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Acral lymphomatoid papulosis [Case Report]

Yancovitz, Molly; Walters, Ruth F; Kamino, Hideko; Brown, Lance H
PMID: 20159331
ISSN: 0190-9622
CID: 107287

Exogenous ochronosis

Merola, Joseph F; Meehan, Shane; Walters, Ruth F; Brown, Lance
A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use. A limited number of similar reports exist in the US literature and are the basis for an FDA call to review hydroquinone-based products. This case underscores the difficult therapeutic dilemma which this diagnosis presents to dermatologists
PMID: 19061605
ISSN: 1087-2108
CID: 115716

Bleomycin in dermatology: a review of intralesional applications

Saitta, Peter; Krishnamurthy, Karthik; Brown, Lance H
Intralesional bleomycin has been favorably used off-label to treat various skin conditions. These include warts, hemangiomas, vascular malformations, telangiectasias, several types of cutaneous malignancies, condyloma acuminata, and the lesions of leishmaniasis cutis. Currently, there is a limited amount of evidence from randomized placebo-controlled trials comparing intralesional bleomycin with other local treatments for these disorders. In this article, we review the pharmacodynamics, mechanism of action, safety profile, and clinical applications of intralesional bleomycin. Dosages, techniques for administration, and efficacy of intralesional bleomycin for each aforementioned clinical entity are also provided. Given its ease and safety in administration, efficacy, and availability, off-label use of intralesional bleomycin can be considered another primary and/or adjunctive therapy for various common cutaneous conditions by practitioners in dermatology today
PMID: 18616538
ISSN: 1524-4725
CID: 126498

Cutaneous and systemic plasmacytosis [Case Report]

Leonard, Aimee L; Meehan, Shane A; Ramsey, David; Brown, Lance; Sen, Filiz
PMID: 17097369
ISSN: 1097-6787
CID: 71335

Primary cutaneous B-cell lymphoma (low-grade, non large cell) [Case Report]

Moore, Megan M; Kovich, Olympia I; Brown, Lance H
A 43-year-old man presented with erythematous, indurated plaques on the scalp in the setting of a 16-year history of recurrent cutaneous tumors of the head and trunk. Clinical and histopathologic findings were consistent with a diagnosis of primary cutaneous B-cell lymphoma. Laboratory data and computed tomography imaging of the chest, abdomen, and pelvis failed to show an associated systemic lymphoma. Primary cutaneous B-cell lymphomas are a heterogenous group of lymphomas that primarily involve the skin but have variable clinical, histopathologic, and immunologic phenotypes. Successful treatment for most localized subtypes consists of surgical excision and radiation therapy. Rituximab, a chimeric monoclonal antibody that binds the B-cell-specific antigen CD20, has shown promise in treating a number of primary cutaneous B-cell lymphomas
PMID: 17511941
ISSN: 1087-2108
CID: 94937

Atypical mycobacterial outbreaks associated with cosmetic surgery and aesthetic procedures

Leonard, AL; Brown, LH
Atypical mycobacterial infections represent an uncommon yet insidious late postprocedural complication. These infections can result in significant morbidity, including scarring, disfigurement, and the need for long-term antibiotic therapy. Recent reports of outbreaks of mycobacterial infection highlight the need for awareness of the environmental and epidemiological factors contributing to these injections. Clinicians should maintain a high level of suspicion for this unusual complication when confronted with a postprocedural infection that is unresponsive to conventional antibiotic therapy
ISSN: 1041-3766
CID: 648832

What's new in fillers?

Brown, Lance H; Frank, Paul J
This article is an in-depth review of various materials and products that have been used for the augmentation of soft tissue in the past, and covers several new products, methods, and techniques that may provide new options for dermatologists who use fillers in their practice. Pros and cons of each are discussed, along with mechanisms of action, dosages, approved and off-label uses, as well as a look ahead at some prospective technology
PMID: 12848108
ISSN: 1545-9616
CID: 37752

Identification and quantification of para-phenylenediamine in a temporary black henna tattoo [Case Report]

Brancaccio, Ronald R; Brown, Lance H; Chang, Young Tae; Fogelman, Joshua P; Mafong, Erick A; Cohen, David E
BACKGROUND: Temporary black henna tattoos are very popular as body adornment. Although contact allergy to natural henna is unusual, the inclusion of hair dye, p-phenylenediamine (PPD), increases the risk of contact sensitization. OBJECTIVE: This study was performed to identify the presence and concentration of PPD in a black henna tattoo mixture to which our patient developed contact allergy. METHODS: The presence of PPD in a black henna tattoo mixture, various samples of commercially available henna powders, and several hair dye products was qualitatively and quantitatively detected using high performance liquid chromatography (HPLC). RESULTS: This study demonstrated that PPD was present in the black henna tattoo mixture at a concentration of 15.7%, which is significantly higher than commercial hair dye preparations. CONCLUSION: The presence of PPD in black henna tattoo mixtures in high concentration poses a health hazard and a risk of allergic contact sensitization with potential long-term consequences
PMID: 11887099
ISSN: 1046-199x
CID: 34899

Hyperhidrosis and disorders of sweating

Chapter by: Brown LH
in: Current dermatologic diagnosis & treatment by Freedberg IM; Sanchez MR [Eds]
Philadelphia : Lippincott Williams & Wilkins, 2001
pp. 84-85
ISBN: 0781735319
CID: 3709