Faculty Bibliography

Calciphylaxis is a rare, painful, and debilitating disease of widespread metastatic calcification that progresses to ischemic tissue necrosis. It occurs almost exclusively in patients with end-stage renal disease and secondary hyperparathyroidism. Reticulated, violaceous, mottled patches commonly appear on the lower extremities and progress to cordlike nodules and necrotic ulcers with overlying eschars. Septicemia, which may occur after secondary infection of the ulcers, is the most common cause of death. Treatment with phosphate-binding antacids, total or partial parathyroidectomy, and avoidance of local tissue trauma remain the mainstays of therapy, although a uniform cure for calciphylaxis remains elusive. Prognosis for patients with calciphylaxis is dismal, even after surgical intervention. Early diagnosis and treatment is critical to prevent progression of the disease process

A case is presented of a man with a 3-year history of ulcers in the setting of pigmented, annular and purpuric lesions of the lower extremities. A skin biopsy suggested a diagnosis of purpura annularis telangiectodes of Majocchi. First described in 1896 by Majocchi [1], purpura annularis telangiectodes is an uncommon pigmented purpuric eruption, which is characterized by symmetrical, purpuric, telangiectatic, and atrophic patches with a predilection for the lower extremities and buttocks. Histopathology and immunopathogenesis of this disease are similar to the other subtypes of pigmented purpuric dermatoses

A case is presented of a man with a history of melanoma treated with sentinel lymphadenectomy and interferon therapy, who subsequently developed diffuse hypopigmented patches thought to be consistent with a diagnosis of melanoma-associated leukoderma. Clinically, melanoma-associated leukoderma is a diffuse macular hypomelanosis or depigmentation, which often develops at sites distant to the location of the primary melanoma. The leukoderma may be hypomelanotic and mottled or depigmented and milk-white. Spontaneous repigmentation may occur. A recent study has demonstrated that T cells involved in the destruction of neoplastic melanocytes are identical clones of those that accumulate in melanoma-associated leukoderma

We describe the case of a 71-year-old-woman with a 6-year history of generalized eruptive keratoacanthomas on the extremities. We review the diagnostic clinical and histologic features of the rare Grzybowski variant of generalized eruptive keratoacanthoma. The course of this disease is chronic and often demonstrates a poor response to therapy

We describe the case of a 71-year-old woman with a six-year history of generalized eruptive keratoacanthomas on the extremities. We review the diagnostic clinical and histologic features of the rare Grzybowski variant of generalized eruptive keratoacanthoma. The course of this disease is chronic and often demonstrates a poor response to therapy

It has been over 30 years since Dr. Mohs first realized the potential for the surgery that now bears his name, and since then hundreds of articles have been published in dozens of Journals regarding his research and clinical experience, and the work of those who followed him. Collated in his memory by Drs. David Goldberg and C. William Hanke, and Ronald Moy, these 25 articles are meant to represent a cross-section of the most important articles ever published on the subject of Mohs surgery, and provide an excellent resource for those interested in learning about its development and refinement over the years