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Smartphone application alerts for early trauma team activation: Millennial technology in healthcare
Goulet, Nicole D; Liu, Helen; Petrone, Patrizio; Islam, Shahidul; Glinik, Galina; Joseph, D'Andrea K; Baltazar, Gerard A
BACKGROUND:Data access through smartphone applications (apps) has reframed procedure and policy in healthcare, but its impact in trauma remains unclear. Citizen is a free app that provides real-time alerts curated from 911 dispatch data. Our primary objective was to determine whether app alerts occurred earlier than recorded times for trauma team activation and emergency department arrival. METHODS:Trauma registry entries were extracted from a level one urban trauma center from January 1, 2018 to June 30, 2019 and compared with app metadata from the center catchment area. We matched entries to metadata according to description, date, time, and location then compared metadata timestamps to trauma team activation and emergency department arrival times. We computed percentage of time the app reported traumatic events earlier than trauma team activation or emergency department arrival along with exact binomial 95% confidence interval; median differences between times were presented along with interquartile ranges. RESULTS:Of 3,684 trauma registry entries, 209 (5.7%) matched app metadata. App alerts were earlier for 96.1% and 96.2% of trauma team activation and emergency department arrival times, respectively, with events reported median 36 (24-53, IQR) minutes earlier than trauma team activation and 32 (25-42, IQR) minutes earlier than emergency department arrival. Registry entries for younger males, motor vehicle-related injuries and penetrating traumas were more likely to match alerts (P < .0001). CONCLUSION/CONCLUSIONS:Apps like Citizen may provide earlier notification of traumatic events and therefore earlier mobilization of trauma service resources. Earlier notification may translate into improved patient outcomes. Additional studies into the benefit of apps for trauma care are warranted.
PMID: 34210527
ISSN: 1532-7361
CID: 4927182
Correlation of brain flow variables and metabolic crisis: a prospective study in patients with severe traumatic brain injury
Marini, Corrado P; Stoller, Christy; McNelis, John; Del Deo, Vito; Prabhakaran, Kartik; Petrone, Patrizio
INTRODUCTION/BACKGROUND:Current treatment guidelines for patients with severe TBI (sTBI) are aimed at preventing secondary brain injury targeting specific endpoints of intracranial physiology to avoid the development of metabolic crisis. We sought to identify factors contributing to development of metabolic crisis in the setting of a Multi-modality Monitoring and Goal-Directed Therapy (MM&GDTP) approach to patients with severe TBI. METHODS: < 20 mmHg with NIRS < 55% (Type 3). Cerebral micro-dialysate was analyzed hourly for glucose, lactate, pyruvate, glutamate, glycerol, and lactate/pyruvate ratio (LPR). Statistical analysis was performed with student t-test, chi-square and Pearson's tests as applicable. RESULTS: < 20 mmHg), r = 0.97, p < 0.001, but not with Type 1 and 3. CONCLUSIONS:The occurrence of severe metabolic crisis portends a poor prognosis in patients with sTBI.
PMID: 32719895
ISSN: 1863-9941
CID: 4599082
Cardiac air emboli secondary to traumatic skull fractures: a rare, successful aspiration in the trauma bay
Sajan, Abin; Hakmi, Hazim; Goldstein, Adam; Maniar, Yesha; Sohail, Amir H; Joseph, D'Andrea; Petrone, Patrizio; Jacquez, Ricardo
PMCID:8292812
PMID: 34368463
ISSN: 2397-5776
CID: 5252912
Fatal and non-fatal injuries due to suspension trauma syndrome: A systematic review of definition, pathophysiology, and management controversies
Petrone, Patrizio; Espinoza-Villalobos, SofÃa; Baltazar, Gerard A; Søreide, Kjetil; Stright, Adam; Brathwaite, Collin E M; Joseph, D'Andrea K
BACKGROUND:Suspension trauma syndrome is a life-threatening event that occurs when a person is "trapped" in a prolonged passive suspension. It is most commonly seen in people who engage in occupational or sport activities that require harness suspension. The aim of this study is to identify the predisposing factors, pathophysiology, and management of suspension trauma. METHODS:A review and analysis of the literature published in English and Spanish from 1972 to 2020 on suspension trauma were performed. Search sources were PubMed, Medline, Cochrane Library, MeSH, UpToDate, and Google Scholar. Articles referring to suspension trauma associated with other injury mechanisms (traumatic impact injuries, drowning, asphyxiation, or bleeding), case reports, and pediatric population were excluded. RESULTS:Forty-one articles were identified. Of these, 29 articles related to mechanism, pathophysiology, and management of individuals who suffered prolonged suspension trauma without associated traumatic injuries were included in the study. We encountered several controversies describing the putative pathophysiology, ranging from blood sequestration in the lower extremities versus accumulation of metabolic waste and hyperkalemia to dorsal hook-type harness as a trigger cause of positional asphyxia; to vascular compression of femoral vessels exerted by the harness causing decreased venous return. Pstients suspended in a full-body harness with dorsal hook showed more hemodynamic alterations in response to the compressive effect on the rib cage, causing a reduction in perfusion by presenting a decrease in pulse pressure. Management strategies varied across studies. CONCLUSIONS:Progress has been made in individualizing the population at risk and in the management of suspension trauma. We recommend the formation of consensus definitions, larger cohort or registry studies to be conducted, and experimental animal models to better understand the mechanisms in order to develop management and life support guidelines from a trauma and emergency medicine perspective.
PMCID:8390355
PMID: 34512820
ISSN: 1920-8642
CID: 5082812
Stop the Bleed: A Prospective Evaluation and Comparison of Tourniquet Application in Security Personnel vs Civilian Population [Meeting Abstract]
Petrone, P; Baltazar, G A; Jacquez, R A; Akerman, M; Brathwaite, C E M; Joseph, D K
Introduction: Stop the Bleed (STB) is a national training program aiming to decrease the mortality associated with life-threatening bleeding due to injury. The purpose of this study was to evaluate the efficacy and confidence level of security personnel placing a tourniquet (TQ) compared to civilians.
Method(s): Pre and post questionnaires were shared with security personnel (Group 1), and civilians (Group 2). Both groups were assessed to determine comfort level with TQ placement. Time and success rate for placement was recorded pre- and post-STB training. A generalized linear mixed model or generalized estimating equations were used.
Result(s): 234 subjects were enrolled. There was a statistically significant improvement between the pre- and post-training responses in both groups with respect to comfort level in TQ placing. Participants also demonstrated increased familiarity with the anatomy and bleeding control after being trained. A higher successful tourniquet placement was obtained in both groups after training (Pre-training: Group-1[17.4%], Group-2[12.8%], Post-training: Group-1[94.8%], Group-2[92.3%]). Both groups demonstrated improved time to placement with a longer mean time improvement achieved in Group 1. Although the time to TQ placement pre-and post-training was statistically significant, we found that the post-training times between groups 1 and 2 were similar (p=0.983).
Conclusion(s): Participants improved their confidence level and dramatically increased the rate and time to successful TQ placement. While civilians had the greatest increase in comfort level, the security personnel group saw the most significant reduction in the time to successful placement. These findings highlight the critical role of STB in bleeding control techniques.
Copyright
EMBASE:2014926820
ISSN: 1879-1190
CID: 5024632
Outcomes of Bariatric Surgery: Patients with Body Mass Index 60 or Greater
Howell, Raelina S; Liu, Helen H; Boinpally, Harika; Akerman, Meredith; Carruthers, Elizabeth; Brathwaite, Barbara M; Petrone, Patrizio; Brathwaite, Collin E M
Introduction/UNASSIGNED:) merit further investigation. Methods/UNASSIGNED:A retrospective review was conducted of patients with SSO who underwent surgery from Jun 2005 through Jun 2018 at a Metabolic and Bariatric Surgery Center of Excellence. Quantitative demographic data was summarized using descriptive statistics; categorical variables were compared using Fisher's exact test. Results/UNASSIGNED:0.7051). Conclusion/UNASSIGNED:Bariatric surgery is feasible in patients with SSO. Revision procedures may increase risk of operative complications.
PMCID:8241285
PMID: 34248332
ISSN: 1938-3797
CID: 4938162
Management of mass casualties due to COVID-19: handling the dead
Petrone, Patrizio; Joseph, D'Andrea K; Jacquez, Ricardo A; Baltazar, Gerard A; Brathwaite, Collin E M
A high number of fatalities can occur during major disasters or during events like the COVID-19 pandemic. In a natural disaster, the dead must be removed from disaster sites while rescue work is in progress; otherwise, the health and safety of the community are threatened. The COVID-19 pandemic is analogous to a natural disaster with mass casualties where the disaster sites are hospitals with morgues that are overwhelmed. As the number of the deceased rise rapidly and hospital morgues are at their full capacity, hospitals use what is called a Body Collection Point (BCP). BCP is defined as a temporary refrigeration unit used to store decedents until transport is arranged. Decedents should always be handled in a manner denoting respect, and provisions and management of resources should be properly mobilized to ensure this. Contingency plans must be created to prepare for worsening of the disaster that further overwhelms the capacity of the health care systems.
PMCID:8178665
PMID: 34089336
ISSN: 1863-9941
CID: 4899342
Development of a Method for Clinical Evaluation of Artificial Intelligence-Based Digital Wound Assessment Tools
Howell, Raelina S; Liu, Helen H; Khan, Aziz A; Woods, Jon S; Lin, Lawrence J; Saxena, Mayur; Saxena, Harshit; Castellano, Michael; Petrone, Patrizio; Slone, Eric; Chiu, Ernest S; Gillette, Brian M; Gorenstein, Scott A
Importance/UNASSIGNED:Accurate assessment of wound area and percentage of granulation tissue (PGT) are important for optimizing wound care and healing outcomes. Artificial intelligence (AI)-based wound assessment tools have the potential to improve the accuracy and consistency of wound area and PGT measurement, while improving efficiency of wound care workflows. Objective/UNASSIGNED:To develop a quantitative and qualitative method to evaluate AI-based wound assessment tools compared with expert human assessments. Design, Setting, and Participants/UNASSIGNED:This diagnostic study was performed across 2 independent wound centers using deidentified wound photographs collected for routine care (site 1, 110 photographs taken between May 1 and 31, 2018; site 2, 89 photographs taken between January 1 and December 31, 2019). Digital wound photographs of patients were selected chronologically from the electronic medical records from the general population of patients visiting the wound centers. For inclusion in the study, the complete wound edge and a ruler were required to be visible; circumferential ulcers were specifically excluded. Four wound specialists (2 per site) and an AI-based wound assessment service independently traced wound area and granulation tissue. Main Outcomes and Measures/UNASSIGNED:The quantitative performance of AI tracings was evaluated by statistically comparing error measure distributions between test AI traces and reference human traces (AI vs human) with error distributions between independent traces by 2 humans (human vs human). Quantitative outcomes included statistically significant differences in error measures of false-negative area (FNA), false-positive area (FPA), and absolute relative error (ARE) between AI vs human and human vs human comparisons of wound area and granulation tissue tracings. Six masked attending physician reviewers (3 per site) viewed randomized area tracings for AI and human annotators and qualitatively assessed them. Qualitative outcomes included statistically significant difference in the absolute difference between AI-based PGT measurements and mean reviewer visual PGT estimates compared with PGT estimate variability measures (ie, range, standard deviation) across reviewers. Results/UNASSIGNED:A total of 199 photographs were selected for the study across both sites; mean (SD) patient age was 64 (18) years (range, 17-95 years) and 127 (63.8%) were women. The comparisons of AI vs human with human vs human for FPA and ARE were not statistically significant. AI vs human FNA was slightly elevated compared with human vs human FNA (median [IQR], 7.7% [2.7%-21.2%] vs 5.7% [1.6%-14.9%]; P < .001), indicating that AI traces tended to slightly underestimate the human reference wound boundaries compared with human test traces. Two of 6 reviewers had a statistically higher frequency in agreement that human tracings met the standard area definition, but overall agreement was moderate (352 yes responses of 583 total responses [60.4%] for AI and 793 yes responses of 1166 total responses [68.0%] for human tracings). AI PGT measurements fell in the typical range of variation in interreviewer visual PGT estimates; however, visual PGT estimates varied considerably (mean range, 34.8%; mean SD, 19.6%). Conclusions and Relevance/UNASSIGNED:This study provides a framework for evaluating AI-based digital wound assessment tools that can be extended to automated measurements of other wound features or adapted to evaluate other AI-based digital image diagnostic tools. As AI-based wound assessment tools become more common across wound care settings, it will be important to rigorously validate their performance in helping clinicians obtain accurate wound assessments to guide clinical care.
PMID: 34009348
ISSN: 2574-3805
CID: 4877232
Safety of Bariatric Surgery in Patients With Congestive Heart Failure: Results of an 11-Year Retrospective Study
Brathwaite, Barbara M; Howell, Raelina S; Petrone, Patrizio; Brathwaite, Collin E M
INTRODUCTION/BACKGROUND:Congestive heart failure (CHF) is a known risk factor for increased postoperative morbidity. However, the safety in patients with CHF has not been well established. The objective of this study was to assess the safety of surgery in patients with a history of CHF undergoing bariatric surgical procedures. METHODS:Retrospective review of a prospectively maintained Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Center of Excellence database. Patients with known CHF undergoing bariatric procedures over an 11-year period were reviewed. RESULTS:Over the 11-year period, 4470 total bariatric surgeries were performed, of which 41 (.92%) patients had known CHF. Twenty-one patients were men (51.2%) with a mean age of 55.8Â years and mean body mass index (BMI) of 51.9. Comorbidities included hypertension (87.8%), obstructive sleep apnea (80.5%), osteoarthritis (63.4%), gastroesophageal reflux disease (56%), and diabetes (53.7%). Surgical procedures included 16 sleeve gastrectomies (SGs) (39%), 11 Roux-en-Y gastric bypasses (RYGBs) (26.8%), 10 laparoscopic adjustable gastric bands (LAGBs) (24.4%), 1 removal of a gastric band and conversion to SG (2.4%), 1 removal of a gastric band to RYGB (2.4%), 1 gastric band over RYGB pouch (2.4%), and 1 gastric band replacement (2.4%). All cases were performed minimally invasively (73.2% laparoscopic and 26.8% robotic). Mean LOS was 2.53Â days. Thirty-day complications included 2 readmissions (4.9% [1 small bowel obstruction and 1 pulmonary edema]), 1 reoperation (2.4% [small bowel obstruction]), and 1 mortality (2.4%) on postoperative day 30 unrelated to the surgery. CONCLUSIONS:Bariatric surgery can be performed safely in patients with CHF.
PMID: 33522255
ISSN: 1555-9823
CID: 4775892
Prone ventilation as treatment of acute respiratory distress syndrome related to COVID-19
Petrone, Patrizio; Brathwaite, Collin E M; Joseph, D'Andrea K
Prone ventilation refers to the delivery of mechanical ventilation with the patient lying in the prone position. The improvement of oxygenation during prone ventilation is multifactorial, but occurs mainly by reducing lung compression and improving lung perfusion. CT imaging modeling data demonstrated that the asymmetry of lung shape leads to a greater induced pleural pressure gravity gradient when supine as compared to prone positioning. Although proning is indicated in patients with severe ARDS who are not responding to other ventilator modalities, this technique has moved away from a salvage therapy for refractory hypoxemia to an upfront lung-protective strategy intended to improve survival in severe ARDS, especially due to the current COVID-19 pandemic. In view of different roles, we surgeons had to take during the COVID-19 pandemic, it is of importance to learn how to implement this therapeutic measure, especially in a surgical critical care unit setting. As such, this article aims to review the physiological principles and effects of the prone ventilation, positioning, as well as its contraindications and complications.
PMCID:7670293
PMID: 33201268
ISSN: 1863-9941
CID: 4672572