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Rhabdomyolysis with acute kidney injury in deceased donors is not a contraindication for kidney donation [Case Report]

Joshi, Shivam; Ayyathurai, Rajinikanth; Eldefrawy, Ahmed; Aminsharifi, Jason; Ekwenna, Obi; Sageshima, Junichiro; Chen, Linda; Burke, George; Ciancio, Gaetano
PURPOSE/OBJECTIVE:Deceased patients with acute kidney injury (AKI) from rhabdomyolysis can be considered as potential kidney donors. METHODS:We performed a retrospective chart review from January 2005 to January 2011 of three donors with AKI from rhabdomyolysis and the four recipients of the donated kidneys. Three donors had AKI from rhabdomyolysis as evidenced by elevated serum creatinine levels, myoglobinuria, and plasma creatinine kinase levels greater than five times the upper limit of normal. All grafts were maintained on pulsatile machine perfusion (MP) prior to transplantation. In one of the patients, serial venous perfusate myoglobin levels were measured from the donor kidney while on MP. RESULTS:Three of the four recipients had delayed graft function, but all had normalized creatinine function after 1 month. One recipient had a creatinine of 1.2 after 79 months, the longest documented follow-up of this kind. Although we measured venous perfusate myoglobin levels from one of the grafts, we found the levels to decrease with increasing time spent on MP. CONCLUSION/CONCLUSIONS:Potential donors with AKI secondary to rhabdomyolysis should not be restricted from the donor pool. MP may play a role in minimizing the effects of AKI in these types of donors.
PMID: 22552709
ISSN: 1573-2584
CID: 3142342

RADICAL NEPHRECTOMY FOR RENAL CELL CARCINOMA IN A MALROTATED FUSED ECTOPIC PELVIC KIDNEY [Meeting Abstract]

Ayyathurai, Rajinikanth; Joshi, Shivam; Pan, David; Ciancio, Gaetano; Manoharan, Murugesan
ISI:000302912500404
ISSN: 0022-5347
CID: 3142532

PROGNOSTIC SIGNIFICANCE OF CYSTOSCOPY FINDINGS FOLLOWING NEOADJUVANT CHEMOTHERAPY FOR MUSCLEINVASIVE BLADDER CANCER [Meeting Abstract]

Mansour, Ahmed M.; Singal, Rakesh; Eldefrawy, Ahmed; Joshi, Shivam; Soloway, Mark S.; Manoharan, Murugesan
ISI:000302912503043
ISSN: 0022-5347
CID: 3142542

RHABDOMYOLYSIS WITH ACUTE RENAL FAILURE IN DECEASED DONORS IS NOT A CONTRAINDICATION FOR KIDNEY DONATION [Meeting Abstract]

Ayyathurai, Rajinikanth; Joshi, Shivam; Ekwenna, Obi; Sageshima, Junichiro; Chen, Linda; Burke, George, III
ISI:000302912503567
ISSN: 0022-5347
CID: 3142552

Overview of pediatric orbital fractures

Joshi, Shivam; Kassira, Wrood; Thaller, Seth R
Orbital fractures in children are uncommon. The pattern of orbital fractures changes as children age. Although the management of pediatric orbital fractures is evolving, a thorough clinical assessment with computed tomographic scan imaging is essential. Urgent surgical intervention is indicated in cases of entrapment or acute enophthalmos. Entrapment with oculocardiac reflex is common in the white-eyed blow-out or trapdoor fractures. Otherwise, pediatric fractures may be treated conservatively with surveillance. A variety of autogenous and allogenic materials may be used to repair the fractured orbit. Resorbable plating systems are an alternative to rigid metallic fixation and may be used on the developing craniofacial skeleton.
PMID: 21772188
ISSN: 1536-3732
CID: 3142332