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Acute stress symptoms in young children with burns

Stoddard, Frederick J; Saxe, Glenn; Ronfeldt, Heidi; Drake, Jennifer E; Burns, Jennifer; Edgren, Christy; Sheridan, Robert
OBJECTIVE: Posttraumatic stress disorder symptoms are a focus of much research with older children, but little research has been conducted with young children, who account for about 50% of all pediatric burn injuries. This is a 3-year study of 12- to 48-month-old acutely burned children to assess acute traumatic stress outcomes. The aims were to (1) assess the prevalence of acute traumatic stress symptoms and (2) develop a model of risk factors for these symptoms in these children. METHOD: Acute stress symptoms were measured using the Posttraumatic Stress Disorder Semi-Structured Interview and Observational Record for Infants and Young Children. Children's responses were then assessed, including behavior and physiological measures for developmental/functional consequences. A path analysis strategy was used to build a model of risk factors. Risk factors assessed in this model included observed pain (Visual Analogue Scale), parent symptoms (Stanford Acute Stress Reaction Questionnaire), and magnitude of trauma (total body surface area burned). RESULTS: Of the 64 subjects meeting inclusion criteria, 52 subjects agreed to participate. These children were highly symptomatic; almost 30% of these children had acute stress symptoms. A path analysis model yielded two independent pathways to acute stress symptoms: (1) from the size of the burn to the mean pulse rate in the hospital to acute stress symptoms and (2) from the child's pain to the parents' stress symptoms to acute stress symptoms. This model accounted for 39% of the variance of acute stress symptoms and yielded excellent fit indexes. CONCLUSIONS: A high percentage of acute stress symptoms were identified in young children with burns. A model of risk factors, including the size of the burn, pain, pulse rate, and parents' symptoms, was identified
PMID: 16327585
ISSN: 0890-8567
CID: 111844

Mental Health Interventions for Children Affected by War or Terrorism

Chapter by: Ellis, B. Heidi; Rubin, Audrey; Betancourt, Theresa Stichick; Saxe, Glenn
in: Children exposed to violence by Feerick, Margaret M; Silverman, Gerald B [Eds]
Baltimore, MD, US: Paul H Brookes Publishing, 2006
pp. 159-187
ISBN: 1-55766-804-3
CID: 5387

The long-term consequences of early childhood trauma: a case study and discussion [Case Report]

Kaplow, Julie B; Saxe, Glenn N; Putnam, Frank W; Pynoos, Robert S; Lieberman, Alicia F
There is a great need to better understand the impact of traumatic events very early in life on the course of children's future development. This report focuses on the intriguing case of a girl who witnessed the murder of her mother by her father at the age of 19 months and seemed to have no recollection of this incident until the age of 11, when she began to exhibit severe symptoms of posttraumatic stress disorder (PTSD) in response to a traumatic reminder. The case presentation serves as the basis for a discussion regarding pertinent issues involved in early childhood trauma. This case and accompanying discussion were originally presented at the 19th Annual Meeting of the International Society for Traumatic Stress Studies and were transcribed and revised for use in this article. Specific topics include early childhood memory and trauma, learning and the appraisal of danger, and PTSD and traumatic grief in early childhood. Clinical and public health implications are also discussed. This case illustrates the dramatic impact that 'preverbal' traumatic memories can have on children's later functioning and speaks to the importance of assisting very young children in the immediate aftermath of traumatic events
PMID: 17326730
ISSN: 0033-2747
CID: 111852

Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children [Letter]

Koenen, K C; Saxe, G; Purcell, S; Smoller, J W; Bartholomew, D; Miller, A; Hall, E; Kaplow, J; Bosquet, M; Moulton, S; Baldwin, C
PMID: 16088328
ISSN: 1359-4184
CID: 864312

Incidence of and risk factors for acute stress disorder in children with injuries

Saxe, Glenn N; Miller, Alisa; Bartholomew, David; Hall, Erin; Lopez, Carlos; Kaplow, Julie; Koenen, Karestan C; Bosquet, Michelle; Allee, Lisa; Erikson, Ingrid; Moulton, Steve
BACKGROUND: To assess the incidence of and risk factors for Acute Stress Disorder (ASD) in children with injuries. Numerous studies have documented the increased incidence of PTSD in those initially diagnosed with ASD. PTSD symptoms cause tremendous morbidity and may persist for many years in some children. METHODS: Children hospitalized with one or more injuries were interviewed and assessed with the following: Child Stress Disorders Checklist (CSDC), Family Strains Scale, Brief Symptom Inventory (BSI) and Facial Pain Scale. RESULTS: Participants included sixty-five children (ages 7-18 years). The mechanisms of injury varied (e.g. MVC, penetrating). The mean injury severity score was 8.9 +/- 7. The mean length of hospital stay was 4.6 +/- 4.6 days. Altogether, 18 (27.7%) of participants met DSM IV criteria for ASD during their acute hospital stay. Risk factors such as level of family stress, caregiver stress, child's experience of pain, and child's age were predictive of acute stress symptoms. CONCLUSION: We have identified four risk factors of ASD that have implications for the treatment, and possibly, preventative intervention for PTSD. Further investigation and greater understanding of risk factors for ASD in children with injuries may facilitate the design of acute interventions to prevent the long-term negative outcomes of traumatic events
PMID: 16374286
ISSN: 0022-5282
CID: 111845

Pathways to PTSD, part II: Sexually abused children

Kaplow, Julie B; Dodge, Kenneth A; Amaya-Jackson, Lisa; Saxe, Glenn N
OBJECTIVE: The goal of this research was to develop and test a prospective model of posttraumatic stress symptoms in sexually abused children that includes pretrauma, trauma, and disclosure-related pathways. METHOD: At time 1, several measures were used to assess pretrauma variables, trauma variables, and stress reactions upon disclosure for 156 sexually abused children ages 8 to 13 years. At the time 2 follow-up (7 to 36 months following the initial interview), the children were assessed for posttraumatic stress disorder (PTSD) symptoms. RESULTS: A path analysis involving a series of hierarchically nested ordinary least squares multiple regression analyses indicated three direct paths to PTSD symptoms: avoidant coping, anxiety/arousal, and dissociation, all measured during or immediately after disclosure of sexual abuse. Additionally, age and gender predicted avoidant coping, while life stress and age at abuse onset predicted symptoms of anxiety/arousal. Taken together, these pathways accounted for approximately 57% of the variance in PTSD symptoms. CONCLUSIONS: Symptoms measured at the time of disclosure constitute direct, independent pathways by which sexually abused children are likely to develop later PTSD symptoms. These findings speak to the importance of assessing children during the disclosure of abuse in order to identify those at greatest risk for later PTSD symptoms
PMCID:2754170
PMID: 15994713
ISSN: 0002-953x
CID: 111842

Pathways to PTSD, part I: Children with burns

Saxe, Glenn N; Stoddard, Frederick; Hall, Erin; Chawla, Neharika; Lopez, Carlos; Sheridan, Robert; King, Daniel; King, Lynda; Yehuda, Rachel
OBJECTIVE: The goal of this study was to develop a model of risk factors for posttraumatic stress disorder (PTSD) in a group of acutely burned children. METHOD: Seventy-two children between the ages of 7 and 17 who were admitted to the hospital for an acute burn were eligible for study. Members of families who consented completed the Child PTSD Reaction Index, the Multidimensional Anxiety Scale for Children, and other self-report measures of psychopathology and environmental stress both during the hospitalization and 3 months following the burn. A path analytic strategy was used to build a model of risk factors for PTSD. RESULTS: Two pathways to PTSD were discerned: 1) from the size of the burn and level of pain following the burn to the child's level of acute separation anxiety, and then to PTSD, and 2) from the size of the burn to the child's level of acute dissociation following the burn, and then to PTSD. Together these pathways accounted for almost 60% of the variance in PTSD symptoms and constituted a model with excellent fit indices. CONCLUSIONS: These findings support a model of complex etiology for childhood PTSD in which two independent pathways may be mediated by different biobehavioral systems
PMID: 15994712
ISSN: 0002-953x
CID: 111841

Comprehensive care for traumatized children

Saxe, GN; Ells, H; Fogler, J; Hansen, S; Sorkin, B
ISI:000229100900014
ISSN: 0048-5713
CID: 864382

Risk factors for acute stress disorder in children with burns

Saxe, Glenn; Stoddard, Frederick; Chawla, Neharika; Lopez, Carlos G; Hall, Erin; Sheridan, Robert; King, Daniel; King, Lynda
The purpose of this study was to (1) estimate the prevalence of acute stress disorder (ASD) in a sample of burned children, and (2) determine risk factors for ASD in these children. Seventy-two children were assessed for acute stress disorder approximately 10 days after being hospitalized for a burn. Variables hypothesized to predict ASD symptoms (i.e., size of the burn, prior behavioral symptoms, body image, parents' symptoms, heart rate) were also assessed. Based on a diagnosis derived from the ASD module of the Diagnostic Interview for Children and Adolescents (DICA), 31% of children met criteria for ASD. Path analyses revealed that the variables of heart rate, body image, and parents' acute stress symptoms were directly related to the development of ASD symptoms and accounted for 41% of its variance. These variables also mediated the relationship between the size of the burn and ASD symptoms. ASD is found in almost one third of children hospitalized for a burn. A high resting heart rate, lowered body image, and parent's acute stress symptoms were found to be significant risk factors for ASD symptoms
PMID: 16150668
ISSN: 1529-9732
CID: 111843

Association of in utero cocaine exposure and caregiver and environmental characteristics with psychiatric diagnoses among school-aged children [Meeting Abstract]

Grant-Knight, W; MacDonald, H; Augustyn, M; Woods, R; Cabral, H; Rose-Jacobs, R; Saxe, G; Frank, D
ISI:000220591103517
ISSN: 0031-3998
CID: 864362