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Re-excision Rate after Partial Mastectomy in Oncoplastic Breast-Conserving Surgery: A Single-Institutional Experience and Review of the Literature

Benjamin, Martin A; Sinnott, Catherine; Bawa, Sheina; Kaufman, David I; Guarino, Katie; Addona, Tommaso
BACKGROUND:Applying oncoplastic techniques to breast conservation therapy is believed to improve cosmetic and oncologic outcomes, compared with standard breast conservation therapy alone. This study aimed to perform a comprehensive review of the literature comparing outcomes of oncoplastic breast conservation therapy (BCT + R) with that of standard breast conservation therapy alone (BCT). A secondary objective was to compare these results to outcomes after oncoplastic breast conservation therapy performed at our institution (BCT + r). METHODS:A literature search was performed in PubMed using key words, "oncoplastic," "partial breast reconstruction," and "breast conservation therapy." Case reports, case series, and studies with fewer than 10 patients and studies that did not report re-excision rates were excluded. A retrospective chart review was performed from 2011 to 2017 of all cases of oncoplastic breast conservation therapy performed at our institution by a single 2-surgeon team consisting of 1 breast surgeon and 1 plastic surgeon. Outcomes were assessed by comparing re-excision rates between the 3 comparison groups (BCT, BCT + R, BCT + r). RESULTS:The BCT group was made of 5965 patients (22 articles), and the BCT + R group comprised 2564 patients (41 articles). Re-excision rates in the BCT + R group were lower (4.0%) than the BCT group (17.2%, P = 0.0001). One hundred seventy-two patients comprised the BCT + r group and underwent oncoplastic breast conservation therapy during the study period at our institution. The re-excision rate in the BCT + r group was 1.7% and was significantly lower than the BCT group (P = 0.0001) and lower but not significantly different from the BCT + R group (P = 0.2113). CONCLUSIONS:Oncoplastic breast conservation therapy leads to lower re-excision rates compared with standard breast conservation therapy. Oncoplastic breast conservation therapy may improve oncologic outcomes compared with standard breast conservation therapy by allowing for more extensive resection without compromising aesthetic results.
PMID: 30855383
ISSN: 1536-3708
CID: 5043992

Treatment of the Open Glenohumeral Joint with the Anterior Deltoid Muscle Flap [Case Report]

Xipoleas, George D; Woods, Daniel; Batac, Joseph; Addona, Tommaso
Upper extremity reconstruction is most often encountered in trauma patients. Although the rate of complications from elective orthopedic procedures remains relatively low, these complications are oftentimes in the form of open joints or joint infections that can be devastating. Classically, wounds of the shoulder girdle have been treated with large muscles such as the pectoralis major, pectoralis minor, and latissimus dorsi. Flaps more local to the area including the deltoid muscle flap have been overlooked due to their small size. Despite its size, the anterior deltoid can be used for shoulder girdle reconstruction with minimal functional deficit and allows for reconstruction of the glenohumeral joint without sacrifice of the larger muscles of the upper trunk. This study reports a case of a chronic shoulder girdle wound and successful management with the use of an anterior deltoid muscle flap.
PMCID:5096525
PMID: 27826470
ISSN: 2169-7574
CID: 5043982

Spinal reconstruction for osteomyelitis with free vascularized fibular grafts using intra-abdominal recipient vessels: A series of three cases

Aliano, Kristen A; Agulnick, Marc; Cohen, Benjamin; Gonya, Gary; Low, Christopher; Stavrides, Steve; Addona, Tommaso; Goncalves, John; Shin, David; Kilgo, Matthew S; Davenport, Thomas A
Reconstruction of bony defects in the surgical management of vertebral osteomyelitis is a challenging endeavor. Our objective is to report the use of intra-abdominal vessels as the recipient vessels for microanastomosis of vascularized bone graft and the use of a spinal cage for fixation. Three patients failed conservative treatment for vertebral osteomyelitis and suffered pathologic fracture. Their treatment consisted of staged posterior irrigation and debridement with segmental fixation, followed by a thoracoabdominal approach multiple-level corpectomy. Reconstruction was performed with a free vascularized fibular graft placed within a custom, expandable cage. The vascularized fibular graft was anastomosed to an intra-abdominal recipient vessel. All patients improved clinically with no neurologic deficits noted. All showed evidence of successful fusion. Free vascularized bone grafts continue to be an excellent option for multi-level spinal defects related to osteomyelitis. Intra-abdominal recipient vessels are appropriate recipient vessels, as their diameter, length, and accessibility allow vascularized bone graft reconstruction of vertebral column defects of the thoracolumbar region. These vessels are also easily accessible and the anastomoses can be performed in the superficial operating incision.
PMID: 24014308
ISSN: 1098-2752
CID: 3508852

Complete calvarial agenesis in conjunction with a Tessier 1-13 facial cleft [Case Report]

Addona, Tommaso; Friedman, Ariella; Post, Alexander; Weiss, Nirit; Silver, Lester; Taub, Peter J
Amniotic band sequence (ABS) is a condition in which rupture of the amniotic sac leads to the development of a broad spectrum of fetal anomalies. A newborn male presented at term with multiple craniofacial and skeletal anomalies, including attachment of the placenta to the head, a paramedian facial cleft, and multiple skeletal anomalies. The patient has undergone several operations to date. The initial operation was performed to remove the attached placenta off the underlying dura, which was with a collagen matrix bound to a silicone membrane. The patient subsequently underwent split-thickness skin grafting with complete survival of the graft.
PMID: 22839097
ISSN: 1545-1569
CID: 5043972

Leadership trends in plastic surgery

Addona, Tommaso; Polcino, Michael; Silver, Lester; Taub, Peter J
BACKGROUND: The authors examined the recent trends in the composition, appointment, and turnover of chairpersons in academic plastic surgery. METHODS: A survey regarding the characteristics of the current and former department chairpersons in plastic surgery was mailed to the 89 existing academic plastic surgery programs. The survey focused on the age, gender, subspecialty, interim tenure, and overall tenure of the two groups. RESULTS: An initial response was received from 60 chairpersons. The majority of current chairpersons are male (81 of 89, 91 percent), which is slightly lower than the group of immediate past chairs, of whom 98 percent (87 of 89) were male. From the questionnaires, it was noted that for both the current and former groups of chairpersons, the 40- to 50-year age range was the most frequent age group at which an individual was appointed to that position. Approximately one-third (35.7 percent) of the current group consider themselves 'general plastic surgeons.' This differs from their predecessors, of whom 56.0 percent reported the same designation. An increase in the promotion of existing faculty to chairpersons was also noted. As compared with 44.2 percent of the previous group, 69.5 percent of the current chairpersons were promoted from within the department. CONCLUSIONS: The population of academic chairpersons in plastic surgery is changing. Today, more chairpersons appear to be younger and specialty trained. Examining the history of academic leadership and identifying trends in any field of medicine can only help to better prepare the specialty for the future
PMID: 19182639
ISSN: 1529-4242
CID: 93479

Safety and reliability of tattooing colorectal neoplasms prior to laparoscopic resection

Feingold, Daniel L; Addona, Tommaso; Forde, Kenneth A; Arnell, Tracey D; Carter, Joseph J; Huang, Emina H; Whelan, Richard L
Accurate tumor localization is critical to performing minimally invasive colorectal resection. This study reviews the safety and reliability of tattooing colorectal neoplasms prior to laparoscopic resection. We retrospectively reviewed 50 consecutive patients with colorectal neoplasms who underwent endoscopic tattooing prior to laparoscopic resection. Data were obtained from medical charts, endoscopy records, and pathology reports. No complications related to endoscopy or tattooing were incurred. Five neoplasms (10%) were in the ascending colon, five (10%) were in the transverse colon, eight (16%) were in the descending colon, 23 (46%) were in the sigmoid colon, and nine (18%) were in the rectum. Tattoos were visualized intraoperatively and accurately localized the neoplasm in 44 patients (88%). Six patients (12%) did not have tattoos visualized laparoscopically and required intraoperative localization. On average, the pathology specimens in this series had a 15 cm proximal margin, a 12 cm distal margin, and 15 lymph nodes. In the context of laparoscopic colorectal resection, preoperative endoscopic tattooing is a safe and reliable method of tumor localization in most cases. Localizing colon and proximal rectal lesions with tattoos may be preferable to other localization techniques including intraoperative endoscopy
PMID: 15239988
ISSN: 1091-255x
CID: 96139

The temporal sequence of periosteal attachment after elevation

Boutros, Sean; Bernard, Robert W; Galiano, Robert D; Addona, Tommaso; Stokes, Barry; McCarthy, Joseph G
This study investigated the adherence of periosteum to bone after elevation to document the temporal sequence of healing at the periosteal/bone interface. There has been a lack of consensus among surgeons as to the time required for healing at this interface; some believe that the healing achieves significant strength in a few days, whereas others believe that the periosteum does not adhere to the bone for many weeks. The aim of this study was to document the time course for healing, completeness of the reattachment, and structural characteristics of the union of bone and periosteum.To test the hypothesis, scalp flaps were elevated in a subperiosteal plane and were reattached in 40 adult guinea pigs and controls. The individual groups were studied at 3, 6, 12, 30, and 90 days postoperatively. Postmortem study consisted of analysis of the mechanical and histologic findings. Strength of adherence was documented by measuring the force required for reverse avulsion of the flaps with an Instron Mini 44 tensiometer. The specimens were also submitted for electron microscopic examination. The mean tension recorded in the plateau phase of avulsion of the flaps was as follows: controls, 78 g; experimental at 3 and 6 days, not applicable (weak adherence not permitting exposure for reverse avulsion); 12 days, 39 g (p = 0.0001); 30 days, 58 g (p = 0.0012), and 90 days, 63 g (p = 0.0229). There was a significant difference between all groups and the controls. Electron microscopic study showed collagen deposition at the bone periosteal interface, which became progressively more organized in the groups studied at 30 and 90 days, with decreasing amounts of inflammation and inflammatory cells.This study demonstrated that healing at the bone/periosteal interface progresses at a rate consistent with healing of most other wounds, dispelling many widespread beliefs that the adherence at this interface was accelerated. The temporal sequence of healing at the periosteal bone interface should be considered in the various procedures in which periosteal flaps are elevated. For example, there is clinical relevance in subperiosteal brow lift procedures, in which the periosteum should be reattached by a fixation technique that will remain stable for a minimum of 30 days to allow adequate adherence between the bone and periosteum at the postoperative elevated brow position
PMID: 12711956
ISSN: 0032-1052
CID: 99033

Apoptosis induced by cryo-injury in human colorectal cancer cells is associated with mitochondrial dysfunction

Yang, Weng-Lang; Addona, Tommaso; Nair, Deepak G; Qi, Lixin; Ravikumar, T S
Cryotherapy, a method of in situ ablation, is used in the treatment of colorectal liver metastases with variable results. During the treatment, the central area of treated tumor undergoes necrotic destruction by lethal cryo-injury; however, the cellular response of tumor exposed to sublethal cryo-injury at the peripheral zone is unclear. In our study, we have identified the induction of apoptosis by cryo-injury at -10 degrees C in 4 colorectal cancer cell lines (HT29, HCT116, KM12C and KM12SM). The apoptosis was characterized by chromatin condensation, transferase-mediated dUTP nick end-labeling (TUNEL) staining, proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and cytokeratin 18, and activation of caspase-3. The occurrence and intensity of cryo-induced apoptosis did not correlate with the functional status of p53 in the cell lines studied. The expression of anti-apoptotic proteins (Bcl-2, Bcl-X(L)) and pro-apoptotic proteins (Bax, Bcl-X(S), Bad, and Bak) in response to cryo-injury varied in this cell line panel. The basal level of Bcl-2/Bax protein ratio correlated inversely to the apoptotic rate. We further demonstrated that Bax level decreased in cytosol and increased in mitochondria, followed by a loss of mitochondrial membrane potential after cryo-injury in HT29 cells. These findings indicate that cryo-injury induces apoptosis in colorectal cancer cells via disruption of mitochondrial integrity. The cryo-induced apoptosis was also identified in a nude mouse tumor xenograft model. Our elucidation of the apoptosis pathway induced by cryo-injury implies that synergistic combination of cryosurgery with pharmacological agents that augment of apoptosis induction may have clinical relevance in treating colorectal liver metastasis.
PMID: 12471619
ISSN: 0020-7136
CID: 5043962