Faculty Bibliography

The new study was undertaken in part to address the questions of timing and duration of the use of a specific combination of drugs. It involved 1,229 women in Italy, Spain, Sweden, Switzerland, West Germany, Yugoslavia, South Africa, Australia and New Zealand. The Ludwig Institute for Cancer Research in Berne, Switzerland, reported on the study in today's issue of The New England Journal of Medicine. Toxic Effects Countered Two patients died from the drug therapy during the first year after the surgery. Other reported toxic effects included systemic infections, tearing of the surgical scar, painful inflammation of the mouth, an abnormally low white cell count that could lead to infections and a low platelet count that could lead to bleeding

The researchers said this and other data in the study suggested that the herpes and syphilis infections predated infection with the AIDS virus. Further comparisons among the men indicated that, depending on which prior ulcerative disease they had and whether it was currently active, the chance of AIDS virus infection ranged from threefold to eightfold higher than among men with no ulcerative disease. The study took into account differences in rates of sexual intercourse that might have exposed the men to the AIDS virus. The study lends new weight to the growing belief among experts, based on theory and observations of various groups at risk of AIDS, that sexually transmitted diseases involving open sores enhance the chances that the AIDS virus will spread from person to person through sexual intercourse. Similar links between genital ulcer diseases and susceptibility to infection with the AIDS virus have been found in studies of heterosexuals in Africa. Scientists theorize that the open sores provide a ready pathway for the virus to the bloodstream

LEAD: IN a novel approach to teaching the intricate details of human anatomy, some medical schools are experimenting with advanced computer-imaging techniques to create electronic ''cadavers.'' Systems are being designed so that young medical students can ''dissect'' electronic images, rather than using real cadavers for their initial lessons. IN a novel approach to teaching the intricate details of human anatomy, some medical schools are experimenting with advanced computer-imaging techniques to create electronic ''cadavers.'' Systems are being designed so that young medical students can ''dissect'' electronic images, rather than using real cadavers for their initial lessons. ''Human cadavers are used extremely ineffectively in education,'' Dr. [Cornelius Rosse] said. ''Even if students have learned some anatomy before, they often will miss many details doing their first dissection. The very act of dissection often destroys many of the structures that they want to study and you can't come back the second time.''

LEAD: A new study has added to evidence that many pain killing anti-inflammatory drugs, in addition to aspirin, are causing severe, even life-threatening stomach problems in elderly people. A high incidence of abdominal complications from these drugs was found in patients who died of gastric or duodenal ulcers or bleeding from the stomach or upper portion of the intestines. A new study has added to evidence that many pain killing anti-inflammatory drugs, in addition to aspirin, are causing severe, even life-threatening stomach problems in elderly people. A high incidence of abdominal complications from these drugs was found in patients who died of gastric or duodenal ulcers or bleeding from the stomach or upper portion of the intestines. In an editorial, Dr. Sanford H. Roth of Phoenix, an arthritis specialist, said that thousands of people die every year in the United States alone'' because of ''preventable'' bleeding resulting from use of nonsteroidal anti-inflammatory drugs

The next day, Dr. Michael A. Denborough, Dr. Roger R. H. Lovell and their colleagues in Melbourne, Australia, began studying records of the patient's relatives. These consultants and other researchers pinned the man's problem to a rare hereditary biochemical condition now known as malignant hyperthermia. It can strike unpredictably in patients who receive general anesthesia for any procedure in any hospital or out-patient facility. Although the name malignant hyperthermia implies that the condition is a cancer, it is not. In medical parlance, malignant means fast-moving and deadly; malignant hyperthermia got its name because it rapidly raises a patient's body temperature to lethal levels. New research indicates that malignant hyperthermia may underlie some symptoms previously thought to be related to a person's job. Dr. Denborough, who now works in Canberra, recently reported a case involving the father of a girl who survived an episode of malignant hyperthermia. The man suffered malaise and stiffness and weakness of his forearms and hands after he began working in a factory that made fire extinguishers

The high neurotic scores persisted when the psychological tests were administered again a year later, demonstrating to the researchers that the anxiety was an ''enduring disposition'' and not simply the result of the difficult medical examinations associated with the search for a cause of the chest pain. ''This sustained cardiologic focus of treatment can only serve to perpetuate their skepticism about their cardiac soundness,'' Dr. [Larry J. Lantinga]'s team said.

''There has not been adequate systematic studies of antifungal agents for Pneumocystis,'' Dr. [Donald B. Louria] said. Dr. Donald Armstrong, an expert in fungal diseases at the Memorial Sloan-Kettering Cancer Center in New York City, said evidence that the organism is a fungus will provide an impetus for scientists to renew their efforts to ''learn how we might grow it.'' The RNA, or ribonucleic acid, a key component of the microbe's machinery that makes proteins, is similar in all forms of life, from microbes to humans. But the small differences that exist in the sequences of the genes allow comparisons that are used for classification. Dr. [Jeffrey C. Edman]'s team found that Pneumocystis's RNA was closer to that of yeast than that of malarial parasites. Dr. Peter D. Walzer, an expert in fungi at the University of Cincinnati, said a group he heads and a group in Japan had also found that Pneumocystis seemed to be a fungus by using techniques that were different from those used in Dr. Edman's study.

Rather than using sections of a leg vein to bypass blocked coronary arteries, the doctors are turning to a blood vessel in the chest. Surgeons are using the arteries, also known as internal thoracic arteries, whenever possible in the operation that is commonly done to relieve the chest pains from angina. The studies have also found that patients who undergo such grafts live longer, take longer to develop recurrences of angina, have fewer heart attacks, fewer repeat bypass operations and fewer complications than did those who had vein grafts

At the time, many experts believed that the internal mammary artery, often only two millimeters in diameter, was too small for splicing into the coronary arteries. But Dr. [George E. Green] recalled in an interview that he shifted his research from other vessels to the internal mammary artery after another surgeon made him aware that ''the limiting factor was the eye, not the hand.'' By using the operating microscope to magnify the vessel, Dr. Green was able to accomplish the mammary artery graft successfully. ''Many years ago George Green stood alone in support of the internal mammary artery as a superior conduit,'' Dr. John L. Ochsner of the Ochsner Clinic in New Orleans has written. ''In the years since, many of us have joined his ranks.'' ''Certain vessels may carry blood for a whole lifetime without showing significant arterial disease,'' said Dr. Frank H. Sims, a pathologist at the University of Auckland Medical School in New Zealand, who has made anatomical studies of the artery. ''Any valid theory of arteriosclerosis must explain the freedom of these vessels from disease as well as the lesions in the affected arteries.''

In making disclosures about their health, candidates are obviously concerned about public reaction. An official of the American Psychological Association noted that fear yesterday in saying that the ''decision-makers are being discouraged from seeking psychological care for fear that the very act of seeking care will subject them to being labeled 'mentally ill' and unfit for public service.'' The association's official, Dr. Bryant L. Welch, cited no specific examples, but cautioned that such attention could make it ''impossible'' for even a President ''to receive appropriate and preventive psychological care in times of personal crisis.'' The Public's Right to Know Dr. Welch, for instance, expressed ''deep caution about the current insistence on releasing raw medical records to the general public.'' In the past, however, in those instances when candidates have made medical documents public, the documents have usually been accompanied by letters of explanation and interpretation