The First Successful Combined Full Face and Bilateral Hand Transplant
Ramly, Elie P; Alfonso, Allyson R; Berman, Zoe P; Diep, Gustave K; Bass, Jonathan L; Catalano, Louis W; Ceradini, Daniel J; Choi, Mihye; Cohen, Oriana D; Flores, Roberto L; Golas, Alyssa R; Hacquebord, Jacques H; Levine, Jamie P; Saadeh, Pierre B; Sharma, Sheel; Staffenberg, David A; Thanik, Vishal D; Rojas, Allison; Bernstein, G Leslie; Gelb, Bruce E; Rodriguez, Eduardo D
BACKGROUND:Vascularized composite allotransplantation (VCA) has redefined the frontiers of plastic and reconstructive surgery. At the cutting edge of this evolving paradigm, we present the first successful combined full face and bilateral hand transplant (FT-BHT). METHODS:A 21-year-old man with sequelae of an 80% total body surface area burn injury sustained following a motor vehicle accident presented for evaluation. The injury included full face and bilateral upper extremity composite tissue defects, resulting in reduced quality of life and loss of independence. Multidisciplinary evaluation confirmed eligibility for combined FT-BHT. The operative approach was validated through 11 cadaveric rehearsals utilizing computerized surgical planning. Institutional review board and organ procurement organization approvals were obtained. The recipient, his caregiver, and the donor family consented to the procedure. RESULTS:Combined full face (eyelids, ears, nose, lips, and skeletal subunits) and bilateral hand transplantation (forearm level) was performed over 23 hours on August 12-13th, 2020. Triple induction and maintenance immunosuppressive therapy and infection prophylaxis were administered. Plasmapheresis was necessary postoperatively. Minor revisions were performed over seven subsequent operations, including five left upper extremity, seven right upper extremity, and seven facial secondary procedures. At eight months, the patient is approaching functional independence and remains free of acute rejection. He has significantly improved range of motion, motor power, and sensation of the face and hand allografts. CONCLUSION/CONCLUSIONS:Combined FT-BHT is feasible. This is the most comprehensive VCA procedure successfully performed to date, marking a new milestone in plastic and reconstructive surgery for patients with otherwise irremediable injuries.
PMID: 35674521
ISSN: 1529-4242
CID: 5248392
Surgical management of digital ischemia caused by constriction band formation in a patient with ichthyosis vulgaris [Case Report]
Ran Zhu, Tian; Bass, Jonathan; Schmidt, Scott
Ichthyosis is a broad and loosely defined group of hereditary and acquired disorders characterized by filaggrin dysfunction and impaired epidermal homeostasis that results in dry, scaly and thickened skin. Individuals with truncation mutations in the profilaggrin gene coding for filaggrin are strongly predisposed to severe forms of ichthyosis. The phenotypical expression of ichthyosis caused by the same genotypical mutation can vary considerably in severity and in regards to how much constricting scar tissue develops. Here, we report a case of digital ichthyosis threatening the neurovascular integrity to the small finger to discuss the importance of early diagnosis and role of Z-plasty flaps in the surgical treatment of constriction band formation.
PMCID:5798143
PMID: 29423165
ISSN: 2042-8812
CID: 3988562