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378


Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis

Tian, Henghe; Cronstein, Bruce N
Methotrexate has been widely used for the treatment of rheumatoid arthritis (RA). The mechanisms of action of methotrexate are complex. Developed as a folic acid analogue, methotrexate inhibits purine and pyrimidine synthesis, which accounts for its efficacy in the therapy of cancer as well as for some of its toxicities. Recently, many studies have focused on the adenosine-mediated antiinflammatory effects of methotrexate. Certain aspects of methotrexate toxicities are also attributed to adenosine release. A better understanding of the mechanisms of action and toxicities of methotrexate will direct clinicians in their treatment approach and toxicity monitoring. Toward that objective, the latest developments in the pharmacokinetics, mechanism of action, pharmacogenetics, and toxicity of methotrexate are herein discussed
PMID: 17922664
ISSN: 1936-9719
CID: 75659

Future treatment of rheumatic diseases: The role of pharmacogenetics

Fisher M.C.; Cronstein B.N.; Greenberg J.D.
EMBASE:2008009228
ISSN: 1746-0816
CID: 75700

Adenosine receptors, wound healing, and angiogenesis

Chapter by: Sheth, Aneesh; Cronstein, Bruce
in: Adenosine receptors : therapeutic aspects for inflammatory and immune diseases by
Boca Raton FL : CRC/Taylor & Francis, 2007
pp. ?-?
ISBN: 0849339995
CID: 4824

Adenosine receptors : therapeutic aspects for inflammatory and immune diseases

Hasko, Gyorgy; Cronstein, Bruce N; Szabo, Csaba
Boca Raton FL : CRC/Taylor & Francis, 2007
Extent: 363 p. ; 25cm
ISBN: 0849339995
CID: 1599

Neutrophils (Polymorphonuclear Leukocytes) in Systemic Lupus Erythematosus

Chapter by: Molad, Y; Cronstein, B
in: Systemic Lupus Erythematosus by Tsokos, George C; Gordon, Caroline; Smolen, Josef S. [Eds]
Philadelphia : Mosby Elsevier, c2007
pp. 281-286
ISBN: 0323044344
CID: 644372

Do genetic variations in the adenosine pathway affect patient response to methotrexate? [Comment]

Cronstein, Bruce N
PMID: 17133247
ISSN: 1745-8382
CID: 111678

Adenosine 5 '-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation [Review]

Bours, MJL; Swennen, ELR; Di Virgilio, F; Cronstein, BN; Dagnelie, PC
Human health is under constant threat of a wide variety of dangers, both self and nonself. The immune system is occupied with protecting the host against such dangers in order to preserve human health. For that purpose, the immune system is equipped with a diverse array of both cellular and non-cellular effectors that are in continuous communication with each other. The naturally occurring nucleotide adenosine 5'-triphosphate (ATP) and its metabolite adenosine (Ado) probably constitute an intrinsic part of this extensive immunological network through purinergic signaling by their cognate receptors, which are widely expressed throughout the body. This review provides a thorough overview of the effects of ATP and Ado on major immune cell types. The overwhelming evidence indicates that ATP and Ado are important endogenous signaling molecules in immunity and inflammation. Although the role of ATP and Ado during the course of inflammatory and immune responses in vivo appears to be extremely complex, we propose that their immunological role is both interdependent and multifaceted, meaning that the nature of their effects may shift from immunostimulatory to immunoregulatory or vice versa depending on extracellular concentrations as well as on expression patterns of purinergic receptors and ecto-enzymes. Purinergic signaling thus contributes to the fine-tuning of inflammatory and immune responses in such a way that the danger to the host is eliminated efficiently with minimal damage to healthy tissues. (c) 2006 Elsevier Inc. All rights reserved
ISI:000241567500002
ISSN: 0163-7258
CID: 69186

Augmentation of cutaneous hypersensitivity by acute perceived stress is mediated by the adenosine a1 receptor [Meeting Abstract]

Mathew, S; Wilder, T; Cronstein, BN; Oliver, SJ
ISI:000240877200162
ISSN: 0004-3591
CID: 70105

COX-2 inhibitor-mediated disruption of cholesterol transport is abrogated by addition of prostaglandin D-2 or E-2: Anti-atherogenicity of a functional prostaglandin system [Meeting Abstract]

Reiss, AB; Zhang, HW; Edelman, SD; Fernandez, P; Cronstein, BN; Pillinger, MH; Ragolia, L; Carsons, S; Chan, ESL
ISI:000240877202069
ISSN: 0004-3591
CID: 70118

Atherogenic properties of lupus plasma: Increased foam cell transformation and CD36 scavenger receptor and diminished cholesterol 27-hydroxylase [Meeting Abstract]

Reiss, AB; Wan, DW; Merrill, JT; Zhang, HW; Chan, ESL; Rao, S; Belilos, E; Bonetti, L; Rosenblum, G; Belostocki, K; Belmont, HM; Cronstein, BN; Carsons, S
ISI:000240877202224
ISSN: 0004-3591
CID: 70122