Increased Interferon Production in Human Cells Irradiated with Ultraviolet Light
Mozes LW; Havell EA; Gradoville ML; Vilcek J
Polyinosinate-polycytidylate [poly(I).poly(C)]-induced interferon production in cultures of human foreskin fibroblast strains was increased by ultraviolet irradiation of cells at the time of exposure to inducer or at 2 h after induction. Incubation of cells with interferon prior to induction (priming) and ultraviolet irradiation exerted a cooperative enhancing effect on interferon production. The resulting interferon yields were generally somewhat higher than the yields from cultures subjected to sequential treatment with cycloheximide and actinomycin D
PMCID:423082
PMID: 16558110
ISSN: 1098-5522
CID: 78904