Faculty Bibliography

Anterior cruciate ligament reconstruction (ACLR) is a reliable method to restore knee stability and function in professional and recreational athletes. Reasons for failure of ACLR include re-rupture, suboptimal surgical technique, issues with graft incorporation, timing and efficacy of rehabilitation programs, time of return to sport, and unrecognized concomitant pathology such as malalignment, meniscal or ligamentous injuries. Surgical technique continues to play a pivotal role in the success or failure of ACLR. The purpose of the current review is to provide an update on modifiable surgical risk factors for failure of ACLR and potential pitfalls to avoid in order to optimize postoperative outcomes and patient satisfaction

OBJECTIVE: Anterior cruciate ligament reconstruction (ACLR) depends on proper healing of the graft or bone plug at the cellular level. The effect of cigarette smoke on ACLR was not commonly reported until recently. The primary purpose of this review was to determine if smoking has a negative effect on subjective or objective outcome scores after ACLR. The secondary purpose was to identify any increased risk of complications, infection, ACL re-tear, or revision procedures. METHODS: A systematic literature review of the MEDLINE, SCOPUS and PubMed databases was performed to identify all studies that compared outcomes of ACLR surgery between smokers and nonsmokers. The frequency-weighted mean was calculated for outcome measures that were similar across several studies. RESULTS: Seventeen studies were identified that met inclusion criteria for patients undergoing ACLR (mean age, 26.8 years) with a mean follow-up of 37 months. Smokers had significantly worse subjective outcome measures and worse side-to-side difference in anterior translation compared to non-smokers (2.68mm vs 1.89mm, respectively). In 2 studies, smokers were found to have a significantly higher risk of developing an infection and VTE (venous thromboembolism) post-operatively. The evidence for the effect of smoking on risk for subsequent re-tear is mixed. No study reported a higher rate of development of radiographic knee osteoarthritis among smokers compared to nonsmokers. CONCLUSIONS: Cigarette smoke is associated with significantly worse clinical outcome scores, an increase in anterior translation, and increased complication rates after ACL reconstruction. These findings may help orthopaedic surgeons better inform their patients about the potential negative effects of smoking on the outcomes of ACL reconstruction. LEVEL OF EVIDENCE: Therapeutic Level IV.

Background/Purpose: Persistent inflammation is a characteristic of several joint diseases, including OA. It is nowadays appreciated that this could be a result of a failure to (optimally) activate inflammation resolution pathways. Therefore, we investigated the presence of specialized pro-resolving lipid mediators (SPM) and their precursors as pathway markers of the resolution process in the joint of OA patients and controls. Methods: SF was obtained from knee OA (2 populations) and rheumatoid arthritis (RA) patients fulfilling the ACR criteria for OA and RA, respectively, and healthy controls. Lipid mediators (LMs) were determined by targeted lipidomics using liquid-chromatography mass spectrometry. Sixty different lipids including pro-inflammatory (e.g. prostaglandins, leukotrienes) and anti-inflammatory/pro-resolving LM (e.g. SPM), as well as their precursors can be detected with our technique. Results: SF from 24 OA and 12 RA patients were first studied. Thirty-seven lipids were detected in the soluble fraction of SF, including polyunsaturated fatty acids (PUFA) and their lipoxygenase (LOX) and cyclooxygenase (COX) pathway markers in both OA and RA patients. Among these, pro-inflammatory LM such as PGE2 and thromboxane B2, as well as the pathway markers of resolution and precursors of SPM, 17-HDHA and 18-HEPE, were detected. Except for the LOX products of arachidonic acid: 15-HETE, 6-trans-LTB4 and 20-OH- LTB4, which were lower in OA than in RA SF, all other lipid mediators and PUFA were comparable between OA and RA samples. Ratios of metabolites to their precursors indicated that both pro- (e.g. LTB4) and anti-inflammatory LOX products (e.g. 17- HDHA) are more efficiently generated in RA than in OA patients, while no differences were observed in COX products. Interestingly, the SPM resolvin D2 (RvD2) could also be detected, but only in the insoluble fraction (cells and undigested matrix), indicating that the resolution pathways are activated in OA. This expands our previous publication showing activation of resolution in RA patients. To assess the efficiency of activation of resolution in OA, we have performed targeted lipidomics on total SF in an additional study with 32 OA patients and 10 healthy controls. Confirming earlier data, most LMs were also detected in this study, including the pro-inflammatory PGE2, the SPM precursors 17-HDHA and 18-HEPE, and the SPM RvD2. Additionally, we detected 18S-resolvin E3 (18S-RvE3). Remarkably, both the absolute concentrations of the SPM RvD2 and 18S-RvE3, and the ratio to their precursors, 17-HDHA and 18-HEPE, were lower in OA compared to healthy SF, indicating less efficient generation of SPM in OA compared to healthy joints. In contrast, the proinflammatory lipid PGE2was higher in OA than in healthy SF, indicating that the lower activation of resolution is paired by a higher inflammatory load in OA compared with healthy individuals. Conclusion: By using a state-of-the-art technique, we show for the first time that resolution pathways are activated in OA patients. Importantly, resolution seems to be less efficiently activated than in healthy individuals, which could account for the persistent inflammation observed in OA and RA patients

OBJECTIVE: A discoid meniscus is more prone to tears than a normal meniscus. Patients with a torn discoid lateral meniscus are at increased risk for early onset osteoarthritis requiring total knee arthroplasty (TKA). Optimal management for this condition is controversial given the up-front cost difference between the two treatment options: the more expensive meniscal allograft transplantation compared with standard partial meniscectomy. We hypothesize that meniscal allograft transplantation following excision of a torn discoid lateral meniscus is more cost-effective compared with partial meniscectomy alone because allografts will extend the time to TKA. METHODS: A decision analytic Markov model was created to compare the cost effectiveness of two treatments for symptomatic, torn discoid lateral meniscus: meniscal allograft and partial meniscectomy. Probability estimates and event rates were derived from the scientific literature, and costs and benefits were discounted by 3%. One-way sensitivity analyses were performed to test model robustness. RESULTS: Over 25 years, the partial meniscectomy strategy cost $10,430, whereas meniscal allograft cost on average $4040 more, at $14,470. Partial meniscectomy postponed TKA an average of 12.5 years, compared with 17.30 years for meniscal allograft, an increase of 4.8 years. Allograft cost $842 per-year-gained in time to TKA. CONCLUSION: Meniscal allografts have been shown to reduce pain and improve function in patients with discoid lateral meniscus tears. Though more costly, meniscal allografts may be more effective than partial meniscectomy in delaying TKA in this model. Additional future long term clinical studies will provide more insight into optimal surgical options.

Objectives: Introduction: Though outcomes following ACL reconstruction are largely positive, patients' postoperative recovery is highly variable, and is typically based off generalized timetables derived from population data. In an attempt to individualize prognostic estimates and establish how biomarker concentrations may change with injury, we sampled knee joint synovial fluid from patients with ACL tears with and without associated cartilage injuries and compared biomarker concentrations to samples obtained from the contralateral non-injured knee. Methods: 480 patients indicated for knee arthroscopy had samples drawn to form a synovial fluid database. If no injury history or symptoms were present in the contralateral knee, samples were drawn as well. For the current study, only patients that had confirmed ACL injury at the time of arthroscopy were included. Associated cartilage injury location, size and depth was documented. Synovial fluid samples were centrifuged, and the concentrations of 20 biomarkers were determined using a multiplex magnetic bead immunoassay. Concentrations were then compared between the three study groups (ACL tear with cartilage injury, ACL tears without cartilage injury, and healthy contralateral knees) using a Welch ANOVA test with pairwise comparisons. Results: The study included samples from 132 knees: 34 ACL tears without cartilage injury (mean age 34.0 years); 28 ACL tears with cartilage injury (mean age 36.3 years), and 72 contralateral knees (41.1 years). ANOVA testing demonstrated significant differences among groups for: MMP-3 (p>001); TIMP-1 (p=.001); TIMP-2 (p=.015); FGF-2 (p=.011); IL-6 (p=.001); and MIP-1b (p=.001). Pairwise comparisons demonstrated no significant differences between ACL tears with, and without cartilage damage, but did show both types of ACL tears had significantly higher concentrations of MMP-3, TIMP-1, IL-6, and MIP-1b than contralaterals. ACL tears without cartilage damage had significantly lower concentrations of TIMP-2 and FGF-2 (13) than contralaterals (Table 1). Conclusion: The course from surgery to symptomatic relief and functional improvement following ACL reconstruction is highly variable. Data from the current study demonstrated that cytokine concentrations are significantly different between ACL tears (+/- cartilage damage) and healthy knees. These validated differences can help establish synovial fluid biomarker analysis as a method for injury stratification ultimately providing patientspecific prognostic data. (Table Presented)

In cases of chronic distal biceps ruptures, the combination of muscle atrophy, distal tendon retraction, and fibrosis makes primary anatomic reattachment of the tendon particularly challenging. To regain tendon length and avoid flexion contractures, reconstruction with graft augmentation has been proposed as an alternative for cases not amenable to primary repair. We describe our technique using an Achilles allograft through a modified Henry approach to reconstruct the distal biceps tendon to regain length as well as restore flexion and supination strength. With proper and detailed exposure, chronic distal biceps injuries can be reconstructed safely and efficaciously using an Achilles allograft.

PURPOSE: To analyze orthopaedic resident case log data to report temporal trends in performing arthroscopic procedures and to assess variability in arthroscopic case volume among residents. METHODS: Accreditation Council for Graduate Medical Education orthopaedic surgery resident case logs were reviewed from 2007 to 2013. The mean number of wrist, elbow, shoulder, knee, and ankle arthroscopic procedures performed by graduating residents was analyzed. The median number of arthroscopic procedures reported by the 70th and 30th percentiles of graduating residents (by arthroscopic case volume) was also recorded. Temporal trends were assessed using a linear regression model. RESULTS: From 2007 to 2013, there were significant increases in the mean number of wrist (5.8 to 6.3; P = .038), elbow (2.5 to 3.2; P < .001), shoulder (93.5 to 133.8; P < .001), knee (170.6 to 185.1; P = .011), and ankle (5.8 to 7.4; P < .001) arthroscopies performed per resident. Residents in the 70th percentile of caseload performed significantly more wrist (7 v 2; P < .001), elbow (3.3 v 1; P < .001), shoulder (134.1 v 70.6; P < .001), knee (205 v 128.7; P < .001), and ankle (7.9 v 2.9; P < .001) arthroscopies than residents in the 30th percentile. CONCLUSIONS: Our findings indicate that arthroscopic caseload is increasing among orthopaedic residents. However, resident experience performing arthroscopic procedures is substantially disparate. Although the educational implications of this disparity are not well understood, our findings may aid in efforts to optimize arthroscopic training during orthopaedic residency.