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290


Periependymal Abnormalities in Neuromyelitis Optica Spectrum Disorders and Multiple Sclerosis: A Case-Control Study [Meeting Abstract]

Raz, Eytan; Kister, Ilya; Omari, Mirza; Herbert, Joseph; Lui, Yvonne; Loh, John
ISI:000303204804208
ISSN: 0028-3878
CID: 166859

Differential Diagnosis of Adult-Onset Chronic Myelopathy: MRI-Based Approach [Meeting Abstract]

Zhovtis, Svetlana; Howard, Jonathan; Herbert, Joseph; Kister, Ilya
ISI:000303204801226
ISSN: 0028-3878
CID: 166865

The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry

Hughes, S; Spelman, T; Trojano, M; Lugaresi, A; Izquierdo, G; Grand'maison, F; Duquette, P; Girard, M; Grammond, P; Oreja-Guevara, C; Hupperts, R; Boz, C; Bergamaschi, R; Giuliani, G; Rio, ME; Lechner-Scott, J; van, Pesch V; Iuliano, G; Fiol, M; Verheul, F; Barnett, M; Slee, M; Herbert, J; Kister, I; Vella, N; Moore, F; Petkovska-Boskova, T; Shaygannejad, V; Jokubaitis, V; McDonnell, G; Hawkins, S; Kee, F; Gray, O; Butzkueven, H
Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry. Methods Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scores. Results Correlation coefficients for EDSS rank over 5-year intervals increased with MS duration: years 1-6=0.55, years 4-9=0.74, years 7-12=0.80 and years 10-15=0.83. EDSS progression risk at 10 years after onset was highly dependent on EDSS at 5 years; one-point progression risk was greater for EDSS score of >2 than
PMID: 22205675
ISSN: 0022-3050
CID: 158644

Increased risk of multiple sclerosis among women with migraine in the Nurses' Health Study II

Kister, Ilya; Munger, Kassandra L; Herbert, Joseph; Ascherio, Alberto
Background: The prospective Nurses' Health Study II (NHS-II), which enrolled over 116,000 female nurses, provides a unique opportunity to test the hypothesis of whether migraine is associated with multiple sclerosis (MS) and to explore the temporal aspects of the interrelationship. Objectives: To calculate relative risk of MS among NHS-II participants with and without migraine and to estimate odds ratio (OR) of being diagnosed with migraine in women with and without pre-existing MS. Methods: Cox proportional hazards regression was used to estimate rate ratios and 95% confidence intervals (CIs) of being diagnosed with MS in women with and without pre-existing migraine adjusted for potential confounders. Multivariate adjusted ORs of being diagnosed with migraine in women with and without pre-existing MS were estimated using logistic regression. Results: The prevalence of migraine in women with MS at baseline (26%, p = 0.11) and those diagnosed with MS after enrolment (29%, p < 0.0001) was higher than in the non-MS cases (21%). The relative risk of developing MS in migraineurs was 1.39 times higher than in non-migraineurs (95% CI 1.10-1.77, p = 0.008). The absolute risk of developing MS in women migraineurs over a 15-year follow-up was 0.47% and among non-migraineurs 0.32%. The odds of being diagnosed with migraine was higher in women with pre-existing MS compared with those without MS, but did not reach statistical significance (OR = 1.57, 95% CI 0.97-2.52; p = 0.06). Conclusions: Using a large, cohort of women-nurses, history of migraine was associated with an increased risk of MS. However, the difference in absolute risk of MS in migraineurs and non-migraineurs was small
PMCID:3627491
PMID: 21816759
ISSN: 1477-0970
CID: 149943

Episodic Headache in North American Patients with Behcet's Disease [Meeting Abstract]

Crystal, Sara C.; Robbins, Matthew S.; Filopoulos, Maria T.; Kister, Ilya; Lipton, Richard B.; Yazici, Yusuf
ISI:000288149301076
ISSN: 0028-3878
CID: 2956832

Decrease in Individual Multiple Sclerosis Severity Scores during Follow-Up Period: Analysis of the New York State Multiple Sclerosis Consortium Dataset [Meeting Abstract]

Kister, Ilya; Bacon, Tamar; Chamot, Eric; Cutter, Gary; Bacon, Joshua; Apatoff, Brian; Coyle, Patricia; Goodman, Andrew; Gottesman, Malcolm; Edwards, Keith; Frontera, Alfred; Holub, Richard; Jubelt, Burk; Khan, Mustafa; Krupp, Lauren; Lenihan, Michael; Mihai, Cornelia; Miller, Aaron; Lublin, Fred; Perel, Allan; Snyder, David; Teter, Barbara; Weinstock-Guttman, Bianca; Zivadinov, Robert; Herbert, Joseph
ISI:000288149303353
ISSN: 0028-3878
CID: 2225212

Pregnancy Related to Disability Outcomes for Women with Progressive Multiple Sclerosis [Meeting Abstract]

Teter, Barbara; Apatoff, Brian; Coyle, Patricia; Edwards, Keith; Goodman, Andrew; Gottesman, Malcolm; Granger, Carl; Herbert, Joseph; Jubelt, Burk; Kister, Ilya; Krupp, Lauren; Lenihan, Michael; Miller, Aaron; Perel, Allan; Snyder, David; Tullman, Mark; Zivadinov, Robert; Weinstock-Guttman, Bianca
ISI:000288149303373
ISSN: 0028-3878
CID: 2225802

Capture of Patient-Perceived Negative Mood Traits To Improve Treatment for Patients with Multiple Sclerosis [Meeting Abstract]

Teter, Barbara E; Apatoff, Brian; Coyle, Patricia; Edwards, Keith; Goodman, Andrew; Gottesman, Malcolm; Granger, Carl; Herbert, Joseph; Lawn, Fair; Jubelt, Burk; Kister, Ilya; Krupp, Lauren; Lenihan, Michael; Lublin, Fred; Miller, Aaron; Ostroff, Joseph; Perel, Allan; Snyder, David; Tullman, Mark; Zivadinou, Robert; Weinstock-Guttman, Bianca
ISI:000288149300278
ISSN: 0028-3878
CID: 2226002

Subcutaneous Administration of Alemtuzumab (Campath (R)) in Fulminant Multiple Sclerosis [Meeting Abstract]

Perumal, Jai S; Foo, Farng-Yang; Cook, Perry; Sammarco, Carrie; Kister, Ilya; Khan, Omar; Herbert, Joseph
ISI:000288149300265
ISSN: 0028-3878
CID: 1788452

Subacute Amotivational Syndrome as the Only Symptom of Progressive Multifocal Leukoencephalopathy in a Natalizumab-Treated Multiple Sclerosis Patient [Meeting Abstract]

Babinski, Kristen; Howard, Jonathan; Gottschalk, Christopher; Herbert, Joseph; Kister, Ilya
ISI:000288149303477
ISSN: 0028-3878
CID: 591412