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Keratoacanthoma arising within a port wine stain [Meeting Abstract]

Ng, Elise; Bae, Yoon-Soo Cindy; Meehan, Shane; Geronemus, Roy G
ISSN: 0190-9622
CID: 1788932

Collagenase followed by compression for the treatment of earlobe keloids

Bae-Harboe, Yoon-Soo Cindy; Harboe-Schmidt, Jens Erik; Graber, Emmy; Gilchrest, Barbara A
BACKGROUND: Many therapeutic options are available for treating keloids, but success rates vary widely, and the keloids often recur. The Food and Drug Administration has recently approved intralesional collagenase for the treatment of Dupuytren's contracture. This medication has not been explored for the treatment of earlobe keloids, a common problem. OBJECTIVE: To evaluate the safety and clinical efficacy of intralesional collagenase followed by compression for the treatment of earlobe keloids. MATERIALS AND METHODS: Six earlobe keloids in six patients were injected with a commercial collagenase preparation. Study participants were asked to use compression earrings daily thereafter. Patients were examined and photographed 1 day, 2 weeks, 4 weeks, 10 months, and 12 months after injection. Adverse events were assessed at each visit, and the keloids were measured and photographed. RESULTS: All patients had a decrease in the size of their earlobe keloid by an average of 50% (p = .02). Three of the six participants chose to have their earlobe keloids surgically excised for cosmetic reasons 6, 8, and 11 months after enrollment, so measurements for data analysis for these patients were taken after only 1, 1 and 10 months. All participants returned for follow-up at the last study visit 1 year after study commencement. The three patients who completed the study were pleased with the improvement of their earlobe keloid, although complete clearance was not achieved. Side effects included injection site swelling, tenderness, and one ulceration that spontaneously resolved within 2 weeks. CONCLUSION: Intralesional collagenase followed by compression appears to be a safe and modestly effective treatment for earlobe keloids. This approach warrants further investigation in larger studies with longer follow-up in motivated patients who decline surgical excision.
PMID: 24602136
ISSN: 1076-0512
CID: 1262262

Nonablative fractional resurfacing for the treatment of iatrogenic hypopigmentation [Letter]

Gan, Stephanie D; Bae-Harboe, Yoon-Soo Cindy; Graber, Emmy M
PMID: 24237887
ISSN: 1076-0512
CID: 1262272

Unilateral eruption on the face [Editorial]

Olazagasti, Jeannette; Bae-Harboe, Yoon-Soo Cindy; Wolpowitz, Deon
ISSN: 0190-9622
CID: 1881622

Targeted topical and combination laser surgery for the treatment of angiofibromas

Bae-Harboe, Yoon-Soo Cindy; Geronemus, Roy G
BACKGROUND AND OBJECTIVE: The angiofibromas of Tuberous sclerosis (TS) is well described manifestation. Due to the progressive nature of the skin lesion, a safe and effective technique for treating these disfiguring skin lesions is needed. STUDY DESIGN/PATIENTS AND METHODS: We report a targeted topical and combination laser technique for treating the angiofibromas of TS in one patient. This includes treatment with topical sirolimus, pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR). RESULTS: Improvement in the number and appearance of facial angiofibromas and erythema is noted, without scarring or adverse events. CONCLUSION: The technique of targeted therapy with sirolimus with electrosurgery, pulsed dye laser treatment, and AFR represents an innovative, safe therapeutic option for treating facial angiofibromas associated with TS.
PMID: 24136238
ISSN: 0196-8092
CID: 906972

Perioperative antibiotic use of dermatologic surgeons in 2012

Bae-Harboe, Yoon-Soo C; Liang, Christine A
BACKGROUND: Recommendations for antibiotic prophylaxis in dermatologic surgery have been established, but there is variability in perioperative antibiotic use of dermatologists. Authoritative guidelines have shifted away from routine use of antibiotic prophylaxis because there is no conclusive evidence that antibiotic use reduces risk of infective endocarditis or prosthetic joint infection. OBJECTIVE: To determine current practices of perioperative antibiotic use of Mohs-trained surgeons and to compare patterns of use with updated administration guidelines. METHODS AND MATERIALS: A survey was sent to American College of Mohs Surgery members in 2012. The main outcome measures were survey responses relating to demographic characteristics, experience with postoperative infection, familiarity with antibiotic guidelines, perioperative antibiotic practices, attitudes regarding antibiotic use, and antibiotic selection. RESULTS: Most survey respondents are familiar with the Antibiotic Prophylaxis in Dermatologic Surgery Advisory Statement 2008, but respondents give antibiotics for more indications than are recommended. Although not recommended, a high percentage reported giving antibiotics to patients at high risk of infective endocarditis or joint infection even when surgery does not breach oral mucosa or involve infected skin. CONCLUSION: Dermatologic surgeons overuse perioperative antibiotics for prevention of surgical site infection, infective endocarditis, and prosthetic joint infection based on current recommendations.
PMID: 23865410
ISSN: 1076-0512
CID: 1262282

JAAD Grand Rounds quiz: nail dystrophy and multiple hyperkeratotic papules on the face and neck [Case Report]

Bae-Harboe, Yoon-Soo Cindy; Mirzabeigi, Marjan; Gilchrest, Barbara A
PMID: 24124832
ISSN: 0190-9622
CID: 1262292

Botanical briefs: cashew apple (Anacardium occidentale)

Bae-Harboe, Yoon-Soo Cindy; Masterpol, Katherine Szyfelbein
PMID: 24195089
ISSN: 0011-4162
CID: 1262302

Easy as PIE (Postinflammatory Erythema)

Bae-Harboe, Yoon-Soo Cindy; Graber, Emmy M
BACKGROUND: No term exists to date describing the phenomenon of pink-to-red discoloration after an inflammatory acne lesion. OBJECTIVES: To introduce new terminology into the dermatology literature to describe erythema often seen after inflammatory acne vulgaris and to present a treatment option for this type of erythema. METHODS: New terminology describing erythema after inflammatory acne is addressed, and a treatment option for postinflammatory erythema is presented. RESULTS: Postinflammatory erythema is a new, accurate descriptor of erythema that occurs after inflammatory acne. Additionally, pulsed dye laser treatment improved postinflammatory erythema in the authors' patients. LIMITATIONS: This paper only presents anecdotal cases. CONCLUSION: The addition of postinflammatory erythema to the dermatology literature may facilitate accurate communication among providers and direct laser treatment for postinflammatory erythema.
PMID: 24062874
ISSN: 1941-2789
CID: 1262312

Herpes folliculitis masquerading as cutaneous lymphoma [Case Report]

Bae-Harboe, Yoon-Soo C; Bhawan, Jag; Demierre, Marie-France; Goldberg, Lynne J
Herpes virus infections presenting as folliculitis are uncommon. We describe a 48-year-old white man with a distant history of a childhood gastric lymphoma and renal cell carcinoma presenting with an itchy eruption. He was concerned about recurrence. A punch biopsy revealed interface dermatitis with a dense atypical superficial and deep perivascular and periadnexal lymphohistiocytic infiltrate with occasional eosinophils extending to the subcutis, with destruction of vessel walls. It was composed of predominantly CD3-positive lymphocytes with scattered CD56-positive cells and CD20-positive cells, concerning for lymphoma. A T-cell gene rearrangement study was negative. Deeper sections uncovered multinucleated giant keratinocytes in the follicular epithelium of 1 hair follicle, consistent with herpes folliculitis. Cutaneous herpes infections can exhibit several variable clinical and histopathological features. Knowledge of alternative presentations of herpes infections, histological clues to the presence of herpes infections, and careful clinicopathological correlation are necessary to differentiate herpes infections from cutaneous lymphomas and other inflammatory dermatoses.
PMID: 23563253
ISSN: 0193-1091
CID: 1262322