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A Patient's-Eye-View of Nurses [Newspaper Article]

Altman, Lawrence K
How is it that a leading medical professor like Dr. Relman -- who has taught hundreds of young doctors at Boston University, the University of Pennsylvania (where he was chairman of the department of medicine) and Harvard -- might not have known about the value of modern-day Florence Nightingales? A number of doctors who have talked to me about Dr. Relman's article suggest that the culture of medical education may be largely to blame
ISSN: 0362-4331
CID: 815252

3 scientists receive Nobel for cell-delivery discovery [Newspaper Article]

Altman, Lawrence K
Their research solved the mystery of how cells organize their transport system, the Karolinska committee said. Dr. [Randy W. Schekman] discovered a set of genes that were required for vesicle traffic. Dr. [James E. Rothman] unraveled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Dr. Sudhof revealed how signals instruct vesicles to release their cargo with precision. Dr. Rothman, 63, who was born in Haverhill, Mass., studied vesicle transport in mammalian cells in the 1980s and 1990s. He discovered that a protein complex allows vesicles to dock and fuse with their target membranes. In the fusion process, proteins on the vesicles and target membranes bind to each other like the two sides of a zipper. The fact that there are many such proteins and that they bind only in specific combinations ensures that cargo is delivered to a precise location. The same principle operates inside the cell and when a vesicle binds to the cell's outer membrane to release its contents. Dr. Rothman received a Ph.D. from Harvard Medical School in 1976, was a postdoctoral fellow at Massachusetts Institute of Technology, and moved in 1978 to Stanford, where he started his research on the vesicles of the cell. Dr. Rothman has also worked at Princeton University, Memorial Sloan-Kettering Cancer Institute and Columbia University
ISSN: 0294-8052
CID: 815262

For 3 Nobel Winners, a Molecular Mystery Solved [Newspaper Article]

Altman, Lawrence K
Three Americans won the Nobel Prize in Physiology or Medicine on Monday for discovering the machinery that regulates how cells transport major molecules in a cargo system that delivers them to the right place at the right time
ISSN: 0362-4331
CID: 815272

Lasker Awards for Medical Advances [Newspaper Article]

Altman, Lawrence K
The prizes -- $250,000 in each category -- were announced Monday; the winners will be honored at a luncheon in Manhattan on Sept. 20. Since the foundation began making the awards, in 1942, 83 laureates have also won Nobel Prizes
ISSN: 0362-4331
CID: 815282

A Kennedy Baby's Life and Death [Newspaper Article]

Altman, Lawrence K
In those days there were no neonatal I.C.U.'s, and ventilators, a standard therapy today, had yet to be used for premature babies. [...]it was August, and most of the senior physicians were on vacation, recalled a third doctor, Welton M. Gersony, then training in pediatric cardiology
ISSN: 0362-4331
CID: 815292

Making the Right Call, Even in Death [Newspaper Article]

Altman, Lawrence K
Some doctors said they had never learned the proper procedures, or were too busy to fill out the documents correctly. Because of restrictions in duty hours, many resident doctors had to enter a cause even though they did not know the patients -- they just assumed care through transfers at the end of work shifts. Particularly disturbing is that most doctors said they had no formal training in filling out death certificates, either in medical school or in their residency programs. Since the study was conducted -- in spring 2010, based on respondents' experience in the preceding three years -- the New York City Department of Health and Mental Hygiene says it has been a national leader in improving the quality of death certificate information
ISSN: 0362-4331
CID: 815302

Of Medical Giants, Accolades and Feet of Clay [Newspaper Article]

Altman, Lawrence K
The study began in 1932, and it was not halted by the United States Public Health Service until 1972, after a whistle-blower complained that infected patients in the study were not given penicillin, the standard therapy after World War II. Paul A. Lombardo of the Georgia State University College of Law, who advised the presidential commission that studied the Guatemala affair, offers a less drastic measure: rewriting the citation to include "an account of Dr. Parran's involvement in two of the most disgraceful episodes in the annals of research ethics."
ISSN: 0362-4331
CID: 815312

Arctic researchers unravel mystery of Rudolph's red nose [Newspaper Article]

Altman, Lawrence K
(The leader of the team, Can Ince, a physiologist at Erasmus University Medical Center in Rotterdam, says he has a financial interest in the company that manufactures the technology, which is used to monitor reactions to various drugs and therapies among critically ill human patients.)
ISSN: 0839-296x
CID: 815322

Journal Offers Dose Of Fun For Holiday [Newspaper Article]

Altman, Lawrence K
By traveling to the Arctic and using video-microscope and thermal imaging technology, the scientists showed that the glow is from tiny blood vessels that are more abundant in the noses of reindeer than in humans'. Alongside Rudolph on the cover of this year's holiday issue is Cliff, a 2-year-old beagle who was trained by another Dutch team to accurately sniff out the sometimes fatal bacterial bowel infection Clostridium difficile and make the diagnosis in minutes -- days faster than standard laboratory tests
ISSN: 0362-4331
CID: 815332

Chasing clues to detect an outbreak [Newspaper Article]

Altman, Lawrence K
Dr. [Marion A. Kainer]'s investigation progressed in steps similar to peeling the layers of an onion. Within two days of receiving Dr. [April C. Pettit]'s e-mail, Dr. Kainer learned that the steroid had come from the New England Compounding Center. Then Dr. Kainer learned of three additional suspect cases of meningitis and stroke linked to the clinic. But fungi had not yet been identified in those patients' spinal fluid. Also, her team could find no correlations in factors like time of day or week when the patients received the injections. One patient had a particular kind of stroke known as posterior circulation, which attracted Dr. Kainer's attention because she had learned in neurology that fungal infections can cause such strokes. "What didn't make sense was that two patients appeared to be improving without antifungal treatment, and that didn't fit the clinical picture," Dr. Kainer said. As a result of their actions, they determined that the first case in the outbreak apparently had occurred in July in Florida. But a perplexing aspect of the outbreak is why the fungus Aspergillus was identified in Dr. Pettit's case but a different one, Exserohilum, in an overwhelming majority of the remaining cases. "I just don't understand it," Dr. Kainer said. The near-miss discovery of the fungal meningitis outbreak raises questions about other outbreaks that possibly were not detected. "Surely things have gone by, but I don't know how often, and as good as our surveillance system is, it is not as good as it could be," Dr. Kainer said
ISSN: 0294-8052
CID: 815342