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Topiramate for Weight Management in Children With Severe Obesity
Berman, Casey; Naguib, Monica; Hegedus, Elizabeth; Vidmar, Alaina P
PMID: 35767803
ISSN: 2153-2176
CID: 5534172
Glucagon-like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes in Youth
Berman, Casey; Vidmar, Alaina P; Chao, Lily C
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained traction for the management of type 2 diabetes and obesity. Unlike several classes of antidiabetic medications that contribute to weight gain, GLP-1RAs not only reduce haemoglobin A1c, but also promote weight loss. While there is a large body of evidence supporting its safety and efficacy in adults, paediatric clinical trial data have only emerged in recent years. This review will discuss the limited treatment options for paediatric type 2 diabetes and the mechanism of action of GLP-1RAs as it pertains to physiological pathways relevant for type 2 diabetes, obesity and their related comorbidities. The outcomes of paediatric trials evaluating liraglutide, exenatide, semaglutide and dulaglutide in paediatric type 2 diabetes and obesity will be closely examined, including differences compared with adult studies. Finally, potential barriers and strategies to expanding GLP-1RA access in adolescents will be discussed. Future studies are needed to determine if the cardio-and renal-protective benefits of GLP-1RAs apply to youth-onset type 2 diabetes.
PMCID:10258616
PMID: 37313232
ISSN: 2752-5457
CID: 5534182
Topiramate for Weight Management in Children < 12 with Severe Obesity [Meeting Abstract]
Berman, Casey; Naguib, Monica; Hegedus, Elizabeth; Vidmar, Alaina P.
ISI:000696303300148
ISSN: 1663-2818
CID: 5534192
Stoned-A Syndrome of D-Lactic Acidosis and Urolithiasis [Case Report]
Berman, Casey M; Merritt, Russell J
Short bowel syndrome (SBS) can lead to many complications related to the condition and its therapy. We describe 2 children with SBS who we believe are the second and third patients documented to have experienced both D-lactic acidosis and urolithiasis. We review aspects of these SBS complications and recent findings on the microbiome of patients with SBS that may predispose to these complications.
PMID: 29570851
ISSN: 1941-2452
CID: 5534162