 months following diagnosis. The third child remains in continuous remission 46 months after diagnosis. None of the children received RT. Chemotherapy may permit long term deferral of RT. More aggressive CHT regimens should be explored in infants with CPC
PMID: 1541980
ISSN: 0167-594x
CID: 13753

Osteoplastic laminotomy in children

Abbott R; Feldstein N; Wisoff JH; Epstein FJ
The article reviews 180 cases of osteoplastic laminotomies, 1 year after operation. The patients were predominantly children undergoing selective dorsal rhizotomies. Also included were a few pediatric patients who received laminotomies for spinal cord tumors. Spinal X-rays were reviewed at 1 and 3 years of follow-up. There was complete to partial bridging of the laminar roof in all cases. This experience confirms that the procedure is well tolerated and is associated with reossification of the replaced bony segment
PMID: 1457375
ISSN: 1016-2291
CID: 13773

Optimal wound closure after tethered cord correction

Zide BM; Epstein FJ; Wisoff JH
ORIGINAL:0005172
ISSN: n/a
CID: 50638

Brain stem and spinal cord tumors in children

Chapter by: Lassoff S; Allen J; Epstein F; Wisoff J
in: Pediatric neuro-oncology : new trends in clinical research by Packer RJ; Bleyer WA; Pochedly C [Eds]
Chur, Switzerland : Harwood Academic Publ, 1992
pp. 111-127
ISBN: 3718605244
CID: 3610

Functional outcome following radical removal of craniopharyngiomas in children [Meeting Abstract]

Rosenberg, ME; Wisoff, JH; Kupersmith, M; Epstein, F
ORIGINAL:0008482
ISSN: 0022-3085
CID: 574832

Chemotherapy for infants with malignant brain tumors : report for the Children's Cancer Study Group trials CCG 921 and CCG 945 [Meeting Abstract]

Geyer, R; Zeltzer, P; Finlay, J; Albright, L; Wisoff, J; Rorke, L; Yates, A; Boyett, J; Milstein, J; Berger, M; Shurin, S; Allen, J; McGuire, P; Stanley, P; Stehbens, J; Stevens, K; Tefft, M; Bertolone, S; Biegel, J; Edwards, M; Sutton, L; Wara, W; Hammond, D
ORIGINAL:0008488
ISSN: 0736-7589
CID: 574892

Current trends in the management of brainstem tumors in childhood

Shiminski-Maher T; Abbott R; Wisoff JH; Epstein FJ
Historically, the prognosis for a child diagnosed with a brainstem tumor has been bleak. The development of magnetic resonance imaging (MRI) has allowed for detailed visualization of tumors within the brainstem. This knowledge combined with the clinical history and neurological examination allows subcategorization of such tumors and delineation of children who might benefit from surgery. Surgical candidates include children with long clinical histories, focal neurological deficits and focal, cystic, exophytic or cervico-medullary tumors on the MRI scan. All children have the potential for multiple cranial nerve abnormalities, extremity weakness and swallowing and breathing difficulties. Nursing care of patients with brainstem tumors is complex and challenging
PMID: 1839543
ISSN: 0888-0395
CID: 13820

Pregnancy in patients with cerebrospinal fluid shunts: report of a series and review of the literature

Wisoff JH; Kratzert KJ; Handwerker SM; Young BK; Epstein F
Hydrocephalic women with cerebrospinal fluid shunts are now surviving to reproductive age. Twenty-one pregnancies in 18 patients with shunts, including 11 from the present series and 10 from previous series, were analyzed for neurological, obstetrical, and perinatal outcome. Fourteen women had preexisting shunts, and 4 had the onset of symptomatic hydrocephalus and the placement of shunts during pregnancy. Neurological complications occurred in 13 of 17 (76%) pregnancies in patients with preexisting shunts, including symptoms of increased intracranial pressure (ICP) in 10 of 17 (59%) pregnancies, exacerbation of seizure disorder in 2 of 17 (12%) pregnancies, and severe headaches without increased ICD in 1 patient. In 7 of 11 (66%) of the symptomatic patients, symptoms spontaneously resolved postpartum. Four of 17 (23%) of these pregnancies were associated with shunt obstruction requiring antepartum or postpartum surgery. Four patients had a primary shunt placement, and one had a shunt revision during pregnancy without complications. There were no unusual obstetrical or perinatal complications in the series. The clinical management of pregnant patients with hydrocephalus should include preconception counseling and magnetic resonance imaging, as well as the use of serial antenatal magnetic resonance images, ICP monitoring, or the judicious use of radioisotope studies of shunt patency if signs of increased ICP appear. A cesarean section is recommended for the delivery of the neurologically unstable patient. For asymptomatic mothers, a vaginal delivery with a shortened second stage and prophylactic antibiotics are advised
PMID: 1758592
ISSN: 0148-396x
CID: 13831