NYUHSL Faculty Bibliography

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131

Trends in cell biology. 2017:27(11):863-875.DOI: 10.1016/j.tcb.2017.06.003

Metabolic Interactions in the Tumor Microenvironment

Lyssiotis, Costas A; Kimmelman, Alec C

Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a unique physiology. Within this network, the malignant cells encounter many challenges and rewire their metabolic properties accordingly. Such changes can be experienced and executed autonomously or through interaction with other cells in the tumor. The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism. They include symbiotic nutrient sharing, nutrient competition, and the role of metabolites as signaling molecules. Examples of such processes abound in normal organismal physiology, and such heterocellular metabolic interactions are repurposed to support tumor metabolism and growth. The importance and ubiquity of these processes are just beginning to be realized, and insights into their role in tumor development and progression are being used to design new drug targets and cancer therapies.

PMCID:5814137

PMID: 28734735

ISSN: 1879-3088

CID: 2654102

Nature communications. 2017:8.DOI: 10.1038/ncomms15965

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, Douglas E; Paulo, Joao A; Malachowska, Beata; Del Rey, Maria Quiles; Sousa, Cristovao M; Wang, Xiaoxu; Sohn, Albert S W; Chu, Gerald C; Gygi, Steven P; Harper, J Wade; Fendler, Wojciech; Mancias, Joseph D; Kimmelman, Alec C

Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and that inhibition of downstream components of Gln metabolism leads to a decrease in tumour growth. Here we test whether recently developed inhibitors of glutaminase (GLS), which mediates an early step in Gln metabolism, represent a viable therapeutic strategy. We show that despite marked early effects on in vitro proliferation caused by GLS inhibition, pancreatic cancer cells have adaptive metabolic networks that sustain proliferation in vitro and in vivo. We use an integrated metabolomic and proteomic platform to understand this adaptive response and thereby design rational combinatorial approaches. We demonstrate that pancreatic cancer metabolism is adaptive and that targeting Gln metabolism in combination with these adaptive responses may yield clinical benefits for patients.

PMCID:5500878

PMID: 28671190

ISSN: 2041-1723

CID: 2616842

EMBO journal. 2017:36(13):1811-1836.DOI: 10.15252/embj.201796697

Molecular definitions of autophagy and related processes

Galluzzi, Lorenzo; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, Jose Manuel; Cecconi, Francesco; Choi, Augustine M; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Debnath, Jayanta; Deretic, Vojo; Dikic, Ivan; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Fulda, Simone; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Harper, J Wade; Jaattela, Marja; Johansen, Terje; Juhasz, Gabor; Kimmelman, Alec C; Kraft, Claudine; Ktistakis, Nicholas T; Kumar, Sharad; Levine, Beth; Lopez-Otin, Carlos; Madeo, Frank; Martens, Sascha; Martinez, Jennifer; Melendez, Alicia; Mizushima, Noboru; Munz, Christian; Murphy, Leon O; Penninger, Josef M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Santambrogio, Laura; Scorrano, Luca; Simon, Anna Katharina; Simon, Hans-Uwe; Simonsen, Anne; Tavernarakis, Nektarios; Tooze, Sharon A; Yoshimori, Tamotsu; Yuan, Junying; Yue, Zhenyu; Zhong, Qing; Kroemer, Guido

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

PMCID:5494474

PMID: 28596378

ISSN: 1460-2075

CID: 2592212

Cell metabolism. 2017:25(5):1037-1043.DOI: 10.1016/j.cmet.2017.04.004

Autophagy and Tumor Metabolism

Kimmelman, Alec C; White, Eileen

Autophagy is a critical cellular process that generally protects cells and organisms from stressors such as nutrient deprivation. In addition to its role in normal physiology, autophagy plays a role in pathological processes such as cancer. Indeed, there has been substantial work exploring the complex and context-dependent role of autophagy in cancer. One of the emerging themes is that in certain cancer types, autophagy is important to support tumor growth; therefore, inhibiting autophagy as a therapeutic approach is actively being tested in clinical trials. A key mechanism of how autophagy promotes the growth and survival of various cancers is its ability to support cellular metabolism. The diverse metabolic fuel sources that can be produced by autophagy provide tumors with metabolic plasticity and can allow them to thrive in what can be an austere microenvironment. Therefore, understanding how autophagy can fuel cellular metabolism will enable more effective combinatorial therapeutic strategies.

PMCID:5604466

PMID: 28467923

ISSN: 1932-7420

CID: 2547692

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017:114(5):1129-1134.DOI: 10.1073/pnas.1620164114

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, Mara H; Yu, Ruth T; Tseng, Tiffany W; Sousa, Cristovao M; Liu, Sihao; Truitt, Morgan L; He, Nanhai; Ding, Ning; Liddle, Christopher; Atkins, Annette R; Leblanc, Mathias; Collisson, Eric A; Asara, John M; Kimmelman, Alec C; Downes, Michael; Evans, Ronald M

A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome, yet the mechanistic underpinning of this crosstalk remains poorly understood. Here we show that stromal cues elicit an adaptive response in the cancer cell including the rapid mobilization of a transcriptional network implicated in accelerated growth, along with anabolic changes of an altered metabolome. The close overlap of stroma-induced changes in vitro with those previously shown to be regulated by oncogenic Kras in vivo suggests that oncogenic Kras signaling-a hallmark and key driver of PDAC-is contingent on stromal inputs. Mechanistically, stroma-activated cancer cells show widespread increases in histone acetylation at transcriptionally enhanced genes, implicating the PDAC epigenome as a presumptive point of convergence between these pathways and a potential therapeutic target. Notably, inhibition of the bromodomain and extraterminal (BET) family of epigenetic readers, and of Bromodomain-containing protein 2 (BRD2) in particular, blocks stroma-inducible transcriptional regulation in vitro and tumor progression in vivo. Our work suggests the existence of a molecular "AND-gate" such that tumor activation is the consequence of mutant Kras and stromal cues, providing insight into the role of the tumor microenvironment in the origin and treatment of Ras-driven tumors.

PMCID:5293019

PMID: 28096419

ISSN: 1091-6490

CID: 2413852

Autophagy. 2016:12(2).DOI: 10.1080/15548627.2016.1147886

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki; Adams, Christopher M.; Adams, Peter D.; Adeli, Khosrow; Adhihetty, Peter J.; Adler, Sharon G.; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K.; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V.; Aguirre-Ghiso, Julio; Airoldi, Edoardo M.; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T.; Al-Rubeai, Mohamed; Albaiceta, Guillermo M.; Albanese, Chris; Albani, Diego; Albert, Matthew L.; Aldudo, Jesus; AlgÃ¼l, Hana; Alirezaei, Mehrdad; Alloza, Iraide; Almasan, Alexandru; Almonte-Beceril, Maylin; Alnemri, Emad S.; Alonso, Covadonga; Altan-Bonnet, Nihal; Altieri, Dario C.; Alvarez, Silvia; Alvarez-Erviti, Lydia; Alves, Sandro; Amadoro, Giuseppina; Amano, Atsuo; Amantini, Consuelo; Ambrosio, Santiago; Amelio, Ivano; Amer, Amal O.; Amessou, Mohamed; Amon, Angelika; An, Zhenyi; Anania, Frank A.; Andersen, Stig U.; Andley, Usha P.; Andreadi, Catherine K.; Andrieu-Abadie, Nathalie; Anel, Alberto; Ann, David K.; Anoopkumar-Dukie, Shailendra; Antonioli, Manuela; Aoki, Hiroshi; Apostolova, Nadezda; Aquila, Saveria; Aquilano, Katia; Araki, Koichi; Arama, Eli; Aranda, Agustin; Araya, Jun; Arcaro, Alexandre; Arias, Esperanza; Arimoto, Hirokazu; Ariosa, Aileen R.; Armstrong, Jane L.; Arnould, Thierry; Arsov, Ivica; Asanuma, Katsuhiko; Askanas, Valerie; Asselin, Eric; Atarashi, Ryuichiro; Atherton, Sally S.; Atkin, Julie D.; Attardi, Laura D.; Auberger, Patrick; Auburger, Georg; Aurelian, Laure; Autelli, Riccardo; Avagliano, Laura; Avantaggiati, Maria Laura; Avrahami, Limor; Azad, Neelam; Awale, Suresh; Bachetti, Tiziana; Backer, Jonathan M.; Bae, Dong Hun; Bae, Jae Sung; Bae, Ok Nam; Bae, Soo Han; Baehrecke, Eric H.; Baek, Seung Hoon; Baghdiguian, Stephen; Bagniewska-Zadworna, Agnieszka; Bai, Hua; Bai, Jie; Bai, Xue Yuan; Bailly, Yannick; Balaji, Kithiganahalli Narayanaswamy; Balduini, Walter; Ballabio, Andrea; Balzan, Rena; Banerjee, Rajkumar; BÃ¡nhegyi, GÃ¡bor; Bao, Haijun; Barbeau, Benoit; Barrachina, Maria D.; Barreiro, Esther; Bartel, Bonnie; BartolomÃ©, Alberto; Bassham, Diane C.; Bassi, Maria Teresa; Bast, Robert C.; Basu, Alakananda; Batista, Maria Teresa; Batoko, Henri; Battino, Maurizio; Bauckman, Kyle; Baumgarner, Bradley L.; Bayer, K. Ulrich; Beale, Rupert; Beaulieu, Jean FranÃ§ois; Beck, George R.; Becker, Christoph; Beckham, J. David; BÃ©dard, Pierre AndrÃ©; Bednarski, Patrick J.; Begley, Thomas J.; Behl, Christian; Behrends, Christian; Behrens, Georg M.N.; Behrns, Kevin E.; Bejarano, Eloy; Belaid, Amine; Belleudi, Francesca; BÃ©nard, Giovanni; Berchem, Guy; Bergamaschi, Daniele; Bergami, Matteo; Berkhout, Ben; Berliocchi, Laura; Bernard, AmÃ©lie; Bernard, Monique; Bernassola, Francesca; Bertolotti, Anne; Bess, Amanda S.; Besteiro, SÃ©bastien; Bettuzzi, Saverio; Bhalla, Savita; Bhattacharyya, Shalmoli; Bhutia, Sujit K.; Biagosch, Caroline; Bianchi, Michele Wolfe; Biard-Piechaczyk, Martine; Billes, Viktor; Bincoletto, Claudia; Bingol, Baris; Bird, Sara W.; Bitoun, Marc; Bjedov, Ivana; Blackstone, Craig; Blanc, Lionel; Blanco, Guillermo A.; Blomhoff, Heidi Kiil; Boada-Romero, Emilio; Bockler, Stefan; Boes, Marianne; Boesze-Battaglia, Kathleen; Boise, Lawrence H.; Bolino, Alessandra; Boman, Andrea; Bonaldo, Paolo; Bordi, Matteo; Bosch, JÃ¼rgen; Botana, Luis M.; Botti, Joelle; Bou, German; BouchÃ©, Marina; Bouchecareilh, Marion; Boucher, Marie JosÃ©e; Boulton, Michael E.; Bouret, Sebastien G.; Boya, Patricia; Boyer-Guittaut, MichaÃ«l; Bozhkov, Peter V.; Brady, Nathan; Braga, Vania M.M.; Brancolini, Claudio; Braus, Gerhard H.; Bravosan-Pedro, JosÃ© M.; Brennan, Lisa A.; Bresnick, Emery H.; Brest, Patrick; Bridges, Dave; Bringer, Marie AgnÃ¨s; Brini, Marisa; Brito, Glauber C.; Brodin, Bertha; Brookes, Paul S.; Brown, Eric J.; Brown, Karen; Broxmeyer, Hal E.; Bruhat, Alain; Brum, Patricia Chakur; Brumell, John H.; Brunetti-Pierri, Nicola; Bryson-Richardson, Robert J.; Buch, Shilpa; Buchan, Alastair M.; Budak, Hikmet; Bulavin, Dmitry V.; Bultman, Scott J.; Bultynck, Geert; Bumbasirevic, Vladimir; Burelle, Yan; Burke, Robert E.; Burmeister, Margit; BÃ¼tikofer, Peter; Caberlotto, Laura; Cadwell, Ken; Cahova, Monika; Cai, Dongsheng; Cai, Jingjing; Cai, Qian; Calatayud, Sara; Camougrand, Nadine; Campanella, Michelangelo; Campbell, Grant R.; Campbell, Matthew; Campello, Silvia; Candau, Robin; Caniggia, Isabella; Cantoni, Lavinia; Cao, Lizhi; Caplan, Allan B.; Caraglia, Michele; Cardinali, Claudio; Cardoso, Sandra Morais; Carew, Jennifer S.; Carleton, Laura A.; Carlin, Cathleen R.; Carloni, Silvia; Carlsson, Sven R.; Carmona-Gutierrez, Didac; Carneiro, Leticia A.M.; Carnevali, Oliana; Carra, Serena; Carrier, Alice; Carroll, Bernadette; Casas, Caty; Casas, Josefina; Cassinelli, Giuliana; Castets, Perrine; Castro-Obregon, Susana; Cavallini, Gabriella; Ceccherini, Isabella; Cecconi, Francesco; Cederbaum, Arthur I.; CeÃ±a, Valentin; Cenci, Simone; Cerella, Claudia; Cervia, Davide; Cetrullo, Silvia; Chaachouay, Hassan; Chae, Han Jung; Chagin, Andrei S.; Chai, Chee Yin; Chakrabarti, Gopal; Chamilos, Georgios; Chan, Edmond Y.W.; Chan, Matthew T.V.; Chandra, Dhyan; Chandra, Pallavi; Chang, Chih Peng; Chang, Raymond Chuen Chung; Chang, Ta Yuan; Chatham, John C.; Chatterjee, Saurabh; Chauhan, Santosh; Che, Yongsheng; Cheetham, Michael E.; Cheluvappa, Rajkumar; Chen, Chun Jung; Chen, Gang; Chen, Guang Chao; Chen, Guoqiang; Chen, Hongzhuan; Chen, Jeff W.; Chen, Jian Kang; Chen, Min; Chen, Mingzhou; Chen, Peiwen; Chen, Qi; Chen, Quan; Chen, Shang Der; Chen, Si; Chen, Steve S.L.; Chen, Wei; Chen, Wei Jung; Chen, Wen Qiang; Chen, Wenli; Chen, Xiangmei; Chen, Yau Hung; Chen, Ye Guang; Chen, Yin; Chen, Yingyu; Chen, Yongshun; Chen, Yu Jen; Chen, Yue Qin; Chen, Yujie; Chen, Zhen; Chen, Zhong; Cheng, Alan; Cheng, Christopher H.K.; Cheng, Hua; Cheong, Heesun; Cherry, Sara; Chesney, Jason; Cheung, Chun Hei Antonio; Chevet, Eric; Chi, Hsiang Cheng; Chi, Sung Gil; Chiacchiera, Fulvio; Chiang, Hui Ling; Chiarelli, Roberto; Chiariello, Mario; Chieppa, Marcello; Chin, Lih Shen; Chiong, Mario; Chiu, Gigi N.C.; Cho, Dong Hyung; Cho, Ssang Goo; Cho, William C.; Cho, Yong Yeon; Cho, Young Seok; Choi, Augustine M.K.; Choi, Eui Ju; Choi, Eun Kyoung; Choi, Jayoung; Choi, Mary E.; Choi, Seung Il; Chou, Tsui Fen; Chouaib, Salem; Choubey, Divaker; Choubey, Vinay; Chow, Kuan Chih; Chowdhury, Kamal; Chu, Charleen T.; Chuang, Tsung Hsien; Chun, Taehoon; Chung, Hyewon; Chung, Taijoon; Chung, Yuen Li; Chwae, Yong Joon; Cianfanelli, Valentina; Ciarcia, Roberto; Ciechomska, Iwona A.; Ciriolo, Maria Rosa; Cirone, Mara; Claerhout, Sofie; Clague, Michael J.; Clï¿½ ria, Joan; Clarke, Peter G.H.; Clarke, Robert; Clementi, Emilio; Cleyrat, CÃ©dric; Cnop, Miriam; Coccia, Eliana M.; Cocco, Tiziana; Codogno, Patrice; Coers, Jorn; Cohen, Ezra E.W.; Colecchia, David; Coletto, Luisa; Coll, Nuria S.; Colucci-Guyon, Emma; Comincini, Sergio; Condello, Maria; Cook, Katherine L.; Coombs, Graham H.; Cooper, Cynthia D.; Cooper, J. Mark; Coppens, Isabelle; Corasaniti, Maria Tiziana; Corazzari, Marco; Corbalan, Ramon; Corcelle-Termeau, Elisabeth; Cordero, Mario D.; Corral-Ramos, Cristina; Corti, Olga; Cossarizza, Andrea; Costelli, Paola; Costes, Safia; Cotman, Susan L.; Coto-Montes, Ana; Cottet, Sandra; Couve, Eduardo; Covey, Lori R.; Cowart, L. Ashley; Cox, Jeffery S.; Coxon, Fraser P.; Coyne, Carolyn B.; Cragg, Mark S.; Craven, Rolf J.; Crepaldi, Tiziana; Crespo, Jose L.; Criollo, Alfredo; Crippa, Valeria; Cruz, Maria Teresa; Cuervo, Ana Maria; Cuezva, Jose M.; Cui, Taixing; Cutillas, Pedro R.; Czaja, Mark J.; Czyzyk-Krzeska, Maria F.; Dagda, Ruben K.; Dahmen, Uta; Dai, Chunsun; Dai, Wenjie; Dai, Yun; Dalby, Kevin N.; Valle, Luisa Dalla; Dalmasso, Guillaume; D'amelio, Marcello; Damme, Markus; Darfeuille-Michaud, Arlette; Dargemont, Catherine; Darley-Usmar, Victor M.; Dasarathy, Srinivasan; Dasgupta, Biplab; Dash, Srikanta; Dass, Crispin R.; Davey, Hazel Marie; Davids, Lester M.; DÃ¡vila, David; Davis, Roger J.; Dawson, Ted M.; Dawson, Valina L.; Daza, Paula; de Belleroche, Jackie; de Figueiredo, Paul; de Figueiredo, Regina Celia Bressan Queiroz; de la Fuente, JosÃ©; De Martino, Luisa; De Matteis, Antonella; De Meyer, Guido R.Y.; De Milito, Angelo; De Santi, Mauro; de Souza, Wanderley; De Tata, Vincenzo; De Zio, Daniela; Debnath, Jayanta; Dechant, Reinhard; Decuypere, Jean Paul; Deegan, Shane; Dehay, Benjamin; Del Bello, Barbara; Del Re, Dominic P.; Delage-Mourroux, RÃ©gis; Delbridge, Lea M.D.; Deldicque, Louise; Delorme-Axford, Elizabeth; Deng, Yizhen; Dengjel, Joern; Denizot, Melanie; Dent, Paul; Der, Channing J.; Deretic, Vojo; Derrien, BenoÃ®t; Deutsch, Eric; Devarenne, Timothy P.; Devenish, Rodney J.; Di Bartolomeo, Sabrina; Di Daniele, Nicola; Di Domenico, Fabio; Di Nardo, Alessia; Di Paola, Simone; Di Pietro, Antonio; Di Renzo, Livia; Di Antonio, Aaron; Diaz-Araya, Guillermo; Diaz-Laviada, Ines; Diaz-Meco, Maria T.; Diaz-Nido, Javier; Dickey, Chad A.; Dickson, Robert C.; Diederich, Marc; Digard, Paul; Dikic, Ivan; Dinesh-Kumar, Savithrama P.; Ding, Chan; Ding, Wen Xing; Ding, Zufeng; Dini, Luciana; Distler, Jorg H.W.; Diwan, Abhinav; Djavaheri-Mergny, Mojgan; Dmytruk, Kostyantyn; Dobson, Renwick C.J.; Doetsch, Volker; Dokladny, Karol; Dokudovskaya, Svetlana; Donadelli, Massimo; Dong, X. Charlie; Dong, Xiaonan; Dong, Zheng; Donohue, Terrence M.; Donohue-Jr, Terrence M.; Doran, Kelly S.; D'orazi, Gabriella; Dorn, Gerald W.; Dosenko, Victor; Dridi, Sami; Drucker, Liat; Du, Jie; Du, Li Lin; Du, Lihuan; du Toit, AndrÃ©; Dua, Priyamvada; Duan, Lei; Duann, Pu; Dubey, Vikash Kumar; Duchen, Michael R.; Duchosal, Michel A.; Duez, Helene; Dugail, Isabelle; Dumit, VerÃ³nica I.; Duncan, Mara C.; Dunlop, Elaine A.; Dunn, William A.; Dupont, Nicolas; Dupuis, Luc; DurÃ¡n, Raul V.; Durcan, Thomas M.; Duvezin-Caubet, StÃ©phane; Duvvuri, Umamaheswar; Eapen, Vinay; Ebrahimi-Fakhari, Darius; Echard, Arnaud; Eckhart, Leopold; Edelstein, Charles L.; Edinger, Aimee L.; Eichinger, Ludwig; Eisenberg, Tobias; Eisenberg-Lerner, Avital; Eissa, N. Tony; El-Deiry, Wafik S.; El-Khoury, Victoria; Elazar, Zvulun; Eldar-Finkelman, Hagit; Elliott, Chris J.H.; Emanuele, Enzo; Emmenegger, Urban; Engedal, Nikolai; Engelbrecht, Anna Mart; Engelender, Simone; Enserink, Jorrit M.; Erdmann, Ralf; Erenpreisa, Jekaterina; Eri, Rajaraman; Eriksen, Jason L.; Erman, Andreja; Escalante, Ricardo; Eskelinen, Eeva Liisa; Espert, Lucile; Esteban-Martinez, Lorena; Evans, Thomas J.; Fabri, Mario; Fabrias, Gemma; Fabrizi, Cinzia; Facchiano, Antonio; FÃ¦rgeman, Nils J.; Faggioni, Alberto; Fairlie, W. Douglas; Fan, Chunhai; Fan, Daping; Fan, Jie; Fang, Shengyun; Fanto, Manolis; Fanzani, Alessandro; Farkas, Thomas; Faure, Mathias; Favier, Francois B.; Fearnhead, Howard; Federici, Massimo; Fei, Erkang; Felizardo, Tania C.; Feng, Hua; Feng, Yibin; Feng, Yuchen; Ferguson, Thomas A.; FernÃ¡ndez, Ãlvaro F.; Fernandez-Barrena, Maite G.; Fernandez-Checa, Jose C.; FernÃ¡ndez-LÃ³pez, Arsenio; Fernandez-Zapico, Martin E.; Feron, Olivier; Ferraro, Elisabetta; Ferreira-Halder, Carmen Verissima; Fesus, Laszlo; Feuer, Ralph; Fiesel, Fabienne C.; Filippi-Chiela, Eduardo C.; Filomeni, Giuseppe; Fimia, Gian Maria; Fingert, John H.; Finkbeiner, Steven; Finkel, Toren; Fiorito, Filomena; Fisher, Paul B.; Flajolet, Marc; Flamigni, Flavio; Florey, Oliver; Florio, Salvatore; Floto, R. Andres; Folini, Marco; Follo, Carlo; Fon, Edward A.; Fornai, Francesco; Fortunato, Franco; Fraldi, Alessandro; Franco, Rodrigo; Francois, Arnaud; FranÃ§ois, AurÃ©lie; Frankel, Lisa B.; Fraser, Iain D.C.; Frey, Norbert; Freyssenet, Damien G.; Frezza, Christian; Friedman, Scott L.; Frigo, Daniel E.; Fu, Dongxu; Fuentes, JosÃ© M.; Fueyo, Juan; Fujitani, Yoshio; Fujiwara, Yuuki; Fujiya, Mikihiro; Fukuda, Mitsunori; Fulda, Simone; Fusco, Carmela; Gabryel, Bozena; Gaestel, Matthias; Gailly, Philippe; Gajewska, Malgorzata; Galadari, Sehamuddin; Galili, Gad; Galindo, Inmaculada; Galindo, Maria F.; Galliciotti, Giovanna; Galluzzi, Lorenzo; Galluzzi, Luca; Galy, Vincent; Gammoh, Noor; Gandy, Sam; Ganesan, Anand K.; Ganesan, Swamynathan; Ganley, Ian G.; GannagÃ©, Monique; Gao, Fen Biao; Gao, Feng; Gao, Jian Xin; Nannig, Lorena Garcia; VÃ©scovi, Eleonora Garcia; Garcia-Macia, Marina; Garcia-Ruiz, Carmen; Garg, Abhishek D.; Garg, Pramod Kumar; Gargini, Ricardo; Gassen, Nils Christian; Gatica, DamiÃ¡n; Gatti, Evelina; Gavard, Julie; Gavathiotis, Evripidis; Ge, Liang; Ge, Pengfei; Ge, Shengfang; Gean, Po Wu; Gelmetti, Vania; Genazzani, Armando A.; Geng, Jiefei; Genschik, Pascal; Gerner, Lisa; Gestwicki, Jason E.; Gewirtz, David A.; Ghavami, Saeid; Ghigo, Eric; Ghosh, Debabrata; Giammarioli, Anna Maria; Giampieri, Francesca; Giampietri, Claudia; Giatromanolaki, Alexandra; Gibbings, Derrick J.; Gibellini, Lara; Gibson, Spencer B.; Ginet, Vanessa; Giordano, Antonio; Giorgini, Flaviano; Giovannetti, Elisa; Girardin, Stephen E.; Gispert, Suzana; Giuliano, Sandy; Gladson, Candece L.; Glavic, Alvaro; Gleave, Martin; Godefroy, Nelly; Gogal, Robert M.; Gokulan, Kuppan; Goldman, Gustavo H.; Goletti, Delia; Goligorsky, Michael S.; Gomes, Aldrin V.; Gomes, Ligia C.; Gomez, Hernando; Gomez-Manzano, Candelaria; GÃ³mez-SÃ¡nchez, RubÃ©n; GonÃ§alves, Dawit A.P.; Goncu, Ebru; Gong, Qingqiu; Gongora, CÃ©line; Gonzalez, Carlos B.; Gonzalez-Alegre, Pedro; Gonzalez-Cabo, Pilar; GonzÃ¡lez-Polo, Rosa Ana; Goping, Ing Swie; Gorbea, Carlos; Gorbunov, Nikolai V.; Goring, Daphne R.; Gorman, Adrienne M.; Gorski, Sharon M.; Goruppi, Sandro; Goto-Yamada, Shino; Gotor, Cecilia; Gottlieb, Roberta A.; Gozes, Illana; Gozuacik, Devrim; Graba, Yacine; Graef, Martin; Granato, Giovanna E.; Grant, Gary Dean; Grant, Steven; Gravina, Giovanni Luca; Green, Douglas R.; Greenhough, Alexander; Greenwood, Michael T.; Grimaldi, Benedetto; Gros, FrÃ©dÃ©ric; Grose, Charles; Groulx, Jean Francois; Gruber, Florian; Grumati, Paolo; Grune, Tilman; Guan, Jun Lin; Guan, Kun Liang; Guerra, Barbara; Guillen, Carlos; Gulshan, Kailash; Gunst, Jan; Guo, Chuanyong; Guo, Lei; Guo, Ming; Guo, Wenjie; Guo, Xu Guang; Gust, Andrea A.; Gustafsson, Ã…sa B.; Gutierrez, Elaine; Gutierrez, Maximiliano G.; Gwak, Ho Shin; Haas, Albert; Haber, James E.; Hadano, Shinji; Hagedorn, Monica; Hahn, David R.; Halayko, Andrew J.; Hamacher-Brady, Anne; Hamada, Kozo; Hamai, Ahmed; Hamann, Andrea; Hamasaki, Maho; Hamer, Isabelle; Hamid, Qutayba; Hammond, Ester M.; Han, Feng; Han, Weidong; Handa, James T.; Hanover, John A.; Hansen, Malene; Harada, Masaru; Harhaji-Trajkovic, Ljubica; Harper, J. Wade; Harrath, Abdel Halim; Harris, Adrian L.; Harris, James; Hasler, Udo; Hasselblatt, Peter; Hasui, Kazuhisa; Hawley, Robert G.; Hawley, Teresa S.; He, Congcong; He, Cynthia Y.; He, Fengtian; He, Gu; He, Rong Rong; He, Xian Hui; He, You Wen; He, Yu Ying; Heath, Joan K.; HÃ©bert, Marie JosÃ©e; Heinzen, Robert A.; Helgason, Gudmundur Vignir; Hensel, Michael; Henske, Elizabeth P.; Her, Chengtao; Herman, Paul K.; HernÃ¡ndez, Agustin; Hernandez, Carlos; HernÃ¡ndez-Tiedra, Sonia; Hetz, Claudio; Hiesinger, P. Robin; Higaki, Katsumi; Hilfiker, Sabine; Hill, Bradford G.; Hill, Joseph A.; Hill, William D.; Hino, Keisuke; Hofius, Daniel; Hofman, Paul; Hoglinger, GÃ¼nter U.; Hohfeld, Jorg; Holz, Marina K.; Hong, Yonggeun; Hood, David A.; Hoozemans, Jeroen J.M.; Hoppe, Thorsten; Hsu, Chin; Hsu, Chin Yuan; Hsu, Li Chung; Hu, Dong; Hu, Guochang; Hu, Hong Ming; Hu, Hongbo; Hu, Ming Chang; Hu, Yu Chen; Hu, Zhuo Wei; Hua, Fang; Hua, Ya; Huang, Canhua; Huang, Huey Lan; Huang, Kuo How; Huang, Kuo Yang; Huang, Shile; Huang, Shiqian; Huang, Wei Pang; Huang, Yi Ran; Huang, Yong; Huang, Yunfei; Huber, Tobias B.; Huebbe, Patricia; Huh, Won Ki; Hulmi, Juha J.; Hur, Gang Min; Hurley, James H.; Husak, Zvenyslava; Hussain, Sabah N.A.; Hussain, Salik; Hwang, Jung Jin; Hwang, Seungmin; Hwang, Thomas I.S.; Ichihara, Atsuhiro; Imai, Yuzuru; Imbriano, Carol; Inomata, Megumi; Into, Takeshi; Iovane, Valentina; Iovanna, Juan L.; Iozzo, Renato V.; Ip, Nancy Y.; Irazoqui, Javier E.; Iribarren, Pablo; Isaka, Yoshitaka; Isakovic, Aleksandra J.; Ischiropoulos, Harry; Isenberg, Jeffrey S.; Ishaq, Mohammad; Ishida, Hiroyuki; Ishii, Isao; Ishmael, Jane E.; Isidoro, Ciro; Isobe, Ken Ichi; Isono, Erika; Issazadeh-Navikas, Shohreh; Itahana, Koji; Itakura, Eisuke; Ivanov, Andrei I.; Iyer, Anand Krishnan V.; Izquierdo, JosÃ© M.; Izumi, Yotaro; Izzo, Valentina; JÃ¤Ã¤ttelÃ¤, Marja; Jaber, Nadia; Jackson, Daniel John; Jackson, William T.; Jacob, Tony George; Jacques, Thomas S.; Jagannath, Chinnaswamy; Jain, Ashish; Jana, Nihar Ranjan; Jang, Byoung Kuk; Jani, Alkesh; Janji, Bassam; Jannig, Paulo Roberto; Jansson, Patric J.; Jean, Steve; Jendrach, Marina; Jeon, Ju Hong; Jessen, Niels; Jeung, Eui Bae; Jia, Kailiang; Jia, Lijun; Jiang, Hong; Jiang, Hongchi; Jiang, Liwen; Jiang, Teng; Jiang, Xiaoyan; Jiang, Xuejun; Jiang, Ying; Jiang, Yongjun; JimÃ©nez, Alberto; Jin, Cheng; Jin, Hongchuan; Jin, Lei; Jin, Meiyan; Jin, Shengkan; Jinwal, Umesh Kumar; Jo, Eun Kyeong; Johansen, Terje; Johnson, Daniel E.; Johnson, Gail V.W.; Johnson, James D.; Jonasch, Eric; Jones, Chris; Joosten, Leo A.B.; Jordan, Joaquin; Joseph, Anna Maria; Joseph, Bertrand; Joubert, Annie M.; Ju, Dianwen; Ju, Jingfang; Juan, Hsueh Fen; Juenemann, Katrin; JuhÃ¡sz, GÃ¡bor; Jung, Hye Seung; Jung, Jae U.; Jung, Yong Keun; Jungbluth, Heinz; Justice, Matthew J.; Jutten, Barry; Kaakoush, Nadeem O.; Kaarniranta, Kai; Kaasik, Allen; Kabuta, Tomohiro; Kaeffer, Bertrand; KÃ¥gedal, Katarina; Kahana, Alon; Kajimura, Shingo; Kakhlon, Or; Kalia, Manjula; Kalvakolanu, Dhan V.; Kamada, Yoshiaki; Kambas, Konstantinos; Kaminskyy, Vitaliy O.; Kampinga, Harm H.; Kandouz, Mustapha; Kang, Chanhee; Kang, Rui; Kang, Tae Cheon; Kanki, Tomotake; Kanneganti, Thirumala Devi; Kanno, Haruo; Kanthasamy, Anumantha G.; Kantorow, Marc; Kaparakis-Liaskos, Maria; Kapuy, Orsolya; Karantza, Vassiliki; Karim, Md Razaul; Karmakar, Parimal; Kaser, Arthur; Kaushik, Susmita; Kawula, Thomas; Kaynar, A. Murat; Ke, Po Yuan; Ke, Zun Ji; Kehrl, John H.; Keller, Kate E.; Kemper, Jongsook Kim; Kenworthy, Anne K.; Kepp, Oliver; Kern, Andreas; Kesari, Santosh; Kessel, David; Ketteler, Robin; Kettelhut, Isis do Carmo; Khambu, Bilon; Khan, Muzamil Majid; Khandelwal, Vinoth K.M.; Khare, Sangeeta; Kiang, Juliann G.; Kiger, Amy A.; Kihara, Akio; Kim, Arianna L.; Kim, Cheol Hyeon; Kim, Deok Ryong; Kim, Do Hyung; Kim, Eung Kweon; Kim, Hye Young; Kim, Hyung Ryong; Kim, Jae Sung; Kim, Jeong Hun; Kim, Jin Cheon; Kim, Jin Hyoung; Kim, Kwang Woon; Kim, Michael D.; Kim, Moon Moo; Kim, Peter K.; Kim, Seong Who; Kim, Soo Youl; Kim, Yong Sun; Kim, Yonghyun; Kimchi, Adi; Kimmelman, Alec C.; Kimura, Tomonori; King, Jason S.; Kirkegaard, Karla; Kirkin, Vladimir; Kirshenbaum, Lorrie A.; Kishi, Shuji; Kitajima, Yasuo; Kitamoto, Katsuhiko; Kitaoka, Yasushi; Kitazato, Kaio; Kley, Rudolf A.; Klimecki, Walter T.; Klinkenberg, Michael; Klucken, Jochen; KnÃ¦velsrud, Helene; Knecht, Erwin; Knuppertz, Laura; Ko, Jiunn Liang; Kobayashi, Satoru; Koch, Jan C.; Koechlin-Ramonatxo, Christelle; Koenig, Ulrich; Koh, Young Ho; Kohler, Katja; Kohlwein, Sepp D.; Koike, Masato; Komatsu, Masaaki; Kominami, Eiki; Kong, Dexin; Kong, Hee Jeong; Konstantakou, Eumorphia G.; Kopp, Benjamin T.; Korcsmaros, Tamas; Korhonen, Laura; Korolchuk, Viktor I.; Koshkina, Nadya V.; Kou, Yanjun; Koukourakis, Michael I.; Koumenis, Constantinos; KovÃ¡cs, Attila L.; KovÃ¡cs, Tibor; Kovacs, Werner J.; Koya, Daisuke; Kraft, Claudine; Krainc, Dimitri; Kramer, Helmut; Kravic-Stevovic, Tamara; Krek, Wilhelm; Kretz-Remy, Carole; Krick, Roswitha; Krishnamurthy, Malathi; Kriston-Vizi, Janos; Kroemer, Guido; Kruer, Michael C.; Kruger, Rejko; Ktistakis, Nicholas T.; Kuchitsu, Kazuyuki; Kuhn, Christian; Kumar, Addanki Pratap; Kumar, Anuj; Kumar, Ashok; Kumar, Deepak; Kumar, Dhiraj; Kumar, Rakesh; Kumar, Sharad; Kundu, Mondira; Kung, Hsing Jien; Kuno, Atsushi; Kuo, Sheng Han; Kuret, Jeff; Kurz, Tino; Kwok, Terry; Kwon, Taeg Kyu; Kwon, Yong Tae; Kyrmizi, Irene; La Spada, Albert R.; Lafont, Frank; Lahm, Tim; Lakkaraju, Aparna; Lam, Truong; Lamark, Trond; Lancel, Steve; Landowski, Terry H.; Lane, Darius J.R.; Lane, Jon D.; Lanzi, Cinzia; Lapaquette, Pierre; Lapierre, Louis R.; Laporte, Jocelyn; Laukkarinen, Johanna; Laurie, Gordon W.; Lavandero, Sergio; Lavie, Lena; Lavoie, Matthew J.; Law, Betty Yuen Kwan; Law, Helen Ka Wai; Law, Kelsey B.; Layfield, Robert; Lazo, Pedro A.; Le Cam, Laurent; Le Roch, Karine G.; Le Stunff, HervÃ©; Leardkamolkarn, Vijittra; Lecuit, Marc; Lee, Byung Hoon; Lee, Che Hsin; Lee, Erinna F.; Lee, Gyun Min; Lee, He Jin; Lee, Hsinyu; Lee, Jae Keun; Lee, Jongdae; Lee, Ju Hyun; Lee, Jun Hee; Lee, Michael; Lee, Myung Shik; Lee, Patty J.; Lee, Sam W.; Lee, Seung Jae; Lee, Shiow Ju; Lee, Stella Y.; Lee, Sug Hyung; Lee, Sung Sik; Lee, Sung Joon; Lee, Sunhee; Lee, Ying Ray; Lee, Yong J.; Lee, Young H.; Leeuwenburgh, Christiaan; Lefort, Sylvain; Legouis, Renaud; Lei, Jinzhi; Lei, Qun Ying; Leib, David A.; Leibowitz, Gil; Lekli, Istvan; Lemaire, StÃ©phane D.; Lemasters, John J.; Lemberg, Marius K.; Lemoine, Antoinette; Leng, Shuilong; Lenz, Guido; Lenzi, Paola; Lerman, Lilach O.; Barbato, Daniele Lettieri; Leu, Julia I.Ju; Leung, Hing Y.; Levine, Beth; Lewis, Patrick A.; Lezoualch, Frank; Li, Chi; Li, Faqiang; Li, Feng Jun; Li, Jun; Li, Ke; Li, Lian; Li, Min; Li, Qiang; Li, Rui; Li, Sheng; Li, Wei; Li, Xiaotao; Li, Yumin; Lian, Jiqin; Liang, Chengyu; Liang, Qiangrong; Liao, Yulin; Liberal, Joana; Liberski, Pawel P.; Lie, Pearl; Lieberman, Andrew P.; Lim, Hyunjung Jade; Lim, Kah Leong; Lim, Kyu; Lima, Raquel T.; Lin, Chang Shen; Lin, Chiou Feng; Lin, Fang; Lin, Fangming; Lin, Fu Cheng; Lin, Kui; Lin, Kwang Huei; Lin, Pei Hui; Lin, Tianwei; Lin, Wan Wan; Lin, Yee Shin; Lin, Yong; Linden, Rafael; Lindholm, Dan; Lindqvist, Lisa M.; Lingor, Paul; Linkermann, Andreas; Liotta, Lance A.; Lipinski, Marta M.; Lira, Vitor A.; Lisanti, Michael P.; Liton, Paloma B.; Liu, Bo; Liu, Chong; Liu, Chun Feng; Liu, Fei; Liu, Hung Jen; Liu, Jianxun; Liu, Jing Jing; Liu, Jing Lan; Liu, Ke; Liu, Leyuan; Liu, Liang; Liu, Quentin; Liu, Rong Yu; Liu, Shiming; Liu, Shuwen; Liu, Wei; Liu, Xian De; Liu, Xiangguo; Liu, Xiao Hong; Liu, Xinfeng; Liu, Xu; Liu, Xueqin; Liu, Yang; Liu, Yule; Liu, Zexian; Liu, Zhe; Liuzzi, Juan P.; Lizard, GÃ©rard; Ljujic, Mila; Lodhi, Irfan J.; Logue, Susan E.; Lokeshwar, Bal L.; Long, Yun Chau; Lonial, Sagar; Loos, Benjamin; LÃ³pez-Otin, Carlos; LÃ³pez-Vicario, Cristina; Lorente, Mar; Lorenzi, Philip L.; LÃµrincz, PÃ©ter; Los, Marek; Lotze, Michael T.; Lovat, Penny E.; Lu, Binfeng; Lu, Bo; Lu, Jiahong; Lu, Qing; Lu, She Min; Lu, Shuyan; Lu, Yingying; Luciano, FrÃ©dÃ©ric; Luckhart, Shirley; Lucocq, John Milton; Ludovico, Paula; Lugea, Aurelia; Lukacs, Nicholas W.; Lum, Julian J.; Lund, Anders H.; Luo, Honglin; Luo, Jia; Luo, Shouqing; Luparello, Claudio; Lyons, Timothy; Ma, Jianjie; Ma, Yi; Ma, Yong; Ma, Zhenyi; Machado, Juliano; Machado-Santelli, Glaucia M.; Macian, Fernando; MacIntosh, Gustavo C.; MacKeigan, Jeffrey P.; Macleod, Kay F.; MacMicking, John D.; MacMillan-Crow, Lee Ann; Madeo, Frank; Madesh, Muniswamy; Madrigal-Matute, Julio; Maeda, Akiko; Maeda, Tatsuya; Maegawa, Gustavo; Maellaro, Emilia; Maes, Hannelore; MagariÃ±os, Marta; Maiese, Kenneth; Maiti, Tapas K.; Maiuri, Luigi; Maiuri, Maria Chiara; Maki, Carl G.; Malli, Roland; Malorni, Walter; Maloyan, Alina; Mami-Chouaib, Fathia; Man, Na; Mancias, Joseph D.; Mandelkow, Eva Maria; Mandell, Michael A.; Manfredi, Angelo A.; ManiÃ©, Serge N.; Manzoni, Claudia; Mao, Kai; Mao, Zixu; Mao, Zong Wan; Marambaud, Philippe; Marconi, Anna Maria; Marelja, Zvonimir; Marfe, Gabriella; Margeta, Marta; Margittai, Eva; Mari, Muriel; Mariani, Francesca V.; Marin, Concepcio; Marinelli, Sara; MariÃ±o, Guillermo; Markovic, Ivanka; Marquez, Rebecca; Martelli, Alberto M.; Martens, Sascha; Martin, Katie R.; Martin, Seamus J.; Martin, Shaun; Martin-Acebes, Miguel A.; Martin-Sanz, Paloma; Martinand-Mari, Camille; Martinet, Wim; Martinez, Jennifer; Martinez-Lopez, Nuria; Martinez-Outschoorn, Ubaldo; Martinez-VelÃ¡zquez, MoisÃ©s; Martinez-Vicente, Marta; Martins, Waleska Kerllen; Mashima, Hirosato; Mastrianni, James A.; Matarese, Giuseppe; Matarrese, Paola; Mateo, Roberto; Matoba, Satoaki; Matsumoto, Naomichi; Matsushita, Takehiko; Matsuura, Akira; Matsuzawa, Takeshi; Mattson, Mark P.; Matus, Soledad; Maugeri, Norma; Mauvezin, Caroline; Mayer, Andreas; Maysinger, Dusica; Mazzolini, Guillermo D.; McBrayer, Mary Kate; McCall, Kimberly; McCormick, Craig; McInerney, Gerald M.; McIver, Skye C.; McKenna, Sharon; McMahon, John J.; McNeish, Iain A.; Mechta-Grigoriou, Fatima; Medema, Jan Paul; Medina, Diego L.; Megyeri, Klara; Mehrpour, Maryam; Mehta, Jawahar L.; Mei, Yide; Meier, Ute Christiane; Meijer, Alfred J.; MelÃ©ndez, Alicia; Melino, Gerry; Melino, Sonia; de Melo, Edesio Jose Tenorio; Mena, Maria A.; Meneghini, Marc D.; Menendez, Javier A.; Menezes, Regina; Meng, Liesu; Meng, Ling Hua; Meng, Songshu; Menghini, Rossella; Menko, A. Sue; Menna-Barreto, Rubem F.S.; Menon, Manoj B.; Meraz-Rios, Marco A.; Merla, Giuseppe; Merlini, Luciano; Merlot, Angelica M.; Meryk, Andreas; Meschini, Stefania; Meyer, Joel N.; Mi, Man Tian; Miao, Chao Yu; Micale, Lucia; Michaeli, Simon; Michiels, Carine; Migliaccio, Anna Rita; Mihailidou, Anastasia Susie; Mijaljica, Dalibor; Mikoshiba, Katsuhiko; Milan, Enrico; Miller-Fleming, Leonor; Mills, Gordon B.; Mills, Ian G.; Minakaki, Georgia; Minassian, Berge A.; Ming, Xiu Fen; Minibayeva, Farida; Minina, Elena A.; Mintern, Justine D.; Minucci, Saverio; Miranda-Vizuete, Antonio; Mitchell, Claire H.; Miyamoto, Shigeki; Miyazawa, Keisuke; Mizushima, Noboru; Mnich, Katarzyna; Mograbi, Baharia; Mohseni, Simin; Moita, Luis Ferreira; Molinari, Marco; Molinari, Maurizio; MÃ¸ller, Andreas Buch; Mollereau, Bertrand; Mollinedo, Faustino; Mongillo, Marco; Monick, Martha M.; Montagnaro, Serena; Montell, Craig; Moore, Darren J.; Moore, Michael N.; Mora-Rodriguez, Rodrigo; Moreira, Paula I.; Morel, Etienne; Morelli, Maria Beatrice; Moreno, Sandra; Morgan, Michael J.; Moris, Arnaud; Moriyasu, Yuji; Morrison, Janna L.; Morrison, Lynda A.; Morselli, Eugenia; Moscat, Jorge; Moseley, Pope L.; Mostowy, Serge; Motori, Elisa; Mottet, Denis; Mottram, Jeremy C.; Moussa, Charbel E.H.; Mpakou, Vassiliki E.; Mukhtar, Hasan; Levy, Jean M.Mulcahy; Muller, Sylviane; MuÃ±oz-Moreno, Raquel; MuÃ±oz-Pinedo, Cristina; MÃ¼nz, Christian; Murphy, Maureen E.; Murray, James T.; Murthy, Aditya; Mysorekar, Indira U.; Nabi, Ivan R.; Nabissi, Massimo; Nader, Gustavo A.; Nagahara, Yukitoshi; Nagai, Yoshitaka; Nagata, Kazuhiro; Nagelkerke, Anika; Nagy, PÃ©ter; Naidu, Samisubbu R.; Nair, Sreejayan; Nakano, Hiroyasu; Nakatogawa, Hitoshi; Nanjundan, Meera; Napolitano, Gennaro; Naqvi, Naweed I.; Nardacci, Roberta; Narendra, Derek P.; Narita, Masashi; Nascimbeni, Anna Chiara; Natarajan, Ramesh; Navegantes, Luiz C.; Nawrocki, Steffan T.; Nazarko, Taras Y.; Nazarko, Volodymyr Y.; Neill, Thomas; Neri, Luca M.; Netea, Mihai G.; Netea-Maier, Romana T.; Neves, Bruno M.; Ney, Paul A.; Nezis, Ioannis P.; Nguyen, Hang T.T.; Nguyen, Huu Phuc; Nicot, Anne Sophie; Nilsen, Hilde; Nilsson, Per; Nishimura, Mikio; Nishino, Ichizo; Niso-Santano, Mireia; Niu, Hua; Nixon, Ralph A.; Njar, Vincent C.O.; Noda, Takeshi; Noegel, Angelika A.; Nolte, Elsie Magdalena; Norberg, Erik; Norga, Koenraad K.; Noureini, Sakineh Kazemi; Notomi, Shoji; Notterpek, Lucia; Nowikovsky, Karin; Nukina, Nobuyuki; NÃ¼rnberger, Thorsten; O'donnell, Valerie B.; O'donovan, Tracey; O'dwyer, Peter J.; Oehme, Ina; Oeste, Clara L.; Ogawa, Michinaga; Ogretmen, Besim; Ogura, Yuji; Oh, Young J.; Ohmuraya, Masaki; Ohshima, Takayuki; Ojha, Rani; Okamoto, Koji; Okazaki, Toshiro; Oliver, F. Javier; Ollinger, Karin; Olsson, Stefan; Orban, Daniel P.; Ordonez, Paulina; Orhon, Idil; Orosz, Laszlo; O'rourke, Eyleen J.; Orozco, Helena; Ortega, Angel L.; Ortona, Elena; Osellame, Laura D.; Oshima, Junko; Oshima, Shigeru; Osiewacz, Heinz D.; Otomo, Takanobu; Otsu, Kinya; Ou, Jing Hsiung James; Outeiro, Tiago F.; Ouyang, Dong Yun; Ouyang, Hongjiao; Overholtzer, Michael; Ozbun, Michelle A.; Ozdinler, P. Hande; Ozpolat, Bulent; Pacelli, Consiglia; Paganetti, Paolo; Page, GuylÃ©ne; Pages, Gilles; Pagnini, Ugo; Pajak, Beata; Pak, Stephen C.; Pakos-Zebrucka, Karolina; Pakpour, Nazzy; PalkovÃ¡, Zdena; Palladino, Francesca; Pallauf, Kathrin; Pallet, Nicolas; Palmieri, Marta; Paludan, SÃ¸ren R.; Palumbo, Camilla; Palumbo, Silvia; Pampliega, Olatz; Pan, Hongming; Pan, Wei; Panaretakis, Theocharis; Pandey, Aseem; Pantazopoulou, Areti; Papackova, Zuzana; Papademetrio, Daniela L.; Papassideri, Issidora; Papini, Alessio; Parajuli, Nirmala; Pardo, Julian; Parekh, Vrajesh V.; Parenti, Giancarlo; Park, Jong In; Park, Junsoo; Park, Ohkmae K.; Parker, Roy; Parlato, Rosanna; Parys, Jan B.; Parzych, Katherine R.; Pasquet, Jean Max; Pasquier, Benoit; Pasumarthi, Kishore B.S.; Patschan, Daniel; Pattingre, Sophie; Pattison, Scott; Pause, Arnim; PavenstÃ¤dt, Hermann; Pavone, Flaminia; Pedrozo, Zully; PeÃ±a, Fernando J.; PeÃ±alva, Miguel A.; Pende, Mario; Peng, Jianxin; Penna, Fabio; Penninger, Josef M.; Pensalfini, Anna; Pepe, Salvatore; Pereira, Gustavo J.S.; Pereira, Paulo C.; de la Cruz, VerÃ³nica Pérez; Pérez-Pérez, Maria Esther; Pérez-Rodriguez, Diego; Pérez-Sala, Dolores; Perier, Celine; Perl, Andras; Perlmutter, David H.; Perrotta, Ida; Pervaiz, Shazib; Pesonen, Maija; Pessin, Jeffrey E.; Peters, Godefridus J.; Petersen, Morten; Petrache, Irina; Petrof, Basil J.; Petrovski, Goran; Phang, James M.; Piacentini, Mauro; Pierdominici, Marina; Pierre, Philippe; Pierrefite-Carle, ValÃ©rie; Pietrocola, Federico; Pimentel-MuiÃ±os, Felipe X.; Pinar, Mario; Pineda, Benjamin; Pinkas-Kramarski, Ronit; Pinti, Marcello; Pinton, Paolo; Piperdi, Bilal; Piret, James M.; Platanias, Leonidas C.; Platta, Harald W.; Plowey, Edward D.; Poggeler, Stefanie; Poirot, Marc; Polcic, Peter; Poletti, Angelo; Poon, Audrey H.; Popelka, Hana; Popova, Blagovesta; Poprawa, Izabela; Poulose, Shibu M.; Poulton, Joanna; Powers, Scott K.; Powers, Ted; Pozuelo-Rubio, Mercedes; Prak, Krisna; Prange, Reinhild; Prescott, Mark; Priault, Muriel; Prince, Sharon; Proia, Richard L.; Proikas-Cezanne, Tassula; Prokisch, Holger; Promponas, Vasilis J.; Przyklenk, Karin; Puertollano, Rosa; Pugazhenthi, Subbiah; Puglielli, Luigi; Pujol, Aurora; Puyal, Julien; Pyeon, Dohun; Qi, Xin; Qian, Wen Bin; Qin, Zheng Hong; Qiu, Yu; Qu, Ziwei; Quadrilatero, Joe; Quinn, Frederick; Raben, Nina; Rabinowich, Hannah; Radogna, Flavia; Ragusa, Michael J.; Rahmani, Mohamed; Raina, Komal; Ramanadham, Sasanka; Ramesh, Rajagopal; Rami, Abdelhaq; Randall-Demllo, Sarron; Randow, Felix; Rao, Hai; Rao, V. Ashutosh; Rasmussen, Blake B.; Rasse, Tobias M.; Ratovitski, Edward A.; Rautou, Pierre Emmanuel; Ray, Swapan K.; Razani, Babak; Reed, Bruce H.; Reggiori, Fulvio; Rehm, Markus; Reichert, Andreas S.; Rein, Theo; Reiner, David J.; Reits, Eric; Ren, Jun; Ren, Xingcong; Renna, Maurizio; Reusch, Jane E.B.; Revuelta, Jose L.; Reyes, Leticia; Rezaie, Alireza R.; Richards, Robert I.; Richardson, Des R.; Richetta, ClÃ©mence; Riehle, Michael A.; Rihn, Bertrand H.; Rikihisa, Yasuko; Riley, Brigit E.; Rimbach, Gerald; Rippo, Maria Rita; Ritis, Konstantinos; Rizzi, Federica; Rizzo, Elizete; Roach, Peter J.; Robbins, Jeffrey; Roberge, Michel; Roca, Gabriela; Roccheri, Maria Carmela; Rocha, Sonia; Rodrigues, Cecilia M.P.; Rodriguez, Clara I.; de Cordoba, Santiago Rodriguez; Rodriguez-Muela, Natalia; Roelofs, Jeroen; Rogov, Vladimir V.; Rohn, Troy T.; Rohrer, BÃ¤rbel; Romanelli, Davide; Romani, Luigina; Romano, Patricia Silvia; Roncero, M. Isabel G.; Rosa, Jose Luis; Rosello, Alicia; Rosen, Kirill V.; Rosenstiel, Philip; Rost-Roszkowska, Magdalena; Roth, Kevin A.; RouÃ©, Gael; Rouis, Mustapha; Rouschop, Kasper M.; Ruan, Daniel T.; Ruano, Diego; Rubinsztein, David C.; Rucker, Edmund B.; Rudich, Assaf; Rudolf, Emil; Rudolf, Ruediger; Ruegg, Markus A.; Ruiz-Roldan, Carmen; Ruparelia, Avnika Ashok; Rusmini, Paola; Russ, David W.; Russo, Gian Luigi; Russo, Giuseppe; Russo, Rossella; Rusten, Tor Erik; Ryabovol, Victoria; Ryan, Kevin M.; Ryter, Stefan W.; Sabatini, David M.; Sacher, Michael; Sachse, Carsten; Sack, Michael N.; Sadoshima, Junichi; Saftig, Paul; Sagi-Eisenberg, Ronit; Sahni, Sumit; Saikumar, Pothana; Saito, Tsunenori; Saitoh, Tatsuya; Sakakura, Koichi; Sakoh-Nakatogawa, Machiko; Sakuraba, Yasuhito; Salazar-Roa, Maria; Salomoni, Paolo; Saluja, Ashok K.; Salvaterra, Paul M.; Salvioli, Rosa; Samali, Afshin; Sanchez, Anthony M.J.; SÃ¡nchez-AlcÃ¡zar, JosÃ© A.; Sanchez-Prieto, Ricardo; Sandri, Marco; Sanjuan, Miguel A.; Santaguida, Stefano; Santambrogio, Laura; Santoni, Giorgio; Dos Santos, Claudia Nunes; Saran, Shweta; Sardiello, Marco; Sargent, Graeme; Sarkar, Pallabi; Sarkar, Sovan; Sarrias, Maria Rosa; Sarwal, Minnie M.; Sasakawa, Chihiro; Sasaki, Motoko; Sass, Miklos; Sato, Ken; Sato, Miyuki; Satriano, Joseph; Savaraj, Niramol; Saveljeva, Svetlana; Schaefer, Liliana; Schaible, Ulrich E.; Scharl, Michael; Schatzl, Hermann M.; Schekman, Randy; Scheper, Wiep; Schiavi, Alfonso; Schipper, Hyman M.; Schmeisser, Hana; Schmidt, Jens; Schmitz, Ingo; Schneider, Bianca E.; Schneider, E. Marion; Schneider, Jaime L.; Schon, Eric A.; Schonenberger, Miriam J.; Schonthal, Axel H.; Schorderet, Daniel F.; Schroder, Bernd; Schuck, Sebastian; Schulze, Ryan J.; Schwarten, Melanie; Schwarz, Thomas L.; Sciarretta, Sebastiano; Scotto, Kathleen; Scovassi, A. Ivana; Screaton, Robert A.; Screen, Mark; Seca, Hugo; Sedej, Simon; Segatori, Laura; Segev, Nava; Seglen, Per O.; Segui-Simarro, Jose M.; Segura-Aguilar, Juan; Seiliez, Iban; Seki, Ekihiro; Sell, Christian; Semenkovich, Clay F.; Semenza, Gregg L.; Sen, Utpal; Serra, Andreas L.; Serrano-Puebla, Ana; Sesaki, Hiromi; Setoguchi, Takao; Settembre, Carmine; Shacka, John J.; Shajahan-Haq, Ayesha N.; Shapiro, Irving M.; Sharma, Shweta; She, Hua; Shen, C. K.James; Shen, Chiung Chyi; Shen, Han Ming; Shen, Sanbing; Shen, Weili; Sheng, Rui; Sheng, Xianyong; Sheng, Zu Hang; Shepherd, Trevor G.; Shi, Junyan; Shi, Qiang; Shi, Qinghua; Shi, Yuguang; Shibutani, Shusaku; Shibuya, Kenichi; Shidoji, Yoshihiro; Shieh, Jeng Jer; Shih, Chwen Ming; Shimada, Yohta; Shimizu, Shigeomi; Shin, Dong Wook; Shinohara, Mari L.; Shintani, Michiko; Shintani, Takahiro; Shioi, Tetsuo; Shirabe, Ken; Shiri-Sverdlov, Ronit; Shirihai, Orian; Shore, Gordon C.; Shu, Chih Wen; Shukla, Deepak; Sibirny, Andriy A.; Sica, Valentina; Sigurdson, Christina J.; Sigurdsson, Einar M.; Sijwali, Puran Singh; Sikorska, Beata; Silveira, Wilian A.; Silvente-Poirot, Sandrine; Silverman, Gary A.; Simak, Jan; Simmet, Thomas; Simon, Anna Katharina; Simon, Hans Uwe; Simone, Cristiano; Simons, Matias; Simonsen, Anne; Singh, Rajat; Singh, Shivendra V.; Singh, Shrawan K.; Sinha, Debasish; Sinha, Sangita; Sinicrope, Frank A.; Sirko, Agnieszka; Sirohi, Kapil; Sishi, Balindiwe J.N.; Sittler, Annie; Siu, Parco M.; Sivridis, Efthimios; Skwarska, Anna; Slack, Ruth; SlaninovÃ¡, Iva; Slavov, Nikolai; Smaili, Soraya S.; Smalley, Keiran S.M.; Smith, Duncan R.; Soenen, Stefaan J.; Soleimanpour, Scott A.; Solhaug, Anita; Somasundaram, Kumaravel; Son, Jin H.; Sonawane, Avinash; Song, Chunjuan; Song, Fuyong; Song, Hyun Kyu; Song, Ju Xian; Song, Wei; Soo, Kai Y.; Sood, Anil K.; Soong, Tuck Wah; Soontornniyomkij, Virawudh; Sorice, Maurizio; Sotgia, Federica; Soto-Pantoja, David R.; Sotthibundhu, Areechun; Sousa, Maria JoÃ£o; Spaink, Herman P.; Span, Paul N.; Spang, Anne; Sparks, Janet D.; Speck, Peter G.; Spector, Stephen A.; Spies, Claudia D.; Springer, Wolfdieter; Clair, Daret St; Stacchiotti, Alessandra; Staels, Bart; Stang, Michael T.; Starczynowski, Daniel T.; Starokadomskyy, Petro; Steegborn, Clemens; Steele, John W.; Stefanis, Leonidas; Steffan, Joan; Stellrecht, Christine M.; Stenmark, Harald; Stepkowski, Tomasz M.; Stern, StÄ™phan T.; Stevens, Craig; Stockwell, Brent R.; Stoka, Veronika; Storchova, Zuzana; Stork, Bjorn; Stratoulias, Vassilis; Stravopodis, Dimitrios J.; Strnad, Pavel; Strohecker, Anne Marie; Strom, Anna Lena; Stromhaug, Per; Stulik, Jiri; Su, Yu Xiong; Su, Zhaoliang; Subauste, Carlos S.; Subramaniam, Srinivasa; Sue, Carolyn M.; Suh, Sang Won; Sui, Xinbing; Sukseree, Supawadee; Sulzer, David; Sun, Fang Lin; Sun, Jiaren; Sun, Jun; Sun, Shi Yong; Sun, Yang; Sun, Yi; Sun, Yingjie; Sundaramoorthy, Vinod; Sung, Joseph; Suzuki, Hidekazu; Suzuki, Kuninori; Suzuki, Naoki; Suzuki, Tadashi; Suzuki, Yuichiro J.; Swanson, Michele S.; Swanton, Charles; SwÃ¤rd, Karl; Swarup, Ghanshyam; Sweeney, Sean T.; Sylvester, Paul W.; Szatmari, Zsuzsanna; Szegezdi, Eva; Szlosarek, Peter W.; Taegtmeyer, Heinrich; Tafani, Marco; Taillebourg, Emmanuel; Tait, Stephen W.G.; Takacs-Vellai, Krisztina; Takahashi, Yoshinori; TakÃ¡ts, Szabolcs; Takemura, Genzou; Takigawa, Nagio; Talbot, Nicholas J.; Tamagno, Elena; Tamburini, Jerome; Tan, Cai Ping; Tan, Lan; Tan, Mei Lan; Tan, Ming; Tan, Yee Joo; Tanaka, Keiji; Tanaka, Masaki; Tang, Daolin; Tang, Dingzhong; Tang, Guomei; Tanida, Isei; Tanji, Kunikazu; Tannous, Bakhos A.; Tapia, Jose A.; Tasset-Cuevas, Inmaculada; Tatar, Marc; Tavassoly, Iman; Tavernarakis, Nektarios; Taylor, Allen; Taylor, Graham S.; Taylor, Gregory A.; Taylor, J. Paul; Taylor, Mark J.; Tchetina, Elena V.; Tee, Andrew R.; Teixeira-Clerc, Fatima; Telang, Sucheta; Tencomnao, Tewin; Teng, Ba Bie; Teng, Ru Jeng; Terro, Faraj; Tettamanti, Gianluca; Theiss, Arianne L.; Theron, Anne E.; Thomas, Kelly Jean; ThomÃ©, Marcos P.; Thomes, Paul G.; Thorburn, Andrew; Thorner, Jeremy; Thum, Thomas; Thumm, Michael; Thurston, Teresa L.M.; Tian, Ling; Till, Andreas; , ; Ting, Jenny Pan Yun; Titorenko, Vladimir I.; Toker, Lilach; Toldo, Stefano; Tooze, Sharon A.; Topisirovic, Ivan; Torgersen, Maria Lyngaas; Torosantucci, Liliana; Torriglia, Alicia; Torrisi, Maria Rosaria; Tournier, Cathy; Towns, Roberto; Trajkovic, Vladimir; Travassos, Leonardo H.; Triola, Gemma; Tripathi, Durga Nand; Trisciuoglio, Daniela; Troncoso, Rodrigo; Trougakos, Ioannis P.; Truttmann, Anita C.; Tsai, Kuen Jer; Tschan, Mario P.; Tseng, Yi Hsin; Tsukuba, Takayuki; Tsung, Allan; Tsvetkov, Andrey S.; Tu, Shuiping; Tuan, Hsing Yu; Tucci, Marco; Tumbarello, David A.; Turk, Boris; Turk, Vito; Turner, Robin F.B.; Tveita, Anders A.; Tyagi, Suresh C.; Ubukata, Makoto; Uchiyama, Yasuo; Udelnow, Andrej; Ueno, Takashi; Umekawa, Midori; Umemiya-Shirafuji, Rika; Underwood, Benjamin R.; Ungermann, Christian; Ureshino, Rodrigo P.; Ushioda, Ryo; Uversky, Vladimir N.; UzcÃ¡tegui, NÃ©stor L.; Vaccari, Thomas; Vaccaro, Maria I.; VÃ¡chovÃ¡, LibuÅ¡e; Vakifahmetoglu-Norberg, Helin; Valdor, Rut; Valente, Enza Maria; Vallette, Francois; Valverde, Angela M.; Van den Berghe, Greet; Van Den Bosch, Ludo; van den Brink, Gijs R.; van der Goot, F. Gisou; van der Klei, Ida J.; van der Laan, Luc J.W.; van Doorn, Wouter G.; van Egmond, Marjolein; van Golen, Kenneth L.; Van Kaer, Luc; Campagne, Menno van Lookeren; Vandenabeele, Peter; Vandenberghe, Wim; Vanhorebeek, Ilse; Varela-Nieto, Isabel; Vasconcelos, M. Helena; Vasko, Radovan; Vavvas, Demetrios G.; Vega-Naredo, Ignacio; Velasco, Guillermo; Velentzas, Athanassios D.; Velentzas, Panagiotis D.; Vellai, Tibor; Vellenga, Edo; Vendelbo, Mikkel Holm; Venkatachalam, Kartik; Ventura, Natascia; Ventura, Salvador; Veras, Patricia S.T.; Verdier, Mireille; Vertessy, Beata G.; Viale, Andrea; Vidal, Michel; Vieira, Helena L.A.; Vierstra, Richard D.; Vigneswaran, Nadarajah; Vij, Neeraj; Vila, Miquel; Villar, Margarita; Villar, Victor H.; Villarroya, Joan; Vindis, CÃ©cile; Viola, Giampietro; Viscomi, Maria Teresa; Vitale, Giovanni; Vogl, Dan T.; Voitsekhovskaja, Olga V.; von Haefen, Clarissa; von Schwarzenberg, Karin; Voth, Daniel E.; Vouret-Craviari, ValÃ©rie; Vuori, Kristina; Vyas, Jatin M.; Waeber, Christian; Walker, Cheryl Lyn; Walker, Mark J.; Walter, Jochen; Wan, Lei; Wan, Xiangbo; Wang, Bo; Wang, Caihong; Wang, Chao Yung; Wang, Chengshu; Wang, Chenran; Wang, Chuangui; Wang, Dong; Wang, Fen; Wang, Fuxin; Wang, Guanghui; Wang, Hai Jie; Wang, Haichao; Wang, Hong Gang; Wang, Hongmin; Wang, Horng Dar; Wang, Jing; Wang, Junjun; Wang, Mei; Wang, Mei Qing; Wang, Pei Yu; Wang, Peng; Wang, Richard C.; Wang, Shuo; Wang, Ting Fang; Wang, Xian; Wang, Xiao Jia; Wang, Xiao Wei; Wang, Xin; Wang, Xuejun; Wang, Yan; Wang, Yanming; Wang, Ying; Wang, Ying Jan; Wang, Yipeng; Wang, Yu; Wang, Yu Tian; Wang, Yuqing; Wang, Zhi Nong; Wappner, Pablo; Ward, Carl; Ward, Diane Mc Vey; Warnes, Gary; Watada, Hirotaka; Watanabe, Yoshihisa; Watase, Kei; Weaver, Timothy E.; Weekes, Colin D.; Wei, Jiwu; Weide, Thomas; Weihl, Conrad C.; Weindl, GÃ¼nther; Weis, Simone Nardin; Wen, Longping; Wen, Xin; Wen, Yunfei; Westermann, Benedikt; Weyand, Cornelia M.; White, Anthony R.; White, Eileen; Whitton, J. Lindsay; Whitworth, Alexander J.; Wiels, JoÃ«lle; Wild, Franziska; Wildenberg, Manon E.; Wileman, Tom; Wilkinson, Deepti Srinivas; Wilkinson, Simon; Willbold, Dieter; Williams, Chris; Williams, Katherine; Williamson, Peter R.; Winklhofer, Konstanze F.; Witkin, Steven S.; Wohlgemuth, Stephanie E.; Wollert, Thomas; Wolvetang, Ernst J.; Wong, Esther; Wong, G. William; Wong, Richard W.; Wong, Vincent Kam Wai; Woodcock, Elizabeth A.; Wright, Karen L.; Wu, Chunlai; Wu, Defeng; Wu, Gen Sheng; Wu, Jian; Wu, Junfang; Wu, Mian; Wu, Min; Wu, Shengzhou; Wu, William K.K.; Wu, Yaohua; Wu, Zhenlong; Xavier, Cristina P.R.; Xavier, Ramnik J.; Xia, Gui Xian; Xia, Tian; Xia, Weiliang; Xia, Yong; Xiao, Hengyi; Xiao, Jian; Xiao, Shi; Xiao, Wuhan; Xie, Chuan Ming; Xie, Zhiping; Xie, Zhonglin; Xilouri, Maria; Xiong, Yuyan; Xu, Chuanshan; Xu, Congfeng; Xu, Feng; Xu, Haoxing; Xu, Hongwei; Xu, Jian; Xu, Jianzhen; Xu, Jinxian; Xu, Liang; Xu, Xiaolei; Xu, Yangqing; Xu, Ye; Xu, Zhi Xiang; Xu, Ziheng; Xue, Yu; Yamada, Takahiro; Yamamoto, Ai; Yamanaka, Koji; Yamashina, Shunhei; Yamashiro, Shigeko; Yan, Bing; Yan, Bo; Yan, Xianghua; Yan, Zhen; Yanagi, Yasuo; Yang, Dun Sheng; Yang, Jin Ming; Yang, Liu; Yang, Minghua; Yang, Pei Ming; Yang, Peixin; Yang, Qian; Yang, Wannian; Yang, Wei Yuan; Yang, Xuesong; Yang, Yi; Yang, Ying; Yang, Zhifen; Yang, Zhihong; Yao, Meng Chao; Yao, Pamela J.; Yao, Xiaofeng; Yao, Zhenyu; Yao, Zhiyuan; Yasui, Linda S.; Ye, Mingxiang; Yedvobnick, Barry; Yeganeh, Behzad; Yeh, Elizabeth S.; Yeyati, Patricia L.; Yi, Fan; Yi, Long; Yin, Xiao Ming; Yip, Calvin K.; Yoo, Yeong Min; Yoo, Young Hyun; Yoon, Seung Yong; Yoshida, Ken Ichi; Yoshimori, Tamotsu; Young, Ken H.; Yu, Huixin; Yu, Jane J.; Yu, Jin Tai; Yu, Jun; Yu, Li; Yu, W. Haung; Yu, Xiao Fang; Yu, Zhengping; Yuan, Junying; Yuan, Zhi Min; Yue, Beatrice Y.J.T.; Yue, Jianbo; Yue, Zhenyu; Zacks, David N.; Zacksenhaus, Eldad; Zaffaroni, Nadia; Zaglia, Tania; Zakeri, Zahra; Zecchini, Vincent; Zeng, Jinsheng; Zeng, Min; Zeng, Qi; Zervos, Antonis S.; Zhang, Donna D.; Zhang, Fan; Zhang, Guo; Zhang, Guo Chang; Zhang, Hao; Zhang, Hong; Zhang, Hongbing; Zhang, Jian; Zhang, Jiangwei; Zhang, Jianhua; Zhang, Jing Pu; Zhang, Li; Zhang, Lin; Zhang, Long; Zhang, Ming Yong; Zhang, Xiangnan; Zhang, Xu Dong; Zhang, Yan; Zhang, Yang; Zhang, Yanjin; Zhang, Yingmei; Zhang, Yunjiao; Zhao, Mei; Zhao, Wei Li; Zhao, Xiaonan; Zhao, Yan G.; Zhao, Ying; Zhao, Yongchao; Zhao, Yu Xia; Zhao, Zhendong; Zhao, Zhizhuang J.; Zheng, Dexian; Zheng, Xi Long; Zheng, Xiaoxiang; Zhivotovsky, Boris; Zhong, Qing; Zhou, Guang Zhou; Zhou, Guofei; Zhou, Huiping; Zhou, Shu Feng; Zhou, Xu Jie; Zhu, Hongxin; Zhu, Hua; Zhu, Wei Guo; Zhu, Wenhua; Zhu, Xiao Feng; Zhu, Yuhua; Zhuang, Shi Mei; Zhuang, Xiaohong; Ziparo, Elio; Zois, Christos E.; Zoladek, Teresa; Zong, Wei Xing; Zorzano, Antonio; Zughaier, Susu M.

SCOPUS:85054826264

ISSN: 1554-8627

CID: 5487622

Cancer immunology research. 2016:4(6):520-30.DOI: 10.1158/2326-6066.CIR-15-0235

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Yang, Shenghong; Imamura, Yu; Jenkins, Russell W; Cañadas, Israel; Kitajima, Shunsuke; Aref, Amir; Brannon, Arthur; Oki, Eiji; Castoreno, Adam; Zhu, Zehua; Thai, Tran; Reibel, Jacob; Qian, Zhirong; Ogino, Shuji; Wong, Kwok K; Baba, Hideo; Kimmelman, Alec C; Pasca Di Magliano, Marina; Barbie, David A

Autophagy promotes tumor progression downstream of oncogenic KRAS, yet also restrains inflammation and dysplasia through mechanisms that remain incompletely characterized. Understanding the basis of this paradox has important implications for the optimal targeting of autophagy in cancer. Using a mouse model of cerulein-induced pancreatitis, we found that loss of autophagy by deletion of Atg5 enhanced activation of the IÎºB kinase (IKK)-related kinase TBK1 in vivo, associated with increased neutrophil and T-cell infiltration and PD-L1 upregulation. Consistent with this observation, pharmacologic or genetic inhibition of autophagy in pancreatic ductal adenocarcinoma cells, including suppression of the autophagy receptors NDP52 or p62, prolonged TBK1 activation and increased expression of CCL5, IL6, and several other T-cell and neutrophil chemotactic cytokines in vitro Defective autophagy also promoted PD-L1 upregulation, which is particularly pronounced downstream of IFNÎ³ signaling and involves JAK pathway activation. Treatment with the TBK1/IKKÎµ/JAK inhibitor CYT387 (also known as momelotinib) not only inhibits autophagy, but also suppresses this feedback inflammation and reduces PD-L1 expression, limiting KRAS-driven pancreatic dysplasia. These findings could contribute to the dual role of autophagy in oncogenesis and have important consequences for its therapeutic targeting. Cancer Immunol Res; 4(6); 520-30. Â©2016 AACR.

PMCID:4891226

PMID: 27068336

ISSN: 2326-6074

CID: 3110572

Nature. 2016:540(7631).DOI: 10.1038/nature19851

Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion [Correction]

Sousa, CristovÃ£o M; Biancur, Douglas E; Wang, Xiaoxu; Halbrook, Christopher J; Sherman, Mara H; Zhang, Li; Kremer, Daniel; Hwang, Rosa F; Witkiewicz, Agnes K; Ying, Haoqiang; Asara, John M; Evans, Ronald M; Cantley, Lewis C; Lyssiotis, Costas A; Kimmelman, Alec C

PMID: 27706144

ISSN: 1476-4687

CID: 3091902

JCI insight. 2016:1(9).DOI: 10.1172/jci.insight.87415

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

Herter-Sprie, Grit S; Koyama, Shohei; Korideck, Houari; Hai, Josephine; Deng, Jiehui; Li, Yvonne Y; Buczkowski, Kevin A; Grant, Aaron K; Ullas, Soumya; Rhee, Kevin; Cavanaugh, Jillian D; Neupane, Neermala Poudel; Christensen, Camilla L; Herter, Jan M; Makrigiorgos, G Mike; Hodi, F Stephen; Freeman, Gordon J; Dranoff, Glenn; Hammerman, Peter S; Kimmelman, Alec C; Wong, Kwok-Kin

Radiation therapy (RT), a critical modality in the treatment of lung cancer, induces direct tumor cell death and augments tumor-specific immunity. However, despite initial tumor control, most patients suffer from locoregional relapse and/or metastatic disease following RT. The use of immunotherapy in non-small-cell lung cancer (NSCLC) could potentially change this outcome by enhancing the effects of RT. Here, we report significant (up to 70% volume reduction of the target lesion) and durable (up to 12 weeks) tumor regressions in conditional Kras-driven genetically engineered mouse models (GEMMs) of NSCLC treated with radiotherapy and a programmed cell death 1 antibody (alphaPD-1). However, while alphaPD-1 therapy was beneficial when combined with RT in radiation-naive tumors, alphaPD-1 therapy had no antineoplastic efficacy in RT-relapsed tumors and further induced T cell inhibitory markers in this setting. Furthermore, there was differential efficacy of alphaPD-1 plus RT among Kras-driven GEMMs, with additional loss of the tumor suppressor serine/threonine kinase 11/liver kinase B1 (Stk11/Lkb1) resulting in no synergistic efficacy. Taken together, our data provide evidence for a close interaction among RT, T cells, and the PD-1/PD-L1 axis and underscore the rationale for clinical combinatorial therapy with immune modulators and radiotherapy.

PMCID:5033933

PMID: 27699275

ISSN: 2379-3708

CID: 2523722

Blood. 2016:128(15):1913-1917.DOI: 10.1182/blood-2016-05-719062

A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia

Lichtenstein, Daniel A; Crispin, Andrew W; Sendamarai, Anoop K; Campagna, Dean R; Schmitz-Abe, Klaus; Sousa, Cristovao M; Kafina, Martin D; Schmidt, Paul J; Niemeyer, Charlotte M; Porter, John; May, Alison; Patnaik, Mrinal M; Heeney, Matthew M; Kimmelman, Alec; Bottomley, Sylvia S; Paw, Barry H; Markianos, Kyriacos; Fleming, Mark D

The congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited blood disorders characterized by pathological mitochondrial iron deposition in erythroid precursors. Each known cause has been attributed to a mutation in a protein associated with heme biosynthesis, iron-sulfur cluster biogenesis, mitochondrial translation, or a component of the mitochondrial respiratory chain. Here, we describe a recurring mutation, c.276_278del, p.F93del, in NDUFB11, a mitochondrial respiratory complex I-associated protein encoded on the X chromosome, in 5 males with a variably syndromic, normocytic CSA. The p.F93del mutation results in respiratory insufficiency and loss of complex I stability and activity in patient-derived fibroblasts. Targeted introduction of this allele into K562 erythroleukemia cells results in a proliferation defect with minimal effect on erythroid differentiation potential, suggesting the mechanism of anemia in this disorder.

PMCID:5064715

PMID: 27488349

ISSN: 1528-0020

CID: 2278842