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'Time out'-more transparency is required in 'Just-in-time' consent [Letter]

Dal-Ré, Rafael; Caplan, Arthur L; Voo, Teck Chuan
PMID: 36460540
ISSN: 1879-0828
CID: 5374222

Informed consent process in the I-SPY COVID trial is questionable [Letter]

Dal-Ré, Rafael; Caplan, Arthur L; Voo, Teck Chuan
PMID: 36283909
ISSN: 1879-0828
CID: 5359382

United in Big Data? Exploring scholars' opinions on academic-industry partnership and the use of corporate data in digital behavioral research

Favaretto, Maddalena; De Clercq, Eva; Caplan, Arthur; Elger, Bernice Simone
The growing amount of data produced through digital technologies holds great promise for advancing behavioral research. Scholars worldwide now have the chance to access an incredible amount of personal information, thanks to the digital trace users continuously leave behind them. Private corporations play a crucial role in this scenario as the leading collectors of data on users, thus creating new incentives for partnerships between academic institutions and private companies. Due to the concerns that academic-company partnerships might raise and the ethical issues connected with Big Data research, our study explores the challenges and opportunities associated with the academic use of corporate data. We conducted 39 semi-structured interviews with academic scholars (professors, senior researchers, and postdocs) involved in Big Data research in Switzerland and the United States. We also investigated their opinions on using corporate data for scholarly research. Researchers generally showed an interest in using corporate data; however, they coincidentally shared ethical reservations towards this practice, such as threats to research integrity and concerns about a lack of transparency of companies' practices. Furthermore, participants mentioned issues of scholarly access to corporate data that might both disadvantage the academic research community and create issues of scientific validity. Academic-company partnerships could be a positive development for the advancement of scholarly behavioral research. However, strategies should be implemented to appropriately guide collaborations and appropriate use of corporate data, like implementing updated protocols and tools to govern conflicts of interest and the institution of transparent regulatory bodies to ensure adequate oversight of academic-corporate research collaborations.
PMCID:9858826
PMID: 36662904
ISSN: 1932-6203
CID: 5426432

In Reply

Bayefsky, Michelle J; Caplan, Arthur L; Hoskins, Iffath A
PMID: 36441934
ISSN: 1873-233x
CID: 5373882

Emerging technologies and ethics-exogenic chimeric humanized organs

Garry, Mary G; Caplan, Arthur L; Garry, Daniel J
Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.
PMID: 36052557
ISSN: 1600-6143
CID: 5332192

Are We What We Eat? The Moral Imperative of the Medical Profession to Promote Plant-Based Nutrition [Editorial]

Hull, Sarah C; Charles, Justin; Caplan, Arthur L
The typical Western diet, high in processed and animal-based foods, is nutritionally and ethically problematic. Beyond the well-documented cruelty to animals that characterizes the practices of the factory-farming industry, current patterns of meat consumption contribute to medical and moral harm in humans on both an individual level and a public health scale. We aim to deconstruct, by highlighting their fallacies, the common positive and normative arguments that are used to defend current nutritional patterns. Animal-based foods promote the mechanisms that underlie chronic cardiometabolic disease, whereas whole-food plant-based nutrition can reverse them. Factory farming of animals also contributes to climate change, antibiotic resistance, and the spread of infectious diseases. Finally, the current allocation of nutritional resources in the United States is unjust. A societal shift toward more whole-food plant-based patterns of eating stands to provide significant health benefits and ethical advantages, and the medical profession has a duty to advocate accordingly. Although it remains important for individuals to make better food choices to promote their own health, personal responsibility is predicated on sound advice and on resource equity, including the availability of healthy options. Nutrition equity is a moral imperative and should be a top priority in the promotion of public health.
PMID: 36446227
ISSN: 1879-1913
CID: 5373952

The approach to informed consent in acute care research [Letter]

Dal-Ré, Rafael; Caplan, Arthur L
PMCID:9633075
PMID: 36335957
ISSN: 2213-2619
CID: 5356902

International policies on posthumous reproduction: a pilot survey study [Letter]

Lawrence, Morgan A; McLean, Laura; Sampson, Amani; Jalili, Dona; Caplan, Arthur; Salama, Mahmoud; Goldman, Kara N; Quinn, Gwendolyn P
PMID: 36208358
ISSN: 1573-7330
CID: 5351802

The legacy of the COVID-19 pandemic for childhood vaccination in the USA

Opel, Douglas J; Brewer, Noel T; Buttenheim, Alison M; Callaghan, Timothy; Carpiano, Richard M; Clinton, Chelsea; Elharake, Jad A; Flowers, Lisa C; Galvani, Alison P; Hotez, Peter J; Schwartz, Jason L; Benjamin, Regina M; Caplan, Arthur; DiResta, Renee; Lakshmanan, Rekha; Maldonado, Yvonne A; Mello, Michelle M; Parmet, Wendy E; Salmon, Daniel A; Sharfstein, Joshua M; Omer, Saad B
PMCID:9605265
PMID: 36309017
ISSN: 1474-547x
CID: 5359762

Ethics and the emerging use of pig organs for xenotransplantation [Letter]

Caplan, Arthur; Parent, Brendan
PMID: 35835681
ISSN: 1557-3117
CID: 5279982