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Clinical photographs in the assessment of adult spinal deformity: a comparison to radiographic parameters

Ryan, Devon J; Stekas, Nicholas D; Ayres, Ethan W; Moawad, Mohamed A; Balouch, Eaman; Vasquez-Montes, Dennis; Fischer, Charla R; Buckland, Aaron J; Errico, Thomas J; Protopsaltis, Themistocles S
OBJECTIVE:The goal of this study was to reliably predict sagittal and coronal spinal alignment with clinical photographs by using markers placed at easily localized anatomical landmarks. METHODS:A consecutive series of patients with adult spinal deformity were enrolled from a single center. Full-length standing radiographs were obtained at the baseline visit. Clinical photographs were taken with reflective markers placed overlying C2, S1, the greater trochanter, and each posterior-superior iliac spine. Sagittal radiographic parameters were C2 pelvic angle (CPA), T1 pelvic angle (TPA), and pelvic tilt. Coronal radiographic parameters were pelvic obliquity and T1 coronal tilt. Linear regressions were performed to evaluate the relationship between radiographic parameters and their photographic "equivalents." The data were reanalyzed after stratifying the cohort into low-body mass index (BMI) (< 30) and high-BMI (≥ 30) groups. Interobserver and intraobserver reliability was assessed for clinical measures via intraclass correlation coefficients (ICCs). RESULTS:A total of 38 patients were enrolled (mean age 61 years, mean BMI 27.4 kg/m2, 63% female). All regression models were significant, but sagittal parameters were more closely correlated to photographic parameters than coronal measurements. TPA and CPA had the strongest associations with their photographic equivalents (both r2 = 0.59, p < 0.001). Radiographic and clinical parameters tended to be more strongly correlated in the low-BMI group. Clinical measures of TPA and CPA had high intraobserver reliability (all ICC > 0.99, p < 0.001) and interobserver reliability (both ICC > 0.99, p < 0.001). CONCLUSIONS:The photographic measures of spinal deformity developed in this study were highly correlated with their radiographic counterparts and had high inter- and intraobserver reliability. Clinical photography can not only reduce radiation exposure in patients with adult spinal deformity, but also be used to assess deformity when full-spine radiographs are unavailable.
PMID: 33990080
ISSN: 1547-5646
CID: 4867902

The Impact of Global Alignment and Proportion Score and Bracing on Proximal Junctional Kyphosis in Adult Spinal Deformity

Lord, Elizabeth L; Ayres, Ethan; Woo, Dainn; Vasquez-Montes, Dennis; Parekh, Yesha; Jain, Deeptee; Buckland, Aaron; Protopsaltis, Themistocles
STUDY DESIGN/UNASSIGNED:Retrospective chart review. OBJECTIVE/UNASSIGNED:The goal of this study is to examine the relationship between global alignment and proportion (GAP) score and postoperative orthoses with likelihood of developing proximal junctional kyphosis (PJK). METHODS/UNASSIGNED:Patients who underwent thoracic or lumbar fusions of ≥4 levels for adult spinal deformity (ASD) with 1-year post-operative alignment x-rays were included. Chart review was conducted to determine spinopelvic alignment parameters, PJK, and reoperation. RESULTS/UNASSIGNED:< .05. GAP change was not correlated with PJKA change. Postoperative orthoses were used in 46% of patients and did not impact sPJK. CONCLUSIONS/UNASSIGNED:There was no correlation between PJK and GAP or change in GAP. Greater correction of UIV-PA and larger postop T1-UIV was associated with greater PJKA change; suggesting that the greater alignment correction led to greater likelihood of failure. Postoperative orthoses had no impact on PJK.
PMID: 33977791
ISSN: 2192-5682
CID: 4886632

Single position circumferential fusion improves operative efficiency, reduces complications and length of stay compared with traditional circumferential fusion

Buckland, Aaron J; Ashayeri, Kimberly; Leon, Carlos; Manning, Jordan; Eisen, Leon; Medley, Mark; Protopsaltis, Themistocles S; Thomas, J Alex
BACKGROUND CONTEXT/BACKGROUND:Anterior Lumbar Interbody Fusion and Lateral Lumbar Interbody Fusion with percutaneous posterior screw fixation are two techniques used to address degenerative lumbar pathologies. Traditionally, these anterior-posterior (AP) surgeries involve repositioning the patient from the supine or lateral decubitus position to prone for posterior fixation. To reduce operative time (OpTime) and subsequent complications of prolonged anesthesia, single-position lumbar surgery (SPLS) is a novel, minimally invasive alternative performed entirely from the lateral decubitus position. PURPOSE/OBJECTIVE:Assess the perioperative safety and efficacy of single position AP lumbar fusion surgery (SPLS). STUDY DESIGN/METHODS:Multicenter retrospective cohort study. PATIENT SAMPLE/METHODS:Three hundred and ninety patients undergoing AP surgery were included, of which 237 underwent SPLS and 153 were in the Flip group. OUTCOME MEASURES/METHODS:Outcome measures included levels fused, percentage of cases including L5-S1 fusion, fluoroscopy radiation dosage, OpTime, estimated blood loss (EBL), length of stay (LOS), and perioperative complications. Radiographic analysis included lumbar lordosis (LL), pelvic incidence, pelvic tilt, and segmental LL. METHODS:Patients undergoing primary Anterior Lumbar Interbody Fusion and/or Lateral Lumbar Interbody Fusion surgery with bilateral percutaneous pedicle screw fixation between L2-S1 were included over a 4-year period. Patients were classified as either traditional repositioned "Flip" surgery or SPLS. Outcome measures included levels fused, percentage of cases including L5-S1 fusion, fluoroscopy radiation dosage, OpTime, EBL, LOS, perioperative complications. Radiographic analysis included LL, pelvic incidence, pelvic tilt, and segmental LL. All measures were compared using independent samples t-tests and chi-squared analyses as appropriate with significance set at p < .05. Propensity matching was completed where demographic differences were found. RESULTS:Three hundred and ninety patients undergoing AP surgery were included, of which 237 underwent SPLS and 153 were in the Flip group. Age, gender, BMI, and CCI were similar between groups. Levels fused (1.47 SPLS vs 1.52 Flip, p = .468) and percent cases including L5-S1 (31% SPLS, 35% Flip, p = .405) were similar between cohorts. SPLS significantly reduced OpTime (103 min vs 306 min, p < .001), EBL (97 vs 313 mL, p < .001), LOS (1.71 vs 4.12 days, p < .001), and fluoroscopy radiation dosage (32 vs 88 mGy, p < .001) compared to Flip. Perioperative complications were similar between cohorts with the exception of postoperative ileus, which was significantly lower in the SPLS group (0% vs 5%, p < .001). There was no significant difference in wound, vascular injury, neurological complications, or Venous Thrombotic Event. There was no significant difference found in 90-day return to operating room (OR). CONCLUSIONS:SPLS improves operative efficiency in addition to reducing blood loss, LOS and ileus in this large cohort study, while maintaining safety.
PMID: 33197616
ISSN: 1878-1632
CID: 4734642

Response to Letter to the Editor on "Stiffness After Total Knee Arthroplasty: Is It a Result of Spinal Deformity?" [Letter]

Vigdorchik, Jonathan M; Sharma, Abhinav K; Mayman, David J; Carroll, Kaitlin M; Sculco, Peter K; Jerabek, Seth A; Feder, Oren I; Buckland, Aaron J; Long, William J
PMID: 33931150
ISSN: 1532-8406
CID: 4865722

Outcomes of Same-Day Orthopedic Surgery: Are Spine Patients More Likely to Have Optimal Immediate Recovery From Outpatient Procedures?

Naessig, Sara; Kapadia, Bhaveen H; Ahmad, Waleed; Pierce, Katherine; Vira, Shaleen; Lafage, Renaud; Lafage, Virginie; Paulino, Carl; Bell, Joshua; Hassanzadeh, Hamid; Gerling, Michael; Protopsaltis, Themistocles; Buckland, Aaron; Diebo, Bassel; Passias, Peter
BACKGROUND:Spinal surgery is associated with an inherently elevated risk profile, and thus far there has been limited discussion about how these outpatient spine patients are benefiting from these same-day procedures against other typical outpatient orthopedic surgeries. METHODS:Orthopedic patients who received either inpatient or outpatient surgery were isolated in the American College of Surgeons National Surgical Quality of Improvement Program (2005-2016). Patients were stratified by type of orthopedic surgery received (spine, knee, ankle, shoulder, or hip). Mean comparisons and chi-squared tests assessed basic demographics. Perioperative complications were analyzed via regression analyses in regard to their principal inpatient or outpatient orthopedic surgery received. RESULTS:< .05) with complications decreasing for IN and OUT patients by 2016. CONCLUSIONS:Over the past decade, spine surgery has decreased in complications for IN and OUT procedures along with IN/OUT knee, ankle, hip, and shoulder procedures, reflecting greater tolerance for risk in an outpatient setting. LEVEL OF EVIDENCE/METHODS:3. CLINICAL RELEVANCE/CONCLUSIONS:Despite the increase in riskier spine procedures, complications have decreased over the years. Surgeons should aim to continue to decrease inpatient spine complications to the level of other orthopedic surgeries.
PMID: 33900991
ISSN: 2211-4599
CID: 4897932

Increased cautiousness in adolescent idiopathic scoliosis patients concordant with syringomyelia fails to improve overall patient outcomes

Pierce, Katherine E; Krol, Oscar; Kummer, Nicholas; Passfall, Lara; O'Connell, Brooke; Maglaras, Constance; Alas, Haddy; Brown, Avery E; Bortz, Cole; Diebo, Bassel G; Paulino, Carl B; Buckland, Aaron J; Gerling, Michael C; Passias, Peter G
Background/UNASSIGNED:Adolescent idiopathic scoliosis (AIS) is a common cause of spinal deformity in adolescents. AIS can be associated with certain intraspinal anomalies such as syringomyelia (SM). This study assessed the rate o f SM in AIS patients and compared trends in surgical approach and postoperative outcomes in AIS patients with and without SM. Methods/UNASSIGNED:-tests and Chi-squared tests for categorical and discrete variables, respectively. Results/UNASSIGNED:< 0.001). Conclusions/UNASSIGNED:These results indicate that patients concordant with AIS and SM may be treated more cautiously (lower invasiveness score and less fusions) than those without SM.
PMID: 34194168
ISSN: 0974-8237
CID: 4926822

Postoperative Prophylactic Antibiotics in Spine Surgery: A Propensity-Matched Analysis

Abola, Matthew V; Lin, Charles C; Lin, Lawrence J; Schreiber-Stainthorp, William; Frempong-Boadu, Anthony; Buckland, Aaron J; Protopsaltis, Themistocles S
BACKGROUND:Surgical site infections are common and costly complications after spine surgery. Prophylactic antibiotics are the standard of care; however, the appropriate duration of antibiotics has yet to be adequately addressed. We sought to determine whether the duration of antibiotic administration (preoperatively only versus preoperatively and for 24 hours postoperatively) impacts postoperative infection rates. METHODS:All patients undergoing inpatient spinal procedures at a single institution from 2011 to 2018 were evaluated for inclusion. A minimum of 1 year of follow-up was used to adequately capture postoperative infections. The 1:1 nearest-neighbor propensity score matching technique was used between patients who did and did not receive postoperative antibiotics, and multivariable logistic regression analysis was conducted to control for confounding. RESULTS:A total of 4,454 patients were evaluated and, of those, 2,672 (60%) received 24 hours of postoperative antibiotics and 1,782 (40%) received no postoperative antibiotics. After propensity-matched analysis, there was no difference between patients who received postoperative antibiotics and those who did not in terms of the infection rate (1.8% compared with 1.5%). No significant decrease in the odds of postoperative infection was noted in association with the use of postoperative antibiotics (odds ratio = 1.17; 95% confidence interval, 0.620 to 2.23; p = 0.628). Additionally, there was no observed increase in the risk of Clostridium difficile infection or in the short-term rate of infection with multidrug-resistant organisms. CONCLUSIONS:There was no difference in the rate of surgical site infections between patients who received 24 hours of postoperative antibiotics and those who did not. Additionally, we found no observable risks, such as more antibiotic-resistant infections and C. difficile infections, with prolonged antibiotic use. LEVEL OF EVIDENCE/METHODS:Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
PMID: 33315695
ISSN: 1535-1386
CID: 4776902

A Cost Benefit Analysis of Increasing Surgical Technology in Lumbar Spine Fusion

Passias, Peter G; Brown, Avery E; Alas, Haddy; Bortz, Cole A; Pierce, Katherine E; Hassanzadeh, Hamid; Labaran, Lawal A; Puvanesarajah, Varun; Vasquez-Montes, Dennis; Wang, Erik; Ihejirika, Rivka C; Diebo, Bassel G; Lafage, Virginie; Lafage, Renaud; Sciubba, Daniel M; Janjua, Muhammad Burhan; Protopsaltis, Themistocles S; Buckland, Aaron J; Gerling, Michael C
BACKGROUND CONTEXT/BACKGROUND:Numerous advances have been made in the field of spine fusion, such as minimally invasive (MIS) or robotic-assisted spine surgery. However, it is unknown how these advances have impacted the cost of care. PURPOSE/OBJECTIVE:Compare the economic outcomes of lumbar spine fusion between open, MIS, and robot-assisted surgery patients. STUDY DESIGN/SETTING/METHODS:Retrospective review of a single center spine surgery database. PATIENT SAMPLE/METHODS:360 propensity matched patients. OUTCOME MEASURES/METHODS:Costs, EuroQol-5D (EQ5D), cost per quality adjusted life years (QALY). METHODS:Inclusion criteria: surgical patients >18 years undergoing lumbar fusion surgery. Patients were categorized into 3 groups based on procedure type: open, MIS, or robotic. Open patients undergoing poster spinal fusion were considered as the control group. MIS patients included those undergoing transforaminal or lateral lumbar interbody fusion with percutaneous screws. Robotic patients were those undergoing robot-assisted fusion. Propensity score matching was performed between all groups for the number of levels fused. Costs were calculated using the PearlDiver database, which reflects both private insurance and Medicare reimbursement claims for ICD-9 codes. For robotic cases, costs were reflective of operational fees and initial purchase cost. Complications and comorbidities (CC) and major complications and comorbidities (MCC) were assessed according to manual definitions. QALYs and cost per QALY were calculated using a 3% discount rate to account for residual decline to life expectancy (78.7 years). Costs per QALY were calculated for both 1 year and life expectancy, assuming no loss of benefit. A 10,000 trial Monte Carlo simulation with probabilistic sensitivity analysis (PSA) assessed our model parameters and costs. RESULTS:360 propensity matched patients (120 open, 120 MIS, 120 robotic) met inclusion criteria. Descriptive statistics for the cohort were: age 58.8 ± 13.5, 50% women, BMI 29.4 ± 6.3, operative time 294.4 ± 119.0, LOS 4.56 ± 3.31 days, EBL 515.9 ± 670.0 cc, and 2.3 ± 2.2 average levels fused. Rates of post-op complications were significantly higher in robotic cases versus open and MIS (43% vs. 21% and 22% for open and MIS, p<0.05). However, revision rates were comparable between all groups (3% open, 3% MIS, 5% robotic, p>0.05). After factoring in complications, revisions, and purchasing and operating fees, the costs of robotic cases was significantly higher than both open and MIS surgery ($60,047.01 vs. $42,538.98 open and $41,471.21 MIS). In a subanalysis of 42 patients with baseline (BL) and 1Y EQ5D data, the cost per QALY at 1Y for open, MIS, and robot-assisted cases was $296,624.48, $115,911.69, and $592,734.30. If utility gained was sustained to life expectancy, the cost per QALY was $14,905.75, $5,824.71, $29,785.64 for open, MIS, and robot-assisted cases. Results of the PSA were consistent with MIS surgery having the most incremental cost effectiveness when compared to open and robotic surgery. CONCLUSIONS:Numerous advances have been made in the field of spine surgery, however, there has been limited discussion of the effect these advances have on economic outcomes. When matched for levels fused, robot-assisted surgery patients had significantly higher rates of complications and 30% higher costs of surgery compared to minimally invasive and open spine surgery patients. While 1 year economic outcomes weren't optimal for robotic surgery cases, the projected costs per quality adjusted life years at life expectancy were well below established acceptable thresholds. The above findings may be reflective of an educational learning curve and emerging surgical technologies undergoing progressive refinement.
PMID: 33069859
ISSN: 1878-1632
CID: 4641872

The Patient-Reported Outcome Measurement Information System (PROMIS) Better Reflects the Impact of Length of Stay and the Occurrence of Complications Within 90 Days Than Legacy Outcome Measures for Lumbar Degenerative Surgery

Bortz, Cole; Pierce, Katherine E; Alas, Haddy; Brown, Avery; Vasquez-Montes, Dennis; Wang, Erik; Varlotta, Christopher G; Woo, Dainn; Abotsi, Edem J; Manning, Jordan; Ayres, Ethan W; Diebo, Bassel G; Gerling, Michael C; Buckland, Aaron J; Passias, Peter G
BACKGROUND:The Patient-Reported Outcome Measurement Information System (PROMIS) and legacy outcome measures like the Oswestry Disability Index (ODI) have not been compared for their sensitivity in reflecting the impact of perioperative complications and length of stay (LOS) in a surgical thoracolumbar population. The purpose of this study is to assess the strength of PROMIS and ODI scores as they correlate with LOS and complication outcomes of surgical thoracolumbar patients. METHODS:Retrospective cohort study. Included: patients ≥18 years undergoing thoracolumbar surgery with available preoperative and 3-month postoperative ODI and PROMIS scores. Pearson correlation assessed the linear relationships between LOS, complications, and scores for PROMIS (physical function, pain intensity, pain interference) and ODI. Linear regression predicted the relationship between complication incidence and scores for ODI and PROMIS. RESULTS:= .014) could predict complications; ODI could not. CONCLUSIONS:PROMIS domains of physical function and pain interference better reflected perioperative complications and LOS than the ODI. These results suggest PROMIS may offer more utility as an outcomes assessment instrument. LEVEL OF EVIDENCE/METHODS:3.
PMID: 33900960
ISSN: 2211-4599
CID: 4853052

The Ankle-Pelvic Angle (APA) and Global Lower Extremity Angle (GLA): Summary Measurements of Pelvic and Lower Extremity Compensation

Vaynrub, Max; Tishelman, Jared; Buckland, Aaron J; Errico, Thomas J; Protopsaltis, Themistocles S
BACKGROUND:Adult sagittal spinal deformity (SSD) leads to the recruitment of compensatory mechanisms to maintain standing balance. After regional spinal compensation is exhausted, lower extremity compensation is recruited. Knee flexion, ankle flexion, and sacrofemoral angle increase to drive pelvic shift posterior and increase pelvic tilt. We aim to describe 2 summary angles termed ankle-pelvic angle (APA) and global lower extremity angle (GLA) that incorporate all aspects of lower extremity and pelvic compensation in a comprehensive measurement that can simplify radiographic analysis. METHODS:Full-body sagittal stereotactic radiographs were retrospectively collected and digitally analyzed. Spinal and lower extremity alignment were quantified with existing measures. Two angles-APA and GLA-were drawn as geometrically complementary angles to T1-pelvic angle (TPA) and global sagittal axis (GSA), respectively. Regression analysis was used to represent the predictive relationship between TPA and APA and between GSA and GLA. RESULTS:= .005). CONCLUSIONS:TPA and GSA are measures of global spinal alignment and APA and GLA, respectively, and are geometrically complementary angles that vary proportionately to SSD and balance the body. APA and GLA increase in SSD patients with lower extremity compensation and decrease with corrective surgery. LEVEL OF EVIDENCE/METHODS:4. CLINICAL RELEVANCE/CONCLUSIONS:APA and GLA offer a concise and simple method of communicating pelvic and lower extremity compensation.
PMID: 33900966
ISSN: 2211-4599
CID: 4853062