Faculty Bibliography

BACKGROUND/UNASSIGNED:Teamwork and communication are critical to reducing medical error, particularly in complex surgical procedures such as vascularized composite allotransplantation (VCA). Although cadaveric rehearsals are used to prepare for VCA, their effect on team development and operative outcomes remains unstudied. We therefore sought to evaluate the evolution of teamwork and its impact on operative outcomes in preparation for the first successful combined full-face and bilateral hand transplant. METHODS/UNASSIGNED:Cadaveric rehearsals were conducted in preparation for a combined full-face and bilateral hand transplant. As a quality improvement effort, teams followed surgical checklists and were assessed for teamwork using the Clinical Teamwork Scale (CTS) and the Oxford Non-Technical Skills (NOTECHS) tool. Face- and hand-specific scores and dissection times were recorded at each rehearsal to guide debriefings and refine subsequent sessions until transplantation. RESULTS/UNASSIGNED:= 0.004). CONCLUSIONS/UNASSIGNED:Teamwork and dissection time significantly improved during 11 cadaveric rehearsals, culminating in the first successful face and bilateral hand transplant. A comprehensive, team-based approach is essential to the success of VCA.

The Substance P/neurokinin-1 receptor (SP/NK1R) pathway plays a significant role in several cancers, including pancreatic, breast, glioblastoma, and lung malignancies. This review highlights its involvement in metastasis, angiogenesis, proliferation, resistance, and apoptosis. Aprepitant, an NK1R antagonist and approved antiemetic, shows promising anticancer and protective effects, supporting its use in combination therapies. NK1R-targeted strategies may enhance treatment efficacy while reducing chemotherapy- and radiotherapy-induced toxicities.

BACKGROUND/UNASSIGNED:Mal de débarquement syndrome (MdDS) is a chronic vestibular disorder of non-spinning vertigo, with various somatic, cognitive, and affective symptoms. The manifestation of MdDS is often only subjective, and different symptoms are variably emphasized when patients appraise the severity of their illness. The etiology of MdDS remains unclear but may lie in improperly sustained neuroplasticity in the velocity storage mechanism of the central vestibular system. Two broad approaches targeting velocity storage-one focusing on correcting velocity storage's maladapted behavior and the other on attenuating its contribution to higher-order processing-have yielded varying degrees of treatment success. METHODS/UNASSIGNED:We conducted a secondary analysis of data from our recent study contrasting the outcomes of the above two approaches. We examined the variations in individual emphases of separate symptoms by correlating the subjective ratings of overall MdDS severity with those of specific symptoms across time points for each subject. We also explored the possibility that variations in symptom presentation influence the responsiveness to the two approaches of treatment. RESULTS/UNASSIGNED:Many symptoms correlated with the overall severity rating, but even those that showed strong correlation among many subjects, such as dizziness, fatigue, and brain fog, were endorsed variably across subjects. A moderate unfavorable dependence on visual sensitivity was found for the responsiveness to the velocity storage attenuation treatment, which distinguished the two treatment approaches. CONCLUSION/UNASSIGNED:Results provide a glimpse into the complexity of MdDS manifestations. Individual variations in what contributes to their perceived overall symptom severity may aid the choice of treatment approach.

BACKGROUND/UNASSIGNED:Frontline (1L) treatment for transplant-eligible (TE) newly diagnosed multiple myeloma (NDMM) has shifted from triplet (e.g. bortezomib [V], lenalidomide [R], dexamethasone [d]) to quadruplet (e.g. daratumumab with VRd [DVRd]) regimens, based on improved efficacy demonstrated in pivotal trials. This real-world study compared progression-free survival (PFS) in TE patients with NDMM treated with DVRd plus DR or R maintenance (DVRd-DR/R) versus VRd plus R maintenance (VRd-R). METHODS/UNASSIGNED:Adult TE patients with NDMM who initiated DVRd-DR/R or VRd-R between 1 January 2020 and 30 June 2022 were identified through a retrospective chart review at 10 US sites. PFS was assessed using Kaplan-Meier analyses and propensity score-weighted hazard ratios (HR) were estimated using Cox regression. RESULTS/UNASSIGNED:= 0.006). CONCLUSION/UNASSIGNED:Findings aligned with pivotal trials, demonstrating the significant PFS benefit of 1L DVRd over VRd and supporting its real-world use for TE NDMM.

UNLABELLED:/mL for nanoparticles. These scalable, cost-effective meta-sensors deliver sensing performance, dynamic range, and stability comparable to, or even surpass, those of state-of-the-art devices fabricated using top-down lithography, thereby bridging the gap toward practical applications. SUPPLEMENTARY INFORMATION/UNASSIGNED:The online version contains supplementary material available at 10.1007/s44258-026-00090-w.

BACKGROUND:This is the quality of life (QOL) analysis of the SPPORT trial of men with a detectable prostate specific antigen (PSA) after prostatectomy for prostate cancer. Primary analysis established a benefit of adding pelvic lymph node radiotherapy (PLNRT) and short-term androgen deprivation therapy (STADT) to salvage prostate bed radiotherapy (PBRT) for biochemical progression-free survival. METHODS:Subjects were randomized to Arm 1, PBRT, Arm 2, 4-6 months of STADT + PBRT, and Arm 3, PLNRT + STADT + PBRT. QOL was assessed at baseline, 6 weeks after the start of RT, 1 and 5 years after the end of RT, including Expanded Prostate Cancer Index Composite (EPIC), Hopkins Symptom Checklist (HSCL-25), EuroQol (EQ-5D), and quality adjusted life years (QALYs). Statistical and clinical significance were calculated. Differences among arms were assessed using pairwise t-tests, Fisher's exact test, and mixed effects regression modeling, controlling for multiplicity. FINDINGS/RESULTS:644 patients consented to QOL; 81% white and 54% <65 years. EPIC, bowel and urinary scores decreased at 6 weeks then increased by years 1 and 5, although not to baseline. For sexual and hormonal domains, there were statistically significant differences between arms at 6 weeks and 1 year with STADT exhibiting poorer QOL scores, but no difference at 5 years. For HSCL-25, statistically significant differences at 6 weeks were not clinically significant. Comparisons of QALYs for overall survival showed no statistical significance. However, freedom from progression QALY means were 5.5, 6.2 and 6.6 years for Arms 1, 2, and 3, respectively, with Arms 3 and 2 indicating statistically significant improvement over Arm 1. INTERPRETATION/CONCLUSIONS:While QOL generally declined the most among all arms at 6 weeks post RT start, and remained lower than baseline at 5 years, there were no clinically significant differences in QOL among arms at 1 and 5 years. QALYs for freedom from progression favored STADT + PLNRT + PBRT for salvage treatment of prostate cancer.

INTRODUCTION/BACKGROUND:The tear trough is one of the areas that most reflects aging. The anatomy of the preseptal, premaxillary, prezygomatic and deep pyriform spaces are essential for successful planning of filler treatments. MATERIAL AND TECHNIQUE/UNASSIGNED:This work analyzes the anatomic relationship between the origin of the orbital septum and the tear trough/ orbicularis retaining ligaments, and between the anatomical spaces and the cheek fat compartments, to classify patients who undergo a filler treatment for tear trough deformity. Patients are classified in 'innie' or 'outie' and blending technique is described based on this classification. RESULTS:A total of 38 patients were evaluated, comprising 21 females and 17 males, with a mean age of 53 years (range, 31-72 years). The mean follow-up period was 10.4 months (range, 5-22 months). All patients presented with an innie-type tear trough deformity. Prior to treatment, 76.3% of patients (n = 29) were classified as Hirmand Type II, and 23.7% (n = 9) as Type III. Following treatment, 84.2% (n = 32) of patients were rated as "very much improved" (GAIS score of 1), and 15.8% (n = 6) as "much improved" (GAIS score of 2). The mean volume of hyaluronic acid injected per unilateral tear trough was 0.35 cc (range of 0.2-0.5 cc), and for the unilateral midcheek was 0.65 cc (range of 0.5 to 2 cc). No complications were reported. CONCLUSION/CONCLUSIONS:The blending technique is an effective technique to improve the appearance of the lid-cheek junction, correcting the TT deformity and the palpebromalar groove. Patients are classified as innies or outies based on the position of the AM on the orbital bone. Innie patients are more favorable to the injection of HA in the gap between AM and ORL (preseptal space) to correct the TT groove. Outie patients benefit from the volumization and support of the DMCFP, but not from direct injection into the TT and preseptal space. LEVEL OF EVIDENCE V/METHODS:This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .