Try a new search

Format these results:

Searched for:

person:accacs01

in-biosketch:true

Total Results:

17


Plasma advanced glycation end products (AGEs), receptors for AGEs and their correlation with inflammatory markers in middle school-age children

Accacha, S; Rosenfeld, W; Jacobson, A; Michel, L; Schnurr, F J; Shelov, S; Ten, S; Boucher-Berry, C; Carey, D E; Speiser, P W; Lowell, B; Conroy, R; Klein, M; Fennoy, I; Rapaport, R; Rosenbaum, M
AIM: Advanced glycation end products (AGEs) and/or their receptors (RAGE) are significantly positively correlated with adiposity, inflammation, dyslipidemia, and insulin resistance in adults. However, the relationships between AGEs, RAGE, and adiposity-related comorbidites in children have not been well studied. METHODS: In a cross-sectional study of 88 children (age 11-15 years) from the New York area enrolled in the Reduce Obesity and Diabetes (ROAD) study, we examined the correlation of the AGE N(epsilon)-(carboxymethyl)lysine (CML), soluble RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) with adiposity, inflammatory markers [interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha], adiponectin, lipids, insulin sensitivity, and insulin secretory capacity. RESULTS: Pediatric CML levels were ~20% below average adult levels. CML was significantly (p < 0.05) positively correlated with age and insulin sensitivity and negatively with adiposity, dyslipidemia and IL-6. sRAGE correlated positively with esRAGE and negatively with adiposity and IL-6. Both sRAGE and esRAGE correlated negatively with insulin secretory capacity. CONCLUSION: Our findings suggest that unlike adults, CML is negatively associated with adiposity and adiposity-related comorbidity risk in children. As in adults, sRAGE and esRAGE were, to varying degrees, negatively correlated with body fatness and risk factors for adiposity-related comorbidities.
PMID: 24217195
ISSN: 1663-2826
CID: 845162

Correlations of Advanced Glycation End Products and their Receptors With Adiposity and Adiposity-Related Co-Morbidity Risk are Different in Children than in Adults [Meeting Abstract]

Accacha, Siham; Altshuler, Lisa; Boucher-Berry, Claudia; Carey, Denis; Conroy, Rushika; Desantis, Deborah; Fennoy, Ilene; Klein, Michelle; Jacobson, Alan; Lowel, Barbara; Michel, Lesly; Malik, Shahid; Rapaport, Robert; Rosenfeld, Warren; Shelov, Steven; Speiser, Phyllis; Ten, Svetlana; Rosenbaum, Michael
ISI:000209842902389
ISSN: 0012-1797
CID: 3486462

Vitamin D, osteocalcin and risk for adiposity as co-morbidities in middle school children

Boucher-Berry C; Speiser PW; Carey DE; Shelov SP; Accacha S; Fennoy I; Rapaport R; Espinal Y; Rosenbaum M
Nonclassic actions of vitamin D include potential regulation of immune function and glucose homeostasis. The bone-metabolism loop has recently been expanded to include osteocalcin, which appears to play a more direct role in pancreatic beta cell function and energy metabolism. We hypothesized that both vitamin D and osteocalcin would correlate negatively with indices of adiposity-related co-morbidity risk in periadolescents, varying by ethnic group. We analyzed anthropometric, metabolic and inflammatory markers from a multi-ethnic population of 106 school children 11-14 yrs of age studied as part of the ROAD (Reduce Obesity and Diabetes) consortium. As expected, 25-hydroxyvitamin D was inversely correlated with intact parathyroid hormone (iPTH); total (OCN) and uncarboxylated osteocalcin (uOCN) were directly correlated with each other. OCN, and uOCN concentrations correlated inversely with age. Vitamin D deficiency was most prevalent among East Asians (EA) and African Americans (AA). The highest lipid risk scores and HOMA-IR values (a measure of insulin resistance) were seen in the South Asian (SA) group. Overall, adiposity measures were inversely correlated with OCN and iPTH, whereas such relationships were not observed for vitamin D. Acute insulin response to glucose challenge correlated negatively with uOCN in all subjects, however, lipid risk score correlated negatively with uOCN only in Caucasians. The relationships between markers of calcium metabolism and body composition, glucose homeostasis, lipids, and inflammation all showed racial and ethnic differences. No consistent relationship was found between Vitamin D, and adiposity or glucose metabolism, rather vitamin D levels varied by race and ethnicity in this school-based group. These findings are consistent with the hypothesis that markers of calcium and bone metabolism may reflect risk for adiposity-related co-morbidities in children. (c) 2011 American Society for Bone and Mineral Research
PMCID:4597472
PMID: 22068892
ISSN: 1523-4681
CID: 143667

Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children

Conroy, Rushika; Espinal, Yomery; Fennoy, Ilene; Accacha, Siham; Boucher-Berry, Claudia; Carey, Dennis E; Close, Sharron; DeSantis, Deborah; Gupta, Rishi; Hassoun, Abeer A; Iazzetti, Loretta; Jacques, Fabean J; Jean, Amy M; Michel, Lesly; Pavlovich, Katherine; Rapaports, Robert; Rosenfeld, Warren; Shamoon, Elisabeth; Shelov, Steven; Speiser, Phyllis W; Ten, Svetlana; Rosenbaum, Michael
OBJECTIVE: In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity. This study examined the relationship between RBP4 and risk factors for co-morbidities of adiposity in a population of ethnically diverse children in early- to mid-adolescence in the public school system of New York City. MATERIALS/METHODS: We analyzed anthropometric (body mass index, % body fat, waist circumference), metabolic (lipids, glucose), and inflammatory (TNF-alpha, interleukin-6, C-reactive protein, adiponectin) markers for adiposity-related co-morbidities and serum alanine aminotransferase (ALT) in 106 school children (65 males, 41 females) 11-15 years of age (mean +/- SD = 13.0 +/- 0.1 years) who were enrolled in the Reduce Obesity and Diabetes (ROAD) project. Insulin sensitivity was assessed by quantitative insulin sensitivity check index. Insulin secretory capacity was measured as acute insulin response and glucose disposal index. RESULTS: Serum RBP4 was significantly correlated directly with ALT, triglycerides, and triglyceride z-score, and inversely correlated with adiponectin. Correlations with ALT and adiponectin remained significant when corrected for % body fat, age, and gender. There were significant ethnic differences in the relationship of RBP4 to ALT, glucose disposal index and adiponectin. CONCLUSIONS: In early- to mid-adolescents, circulating concentrations of RBP4 are correlated with multiple risk factors for adiposity-related co-morbidities. The observation that many associations persisted when corrected for % body fat, suggests that RBP4 can be viewed as an independent marker of adiposity-related co-morbidity risk in children.
PMCID:4758201
PMID: 22308842
ISSN: 0334-018x
CID: 845062

Final adult height in children with Prader-Willi syndrome with and without human growth hormone treatment

Angulo, Moris A; Castro-Magana, Mariano; Lamerson, Michele; Arguello, Raul; Accacha, Siham; Khan, Asjad
Short stature is characteristic of children with Prader-Willi syndrome (PWS). While previous studies have demonstrated acceleration of linear height velocity with growth hormone (GH) treatment, the long-term benefit on final adult height (AH) has not been reported. The objective of this study was to compare AH attained in PWS subjects with and without GH treatment. We reviewed the records of 21 children (aged 8.3 +/- 2.7 years) with PWS and confirmed GH deficiency that attained AH after receiving human GH treatment (0.25 +/- 0.06 mg/kg/week) for a period of 7.9 +/- 1.7 years. A group of 39 non-GH-treated adults with matched initial height standard deviation score (SDS) at age 6.8 +/- 1.3 years was used as control. In the GH-treated group the mean initial height and AH-SDS was -1.9 +/- 1.7 and -0.3 +/- 1.2 respectively (P < 0.0001), whereas the mean initial and AH-SDS in the control group was -1.9 +/- 1.3 and -3.1 +/- 1 respectively (P < 0.0001). Scoliosis was seen in 43% and 39% in the GH-treated and control group respectively. Premature adrenarche (PA) was noticed in 57% of GH-treated group. Six subjects in the control group but none of the GH-treated subjects developed type 2 diabetes mellitus. Our data show that administration of GH to children with PWS restores linear growth and final AH without significant adverse effects other than PA. Further studies will be necessary to determine related morbidity and mortality in individuals with PWS that reached final AH with or without GH treatment.
PMID: 17567883
ISSN: 1552-4825
CID: 3486482

THE MECHANISM OF ACTION OF M-CSF SUPPRESSING 1,25(OH)2D3 INDUCED OSTEOCLAST FORMATION [Meeting Abstract]

Accacha, SD; Niu, QT; Castro-Magana, M; Aloia, JF; Yeh, JK
ISI:000267211300163
ISSN: 0171-967x
CID: 2600942

TSH-induced ovarian hyperstimulation syndrome associated with massive ovarian enlargement and suppressed LH [Meeting Abstract]

Tapiador, CD; Appiagyei-Dankah, Y; Idris, M; Accacha, S; Lamerson, M; Castro-Magana, M
ISI:000174714600731
ISSN: 0031-3998
CID: 3488172