Faculty Bibliography

Each participant received seven injections of the experimental vaccine over six months. The vaccine was targeted against B-cell lymphoma, a cancer of the lymph system that affects at least 20,000 Americans each year and for which current therapies often fail. The vaccine, which takes three months to make for each patient, is available only at Stanford. It is a form of immunotherapy that can be used only among people who have developed a B-cell lymphoma. The vaccine is not intended to prevent the cancer from developing in the first place, the way polio and measles vaccines are used to protect against those infections. The head of the Stanford team, Dr. Ronald Levy, said in an interview that the number of vaccine recipients had been extended to 17, and that the study had moved into a new phase, giving the vaccine to people with more extensive spread of lymphoma than those in the original study

Each participant got seven injections of the experimental vaccine over six months. The vaccine was targeted against B-cell lymphoma, a cancer of the lymph system for which current therapies often fail. The vaccine, which takes three months to make for each patient, is available only at Stanford. It is a form of immunotherapy that can be used only among people who have developed a B-cell lymphoma. The vaccine is not intended to prevent the cancer from developing in the first place. The 'results provide hope for a therapeutic vaccine against B-cell lymphoma,' said Dr. Robert Schwartz of Tufts University

The National Academy of Sciences said in a report issued on Oct 15, 1992 that public health surveillance systems are inadequate to protect people from the sudden appearance of new diseases like AIDS and the resurgence of old ones like tuberculosis. The committee warned against complacency over infectious diseases

Federal health officials, struggling with a resurgence of tuberculosis, which in many cases is now resistant to standard drugs, are looking into the possible benefits of bacillus Calmette-Guerin, or BCG. BCG is the world's most-used vaccine, but doctors in the US have long disdained it

'Obviously it is time for another physical, but we are just having a scheduling problem here,' said Betsey Wright, a deputy campaign manager. 'It's just one of those things that I don't think is going to happen until we get through this election, but we did do the blood tests because the doctors wanted current information to do these letters.' 'Mr. [Bill Clinton]'s exercise tolerance was tremendous,' Dr. [Andrew G. Kumpuris] said. Mr. Clinton exercised for 14 minutes on a standard treadmill regimen. 'I doubt that many 46-year-old guys can go 14 minutes' on a treadmill, Dr. Kumpuris said. Dr. Kumpuris said he recommended a goal of 200 to 220 pounds. Weight is a particular problem for Mr. Clinton, Dr. Kumpuris said, adding: 'He doesn't take good care of himself. I wish he would lose weight.'

The initial focus of interest for Dr. [Edmond Fischer] and Dr. [Edwin Krebs] was on what controls the activity of phosphorylase, Dr. Fischer said. 'The Coris knew that phosphorylase existed in two forms, one active, the other inactive, but they did not know how the forms differed,' Dr. Fischer said. 'The Coris actually dropped the problem

Two American scientists, Dr. Edmond H. Fischer and Dr. Edwin G. Krebs, won the 1992 Nobel Prize in Physiology or Medicine yesterday for an accidental discovery about cell proteins made in the 1950s. Krebs said he learned he had won the prize when a news photographer knocked at the door of his home in Seattle at 7:30 yesterday morning. Because his hearing is impaired, Krebs said he could not hear the telephone ringing or the five messages left on his telephone answering machine early yesterday. At least one call was from Stockholm, he said at a news conference. Fischer and Krebs' initial focus of interest was on what controls the activity of the enzyme phosphorylase, which is involved in the breakdown of glycogen in muscle, Fischer said

Edmond H. Fischer and Edwin G. Krebs, two American scientists who were awarded the 1992 Nobel Prize in Physiology or Medicine, are profiled and their work is explained

Yet another instance of such reticence about presidential disease was published last week in The Journal of the American Medical Association. Two pathologists at the autopsy of John F. Kennedy have broken a long silence and stated that the president's adrenal glands were almost completely gone. This establishes that contrary to repeated denials from Kennedy and his family, and cleverly worded cover stories issued by his aides, Kennedy did suffer for many years from adrenal insufficiency, or Addison's disease. A third pathologist, Dr. Pierre Finck, now says that the Kennedy family at first did not want the pathologists to examine Kennedy's abdominal cavity. The adrenals are on top of the kidneys behind the abdomen

Two American scientists, Dr. Edmond H. Fischer and Dr. Edwin G. Krebs, have won the 1992 Nobel Prize in Physiology or Medicine for an accidental discovery about cell proteins made in the 1950s. Fischer said in a telephone interview that when he and Krebs 'stumbled on' the discovery in the mid-50s, 'we had no idea that it would be a very important and prevalent type of mechanism of control.' In the 1950s, the two were studying the addition and removal of phosphates in the regulation of cell proteins. Scientists knew then that phosphoproteins like casein in milk were important in nutrition. But their dynamic role in regulating cell processes was not understood. A realization that the forward and reverse steps in phosphorylation 'constitute a major regulatory process was relatively slow in developing,' Krebs has written