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Primary small bowel adenocarcinoma with loss of nuclear expression of PMS2 after resection of mucinous cholangiocarcinoma [Case Report]

Mujeeb Ullah, Ateeqa; Jaysing, Anna; Hashmi, Hassan Raza; Sohail, Amir Humza; Li, Wendi; Allendorf, John D; Sarkar, Suparna A
Mucinous cholangiocarcinoma is an extremely rare form of intrahepatic cholangiocarcinoma that has been characterized by rapid growth, widespread metastasis and poor prognosis. These tumors have been shown to be a part of the Lynch syndrome tumor spectrum, however, the role of DNA mismatch repair (MMR) deficiency in their development is poorly understood. We present the case of a 74-year-old male with cholangiocarcinoma, who underwent Roux-en-Y hepaticojejunostomy and extended left hepatectomy and was diagnosed with a primary small bowel adenocarcinoma 2 years later. Immunohistochemistry testing for mismatch repair proteins was significant for the loss of nuclear expression of PMS2. Taken together, the cause of both the mucinous cholangiocarcinoma and primary small bowel adenocarcinoma with PMS2 loss in the patient presented here is likely genetic, suggestive of a cancer syndrome.
PMID: 35111293
ISSN: 2042-8812
CID: 5153712

The Role of Endoscopic Ultrasound-Guided Ki67 in The Management of Non-Functioning Pancreatic Neuroendocrine Tumors

Cui, YongYan; Khanna, Lauren G; Saqi, Anjali; Crapanzano, John P; Mitchell, James M; Sethi, Amrita; Gonda, Tamas A; Kluger, Michael D; Schrope, Beth A; Allendorf, John; Chabot, John A; Poneros, John M
Background/Aims/UNASSIGNED:The management of small, incidentally discovered nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) has been a matter of debate. Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is a tool used to identify and risk-stratify PNETs. This study investigates the concordance rate of Ki67 grading between EUS-FNA and surgical pathology specimens in NFPNETs and whether certain NF-PNET characteristics are associated with disease recurrence and disease-related death. Methods/UNASSIGNED:: We retrospectively reviewed the clinical history, imaging, endoscopic findings, and pathology records of 37 cases of NFPNETs that underwent pre-operative EUS-FNA and surgical resection at a single academic medical center. Results/UNASSIGNED:: There was 73% concordance between Ki67 obtained from EUS-FNA cytology and surgical pathology specimens; concordance was the highest for low- and high-grade NF-PNETs. High-grade Ki67 NF-PNETs based on cytology (p=0.028) and histology (p=0.028) were associated with disease recurrence and disease-related death. Additionally, tumors with high-grade mitotic rate (p=0.005), tumor size >22.5 mm (p=0.104), and lymphovascular invasion (p=0.103) were more likely to have poor prognosis. Conclusions/UNASSIGNED:: NF-PNETs with high-grade Ki67 on EUS-FNA have poor prognosis despite surgical resection. NF-PNETs with intermediate-grade Ki67 on EUS-FNA should be strongly considered for surgical resection. NF-PNETs with low-grade Ki67 on EUSFNA can be monitored without surgical intervention, up to tumor size 20 mm.
PMID: 31302988
ISSN: 2234-2400
CID: 4014882


Stavropoulos, Stavros N.; Modayil, Rani J.; Zhang, Xiaocen; Peller, Hallie; Brathwaite, Collin E.; Allendorf, John; Widmer, Jessica L.; Friedel, David; Grendell, James H.
ISSN: 0016-5107
CID: 4790372


Zhang, Xiaocen; Modayil, Rani J.; Badshah, Maaz B.; Brathwaite, Collin E.; Allendorf, John; Friedel, David; Stavropoulos, Stavros N.
ISSN: 0016-5107
CID: 4790332

Painless Jaundice: A Rare Presentation of Uterine Leiomyosarcoma With Pancreatic Metastasis [Meeting Abstract]

Ali, Mohammad; Sticco, Kristen; Shah, Rakesh; Schneider, Jeffrey; Allendorf, John; Widmer, Jessica
ISSN: 0002-9270
CID: 3897702


Widmer, Jessica L.; Modayil, Rani J.; Friedel, David; Allendorf, John; Grendell, James H.; Stavropoulos, Stavros N.
ISSN: 0016-5107
CID: 3522472

A Prospective Randomized Multicenter Trial of Distal Pancreatectomy With and Without Routine Intraperitoneal Drainage

Van Buren, George; Bloomston, Mark; Schmidt, Carl R; Behrman, Stephen W; Zyromski, Nicholas J; Ball, Chad G; Morgan, Katherine A; Hughes, Steven J; Karanicolas, Paul J; Allendorf, John D; Vollmer, Charles M; Ly, Quan; Brown, Kimberly M; Velanovich, Vic; Winter, Jordan M; McElhany, Amy L; Muscarella, Peter; Schmidt, Christian Max; House, Michael G; Dixon, Elijah; Dillhoff, Mary E; Trevino, Jose G; Hallet, Julie; Coburn, Natalie S G; Nakeeb, Attila; Behrns, Kevin E; Sasson, Aaron R; Ceppa, Eugene P; Abdel-Misih, Sherif R Z; Riall, Taylor S; Silberfein, Eric J; Ellison, Edwin C; Adams, David B; Hsu, Cary; Tran Cao, Hop S; Mohammed, Somala; Villafañe-Ferriol, Nicole; Barakat, Omar; Massarweh, Nader N; Chai, Christy; Mendez-Reyes, Jose E; Fang, Andrew; Jo, Eunji; Mo, Qianxing; Fisher, William E
OBJECTIVE:The objective of this study was to test the hypothesis that distal pancreatectomy (DP) without intraperitoneal drainage does not affect the frequency of grade 2 or higher grade complications. BACKGROUND:The use of routine intraperitoneal drains during DP is controversial. Prior to this study, no prospective trial focusing on DP without intraperitoneal drainage has been reported. METHODS:Patients undergoing DP for all causes at 14 high-volume pancreas centers were preoperatively randomized to placement of a drain or no drain. Complications and their severity were tracked for 60 days and mortality for 90 days. The study was powered to detect a 15% positive or negative difference in the rate of grade 2 or higher grade complications. All data were collected prospectively and source documents were reviewed at the coordinating center to confirm completeness and accuracy. RESULTS:A total of 344 patients underwent DP with (N = 174) and without (N = 170) the use of intraperitoneal drainage. There were no differences between cohorts in demographics, comorbidities, pathology, pancreatic duct size, pancreas texture, or operative technique. There was no difference in the rate of grade 2 or higher grade complications (44% vs. 42%, P = 0.80). There was no difference in clinically relevant postoperative pancreatic fistula (18% vs 12%, P = 0.11) or mortality (0% vs 1%, P = 0.24). DP without routine intraperitoneal drainage was associated with a higher incidence of intra-abdominal fluid collection (9% vs 22%, P = 0.0004). There was no difference in the frequency of postoperative imaging, percutaneous drain placement, reoperation, readmission, or quality of life scores. CONCLUSIONS:This prospective randomized multicenter trial provides evidence that clinical outcomes are comparable in DP with or without intraperitoneal drainage.
PMID: 28692468
ISSN: 1528-1140
CID: 3487002

Comment on: Clinicopathological study on metachronous double cholangiocarcinomas of perihilar and subsequent distal bile duct origin [Comment]

Allendorf, John
PMID: 28318553
ISSN: 1532-7361
CID: 3487322

Differences in single gland and multigland disease are seen in low biochemical profile primary hyperparathyroidism

Lim, James Y; Herman, Max C; Bubis, Lev; Epelboym, Irene; Allendorf, John D; Chabot, John A; Lee, James A; Kuo, Jennifer H
BACKGROUND:Primary hyperparathyroidism is characterized by increased levels of serum calcium and parathyroid hormone. Recently, 2 additional mild biochemical profiles have emerged, normocalcemic and normohormonal primary hyperparathyroidism. We reviewed our surgical experience of mild biochemical profile patients and compared them with classic primary hyperparathyroidism patients. METHODS:test. A logistic regression was performed to identify significantly independent predictor variables for multigland disease. RESULTS:A total of 573 patients underwent parathyroidectomy for primary hyperparathyroidism (classic, n = 405; normohormonal, n = 96; normocalcemic, n = 72). Normocalcemic primary hyperparathyroidism was associated with multigland disease in 43 (45%, P < .001) patients as compared with the normohormonal (7, 10%) and classic (36, 9%) groups. On logistic regression, significant predictors for multigland disease were the normocalcemic subtype and positive family history. Twelve month biochemical normalization rates after operative treatment were >98% in all 3 groups. CONCLUSION:Our series shows that normocalcemic primary hyperparathyroidism is associated with a high incidence of multigland disease. Normohormonal disease is similar to classic disease patients with >90% presenting with single adenomas. Excellent rates of biochemical normalization can be obtained by operative treatment in all 3 groups.
PMID: 27847113
ISSN: 1532-7361
CID: 3486982

Population-Level Incidence and Predictors of Surgically Induced Diabetes and Exocrine Insufficiency after Partial Pancreatic Resection

Elliott, Irmina A; Epelboym, Irene; Winner, Megan; Allendorf, John D; Haigh, Philip I
CONTEXT/BACKGROUND:Endocrine and exocrine insufficiency after partial pancreatectomy affect quality of life, cardiovascular health, and nutritional status. However, their incidence and predictors are unknown. OBJECTIVE:To identify the incidence and predictors of new-onset diabetes and exocrine insufficiency after partial pancreatectomy. DESIGN/METHODS:We retrospectively reviewed 1165 cases of partial pancreatectomy, performed from 1998 to 2010, from a large population-based database. MAIN OUTCOME MEASURES/METHODS:Incidence of new onset diabetes and exocrine insufficiency RESULTS: Of 1165 patients undergoing partial pancreatectomy, 41.8% had preexisting diabetes. In the remaining 678 patients, at a median 3.6 months, diabetes developed in 274 (40.4%) and pancreatic insufficiency developed in 235 (34.7%) patients. Independent predictors of new-onset diabetes were higher Charlson Comorbidity Index (CCI; hazard ratio [HR] = 1.62 for CCI of 1, p = 0.02; HR = 1.95 for CCI ≥ 2, p < 0.01) and pancreatitis (HR = 1.51, p = 0.03). There was no difference in diabetes after Whipple procedure vs distal pancreatic resections, or malignant vs benign pathologic findings. Independent predictors of exocrine insufficiency were female sex (HR = 1.32, p = 0.002) and higher CCI (HR = 1.85 for CCI of 1, p < 0.01; HR = 2.05 for CCI ≥ 2, p < 0.01). Distal resection and Asian race predicted decreased exocrine insufficiency (HR = 0.35, p < 0.01; HR = 0.54, p < 0.01, respectively). CONCLUSION/CONCLUSIONS:In a large population-based database, the rates of postpancreatectomy endocrine and exocrine insufficiency were 40% and 35%, respectively. These data are critical for informing patients' and physicians' expectations.
PMID: 28406793
ISSN: 1552-5775
CID: 3486992