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No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase beta
Harroch S; Palmeri M; Rosenbluth J; Custer A; Okigaki M; Shrager P; Blum M; Buxbaum JD; Schlessinger J
The development of neurons and glia is governed by a multitude of extracellular signals that control protein tyrosine phosphorylation, a process regulated by the action of protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Receptor PTPbeta (RPTPbeta; also known as PTPzeta) is expressed predominantly in the nervous system and exhibits structural features common to cell adhesion proteins, suggesting that this phosphatase participates in cell-cell communication. It has been proposed that the three isoforms of RPTPbeta play a role in regulation of neuronal migration, neurite outgrowth, and gliogenesis. To investigate the biological functions of this PTP, we have generated mice deficient in RPTPbeta. RPTPbeta-deficient mice are viable, are fertile, and showed no gross anatomical alterations in the nervous system or other organs. In contrast to results of in vitro experiments, our study demonstrates that RPTPbeta is not essential for neurite outgrowth and node formation in mice. The ultrastructure of nerves of the central nervous system in RPTPbeta-deficient mice suggests a fragility of myelin. However, conduction velocity was not altered in RPTPbeta-deficient mice. The normal development of neurons and glia in RPTPbeta-deficient mice demonstrates that RPTPbeta function is not necessary for these processes in vivo or that loss of RPTPbeta can be compensated for by other PTPs expressed in the nervous system
PMCID:86347
PMID: 11003666
ISSN: 0270-7306
CID: 11490
Thyrotoxicosis after interferon-alpha therapy [Letter]
Csaki AC; Blum M
PMID: 10691322
ISSN: 1050-7256
CID: 27852
Method of performing ultrasonography of the neck
Chapter by: Blum, Manfred; Yee, J
in: Thyroid ultrasound and ultrasound-guided FNA biopsy by Baskin, H [Eds]
Boston : Kluwer Academic Publishers, 2000
pp. 35-58
ISBN: 0792386620
CID: 1465052
Nonisotopic imaging of the neck in patients with thyroid nodules or cancer
Chapter by: Blum, Manfred
in: Thyroid cancer by Wartofsky, L [Eds]
Totowa, N.J. : Humana Press, 2000
pp. 9-34
ISBN: 9780896034297
CID: 1465042
Thyroid Disease Manager. FDM, 1999-
Ultrasonography of the Thyroid
Blum, Manfred
(Website)CID: 1467132
Thyroid Disease Manager. FDM, 2008-
Reducing the risks of bleeding with FNAB
Blum, Manfred
(Website)CID: 1467142
Thyroid Disease Manager. FDM, 2008-
Role of color-flow Doppler sonography for discovering the etiological diagnosis of hyperthyroidism : a commentary
Blum, Manfred
(Website)CID: 1467152
Reducing suppressive therapy in patients with a history of thyroid cancer [Letter]
Blum M; Perlman S
PMID: 7574204
ISSN: 0003-4819
CID: 30812
Why do clinicians continue to debate the use of levothyroxine in the diagnosis and management of thyroid nodules? [Comment]
Blum M
PMID: 7985898
ISSN: 0003-4819
CID: 6580
The thyroid : diagnosis
Chapter by: Blum, Manfred; Braverman, LE; Holliday, RA; McDougall, IR; Simkin, PH; Spencer, CA; Yee, JM
in: Principles of nuclear medicine by Wagner, Henry N; Szabo, Zsolt; Buchanan, J [Eds]
Philadelphia : Saunders, 1995
pp. 595-621
ISBN: 9780721690919
CID: 1465032