Faculty Bibliography

BACKGROUND:We reviewed the radiologic features of 15 patients with orbital metastases originating from breast cancer. METHODS:This was a retrospective consecutive case series. Fifteen consecutive patients with orbital metastases originating from breast carcinoma were identified between March 1997 and September 2008. A retrospective chart review was carried out, and the radiologic findings were reviewed. RESULTS:The metastases were preseptal in 53%, intraconal in 60%, and both intraconal and extraconal in 33%. Lacrimal gland enlargement was noted in 33%, episcleral space involvement in 33%, bone involvement in 13%, and globe dystopia in 53%. The extraocular muscles were involved in 87%; in 60%, two or more muscles were involved. The medial and lateral rectus muscles were affected in 53% and 47%, respectively, and the inferior and superior rectus muscles in 33%. In 47% one or more radiologic features had not been noted by the radiologist, and in 20% the findings were misinterpreted as an"orbital pseudotumor." CONCLUSION/CONCLUSIONS:Orbital metastases originating from breast cancer may present heterogeneously. Orbital imaging most commonly shows unilateral and multifocal involvement of multiple extraocular muscles and intraconal and preseptal areas by an irregular lesion.

BACKGROUND:Actinidia deliciosa (kiwifruit) is used as a meat tenderizer. It acts rapidly and efficiently to soften meat, liquefying it if allowed to work for more than a few hours. Observing this effect and the lack of studies addressing this subject in the literature, the authors sought to investigate the use of this natural remedy in an animal model for eschar separation and debridement. METHODS:Thirty-five male rats were divided randomly into three groups. Under general anaesthesia, a limited standard full-thickness burn was produced on the back of each rat. For the intervention group (G1, 15 rats), the wounds were covered with fresh kiwifruit; for control groups 2 and 3 (G2, 15 rats; G3, five rats), the dressing was a neutral ointment (Emulsifier 1220). Weekly wound observations were documented for all the groups. G1 and G2 were sacrificed on Day 20, and group 3 was kept alive until complete eschar separation. The wounds of the rats in groups 1 and 2 were excised and subjected to microscopic evaluation. RESULTS:On Day 20, all eschars had detached and fallen off in the intervention group (G1), whereas in groups G2 and G3 the eschars were still firmly attached to the base of the wounds (except in two rats of G2); this finding was statistically significant (p<0.001). The average wound surface area in group G1 was 212 mm(2) (SD=88.80938) whereas in G2 it was 388 mm(2) (SD=140.6967). Thus, the wound surface area was significantly (p<0.001) smaller in the intervention group. The eschars in G3 separated spontaneously between days 30 and 42, while in all the rats of the kiwi-treated group, this phenomenon occurred before Day 20. The pathological study revealed no considerable differences between G1 and G2 (p<0.05). CONCLUSIONS:Debridement and scar contraction occurred faster in the kiwi-treated group than in the untreated group. Following rapid enzymatic debridement, healing appeared to progress normally, with no evidence of damage to adjacent healthy tissue.

BACKGROUND:In most references to the nasal anatomy, the shape of the lower lateral cartilage (LLC) is described as a two-dimensional structure. However, the authors have found different forms of LLC in at least 40% of their open rhinoplasty cases during the past 20 years. This cartilage was found to have a three-dimensional hemispheric appearance and to be connected to the upper lateral cartilage (ULC) at the scroll area by an inward limb of this hemisphere. This inward limb may have an important role in producing asymmetry and flare of the nostril. METHODS:The LLC of 286 patients was evaluated during open rhinoplasty over a 2-year period, with a focus mainly on the shape of this structure, especially at the LLC-ULC junction (scroll area). RESULTS:A dome-shaped appearance of the LLC was noted in 40.9% of cases, and 11.5% of cases had bilateral LLC variation. This different anatomic form was seen mostly in patients with a strong bulbous nasal tip, although it was observed less frequently also in patients with narrow nasal tips. CONCLUSION/CONCLUSIONS:At least one-third of the LLCs analyzed had a medial wall in addition to the lateral wall, which significantly increased the flare and recoil force of this structure. This makes this cartilage more redundant to reshaping procedures (straightening). Thus, special attention must sometimes be paid to this common anatomic variation to produce symmetric nostrils and to obtain a more aesthetically acceptable alar tip.

BACKGROUND:Infectious keratitis after PRK remains a rare but potentially devastating complication. HISTORY AND SIGNS/METHODS:Medical records of 3 male patients with infectious keratitis after uneventful PRK for myopia and astigmatism were reviewed retrospectively. PRK was performed using the Wavelight Allegretto excimer laser. Postoperative care included a bandage contact lens (BCL) for 5 days, topical antibiotics, ketorolac, and artificial tears. THERAPY AND OUTCOME/RESULTS:Keratitis presented 2 - 4 days postoperatively. In one case, each culture was negative (case 1), and was positive for Streptococcus pneumoniae (case 2) and Staphylococcus aureus (case 3). Final BSCVA (best spectacle corrected visual acuity) after intensive antibiotic treatment and removal of BCL were 1.0 (case 1), 0.9 (case 2) and 0.3 correctable to 0.8 with pinhole (case 3). CONCLUSIONS:Postoperative broad-spectrum antibiotics are mandatory after PRK to prevent infectious keratitis. However, resistant organisms are more and more common. The presence of a bandage soft contact lens after surgery is an unfavourable element that may increase risk of infection. Based on our case series, we suggest limiting soft contact lens wear during the two postoperative days even if the corneal ulceration is not healed.

PURPOSE/OBJECTIVE:To report persistent subepithelial haze in two patients following femtosecond LASIK associated with creation of a thin flap. METHODS:Subepithelial haze was assessed by slit-lamp photography, high-resolution Scheimpflug imaging, and corneal confocal microscopy. RESULTS:Two patients showed distinct subepithelial haze and reduced corrected distance visual acuity at 3 months after LASIK with a think-flap generated by a femtosecond laser. The extent of haze was documented, and the haze was treated topically with steroids up to 12 weeks. The haze was localized approximately 20 to 40 microm below Bowman's layer and dissolved slowly during the 2 months of treatment. At 6 months after surgery, uncorrected visual acuity was 20/20. CONCLUSIONS:Subepithelial haze formation represents a new potential complication in the thin-flap LASIK.

BACKGROUND:To evaluate the frequency of anterior surface breakdown for three techniques of evisceration with primary implant placement: the "classic" technique, the "scleral modification" technique, and the novel "scleral patch" technique. METHODS:Retrospective comparative case series with 73 consecutive eviscerations with primary implants that were performed in the Eye Clinic Rotterdam between January 2003 and January 2007. RESULTS:The operations involved the classic technique for 55% of the patients, scleral modification for 29%, and the novel scleral patch technique for 16%. In all, 9.6% of the patients had conjunctival breakdown: six in the classic group and one in the patch group. Although the frequency of this complication was higher in the classic group, the difference was not significant (P>0.05, chi-square test). Anterior surface breakdown was not related to implant size or prior eye surgery. CONCLUSION/CONCLUSIONS:Compared with the scleral modification and scleral patch techniques, conjunctival breakdown and implant extrusion were seen more frequently after classic evisceration with implant placement. Implant size or indication for surgery were not related to the frequency of these complications.

Deviated nose correction is difficult and constitutes a very different issue from septal deviation. When correcting this deformity, traces of asymmetry can be detected. The authors demonstrate facial asymmetry accompanying deviated noses, and such asymmetry is usually ignored by surgeons who typically concentrate only on nose deformities.A total of 5822 pre- and postrhinoplasty photographs related to 547 women and 124 men were reviewed. Out of the total population, the following 3 groups were selected: group A, gross nose and face asymmetry; group B, nose asymmetry with no facial deformity; group C, facial asymmetry with straight nose. Different measurements were applied to the selected photos, presented in . These included measurement from the lateral canthi to the lateral mouth corners (D1) and from the midface to each most lateral part of the zygomatic arch (D2). Measurements from one side were compared with those from the contralateral side to identify true anatomic differences, as presented in .(Table is included in full-text article.)(Figure is included in full-text article.)There was a significant difference in the nose and face deformity group, as evidenced by a meaningful difference in both the D1 and D2 measurements.We report a significant growth retardation of the midface and orbit on the concave side of the nose. This impediment may serve as the etiology for many asymmetries of the face and nose.

We report a case of bilateral lacrimal gland involvement as the first sign of Waldenstrom's macroglobulinaemia in a patient with sarcoidosis. Histological analysis of an incisional biopsy revealed a lymphoplasmocytic lymphoma consistent with Waldenstrom's macroglobulinaemia. No noncaseating granulomas were encountered. Systemic treatment was initiated and resulted in complete resolution of the lesions. In a patient with a systemic disease, such as sarcoidosis, and lacrimal gland involvement, a biopsy of the lacrimal gland mass should be taken to make a correct diagnosis and start appropriate treatment.