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Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
Cloitre, Marylene; Petkova, Eva; Su, Zhe; Weiss, Brandon
BACKGROUND: Post-traumatic stress disorder (PTSD) psychotherapy research has failed to identify patient characteristics that consistently predict differential outcome. AIMS: To identify patient characteristics associated with differential outcome via a statistically generated composite moderator among women with childhood abuse-related PTSD in a randomised controlled trial comparing exposure therapy, skills training and their combination. METHOD: Six baseline patient characteristics were combined in a composite moderator of treatment effects for PTSD symptoms across the three treatment conditions through a 6-month follow-up. RESULTS: The optimal moderator was the combined burden of all symptoms and emotion regulation strength. Those with high moderator scores, reflecting high symptom load relative to emotion regulation, did least well in exposure, moderately well in skills and best in the combination. CONCLUSIONS: A clinically meaningful moderator, which combines patient symptom burden and strengths, was identified. Assessment at follow-up may provide a more accurate indicator of variability in outcome than that obtained immediately post-treatment
PMCID:4995554
PMID: 27703762
ISSN: 2056-4724
CID: 2274092
Case Reports: STAIR for Strengthening Social Support and Relationships Among Veterans With Military Sexual Trauma and PTSD
Cloitre, Marylene; Jackson, Christie; Schmidt, Janet A
Military sexual trauma (MST) is associated with high rates of post-traumatic stress disorder (PTSD) and multiple comorbid symptoms. In addition, women Veterans with MST report negative perceptions of social support, poor relationships, and difficulties in social and role functioning. Treatments for PTSD do not provide interventions to improve social or relationship functioning and do not consistently produce positive benefits regarding these outcomes. This article presents a series of case studies in which an intervention focused on building social support and relationship skills is delivered to Veterans with PTSD and MST. The intervention, Skills Training in Affective and Interpersonal Regulation (STAIR) promotes social engagement and skills that support greater role functioning. It can be used as a stand-alone treatment, as an adjunctive intervention to PTSD therapies or as part of a combination therapy in which skills precede trauma-focused work (STAIR Narrative Therapy). Further investigation is suggested to determine the added benefits of incorporating skills building to PTSD or other diagnosis-specific interventions.
PMID: 26837089
ISSN: 1930-613x
CID: 1932002
Piloting Specialized Mental Health Care for Rural Women Veterans Using STAIR Delivered via Telehealth: Implications for Reducing Health Disparities
Azevedo, Kathryn J; Weiss, Brandon J; Webb, Katie; Gimeno, Julia; Cloitre, Marylene
This pilot project implemented a mental health program, STAIR, targeting basic skills in mood management training and social functioning for women veterans with military-related trauma who live in rural areas. We report on outreach and implementation procedures, the women veterans' reactions to the program, and lessons learned.
PMID: 27818408
ISSN: 1548-6869
CID: 2625232
The factor structure of complex posttraumatic stress disorder in traumatized refugees
Nickerson, Angela; Cloitre, Marylene; Bryant, Richard A; Schnyder, Ulrich; Morina, Naser; Schick, Matthis
BACKGROUND: The construct of complex posttraumatic stress disorder (CPTSD) has attracted much research attention in previous years, however it has not been systematically evaluated in individuals exposed to persecution and displacement. Given that CPTSD has been proposed as a diagnostic category in the ICD-11, it is important that it be examined in refugee groups. OBJECTIVE: In the current study, we proposed to test, for the first time, the factor structure of CPTSD proposed for the ICD-11 in a sample of resettled treatment-seeking refugees. METHOD: The study sample consisted of 134 traumatized refugees from a variety of countries of origin, with approximately 93% of the sample having been exposed to torture. We used confirmatory factor analysis to examine the factor structure of CPTSD in this sample and examined the sensitivity, specificity, positive predictive power and negative predictive power of individual items in relation to the CPTSD diagnosis. RESULTS: Findings revealed that a two-factor higher-order model of CPTSD comprising PTSD and Difficulties in Self-Organization (chi2 (47)=57.322, p=0.144, RMSEA=0.041, CFI=0.981, TLI=0.974) evidenced superior fit compared to a one-factor higher-order model of CPTSD (chi2 (48)=65.745, p=0.045, RMSEA=0.053, CFI=0.968, TLI=0.956). Overall, items evidenced strong sensitivity and negative predictive power, moderate positive predictive power, and poor specificity. CONCLUSIONS: Findings provide preliminary evidence for the validity of the CPTSD construct with highly traumatized treatment-seeking refugees.
PMCID:5165057
PMID: 27989268
ISSN: 2000-8066
CID: 2625222
PTSD and Trauma-Related Difficulties in Sexual Minority Women: The Impact of Perceived Social Support
Weiss, Brandon J; Garvert, Donn W; Cloitre, Marylene
This study examined posttraumatic stress disorder (PTSD) and related symptoms among sexual minority (SM) and heterosexual women and the influence of social support on the relationship between SM status and symptoms. We hypothesized that SM women would endorse higher symptoms of PTSD and related difficulties and that social support would moderate the relationship between SM status and symptoms. The sample, women seeking treatment for PTSD related to interpersonal violence (n = 477; mean age = 36.07 years; 22.9% SM) completed clinician-administered measures of PTSD and self-report measures of trauma-related difficulties and social support. The rate of PTSD diagnosis was higher for SM women. Social support and SM status were significantly associated with suicidality, self-perceptions, depression, somatic complaints, and functional impairment. The interaction between social support and SM status was significant for both functional impairment (beta = -.26) and somatic complaints (beta = -.39). High social support had an equal, positive effect among SM and nonminority women, whereas low social support had a greater negative impact among SM women. Results suggested the particular salience of social support on functioning and symptom severity among SM women and the potential importance of including interventions addressing social support into PTSD treatments for SM women.
PMID: 26625354
ISSN: 1573-6598
CID: 1863392
Trauma and PTSD: setting the research agenda
Olff, Miranda; Armour, Cherie; Brewin, Chris; Cloitre, Marylene; Ford, Julian D; Herlihy, Jane; Lanius, Ruth; Rosner, Rita; Schmidt, Ulrike; Turner, Stuart
PMCID:4439423
PMID: 25994028
ISSN: 2000-8066
CID: 1662452
Update to an evaluation of ICD-11 PTSD and complex PTSD criteria in a sample of adult survivors of childhood institutional abuse by Knefel & Lueger-Schuster (2013): a latent profile analysis
Knefel, Matthias; Garvert, Donn W; Cloitre, Marylene; Lueger-Schuster, Brigitte
BACKGROUND: The World Health Organization (WHO) International Classification of Diseases, 11th version (ICD-11), has proposed a trauma-related diagnosis of complex posttraumatic stress disorder (CPTSD) separate and distinct from posttraumatic stress disorder (PTSD). OBJECTIVE: To determine whether the symptoms endorsed by individuals who had experienced childhood institutional abuse form classes that are consistent with diagnostic criteria for ICD-11 CPTSD as distinct from PTSD. METHODS: A latent profile analysis (LPA) was conducted on 229 adult survivors of institutional abuse using the Brief Symptom Inventory and the PTSD Checklist-Civilian Version to assess current psychopathological symptoms. RESULTS: The LPA revealed four classes of individuals: (1) a class with elevated symptoms of CPTSD (PTSD symptoms and disturbances in self-organization); (2) a class with elevated symptoms of PTSD and low disturbances in self-organization; (3) a class with elevated disturbances in self-organization symptoms and some elevated PTSD symptoms; and (4) a class with low symptoms. CONCLUSIONS: The results support the existence of a distinct group in our sample, that could be described by the proposed diagnostic category termed CPTSD more precisely than by normal PTSD. In addition, there seems to be a group of persons that do not fulfill the criteria for a trauma-related disorder but yet suffer from psychopathological symptoms.
PMCID:4283031
PMID: 25557561
ISSN: 2000-8066
CID: 1428732
The "one size fits all" approach to trauma treatment: should we be satisfied?
Cloitre, Marylene
There have been significant advances in the treatment of posttraumatic stress disorder in the last two decades. Further improvements in outcomes will be supported by recognition of the heterogeneity of symptoms in trauma populations and the development of treatments that promote the tailoring of interventions according to patient needs. Collaboration with patients regarding preferences about treatment structure, process, and outcomes is critical and will benefit the effectiveness and quality of treatments as well as the speed of their dissemination. New research methodologies are required that can incorporate important variables such as patient preferences and symptom heterogeneity without necessarily extending already lengthy study times or further complicating study designs. An example of alternative methodology is proposed.
PMCID:4439409
PMID: 25994021
ISSN: 2000-8066
CID: 1591002
Psychotherapies for PTSD: what do they have in common?
Schnyder, Ulrich; Ehlers, Anke; Elbert, Thomas; Foa, Edna B; Gersons, Berthold P R; Resick, Patricia A; Shapiro, Francine; Cloitre, Marylene
Over the past three decades, research and clinical practice related to the field of traumatic stress have developed tremendously. In parallel with the steady accumulation of basic knowledge, therapeutic approaches have been developed to treat people suffering from posttraumatic stress disorder (PTSD) and other trauma-related psychological problems. Today, a number of evidence-based treatments are available. They differ in various ways; however, they also have a number of commonalities. Given this situation, clinicians may wonder which treatment program to use, or more specifically, which treatment components are critical for a successful therapy. In this article, seven pioneers who have developed empirically supported psychotherapies for trauma-related disorders were asked to compose an essay of three parts: first, to provide a brief summary of the treatment they have developed; second, to identify three key interventions that are common and critical in treating PTSD; and third, to suggest important topics and future directions for research. The paper ends with a summary highlighting the identified commonalities (psychoeducation; emotion regulation and coping skills; imaginal exposure; cognitive processing, restructuring, and/or meaning making; emotions; and memory processes), pointing to future directions such as trying to better understand the underlying mechanisms of action, and developing treatments that are tailored to the needs of different patient groups.
PMCID:4541077
PMID: 26290178
ISSN: 2000-8066
CID: 1732352
STAIR narrative therapy: A skills focused approach to trauma-related distress
Hassija, C M; Cloitre, M
Interest in psychotherapeutic interventions for posttraumatic stress disorder (PTSD) populations that address variants of commonly co-occurring trauma sequelae is emerging. Specifically, treatment approaches that enhance an individual's capacity to experience and successfully modulate emotion, function interpersonally, and access social support are of particular value. The present paper briefly describes emotional and social difficulties commonly experienced by trauma survivors and outlines potential targets for intervention within the context of trauma-focused treatment. Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy is a skills-focused approach designed to foster the development and strengthening of emotion regulation and interpersonal skills and promote resilience. Empirical evidence supporting the efficacy of STAIR Narrative Therapy as an effective treatment for PTSD as well as emotion regulation and social difficulties is reviewed. Implications for treatment and directions for future research are presented
EMBASE:2015320874
ISSN: 1573-4005
CID: 1769372