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A phase I study of systemic sorafenib in combination with isolated limb infusion with melphalan (ILI-M) in patients (pts) with locally advanced in-transit melanoma [Meeting Abstract]

McMahon, N.; Beasley, G. M.; Sanders, G.; Augustine, C.; Padussis, J.; Coleman, A.; Selim, M. A.; Peterson, B.; Brady, M. S.; Tyler, D. S.
ISSN: 0732-183x
CID: 3158992

Fatal head injury in children younger than 2 years in New York City and an overview of the shaken baby syndrome

Gill, James R; Goldfeder, Lara B; Armbrustmacher, Vernon; Coleman, Andrea; Mena, Hernando; Hirsch, Charles S
CONTEXT: Shaken baby syndrome is a controversial topic in forensic pathology. Some forensic pathologists state that shaking alone is insufficient to explain death and that an impact must have occurred even if there is no impact site on the head. OBJECTIVE: To examine a large cohort of fatal, pediatric head injuries for patterns of specific autopsy findings and circumstances that would support or dispute pure shaking as the cause of death. DESIGN: We retrospectively reviewed 59 deaths due to head injuries in children younger than 2 years certified in our office during a 9 year period (1998-2006). The review included autopsy, toxicology, microscopy, neuropathology, and police and investigators' reports. RESULTS: There were 46 homicides, 8 accidents, and 1 undetermined death from blunt-impact injury of the head. In 10 (22%) of the homicides, there was no impact injury to the head, and the cause of death was certified as whiplash shaking. In 4 (40%) of these 10 deaths, there was a history of shaking. In 5 (83%) of the other 6, there was no history of any purported accidental or homicidal injury. All 8 accidental deaths had impact sites. Of the 59 deaths, 4 (6.7%) had only remote injuries (chronic subdural hematomas, remote long bone fractures) that were certified as undetermined cause and manner. These 4 deaths were excluded from the study. CONCLUSIONS: We describe a subset of fatal, nonaccidental head-injury deaths in infants without an impact to the head. The autopsy findings and circumstances are diagnostic of a nonimpact, shaking mechanism as the cause of death. Fatal, accidental head injuries in children younger than 2 years are rare
PMID: 19391663
ISSN: 1543-2165
CID: 132240

Sudden death in toddlers caused by influenza B infection: a report of two cases and a review of the literature [Case Report]

Landi, Kristen K; Coleman, Andrea T
Sudden fatal cases of influenza B infection in a 4-year-old girl and a 2-year-old boy are presented. Both children complained of abdominal pain without respiratory, neurologic or cardiac symptoms; additionally the girl had vomiting within 2 days of death. Autopsy revealed histological changes in the respiratory system consistent with a viral infection. Influenza B infection was identified by immunohistochemistry in the girl and real-time polymerase chain reaction in the boy. Additional testing including cultures, toxicology, and screening for metabolic disorders were negative. These cases illustrate the usefulness of viral testing, especially for influenza, in the medical legal autopsy of children even when the classic respiratory symptoms of flu are lacking
PMID: 18279259
ISSN: 0022-1198
CID: 95786

Aging increases areas of low capillary blood flow in the peripapillary retinal circulation of normal individuals [Meeting Abstract]

Mavroudis, LV; Harris, A; Wilson, MR; Topouzis, F; Yu, F; Kagemann, L; Anastasopoulos, E; Koskosas, A; Pappas, F; Coleman, A
ISSN: 0146-0404
CID: 2218162

Validation and casework application of a Y chromosome specific STR multiplex

Prinz M; Ishii A; Coleman A; Baum HJ; Shaler RC
A series of validation experiments was performed for a Y chromosome specific STR multiplex system following the suggestions made by the Technical Working Group DNA Analysis Methods (TWGDAM). The multiplex PCR products were detected on Perkin-Elmer 373 and 377 automated sequencers using two labeling colors. No problems regarding the stability, robustness and sensitivity of the Y STR multiplex were observed. Mixture studies revealed a cut off rate similar to autosomal STRs for mixtures of male DNAs and no interference of any female admixture. The comparison of the Y STR results to the autosomal typing results for 56 nonprobative semen stains and swabs, showed a slightly higher success rate in detecting the semen donor's alleles for the Y STR multiplex. Two examples are shown to illustrate the usefulness of Y STR typing for DNA mixtures. In one case the Y STR results confirmed an isolated exclusion; in the other case, the interpretation of a mixture was clarified since the Y STR results proved the presence of DNA from at least two semen donors. Y STR typing is a valuable addition to the forensic DNA testing panel
PMID: 11473800
ISSN: 0379-0738
CID: 22972