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Trends in prescription of opioids from 2003-2009 in persons with knee osteoarthritis

Wright, Elizabeth A; Katz, Jeffrey N; Abrams, Stanley; Solomon, Daniel H; Losina, Elena
OBJECTIVE:Osteoarthritis (OA) of the knee is a painful condition affecting ∼13% of persons ages >65 years. We sought to examine whether the use of opioids in older persons with OA has increased over the past decade and what patient characteristics may correlate with their use. METHODS:We assembled national cohorts of individuals with knee OA using data from the 2003, 2006, and 2009 waves of the Medicare Current Beneficiary Survey. The survey data contained information on demographics, health status, and prescribed medications linked to Medicare claims. We used multivariate logistic regression to establish whether opioid use changed over time and to identify factors associated with greater opioid use. The outcome was defined as receiving ≥1 opioid prescription in the study year. RESULTS:The mean age and sex were similar across years (77 years and 69% women, respectively). There was a significant increase in opioid prescribing between 2003 and 2009, with 31% of patients receiving opioids in 2003, 39% in 2006, and 40% in 2009 (odds ratio [OR] 1.5, 95% confidence interval [95% CI] 1.1-2.0 for 2006 and 2009 compared with 2003). Independent correlates of opioid use across time periods included female sex (OR 1.5, 95% CI 1.2-2.0), functional limitation (OR 2.1, 95% CI 1.6-2.7), poor self-reported health status (OR 1.6, 95% CI 1.2-2.0), chronic obstructive pulmonary disease (OR 1.4, 95% CI 1.0-1.8), and musculoskeletal disease besides OA (OR 1.9, 95% CI 1.2-2.8). CONCLUSION/CONCLUSIONS:As the prevalence and incidence of knee OA continues to increase, the public health impact of greater opioid use should be monitored carefully.
PMID: 24782079
ISSN: 2151-4658
CID: 5429952

Randomized Controlled Trial of Postoperative Care Navigation in Total Knee Arthroplasty Patients: Does One Size Fit All? [Meeting Abstract]

Losina, Elena; Collins, Jamie E.; Wright, John; Daigle, Meghan E.; Donnell-Fink, Laurel; Strnad, Doris; Lerner, Vladislav; Abrams, Stanley; Katz, Jeffrey N.
ISSN: 2326-5191
CID: 5429962

Placing a price on medical device innovation: the example of total knee arthroplasty

Suter, Lisa G; Paltiel, A David; Rome, Benjamin N; Solomon, Daniel H; Thornhill, Thomas S; Abrams, Stanley K; Katz, Jeffrey N; Losina, Elena
BACKGROUND:Total knee arthroplasty (TKA) is common, effective, and cost-effective. Innovative implants promising reduced long-term failure at increased cost are under continual development. We sought to define the implant cost and performance thresholds under which innovative TKA implants are cost-effective. METHODS:We performed a cost-effectiveness analysis using a validated, published computer simulation model of knee osteoarthritis. Model inputs were derived using published literature, Medicare claims, and National Health and Nutrition Examination Survey data. We compared projected TKA implant survival, quality-adjusted life expectancy (QALE), lifetime costs, and cost-effectiveness (incremental cost-effectiveness ratios or ICERs) of standard versus innovative TKA implants. We assumed innovative implants offered 5-70% decreased long-term TKA failure rates at costs 20-400% increased above standard implants. We examined the impact of patient age, comorbidity, and potential increases in short-term failure on innovative implant cost-effectiveness. RESULTS:Implants offering ≥50% decrease in long-term TKA failure at ≤50% increased cost offered ICERs <$100,000 regardless of age or baseline comorbidity. An implant offering a 20% decrease in long-term failure at 50% increased cost provided ICERs <$150,000 per QALY gained only among healthy 50-59-year-olds. Increasing short-term failure, consistent with recent device failures, reduced cost-effectiveness across all groups. Increasing the baseline likelihood of long-term TKA failure among younger, healthier and more active individuals further enhanced innovative implant cost-effectiveness among younger patients. CONCLUSIONS:Innovative implants must decrease actual TKA failure, not just radiographic wear, by 50-55% or more over standard implants to be broadly cost-effective. Comorbidity and remaining life span significantly affect innovative implant cost-effectiveness and should be considered in the development, approval and implementation of novel technologies, particularly in orthopedics. Model-based evaluations such as this offer valuable, unique insights for evaluating technological innovation in medical devices.
PMID: 23671626
ISSN: 1932-6203
CID: 5429942

Trends In Prescription Of Opioids From 2003-2009 In Persons With Knee Osteoarthritis [Meeting Abstract]

Wright, Elizabeth; Katz, Jeffrey N.; Abrams, Stanley; Solomon, Daniel H.; Losina, Elena
ISSN: 0004-3591
CID: 5429972