Searched for: person:karajm01
Multicenter, phase 2 study of bevacizumab in children and adults with neurofibromatosis 2 and progressive vestibular schwannomas: an NF Clinical Trials Consortium study [Meeting Abstract]
Plotkin, Scott; Tonsgard, James; Ullrich, Nicole; Allen, Jeffrey; Blakeley, Jaishri; Rosser, Tena; Clapp, David; Campion, Jian; Fisher, Michael; Cutter, Gary; Korf, Bruce; Packer, Roger; Thomas, Coretta; Karajannis, Matthias
ISI:000453090805278
ISSN: 0028-3878
CID: 3561652
DNA methylation-based classification of central nervous system tumours
Capper, David; Jones, David T W; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E; Kratz, Annekathrin; Wefers, Annika K; Huang, Kristin; Pajtler, Kristian W; Schweizer, Leonille; Stichel, Damian; Olar, Adriana; Engel, Nils W; Lindenberg, Kerstin; Harter, Patrick N; Braczynski, Anne K; Plate, Karl H; Dohmen, Hildegard; Garvalov, Boyan K; Coras, Roland; Hölsken, Annett; Hewer, Ekkehard; Bewerunge-Hudler, Melanie; Schick, Matthias; Fischer, Roger; Beschorner, Rudi; Schittenhelm, Jens; Staszewski, Ori; Wani, Khalida; Varlet, Pascale; Pages, Melanie; Temming, Petra; Lohmann, Dietmar; Selt, Florian; Witt, Hendrik; Milde, Till; Witt, Olaf; Aronica, Eleonora; Giangaspero, Felice; Rushing, Elisabeth; Scheurlen, Wolfram; Geisenberger, Christoph; Rodriguez, Fausto J; Becker, Albert; Preusser, Matthias; Haberler, Christine; Bjerkvig, Rolf; Cryan, Jane; Farrell, Michael; Deckert, Martina; Hench, Jürgen; Frank, Stephan; Serrano, Jonathan; Kannan, Kasthuri; Tsirigos, Aristotelis; Brück, Wolfgang; Hofer, Silvia; Brehmer, Stefanie; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Hans, Volkmar; Rozsnoki, Stephanie; Hansford, Jordan R; Kohlhof, Patricia; Kristensen, Bjarne W; Lechner, Matt; Lopes, Beatriz; Mawrin, Christian; Ketter, Ralf; Kulozik, Andreas; Khatib, Ziad; Heppner, Frank; Koch, Arend; Jouvet, Anne; Keohane, Catherine; Mühleisen, Helmut; Mueller, Wolf; Pohl, Ute; Prinz, Marco; Benner, Axel; Zapatka, Marc; Gottardo, Nicholas G; Driever, Pablo Hernáiz; Kramm, Christof M; Müller, Hermann L; Rutkowski, Stefan; von Hoff, Katja; Frühwald, Michael C; Gnekow, Astrid; Fleischhack, Gudrun; Tippelt, Stephan; Calaminus, Gabriele; Monoranu, Camelia-Maria; Perry, Arie; Jones, Chris; Jacques, Thomas S; Radlwimmer, Bernhard; Gessi, Marco; Pietsch, Torsten; Schramm, Johannes; Schackert, Gabriele; Westphal, Manfred; Reifenberger, Guido; Wesseling, Pieter; Weller, Michael; Collins, Vincent Peter; Blümcke, Ingmar; Bendszus, Martin; Debus, Jürgen; Huang, Annie; Jabado, Nada; Northcott, Paul A; Paulus, Werner; Gajjar, Amar; Robinson, Giles W; Taylor, Michael D; Jaunmuktane, Zane; Ryzhova, Marina; Platten, Michael; Unterberg, Andreas; Wick, Wolfgang; Karajannis, Matthias A; Mittelbronn, Michel; Acker, Till; Hartmann, Christian; Aldape, Kenneth; Schüller, Ulrich; Buslei, Rolf; Lichter, Peter; Kool, Marcel; Herold-Mende, Christel; Ellison, David W; Hasselblatt, Martin; Snuderl, Matija; Brandner, Sebastian; Korshunov, Andrey; von Deimling, Andreas; Pfister, Stefan M
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
PMCID:6093218
PMID: 29539639
ISSN: 1476-4687
CID: 2992882
Pre-treatment lymphopenia and indication of tumor-induced systemic immunosuppression in medulloblastoma
Patel, Seema; Wang, Shiyang; Snuderl, Matija; Karajannis, Matthias A
The presence of tumor-induced systemic immune suppression, including lymphopenia, has been recognized in adult patients with glioblastoma for several decades, and pre-treatment neutrophil-to-lymphocyte count ratio (NLCR) is associated with inferior clinical outcome in patients with glioblastoma. Whether tumor-induced systemic immune suppression is also present in children with malignant brain tumors is not known. We performed a retrospective analysis of pretreatment neutrophil and lymphocyte counts in pediatric patients with medulloblastoma (MB) compared to a control group of children with posterior fossa pilocytic astrocytoma (PA). Compared to the control group, we observed statistically significantly lower absolute lymphocyte counts (ALCs) and higher NLCRs in the medulloblastoma group. Our findings suggest the presence of tumor-induced systemic immune suppression in MB patients already present at the time of diagnosis, with potential implications for the development of immune therapies in this population.
PMCID:5807109
PMID: 29143922
ISSN: 1573-7373
CID: 2947242
High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma
Chapter by: Karajannis, Matthias A; Snuderl, Matija; Yeh, Brian K; Walsh, Michael F; Jain, Rajan; Sahasrabudhe, Nikhil A; Wisoff, Jeffrey H
in: Brain Tumors in Children by Gajjar, Amar; Reaman, Gregory H; Racadio, Judy M; Smith, Franklin O (Eds)
Cham : Springer, 2018
pp. 193-221
ISBN: 3319432052
CID: 3732452
RECURRENT HOMOZYGOUS DELETION OF DROSHA AND MICRODUPLICATION OF PDE4DIP CONTAINING THE ANCESTRAL DUF1220 DOMAIN IN PINEOBLASTOMA [Meeting Abstract]
Snuderl, Matija; Kannan, Kasthuri; Pfaff, Elke; Wang, Shiyang; Stafford, James; Serrano, Jonathan; Heguy, Adriana; Ray, Karina; Faustin, Arline; Aminova, Olga; Dolgalev, Igor; Stapleton, Stacie; Zagzag, David; Chiriboga, Luis; Gardner, Sharon; Wisoff, Jeffrey; Golfinos, John; Capper, David; Hovestadt, Volker; Rosenblum, Marc; Placantonakis, Dimitris; LeBoeuf, Sarah; Papagiannakopoulos, Thales; Chavez, Lukas; Ahsan, Sama; Eberhart, Charles; Pfister, Stefan; Jones, David; Karajannis, Matthias
ISI:000438339000189
ISSN: 1522-8517
CID: 5525552
FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS [Meeting Abstract]
Gupta, Nalin; Goumnerova, Liliana; Ayyanar, Kanya; Gump, William; Bendel, Anne; Nagib, Mahmoud; Bowers, Daniel; Weprin, Bradley; Bredlau, Amy-Lee; Gururangan, Sridharan; Fuchs, Herbert; Cohen, Kenneth; Jallo, George; Dorris, Kathleen; Handler, Michael; Comito, Melanie; Dias, Mark; Fangusaro, Jason R; Goldman, Stewart; Tomita, Tadanori; Alden, Tord; DiPatri, Arthur; Gardner, Sharon; Karajannis, Matthias; Harter, David; Gauvain, Karen; Limbrick, David; Leonard, Jeffrey; Geyer, JRuss; Leary, Sarah; Browd, Samuel; Khatib, Ziad; Ragheb, John; Bhatia, Sanjiv; MacDonald, Tobey; Aguilera, Dolly; Brahma, Barun; Manley, Peter; Chi, Susan; Mueller, Sabine; Banerjee, Anuradha; Murray, Jeffrey; Nazemi, Kellie; Baird, Lissa; Robison, Nathan; Kiehna, Erin; Krieger, Mark; Sandler, Eric; Aldana, Philipp; Wang, Joanne; Sood, Sandeep; Neuberg, Donna; Puligandla, Maneka; Greenspan, Lianne; Wright, Karen; Prados, Michael; Bandopadhayay, Pratiti; Ligon, Keith; Kieran, Mark
ISI:000415152503125
ISSN: 1523-5866
CID: 2802382
A DNA Methylation-Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas [Meeting Abstract]
Wu, P; Cooper, B; Bu, F; Bowman, C; Jonathan, K; Serrano, J; Wang, S; Jackson, T; Gorovets, D; Gorlick, R; Ladanyi, M; Thomas, K; Snuderl, M; Karajannis, M
ISI:000408978202292
ISSN: 1545-5017
CID: 2766962
PERIPHERAL BLOOD DNA METHYLATION PROFILES IDENTIFY IDH1/2 MUTATION STATUS IN ADULTS WITH DIFFUSE GLIOMA [Meeting Abstract]
Kloetgen, Andreas; Serrano, Jonathan; Patel, Seema; Bowman, Christopher; Shen, Guomiao; Zagzag, David; Karajannis, Matthias; Golfinos, John; Placantonakis, Dimitris; Tsirigos, Aristotelis; Chi, Andrew S; Snuderl, Matija
ISI:000415152501194
ISSN: 1523-5866
CID: 2802432
GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS [Meeting Abstract]
Vennneti, Sriram; Panwalkar, Pooja; Clark, Jonathan; Ramaswamy, Vijay; Hawes, Debra; Yang, Fusheng; Dunham, Christopher; Yip, Stephen; Hukin, Juliette; Sun, Yilun; Schipper, Matthew; Chavez, Lukas; Margol, Ashley; Pekmezci, Melike; Chung, Chan; Banda, Adam; Bayliss, Jill; Curry, Sarah; Santi, Mariarita; Rodriguez, Fausto; Snuderl, Matija; Karajannis, Matthias; Saratsis, Amanda; Horbinski, Craig M; Kool, Marcel; Pfister, Stefan M; Taylor, Michael; Hawkins, Cynthia; Korshunov, Andrey; Judkins, Alexander
ISI:000415152503174
ISSN: 1523-5866
CID: 2802362
PROGRAMMED DEATH LIGAND 1 EXPRESSION AND TUMOR INFILTRATING LYMPHOCYTES IN TUMORS ASSOCIATED WITH NEUROFIBROMATOSIS TYPE 1 AND 2 [Meeting Abstract]
Wang, Shiyang; Liechty, Benjamin; Patel, Seema; Weber, Jeffrey; Hollman, Travis; Snuderl, Matija; Karajannis, Matthias
ISI:000415152503236
ISSN: 1523-5866
CID: 2802342
