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Outside the Bone: What Is Happening Systemically to Influence Fracture Healing?

Kates, Stephen L; Satpathy, Jibanananda; Petrisor, Brad A; Konda, Sanjit R; McKee, Michael D; Schemitsch, Emil H
This article summarizes presentations of a symposium on bone health-related hot topics of the 2016 Basic Science Focus Forum. Taken together, these topics emphasize the critical importance of bone health in fracture management, the systemic factors that influence fracture healing, and the need to focus on issues other than simply the technical aspects of fracture repair.
PMID: 29461401
ISSN: 1531-2291
CID: 2963262

Open surgical elbow contracture release after trauma: results and recommendations

Haglin, Jack M; Kugelman, David N; Christiano, Anthony; Konda, Sanjit R; Paksima, Nader; Egol, Kenneth A
BACKGROUND:Post-traumatic elbow contracture is a debilitating complication after elbow trauma. The purpose of this study was to characterize the affected patient population, operative management, and outcomes after operative elbow contracture release for treatment of post-traumatic elbow contracture. METHODS:A retrospective record review was conducted to identify all patients who underwent post-traumatic elbow contracture release performed by 1 of 3 surgeons at one academic medical center. Patient demographics, injuries, operative details, outcomes, and complications were recorded. RESULTS:The study included 103 patients who met inclusion criteria. At the time of contracture release, patients were a mean age of 45.2 ± 15.6 years. Contracture release resulted in a significant mean increase to elbow extension/flexion arc of motion of 52° ± 18° (P < .0005). Not including recurrence of contracture, a subsequent complication occurred in 10 patients (10%). Radiographic recurrence of heterotopic ossification (HO) occurred in 14 patients (14%) after release. Ten patients (11%) elected to undergo a secondary operation to gain more motion. CONCLUSION/CONCLUSIONS:Soft tissue and bony elbow contracture release is effective. Patients with post-traumatic elbow contracture can make significant gains to their arc of motion after contracture release surgery and can expect to recover a functional elbow arc of motion. Patients with severe preoperative contracture may benefit from concomitant ulnar nerve decompression. HO prophylaxis did not affect the rate of HO recurrence or ultimate elbow range of motion. However, patients must be counseled that contracture may reoccur, and some patients may require or elect to have more than one procedure to achieve functional motion.
PMID: 29290605
ISSN: 1532-6500
CID: 2957692

Risk factors for complications after primary repair of Achilles tendon ruptures

Pean, Christian A; Christiano, Anthony; Rubenstein, William J; Konda, Sanjit R; Egol, Kenneth A
Purpose/UNASSIGNED:To identify patient characteristics associated with adverse events in Achilles tendon rupture (ATR) surgical repair cases. Methods/UNASSIGNED:A high risk (HR) cohort group of ATR patients were compared to healthy controls in the ACSNSQIP database with multivariate regression analysis. Results/UNASSIGNED:Overall, 2% (n = 23) of the group sustained an AE postoperatively, most commonly superficial SSI (0.9%, n = 10). Multivariate analysis did not reveal any patient characteristics to be significantly associated with the occurrence of an AE or superficial SSI. Conclusions/UNASSIGNED:Obesity, diabetes and a history of smoking did not predispose patients to significantly more AEs in the 30 day postoperative period following ATR repair in this study.
PMCID:5895883
PMID: 29657473
ISSN: 0972-978x
CID: 3040792

Results after radial head arthroplasty in unstable fractures

Lott, Ariana; Broder, Kari; Goch, Abraham; Konda, Sanjit R; Egol, Kenneth A
BACKGROUND:Whereas most radial head fractures are stable injuries, they sometimes occur as part of complex injury patterns with associated elbow instability. Radial head arthroplasty has been favored in patients with unreconstructable radial head fractures and unstable elbow injuries. The purpose of this study was to review radiographic outcomes, functional outcomes, and complications after radial head arthroplasty for radial head fracture in unstable elbow injuries. METHODS:This study was a retrospective review of radial head fractures treated with radial head arthroplasty by a single surgeon during a 15-year period. Demographics of the patients, injury details, operative reports, radiographic and clinical outcomes, and any complications were recorded. Patients were divided into stable and unstable elbow injury groups. RESULTS:A total of 68 patients were included. There were 50 unstable fractures that were compared with 18 stable fractures. Patients with unstable radial head fractures with associated elbow dislocation achieved mean flexion and mean forearm rotational arc of motion similar to that of patients with stable radial head fractures. However, supination loss was greater in the unstable group than in the stable fracture group, with a mean difference of 10°. Radiographic outcomes and complication rates did not differ between injury groups. There was no observed decrease in implant longevity in patients with unstable elbow injuries. CONCLUSIONS:Radial head arthroplasty is an effective option for treatment of unstable elbow injuries, with recovery of functional elbow range of motion and no difference in complication rate or implant survivorship compared with those patients with stable injuries.
PMID: 29332663
ISSN: 1532-6500
CID: 2915582

Patient Reported Pain After Successful Nonunion Surgery: Can We Completely Eliminate It?

Fisher, Nina; Driesman, Adam S; Konda, Sanjit; Egol, Kenneth A
OBJECTIVES/OBJECTIVE:To investigate what factors are associated with continued long-term pain after fracture nonunion surgery. DESIGN/METHODS:Prospective cohort study. SETTING/METHODS:Single Academic Institution. PATIENTS/PARTICIPANTS/METHODS:Three hundred forty-one patients surgically treated for fracture nonunion were prospectively followed. Demographics, radiographic evaluations, VAS pain scores, and short musculoskeletal functional assessment (SMFA) scores were collected at routine intervals. Only patients who had a minimum of 1-year follow-up and complete healing were included this analysis. Patients were divided into a high-pain and low-pain cohort for comparison. Inclusion criteria for the high-pain cohort were defined as any patient who reported a pain score greater than one standard deviation above the mean. MAIN OUTCOME MEASURES/METHODS:Long-term VAS pain scores and factors contributing to increased patient-reported long-term VAS pain scores. RESULTS:Two hundred seventy patients met criteria and were included in this analysis, with 223 patients (82.6%) in the low-pain cohort and 47 patients (17.4%) in the high-pain cohort. The mean long-term pain score was 7.47 ± 1.2 in the high-pain group and 1.78 ± 1.9 in the low-pain group. Within the high-pain cohort, 55.6% of patients reported a net increase in pain from baseline to long-term follow-up compared with 10.5% in the low-pain cohort (P < 0.0005). High baseline pain score (P = 0.003), increased Charlson comorbidity index (CCI) (P = 0.008), lower income level (P = 0.014), and current smoking status (P = 0.033) were found to be significantly more prevalent in the high-pain cohort. CONCLUSIONS:Patients with higher baseline pain scores, elevated Charlson comorbidity index, lower income level or history of smoking are at an increased risk of reporting significant and potentially debilitating long-term pain after nonunion surgery. Although patients may expect complete relieve of pain, orthopaedic surgeons must inform patients of the possibility of experiencing pain 1 year or more postoperatively. LEVEL OF EVIDENCE/METHODS:Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
PMID: 29373378
ISSN: 1531-2291
CID: 2933252

Does Use of Oral Anticoagulants at the Time of Admission Affect Outcomes Following Hip Fracture

Lott, Ariana; Haglin, Jack; Belayneh, Rebekah; Konda, Sanjit R; Leucht, Philipp; Egol, Kenneth A
Purpose/UNASSIGNED:The purpose of this study was to compare hospital quality outcomes in patients over the age of 60 undergoing fixation of hip fracture based on their anticoagulation status. Materials and Methods/UNASSIGNED:Patients aged 60 and older with isolated hip fracture injuries treated operatively at 1 academic medical center between October 2014 and September 2016 were analyzed. Patients on the following medications were included in the anticoagulation cohort: warfarin, clopidogrel, aspirin 325 mg, rivaroxaban, apixaban, dabigatran, and dipyridamole/aspirin. We compared outcome measures including time to surgery, length of stay (LOS), transfusion rate, blood loss, procedure time, complication rate, need for intensive care unit (ICU)/step-down unit (SDU) care, discharge disposition, and cost of admission. Outcomes were controlled for age, Charlson comorbidity index (CCI), and anesthesia type. Results/UNASSIGNED:= .026). Lastly, there was no difference in cost of care. Conclusion/UNASSIGNED:This study highlights that anticoagulation status alone does not independently put patients at increased risk with respect to LOS, surgical outcomes, and cost of hospitalization.
PMCID:5882043
PMID: 29623236
ISSN: 2151-4585
CID: 3025842

Set it and Forget it: Diaphyseal Fractures of the Humerus Undergo Minimal Change in Angulation After Functional Brace Application

Crespo, Alexander M; Konda, Sanjit R; Egol, Kenneth A
Objectives/UNASSIGNED:To quantify radiographic changes observed in humeral shaft frctures throughout course of treatment with functional bracing. Design/UNASSIGNED:Retrospective cohort study. Setting/UNASSIGNED:Level 1 Trauma Center and affiliated Tertiary Care Center. Patients/UNASSIGNED:72 retrospectively identified patients with fracture of the humeral diaphysis. Intervention/UNASSIGNED:Application of functional brace with radiographs obtained immediately after brace application and at 1 week, 2 weeks, 3 weeks, 6 weeks, 3 months, 6 months and 12 month follow-up.Main Outcome Measure: Fracture angulation, measured in the coronal and sagittal planes. Results/UNASSIGNED:522 radiographs from 72 patients were critically reviewed. All fractures were followed to healing. Sixty-six patients (92%) successfully healed their fractures with non-operative treatment. The average angulation on immediate post-brace X-ray was 12 degrees varus ad 7 degrees procurvatum. At final follow-up, average coronal angulation was 14 degrees and 4 degrees procurvatum. Fracture angulation changed a mean 2 degrees in the AP plane and 3 degrees in the sagittal plane over the course of care. Linear regression determined fracture angulation proceeds toward both varus and recurvatum at 0.01 degrees per day. Conclusion/UNASSIGNED:Humeral shaft fractures treated non-operatively heal with minimal change in angulation after brace application. If angulation on the post-brace radiograph is acceptable and there is no history of repeat trauma and no cosmetic deformity, radiographs may be utilized less frequently. Patients should be evaluated via history and physical exam at follow-up prior to the 6-week point, at which time regular radiographs (6 week, 3 month, 6 month, 12 month) should commence.
PMCID:6047395
PMID: 30104927
ISSN: 1555-1377
CID: 3240952

The Coming Hip and Femur Fracture Bundle: A New Inpatient Risk Stratification Tool for Care Providers

Konda, Sanjit R; Lott, Ariana; Egol, Kenneth A
Introduction/UNASSIGNED:In response to increasing health-care costs, Centers for Medicare & Medicaid Services has initiated several programs to transition from a fee-for-service model to a value-based care model. One such voluntary program is Bundled Payments for Care Improvement Advanced (BPCI Advanced) which includes all hip and femur fractures that undergo operative fixation. The purpose of this study was to analyze the current cost and resource utilization of operatively fixed (nonarthroplasty) hip and femur fracture procedure bundle patients at a single level 1 trauma center within the framework of a risk stratification tool (Score for Trauma Triage in the Geriatric and Middle-Aged [STTGMA]) to identify areas of high utilization before our hospitals transition to bundle period. Materials and Methods/UNASSIGNED:A cohort of Medicare-eligible patients discharged with the Diagnosis-Related Group (DRG) codes 480 to 482 (hip and femur fractures requiring surgical fixation) from a level 1 trauma center between October 2014 and September 2016 was evaluated and assigned a trauma triage risk score (STTGMA score). Patients were stratified into groups based on these scores to create a minimal-, low-, moderate-, and high-risk cohort. Length of stay (LOS), discharge location, need for Intensive Care Unit (ICU)/Step Down Unit (SDU) care, inpatient complications, readmission within 90 days, and inpatient admission costs were recorded. Results/UNASSIGNED:= .029). The mean total cost of admission for the entire cohort of patients was US$25,446 (US$9725), with a nearly US$9000 greater cost for high-risk patients compared to the low-risk patients. High-cost areas of care included room/board, procedure, and radiology. Discussion/UNASSIGNED:High-risk patients were more likely to have longer and more costly admissions with average index admission costs nearly US$9000 more than the lower risk patient cohorts. These high-risk patients were also more likely to develop inpatient complications and require higher levels of care. Conclusion/UNASSIGNED:This analysis of a 2-year cohort of patients who would qualify for the BPCI Advanced hip and femur procedure bundle demonstrates that the STTGMA tool can be used to identify high-risk patients who fall outside the bundle.
PMCID:6156205
PMID: 30263869
ISSN: 2151-4585
CID: 3314522

Admitting Service Affects Cost and Length of Stay of Hip Fracture Patients

Lott, Ariana; Haglin, Jack; Belayneh, Rebekah; Konda, Sanjit R; Egol, Kenneth A
Introduction/UNASSIGNED:The purpose of this study was to analyze the effect of the admitting service on cost of care for hip fracture patients by comparing the cost difference between patients admitted to the medicine service versus those admitted to a surgical service. Methods/UNASSIGNED:value of <.05 as significant. Results/UNASSIGNED:= .034) compared to patients admitted to the medicine service. Discussions/UNASSIGNED:In our urban safety net hospital, hip fracture patients admitted to medicine service had longer lengths of stay and higher total hospitalization costs than patients who were admitted to surgery service. Conclusions/UNASSIGNED:This study highlights that the admitting service should be an area of focus for hospitals when developing programs to provide effective and cost-conscious care to hip fracture patients.
PMID: 30479850
ISSN: 2151-4585
CID: 3500542

Predicting Discharge Location among Low-Energy Hip Fracture Patients Using the Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA)

Konda, Sanjit R; Saleh, Hesham; Lott, Ariana; Egol, Kenneth A
Patterns of discharge location may be evident based on the "sickness" profile of the patient. This study sought to evaluate the ability of the STTGMA tool, a validated mortality risk index for middle-aged and geriatric trauma patients, to predict discharge location in a cohort of low-energy elderly hip fracture patients, with successful discharge planning measured by readmission rates. Low-energy hip fracture patients aged 55 years and older were prospectively followed throughout their hospitalization. On initial evaluation in the Emergency Department, each patient's age, comorbidities, injury severity, and functional status were utilized to calculate a STTGMA score. Discharge location was recorded with the primary outcome measure of an unsuccessful discharge being readmission within 30 days. Patients were risk stratified into minimal-, low-, moderate-, and high-risk STTGMA cohorts. A p-value of <0.05 was considered significant for all statistical tests. 408 low-energy hip fractures were enrolled in the study with a mean age of 81.3±10.6 years. There were 214 (52.5%) intertrochanteric fractures, 167 (40.9%) femoral neck fractures, and 27 (6.6%) subtrochanteric femur fractures. There was no difference in readmission rates within STTGMA risk cohorts with respect to discharge location; however, among individual discharge locations there was significant variation in readmission rates when patients were risk stratified. Overall, STTGMA risk cohorts appeared to adequately risk-stratify readmission with 3.5% of minimal-risk patients experiencing readmission compared to 24.5% of moderate-risk patients. Specific cohorts deemed high-risk for readmission were adequately identified. The STTGMA tool allows for prediction of unfavorable discharge location in hip fracture patients. Based on observations made via the STTGMA tool, improvements in discharge planning can be undertaken to increase home discharge and to more closely track "high-risk" discharges to help prevent readmissions.
PMCID:6276529
PMID: 30581627
ISSN: 2090-3464
CID: 3555632