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Posttraumatisch Stress stoornis. deel I neurobiologische aangrijpingspunten voor farmacotherapie
Vermetten, Eric
ORIGINAL:0009557
ISSN: 1872-1559
CID: 1481562
Glucocorticoid Receptor Number Predicts Increase in Amygdala Activity After Severe Stress [Meeting Abstract]
Geuze, Elbert; van Wingen, Guido; van Zuiden, Mirjam; Rademaker, Arthur; Vermetten, Eric; Kavelaars, Annemieke; Fernandez, Guillen; Heijnen, Gobi
ISI:000302466000561
ISSN: 0006-3223
CID: 1507322
Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study
van Zuiden, Mirjam; Geuze, Elbert; Willemen, Hanneke L D M; Vermetten, Eric; Maas, Mirjam; Amarouchi, Karima; Kavelaars, Annemieke; Heijnen, Cobi J
BACKGROUND: Biological correlates of posttraumatic stress disorder (PTSD) have mostly been studied using cross-sectional or posttrauma prospective designs. Therefore, it remains largely unknown whether previously observed biological correlates of PTSD precede trauma exposure. We investigated whether glucocorticoid receptor (GR) pathway components assessed in leukocytes before military deployment represent preexisting vulnerability factors for development of PTSD symptoms. METHODS: Four hundred forty-eight male soldiers were assessed before and 6 months after deployment to a combat zone. Participants were assigned to the PTSD or comparison group based on Self-Rating Inventory for PTSD scores after deployment. Logistic regression analysis was applied to predict development of a high level of PTSD symptoms based on predeployment GR number, messenger (m)RNA expression of GR target genes FKBP5, GILZ, and SGK1, plasma cortisol, and childhood trauma. We also investigated whether predeployment GR number and FKBP5 mRNA expression were associated with single nucleotide polymorphisms in the GR and FKBP5 genes, either alone or in interaction with childhood trauma. RESULTS: Several GR pathway components predicted subsequent development of a high level of PTSD symptoms: predeployment high GR number, low FKBP5 mRNA expression, and high GILZ mRNA expression were independently associated with increased risk for a high level of PTSD symptoms. Childhood trauma also independently predicted development of a high level of PTSD symptoms. Additionally, we observed a significant interaction effect of GR haplotype BclI and childhood trauma on GR number. CONCLUSIONS: Collectively, our results indicate that predeployment GR pathway components are vulnerability factors for subsequent development of a high level of PTSD symptoms.
PMID: 22137507
ISSN: 0006-3223
CID: 1469982
The neural consequences of combat stress: long-term follow-up [Letter]
van Wingen, G A; Geuze, E; Vermetten, E; Fernandez, G
PMID: 21876542
ISSN: 1359-4184
CID: 1469992
Psychotraumatologie in Nederland: historische ontwikkelingen
Chapter by: Van der Hart, O; Hermans, F; Kleber, R; Vermetten, Eric
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 45-64
ISBN: 9058981215
CID: 1479082
Neurbiologie van Posttraumatische Stress Stoornissen
Chapter by: Vermetten, Eric
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 241-262
ISBN: 9058981215
CID: 1479102
'Rouwen is ontzettend hard werken' : Tripoli 12 mei 2010 - 12 mei 2012
Sardemann, Rob; Netten, J; Vermetten, Eric
Utrecht : Slachtofferhulp Nederland, [2012]
Extent: 60 p. ; 24 cm.
ISBN: 9072970004
CID: 1479062
Neuronale systemen bij stress: preklinische en
Chapter by: Vermetten, Eric; Krugers, H
in: Handboek posttraumatische stressstoornissen by Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke [Eds]
Utrecht : De Tijdstroom, 2012
pp. 219-240
ISBN: 9058981215
CID: 1479092
L'impatto del trauma infantile sulla salute e sulla malattia : l'epidemia nascosta = [The impact of early life trauma on health and disease : the hidden epidemic]
Lanius, Ruth A; Vermetten, Eric; Pain, Clare
Roma : Giovanni Fioriti Editore, 2012
Extent: 528 p
ISBN: 8895930533
CID: 1476972
Handboek posttraumatische stressstoornissen
Vermetten, H; Kleber, R; Hart, Onno van der; Haagen, Joris; Sleijpen, Marieke
Utrecht : De Tijdstroom, cop. 2012
Extent: 808 p. ; 25 cm.
ISBN: 9058981215
CID: 1476982