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HIGHER CAP SCORES PREDICT DISCORDANCE BETWEEN FIBROSIS SCORES AS PREDICTED BY TE AND MRE [Meeting Abstract]

Botros, Mina; Olsen, Sonja K.; Aneke-Nash, Chino; Shanbhougue, Krishna; Jacobson, Ira M.
ISI:000488653504034
ISSN: 0270-9139
CID: 4155802

Ain't No Stopping U/S Now [Meeting Abstract]

Cui, Yongyan; Mathews, Steven N; Tzimas, Demetrios; Solis-Cohen, Adam; Botros, Mina; Buscaglia, Jonathan M; Bucobo, Juan Carlos
ISI:000395764602431
ISSN: 1572-0241
CID: 2544482

Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor beta/delta agonists with neuroprotective activity

Kinarivala, Nihar; Suh, Ji Ho; Botros, Mina; Webb, Paul; Trippier, Paul C
We report the pharmacophore of the peroxisome proliferator-activated receptor delta (PPARdelta) agonist natural product phosphoiodyn A is the phosphonate core. Synthesis of simplified phosphonate esters 13 and 15 provide structurally novel, highly selective and potent PPARdelta agonists (EC50=78 and 112 nM, respectively). Further, both compounds demonstrate significant neuroprotective activity in an in vitro cellular model indicating that phosphonates may be an effective novel scaffold for the design of therapeutics for the treatment of neurodegenerative disorders.
PMID: 26988304
ISSN: 1464-3405
CID: 2544462

Anaylsis of Bedside Percutaneous Tracheostomies in A Community Hospital Setting [Meeting Abstract]

Abdelmessieh, Peter; Botros, Mina; Eridon, Jamie; Walczyszyn, Bartosz; Mina, Bushra; Dawson, Shane
ISI:000330476000342
ISSN: 1530-0293
CID: 2544472