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Medicinal use of cocaine: a shifting paradigm over 25 years

Long, Heather; Greller, Howard; Mercurio-Zappala, Maria; Nelson, Lewis S; Hoffman, Robert S
OBJECTIVES/HYPOTHESIS: Human cocaine research is predicated on data from the clinical practice of otolaryngology that are more than 25 years old and predate both the cocaine epidemic and the first reported association between cocaine use and myocardial infarction. The authors' objective was to reassess the epidemiology and toxicity of medicinal cocaine use among otolaryngologists and to compare current trends in usage and safety data with previously reported data. STUDY DESIGN: An anonymous closed-question survey replicating the methodology of a previous study was used. METHODS: The survey was mailed to active members of the American Academy of Otolaryngology-Head and Neck Surgery. The survey used a closed-question format asking about the use of cocaine, safety measures taken, and adverse outcomes and included information about practice type and location. Results were compared with previously published data using a chi test with P < .05 considered significant. RESULTS: In all, 7815 surveys were mailed. Four thousand seventeen otolaryngologists returned the survey, representing a 54% response rate. Of the respondents, only 50% had used cocaine in their practice during the previous year. Physicians who had been in practice for less than 10 years were less likely to have used cocaine than those who had been in practice for more than 10 years (78% vs. 93% [P < .001]). Compared with the data reported in 1977, fewer physicians reported ever using cocaine in their practice (88% vs. 92% [P < .001]), fewer physicians had used cocaine in their practice at any time in the previous 10 years (68% vs. 92% [P < .001]), and a greater number of adverse reactions were reported by current respondents (26% vs. 22% [P < .001]). Tachycardia and hypertension were the most commonly reported adverse effects. Other important adverse events included 14 deaths, survivable cardiac arrest, ventricular tachycardia, and seizures. CONCLUSION: The clinical use of cocaine in otolaryngology has decreased significantly in the past 25 years as a result of discontinuation of use by physicians who had previously used cocaine and an increasing number of otolaryngologists who have never used it. This decline may reflect a better understanding of its potential toxicities, problems associated with storing and dispensing of a tightly controlled substance, increased availability of safer alternative medications, or a combination of these
PMID: 15475793
ISSN: 0023-852x
CID: 65882

Expired 2-PAM effectively reverses cholinergic crisis in humans [Meeting Abstract]

Bouchard NC; Mercurio-Zappala M; Abreu EM; Mendoza P; Nelson LS; Hoffman RS; Cabral-Baez JM
ORIGINAL:0005849
ISSN: 0731-3810
CID: 70364

Is regional ethnicity related to poison center utilization? [Meeting Abstract]

Schwartz L; Mercurio-Zappala M; Howland MA; Nelson LS; Hoffman RS
ORIGINAL:0005847
ISSN: 0731-3810
CID: 70362

Using GIS software for planning poison education programs [Meeting Abstract]

Schwartz L; Mercurio-Zappla M; Howland MA; Nelson LS; Resnick S; Hoffman RS
ORIGINAL:0005846
ISSN: 0731-3810
CID: 70361

The use of focus groups to plan poison prevention education programs for low-income populations

Schwartz, Lauren; Howland, Mary Ann; Mercurio-Zappala, Maria; Hoffman, Robert S
Children younger than 5 are at greatest risk for unintentional poisonings. Children in low-income situations are particularly vulnerable for exposures to potential poisons. Focus groups were conducted at a Women, Infants, and Children (WIC) program located in a large urban public hospital in New York City to gain information from low-income parents of young children about real and perceived barriers to calling the local poison control center, resources for poison prevention messages, and ideas about public awareness campaigns. All focus group members were low-income parents of young children. Most participants reported that they would call 911 in the event of a poisoning due to child welfare and self-efficacy issues. Health education theory using the social-cognitive theory provides a framework for developing future poison prevention programs to address identified issues with parents of young children
PMID: 14611005
ISSN: 1524-8399
CID: 107303

Medicinal use of cocaine: A shifting paradigm over 25 years [Meeting Abstract]

Long, H.; Greller, H.; Mercurio-Zappala, M.; Nelson, L. S.; Hoffman, R. S.
BIOSIS:PREV200300505329
ISSN: 0731-3810
CID: 107327

Preparing for chemical terrorism: Stability of expired atropine

Schier, J. G.; Mehta, R.; Mercurio-Zappala, M.; Nelson, L. S.; Howland, M. A.; Hoffman, R. S.
BIOSIS:PREV200200581217
ISSN: 0731-3810
CID: 107328

Follow up study with parents given cabinet safety locks

Schwartz, L.; Howland, M. A.; Mercurio-Zappala, M.; Hoffman, R. S.
BIOSIS:PREV200000428345
ISSN: 0731-3810
CID: 107330

The use of focus groups to plan poison prevention programs

Schwartz, L.; Howland, M. A.; Mercurio-Zappala, M.; Hoffman, R.
BIOSIS:PREV200000428343
ISSN: 0731-3810
CID: 107329

Carbaryl poisoning: 2-PAM or not 2-PAM

Mercurio-Zappala, M.; Hack, J.; Salvador, A.; Hoffman, R. S.
BIOSIS:PREV199800467695
ISSN: 0731-3810
CID: 107331