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Anxiety and cardiovascular risk: Review of Epidemiological and Clinical Evidence

Olafiranye, O; Jean-Louis, G; Zizi, F; Nunes, J; Vincent, Mt
An increasing body of evidence suggests that anxiety is an independent predictor of adverse cardiovascular (CV) events. Individuals with high levels of anxiety are at increased risk of coronary heart disease, congestive heart failure, stroke, fatal ventricular arrhythmias, and sudden cardiac death. Anxiety following a major cardiac event can impede recovery, and is associated with a higher morbidity and mortality. This linkage between anxiety and CV disease is further corroborated by evidence suggesting that treatment of anxiety may improve cardiac symptoms. However, the mechanisms underlying the observed associations are not entirely delineated. Several intermediary mechanisms have been suggested, including sympathetic activation, impaired vagal control, reduced heart rate variability, stimulation of the hypothalamic-pituitary axis, hyperventilation-induced coronary spasm, oxidative stress, increased inflammatory mediators, and unhealthy lifestyle. There is a need for several clinical trials to explicate the complex associations between anxiety and CV disease, which may be compounded by the involvement of other psychosocial factors. In this review, we examine the epidemiological evidence for the association between anxiety and CV disease, and discuss the proposed mechanisms that may be responsible for this association.
PMCID:3150179
PMID: 21822473
ISSN: 2042-468x
CID: 307742

Resistant hypertension and obstructive sleep apnea in the primary-care setting

Demede, M; Pandey, A; Zizi, F; Bachmann, R; Donat, M; McFarlane, S I; Jean-Louis, G; Ogedegbe, G
We ascertained the prevalence of resistant hypertension (RH) among blacks and determined whether RH patients are at greater risk for obstructive sleep apnea (OSA) than hypertensives. Method. Data emanated from Metabolic Syndrome Outcome Study (MetSO), a study investigating metabolic syndrome among blacks in the primary-care setting. Sample of 200 patients (mean age = 63 +/- 13 years; female = 61%) with a diagnosis of hypertension provided subjective and clinical data. RH was defined using the JNC 7and European Society guidelines. We assessed OSA risk using the Apnea Risk Evaluation System ARES), defining high risk as a total ARES score >/=6. Results. Overall, 26% met criteria for RH and 40% were at high OSA risk. Logistic regression analysis, adjusting for effects of age, gender, and medical co morbidities, showed that patients with RH were nearly 2.5 times more likely to be at high OSA risk, relative to those with hypertension (OR = 2.46, 95% CI: 1.03-5.88, P < .05). Conclusion. Our findings show that the prevalence of RH among blacks fell within the range of RH for the general hypertensive population (3-29%). However, patients with RH were at significantly greater risk of OSA compared to patients with hypertension.
PMCID:3132606
PMID: 21755035
ISSN: 2090-0392
CID: 307752

Management of hypertension in high-risk ethnic minority with heart failure

Demede, M; Pandey, A; Innasimuthu, L; Jean-Louis, G; McFarlane, S I; Ogedegbe, G
Hypertension (HTN) is the most common co-morbidity in the world, and its sequelae, heart failure (HF) is one of most common causes of mortality and morbidity in the world. Current understanding of pathophysiology and management of HTN in HF is mainly based on studies, which have mainly included whites. Among racial groups, African-American adults have the highest rates (44%) of hypertension in the world and are more resistant to treatment. There is an emerging consensus on the significance of racial disparities in the pathophysiology and treatment options of hypertension and heart failure. However, African Americans had been underrepresented in all the trials until the initiation of the A-HEFT trial. Since the recognition of obstructive sleep apnea (OSA) as an important medical condition, large clinical trials have shown benefits of OSA treatment among patients with HTN and HF. This paper focuses on the pathophysiology, causes of secondary hypertension, and treatment of hypertension among African-American patients with heart failure. There is increasing need for randomized clinical trials testing innovative treatment options for African-American patients.
PMCID:3124316
PMID: 21747977
ISSN: 2090-0392
CID: 307762

Resistant hypertension and sleep apnea: pathophysiologic insights and strategic management

Williams, Stephen K; Ravenell, Joseph; Jean-Louis, Girardin; Zizi, Ferdinand; Underberg, James A; McFarlane, Samy I; Ogedegbe, Gbenga
Resistant hypertension is common among adults with hypertension affecting up to 30% of patients. The treatment of resistant hypertension is important because suboptimal blood pressure control is the leading preventable cause of death worldwide. A frequent comorbid condition in patients with resistant hypertension is obstructive sleep apnea. The pathophysiology of sleep apnea-associated hypertension is characterized by sustained adrenergic activation and volume retention often posing treatment challenges in patients with resistant hypertension. This review will address some of the epidemiologic data associating apnea with the pathogenesis of resistant hypertension. Diagnosis and management of apnea and its associated hypertension will also be considered
PMID: 21104207
ISSN: 1539-0829
CID: 138271

EXCESSIVE DAYTIME SLEEPINESS AND ADHERENCE TO ANTIHYPERTENSIVE MEDICATIONS: ANALYSIS OF THE CAATCH DATA [Meeting Abstract]

Jean-Louis, G.; Zizi, F.; Turner, A.; Von Gizicky, H.; Brown, C.; Boutin-Foster, C.; Fernandez, S.; Ogedegbe, G.
ISI:000208208001391
ISSN: 0161-8105
CID: 2996382

INFLUENCE OF COUNTRY OF ORIGIN ON THE ASSESSMENT OF DAYTIME SLEEPINESS: ANALYSIS OF THE CAATCH DATA [Meeting Abstract]

Al Haija'a, Abo O.; Jean-Louis, G.; Zizi, F.; Hamlet, C.; Brown, C.; Boutin-Foster, C.; Fernandez, S.; Ogedegbe, G.
ISI:000208208001353
ISSN: 0161-8105
CID: 2996392

Sleep duration and the risk of diabetes mellitus: epidemiologic evidence and pathophysiologic insights

Zizi, Ferdinand; Jean-Louis, Girardin; Brown, Clinton D; Ogedegbe, Gbenga; Boutin-Foster, Carla; McFarlane, Samy I
Evidence from well-defined cohort studies has shown that short sleep, through sleep fragmentation caused by obstructive sleep apnea (OSA) or behavioral sleep curtailment because of lifestyle choices, is associated with increased incidence of diabetes. In this report, we review epidemiologic and clinical data suggesting that OSA is involved in the pathogenesis of altered glucose metabolism. Evidence suggesting increased risk of developing diabetes resulting from curtailed sleep duration is also considered. Proposed mechanisms explaining associations between short sleep and diabetes are examined and clinical management of OSA among patients with diabetes is discussed.
PMCID:2976532
PMID: 20425066
ISSN: 1534-4827
CID: 307542

HIV infection and women's sexual functioning

Wilson, Tracey E; Jean-Louis, Girardin; Schwartz, Rebecca; Golub, Elizabeth T; Cohen, Mardge H; Maki, Pauline; Greenblatt, Ruth; Massad, L Stewart; Robison, Esther; Goparaju, Lakshmi; Lindau, Stacy
OBJECTIVE: To compare sexual problems among HIV-positive and HIV-negative women and describe clinical and psychosocial factors associated with these problems. DESIGN: Data were collected during a study visit of the Women's Interagency HIV Study (WIHS). The WIHS studies the natural and treated history of HIV among women in the United States. METHODS: Between October 01, 2006, and March 30, 2007, 1805 women (1279 HIV positive and 526 HIV negative) completed a study visit that included administration of the Female Sexual Function Index. In addition, the visit included completion of standardized interviewer-administered surveys, physical and gynecological examinations, and blood sample collection. RESULTS: Women with HIV reported greater sexual problems than did those without HIV. Women also reported lower sexual function if they were classified as menopausal, had symptoms indicative of depression, or if they reported not being in a relationship. CD4 cell count was associated with Female Sexual Function Index scores, such that those with CD4
PMCID:2900377
PMID: 20179602
ISSN: 1525-4135
CID: 307552

Perceived insomnia, anxiety, and depression among older Russian immigrants

Casimir, G J; Jean-Louis, G; Butler, S; Zizi, F; Nunes, J; Brady, L
There are few data on the relationships of anxiety and depression to insomnia among immigrants in the United States. Observations of high rates of symptoms of these associated conditions among older Russians indicate the need to focus clinical attention on this population. Relationships of self-reported depression and anxiety to insomnia complaints were investigated in a community-based sample of older Russian immigrants. Volunteers (N=307) were urban community-residing Russians (ages 50 to 95 years; 54% women). Surveys were conducted in a semistructured environment by bilingual educators in various community centers. 93% reported a major health problem, 83% experienced pain, and 62% had problems engaging in daily activities. Of the sample, 61% reported an insomnia complaint, and 43% considered depression and/or anxiety to be a major impairment. Logistic regression analysis showed that insomnia was the most important predictor of perceived anxiety and depression; the corresponding multivariate-adjusted odds ratio was 4.37. Insomnia complaints and perceptions of depression and anxiety among older Russians may have a synergistic effect. Both patients and primary-care physicians should be better educated regarding the recognition of barriers limiting access to adequate health care among older Russians.
PMID: 20524564
ISSN: 0033-2941
CID: 307772

Anxiety and cardiovascular symptoms: the modulating role of insomnia

Olafiranye, O; Jean-Louis, G; Magai, C; Zizi, F; Brown, C D; Dweck, M; Borer, J S
BACKGROUND: Anxiety and insomnia are associated with cardiovascular (CV) symptoms. We assessed whether the relation between anxiety and CV symptoms is modulated by insomnia. METHODS: Independently living women (n = 1,440; mean age = 59.36 +/- 6.53 years) were recruited by cluster sampling technique. We obtained data on demographic characteristics, health beliefs, access to health care, CV symptoms, sleep, stress and anxiety levels. RESULTS: Overall, 56% of the sample reported insomnia; 46% reported CV symptoms, and 54% were highly anxious. There was a greater likelihood for highly anxious women and those experiencing insomnia to report CV symptoms (r(s) = 0.31* and r(s) = 0.32*, respectively). In logistic regression analysis, the adjusted odds ratios for reporting CV symptoms were 1.39 for patients with insomnia and 2.79 for those with anxiety. With control for insomnia, we observed a 3-fold reduction in the magnitude of the association between anxiety and CV symptoms (r(p) = 0.09*). Stepwise adjustments for sociodemographic factors, CV risk markers, and factors anchoring health beliefs and access to health care showed lesser impact on the relationships. With simultaneous control for those covariates, the correlation was r(p) = 0.13*; * p < 0.01. CONCLUSION: The association of CV symptoms with anxiety is partly accounted for by insomnia.
PMCID:2813802
PMID: 19907174
ISSN: 0008-6312
CID: 307782