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Coronary Artery Disease and Reticular Macular Disease, a Subphenotype of Early Age-Related Macular Degeneration

Cymerman, Rachel M; Skolnick, Adam H; Cole, William J; Nabati, Camellia; Curcio, Christine A; Smith, R Theodore
PURPOSE: Reticular macular disease (RMD) is the highest risk form of early age-related macular degeneration and also specifically confers decreased longevity. However, because RMD requires advanced retinal imaging for adequate detection of its characteristic subretinal drusenoid deposits (SDD), it has not yet been completely studied with respect to coronary artery disease (CAD), the leading cause of death in the developed world. Because CAD appears in middle age, our purpose was to screen patients aged 45-80 years, documented either with or without CAD, to determine if CAD is associated with RMD. DESIGN: A prospective cohort study of patients with documented CAD status and no known retinal disease in a clinical practice setting at one institution. Subjects and Controls: A number of 76 eyes from 38 consecutive patients (23 with documented CAD, 15 controls documented without CAD; 47.4% female; mean age 66.7 years). METHODS: Patients were imaged with near-infrared reflectance/spectral domain optical coherence tomography and assessed in masked fashion by two graders for the presence of SDD lesions of RMD and soft drusen. MAIN OUTCOME MEASURES: Presence or absence of RMD/SDD and soft drusen. RESULTS: RMD was more frequent in patients with CAD versus those without (Relative Risk [RR] = 2.1, CI = 1.08-3.95, P = 0.03). There was no association of CAD with soft drusen. CONCLUSIONS: A specific relationship between CAD and RMD suggests common systemic causes for both and warrants further study.
PMID: 27159771
ISSN: 1460-2202
CID: 2107482

Giant Cell Myocarditis: Not Always a Presentation of Cardiogenic Shock

Tompkins, Rose; Cole, William J; Rosenzweig, Barry P; Axel, Leon; Bangalore, Sripal; Lala, Anuradha
Giant cell myocarditis is a rare and often fatal disease. The most obvious presentation often described in the literature is one of rapid hemodynamic deterioration due to cardiogenic shock necessitating urgent consideration of mechanical circulatory support and heart transplantation. We present the case of a 60-year-old man whose initial presentation was consistent with myopericarditis but who went on to develop a rapid decline in left ventricular systolic function without overt hemodynamic compromise or dramatic symptomatology. Giant cell myocarditis was confirmed via endomyocardial biopsy. Combined immunosuppression with corticosteroids and calcineurin inhibitor resulted in resolution of symptoms and sustained recovery of left ventricular function one year later. Our case highlights that giant cell myocarditis does not always present with cardiogenic shock and should be considered in the evaluation of new onset cardiomyopathy of uncertain etiology as a timely diagnosis has distinct clinical implications on management and prognosis.
PMID: 26257963
ISSN: 2090-6404
CID: 1720932

Giant Nonfamilial Left Atrial Myxoma Presenting with Eye Embolism and Nonvalvular Streptococcus sanguinis Endocarditis

Laura, Diana M; Quinones, Adriana; Benenstein, Ricardo; Loulmet, Didier F; Cole, William J; Galloway, Dellis A; Suh, James H; Saric, Muhamed
PMID: 24681126
ISSN: 0735-1097
CID: 922512

Candida albicans-infected transvenous pacemaker wire: detection by two-dimensional echocardiography [Case Report]

Cole, W J; Slater, J; Kronzon, I; Galler, M; Trehan, N; Cohen, M; Gargiulo, A
PMID: 3946186
ISSN: 0002-8703
CID: 100118

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome

Greene LW; Cole W; Levy B; Louie E; Raphael B; Waitkevicz HJ; Blum M
ISSN: 0084-3741
CID: 36582

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome

Greene LW; Cole W; Greene JB; Levy B; Louie E; Raphael B; Waitkevicz J; Blum M
PMID: 6089635
ISSN: 0003-4819
CID: 36564