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Designing clinical trials for new drugs: ethics, governance, and reputational challenges

Miller, Jennifer; Caplan, Arthur; Blasimme, Alessandro
ORIGINAL:0011871
ISSN: 2334-1882
CID: 2530412

Beyond the Abortion Wars [Book Review]

Caplan, Arthur L
ISI:000367748800002
ISSN: 1536-0075
CID: 2374162

Medical Ethicist Arthur Caplan Explains Why He Opposes 'Right-to-Try' Laws [Interview]

Caplan, Arthur
PMID: 26791839
ISSN: 0890-9091
CID: 1942142

Compassionate Use: A Modest Proposal

Caplan, Arthur L; Bateman-House, Alison; Waldstreicher, Joanne
PMID: 27249724
ISSN: 1548-8756
CID: 2124842

A Panglossian Analysis of the Abortion Controversy

Caplan, Arthur
PMID: 26982945
ISSN: 1536-0075
CID: 2031412

Historical development and current status of organ procurement from death-row prisoners in China

Allison, Kirk C; Caplan, Arthur; Shapiro, Michael E; Els, Charl; Paul, Norbert W; Li, Huige
BACKGROUND: In December 2014, China announced that only voluntarily donated organs from citizens would be used for transplantation after January 1, 2015. Many medical professionals worldwide believe that China has stopped using organs from death-row prisoners. DISCUSSION: In the present article, we briefly review the historical development of organ procurement from death-row prisoners in China and comprehensively analyze the social-political background and the legal basis of the announcement. The announcement was not accompanied by any change in organ sourcing legislations or regulations. As a fact, the use of prisoner organs remains legal in China. Even after January 2015, key Chinese transplant officials have repeatedly stated that death-row prisoners have the same right as regular citizens to "voluntarily donate" organs. This perpetuates an unethical organ procurement system in ongoing violation of international standards. CONCLUSIONS: Organ sourcing from death-row prisoners has not stopped in China. The 2014 announcement refers to the intention to stop the use of organs illegally harvested without the consent of the prisoners. Prisoner organs procured with "consent" are now simply labelled as "voluntarily donations from citizens". The semantic switch may whitewash sourcing from both death-row prisoners and prisoners of conscience. China can gain credibility only by enacting new legislation prohibiting use of prisoner organs and by making its organ sourcing system open to international inspections. Until international ethical standards are transparently met, sanctions should remain.
PMCID:4668660
PMID: 26630929
ISSN: 1472-6939
CID: 1863512

Right-to-Try Laws: Hope, Hype, and Unintended Consequences

Bateman-House, Alison; Kimberly, Laura; Redman, Barbara; Dubler, Nancy; Caplan, Arthur
PMID: 26413841
ISSN: 1539-3704
CID: 1882622

No time to waste-the ethical challenges created by CRISPR: CRISPR/Cas, being an efficient, simple, and cheap technology to edit the genome of any organism, raises many ethical and regulatory issues beyond the use to manipulate human germ line cells

Caplan, Arthur L; Parent, Brendan; Shen, Michael; Plunkett, Carolyn
PMCID:4641494
PMID: 26450575
ISSN: 1469-3178
CID: 1794772

Organ Donation After Circulatory Death--Reply [Letter]

Wall, Stephen P; Plunkett, Carolyn; Caplan, Arthur
PMID: 26501547
ISSN: 1538-3598
CID: 1816692

Ethics of Provider Risk Factor Modification in Total Joint Arthroplasty

Bronson, Wesley H; Lindsay, David; Lajam, Claudette; Iorio, Richard; Caplan, Arthur; Bosco, Joseph
PMID: 26446971
ISSN: 1535-1386
CID: 1793212