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Metastatic hepatocellular carcinoma presenting as a pancreatic mass by computed tomography scan and mimicking a primary neuroendocrine tumor: a potential pitfall in aspiration cytology [Case Report]

Fitzhugh, Valerie A; Kim, Stacey A; Borcich, Anthony; Zhu, Hongfa; Wu, Maoxin; Szporn, Arnold H; Chen, Hua
Hepatocellular carcinoma (HCC) is a highly malignant neoplasm, often presenting at late stage and portending a poor prognosis for the patient. The peripancreatic fat is a rare site of extrahepatic metastasis, and metastatic HCC can mimic primary pancreatic neoplasms, even in this location. It is crucial to be aware of this pitfall in the evaluation of aspiration cytology of pancreatic neoplasms and to develop a strategy to reach the correct diagnosis. We present an endoscopic ultrasound fine-needle aspiration diagnosis of metastatic HCC presenting as a pancreatic mass radiologically that had neuroendocrine features on various cytological and histological preparations. The metastatic lesions were located surgically in the peripancreatic adipose tissue with involvement of one peripancreatic lymph node. This case illustrates the utility of FNA for diagnosing uncommon presentations of HCC and the importance of clinical history, cell block, and an immunocytochemical panel in determining the origin of the tumor.
PMID: 19582809
ISSN: 1097-0339
CID: 3015082

Retransplantation in hepatitis B--a multicenter experience

Crippin, J; Foster, B; Carlen, S; Borcich, A; Bodenheimer, H
Hepatitis B has become one of the most challenging diseases in liver transplantation. Infection of the allograft with subsequent graft failure is common and may prompt consideration of repeat liver transplantation. The aims of this study were to examine the experience in the United States with retransplantation in hepatitis B patients with recurrent disease as well as for other reasons. Questionnaires were mailed to adult liver transplant centers in the United States, requesting information on retransplantation in HBV patients. Responses were received from 71% of the centers. Thirty-eight patients were retransplanted, 20 for recurrent HBV and 18 for other reasons. The survival rate following retransplantation for HBV was poor. Nine patients (55%) died within 60 days. Eleven patients survived 60 days or longer, though eight died at a mean of 4.1 +/- 2 months, one required a third transplant for recurrent HBV infection at 4 months, and one died at 35 months. Only a single (5%) long-term survivor exists. Recurrent histologic disease occurred earlier in the second transplant at 2.8 +/- 2.9 months versus 6.1 +/- 5.2 months in the first allograft, though this difference did not reach statistical significance (P = .058). Patients transplanted for other reasons (primary non-function [9], hepatic artery thrombosis [6], persistent rejection [2], and a Pseudomonas graft infection [1]) had a better survival rate. Four patients survived less than 60 days. Of the 14 surviving longer than 60 days, 11 patients are alive at a mean of 21.2 +/- 14.8 months. Retransplantation for recurrent HBV appears to be contraindicated due to a high mortality. Retransplantation in HBV patients with graft failure due to other causes, however, should be considered, since over 60% of these patients appear to have good long-term survival. Additional studies examining risk factors for recurrent disease should be considered.
PMID: 8154028
ISSN: 0041-1337
CID: 3015112

Biliary complications in 400 cases of liver transplantation

Popescu, I; Sheiner, P; Mor, E; Forman, W; Borcich, A; Emre, S; Kishikawa, K; Schwartz, M; Miller, C
PMID: 8183295
ISSN: 0027-2507
CID: 3015092

Massive variceal bleeding caused by a hepatic artery-portal vein fistula: a manifestation of hepatocellular carcinoma in a 12-year-old [Case Report]

Sachdeva, R; Yapor, M; Schwersenz, A; Mitty, H; Norton, K; Rosh, J; Borcich, A; Benkov, K; LeLeiko, N S
PMID: 8391075
ISSN: 0277-2116
CID: 3015132

Prophylactic recombinant hepatitis B vaccine in patients undergoing orthotopic liver transplantation

Berner, J; Kadian, M; Post, J; Miller, C; Schwartz, M; Conn, M; Borcich, A
PMID: 8470152
ISSN: 0041-1345
CID: 3015142

Roux-en-Y anastomotic bleeding following orthotopic liver transplantation: experience in our first 300 patients

Mor, E; Borcich, A; Shwersenz, A; Berner, J; Katz, E; Emre, S; Schwartz, M; Miller, C
PMID: 8470229
ISSN: 0041-1345
CID: 3015152

Hepatitis C in liver allografts

Thung, S N; Shim, K S; Shieh, Y S; Schwartz, M; Theise, N; Borcich, A; Katz, E; Miller, C; Gerber, M A
Recurrent or intercurrent hepatitis C represents significant problems in patients with liver transplants and must be differentiated from hepatic allograft rejection and other conditions affecting allografts. Often, the currently available anti-hepatitis C virus (HCV) tests are not helpful in the differential diagnosis, because preexisting anti-HCV may persist after transplantation or its development may be delayed. We determined the presence of HCV RNA by the reverse double polymerase chain reaction in biopsy specimens of liver allografts from nine patients with acute or chronic hepatitis of uncertain origin and from three patients with cellular allograft rejection. The NS3 region sequences of HCV were detected in seven of nine liver allograft biopsy specimens 6 weeks to 20 months after transplantation. Hepatitis C virus RNA was not detected in two patients. One of these patients was anti-HCV positive, showing mild acute hepatitis 5 weeks after transplantation. Anti-HCV was present in three patients with detectable HCV RNA in the liver but was absent from four other patients with HCV RNA. These findings suggest that HCV is a major cause of acute and chronic hepatitis following liver transplantation, that detection of HCV RNA by polymerase chain reaction in the liver biopsy specimen represents a reliable method for the diagnosis of hepatitis C in liver allografts, and that in some patients HCV may be acquired during transplantation while in others it may represent a recurrent infection.
PMID: 8381267
ISSN: 0003-9985
CID: 3015122

Detection, localization, and quantitation of HIV-associated antigens in intestinal biopsies from patients with HIV

Kotler, D P; Reka, S; Borcich, A; Cronin, W J
This study determined the prevalence, cellular localization, and content of human immunodeficiency virus (HIV)-associated antigens in intestinal mucosa from HIV-infected subjects. Studies were performed in 168 subjects with gastrointestinal, nutritional, or proctologic complaints, and HIV-seronegative controls. The polymerase chain-reaction technique, which detects viral DNA, was used in 20 subjects and was positive in 70%. In situ hybridization studies, using RNA probes, were employed in 48 cases and were positive in 31%. Immunohistologic studies using monoclonal antibodies to HIV p24 antigen were employed in 73 cases and were positive in 67%. Quantitative ELISA assays for tissue p24 content were performed in 168 cases and was positive in 68%. Evidence of HIV was found throughout the intestine and in different disease stages. The quantitative ELISA studies correlated significantly with in situ hybridization, implying a possible association between the presence of viral RNA and protein expression. The authors conclude that HIV is present in intestinal mucosa from most, if not all HIV-infected subjects. The relationship to intestinal disease currently is unclear.
PMID: 1928302
ISSN: 0002-9440
CID: 3015102