Try a new search

Format these results:

Searched for:

person:davisc27

in-biosketch:yes

Total Results:

100


Prescribing Syringes to People Who Inject Drugs: Advancing Harm Reduction in Primary Care [Editorial]

Chatterjee, Avik; Bannister, Maxwell; Hill, Lucas G; Davis, Corey S
Access to new syringes can reduce the risk of HIV and hepatitis C transmission, skin and soft tissue infections, and infectious endocarditis for people who inject drugs (PWID). Syringe service programs (SSPs) and other harm reduction programs are a good source of syringes. However, they are sometimes not accessible due to limited hours, geographic barriers, and other factors. In this perspective, we argue that when PWID faces barriers to syringes physicians and other providers should prescribe, and pharmacists should dispense, syringes to decrease health risks associated with syringe re-use. This strategy is endorsed by professional organizations and is legally permissible in most states. Such prescribing has numerous benefits, including insurance coverage of the cost of syringes and the sense of legitimacy conveyed by a prescription. We discuss these benefits as well as the legality of prescribing and dispensing syringes and address practical considerations such as type of syringe, quantity, and relevant diagnostic codes, if required. In the face of an unprecedented overdose crisis with many associated health harms, we also make the case for advocacy to change state and federal laws to make access to prescribed syringes uniform, smooth, and universal as part of a suite of harm reduction efforts.
PMID: 37020124
ISSN: 1525-1497
CID: 5463822

Naloxone expansion is not associated with increases in adolescent heroin use and injection drug use: Evidence from 44 US states

Bruzelius, Emilie; Cerdá, Magdalena; Davis, Corey S; Jent, Victoria; Wheeler-Martin, Katherine; Mauro, Christine M; Crystal, Stephen; Keyes, Katherine M; Samples, Hillary; Hasin, Deborah S; Martins, Silvia S
BACKGROUND:Naloxone distribution is central to ongoing efforts to address the opioid overdose crisis. Some critics contend that naloxone expansion may inadvertently promote high-risk substance use behaviors among adolescents, but this question has not been directly investigated. METHODS:We examined relationships between naloxone access laws and pharmacy naloxone distribution with lifetime heroin and injection drug use (IDU), 2007-2019. Models generating adjusted odds ratios (aOR) and 95% confidence intervals (CI) included year and state fixed effects, controlled for demographics and sources of variation in opioid environments (e.g., fentanyl penetration), as well as additional policies expected to impact substance use (e.g., prescription drug monitoring). Exploratory and sensitivity analyses further examined naloxone law provisions (e.g., third-party prescribing) and applied e-value testing to assess vulnerability to unmeasured confounding. RESULTS:Adoption of any naloxone law was not associated with changes in adolescent lifetime heroin or IDU. For pharmacy dispensing, we observed a small decrease in heroin use (aOR: 0.95 [CI: 0.92, 0.99]) and a small increase in IDU (aOR: 1.07 [CI: 1.02, 1.11]). Exploratory analyses of law provisions suggested that third-party prescribing (aOR: 0.80, [CI: 0.66, 0.96]) and non-patient-specific dispensing models (aOR: 0.78, [CI: 0.61, 0.99]) were associated with decreased heroin use but not decreased IDU. Small e-values associated with the pharmacy dispensing and provision estimates indicate that unmeasured confounding may explain observed findings. CONCLUSION:Naloxone access laws and pharmacy naloxone distribution were more consistently associated with decreases rather than increases in lifetime heroin and IDU among adolescents. Our findings therefore do not support concerns that naloxone access promotes high-risk adolescent substance use behaviors. As of 2019, all US states have adopted legislation to improve naloxone access and facilitate use. However, further removal of adolescent naloxone access barriers is an important priority given that the opioid epidemic continues to affect people of all ages.
PMID: 36863285
ISSN: 1873-4758
CID: 5448522

Thirty-day Treatment Continuation After Audio-only Buprenorphine Telehealth Initiation

Wunsch, Caroline; Wightman, Rachel; Pratty, Claire; Jacka, Brendan; Hallowell, Benjamin D; Clark, Seth; Davis, Corey S; Samuels, Elizabeth A
OBJECTIVES/OBJECTIVE:Before the coronavirus disease 2019 pandemic, federal law required in-person evaluation before buprenorphine initiation. Regulatory changes during the pandemic allow for buprenorphine initiation by audio-only or audiovisual telehealth. Little is known about treatment engagement after buprenorphine initiation conducted via audio-only telehealth. METHODS:A retrospective cohort study of 94 individuals who received initial treatment through an audio-only encounter between April 2020 and February 2021 was performed. Participant demographics, substance use history, withdrawal symptoms, 30-day treatment engagement, and adverse outcomes were determined by an electronic chart and REDcap database review. Subsequent buprenorphine prescriptions filled within 30 days of the initial encounter were tracked through the Rhode Island Prescription Drug Monitoring Program. RESULTS:Buprenorphine was prescribed for 94 individuals. Most (92 of 94 [97.9%]) filled their prescription within 30 days. Most had previously taken buprenorphine, including prescribed (42 of 92 [45.7%]) and nonprescribed (58 of 92 [63.0%]). Two thirds were in opioid withdrawal at the time of the call (61 of 92 [66.3%]) with a mean Subjective Opioid Withdrawal Scale of 26.8 (range, 4-57). Four individuals experienced precipitated withdrawal (4 of 94 [4.3%]), and 2 reported persistent withdrawal at their follow-up visit (2 of 94 [2.1%]). More than 70% filled a subsequent prescription for buprenorphine within 30 days of the end of their hotline prescription (65 of 92 [70.7%]), on average of 5.88 days (range, 0-28) after completion of their telehealth prescription. CONCLUSIONS:Expanding telehealth-delivered buprenorphine care has the potential to address treatment gaps and facilitate delivery of on-demand services during peak motivation. This evaluation of audio-only buprenorphine initiation found high rates of unobserved buprenorphine initiation and treatment continuation with low rates of complications.
PMID: 36102540
ISSN: 1935-3227
CID: 5336222

Persistent Criminalization and Structural Racism in US Drug Policy: The Case of Overdose Good Samaritan Laws

Pamplin, John R; Rouhani, Saba; Davis, Corey S; King, Carla; Townsend, Tarlise N
The US overdose crisis continues to worsen and is disproportionately harming Black and Hispanic/Latino people. Although the "War on Drugs" continues to shape drug policy-at the disproportionate expense of Black and Hispanic/Latino people-states have taken some steps to reduce War on Drugs-related harms and adopt a public health-centered approach. However, the rhetoric regarding these changes has, in many cases, outstripped reality. Using overdose Good Samaritan Laws (GSLs) as a case study, we argue that public health-oriented policy changes made in some states are undercut by the broader enduring environment of a structurally racist drug criminalization agenda that continues to permeate and constrict most attempts at change. Drawing from our collective experiences in public health research and practice, we describe 3 key barriers to GSL effectiveness: the narrow parameters within which they apply, the fact that they are subject to police discretion, and the passage of competing laws that further criminalize people who use illicit drugs. All reveal a persisting climate of drug criminalization that may reduce policy effectiveness and explain why current reforms may be destined for failure and further disadvantage Black and Hispanic/Latino people who use drugs. (Am J Public Health. 2023;113(S1):S43-S48. https://doi.org/10.2105/AJPH.2022.307037).
PMCID:9877371
PMID: 36696623
ISSN: 1541-0048
CID: 5426582

Repealing State Drug-Paraphernalia Laws - The Need for Federal Leadership

Davis, Corey S; Carr, Derek H
PMID: 36214589
ISSN: 1533-4406
CID: 5351902

Using an Inverted Synthetic Control Method to Estimate Effects of Recent Overdose Good Samaritan Laws, Overall and by Black/White Race

Townsend, Tarlise N; Hamilton, Leah K; Rivera-Aguirre, Ariadne; Davis, Corey S; Pamplin Ii, John R; Kline, David; Rudolph, Kara E; Cerdá, Magdalena
Overdose Good Samaritan Laws (GSLs) aim to reduce mortality by providing limited legal protections when an overdose bystander summons help. Most research into the impact of these laws is dated or potentially confounded by co-enacted naloxone access laws. Lack of awareness and trust in GSL protections, as well as fear of police involvement and legal repercussions, remain key deterrents of help-seeking. These barriers may be unequally distributed by race due to racist policing and drug policies, potentially producing racial disparities in the effectiveness of GSLs for reducing overdose mortality. We used 2015-2019 vital statistics data to estimate the effect of recent GSLs on overdose mortality, overall (eight states) and by Black/white race (four states). Given GSLs' near ubiquity, few unexposed states were available for comparison. We therefore proposed an "inverted" synthetic control method (SCM) to compare overdose mortality in new-GSL states to states with GSLs throughout the analytic period. The estimated relationships between GSLs and overdose mortality, both overall and stratified by Black/white race, were consistent with chance. An absence of effect could result from insufficient protection provided by the laws, insufficient awareness of them, and/or reticence to summon help not addressable by legal protections. The inverted SCM may be useful for evaluating other widespread policies.
PMID: 35872589
ISSN: 1476-6256
CID: 5276132

When Effects Cannot be Estimated: Redefining Estimands to Understand the Effects of Naloxone Access Laws

Rudolph, Kara E; Gimbrone, Catherine; Matthay, Ellicott C; Díaz, Iván; Davis, Corey S; Keyes, Katherine; Cerdá, Magdalena
Violations of the positivity assumption (also called the common support condition) challenge health policy research and can result in significant bias, large variance, and invalid inference. We define positivity in the single- and multiple-timepoint (i.e., longitudinal) health policy evaluation setting, and discuss real-world threats to positivity. We show empirical evidence of the practical positivity violations that can result when attempting to estimate the effects of health policies (in this case, Naloxone Access Laws). In such scenarios, an alternative is to estimate the effect of a shift in law enactment (e.g., the effect if enactment had been delayed by some number of years). Such an effect corresponds to what is called a modified treatment policy, and dramatically weakens the required positivity assumption, thereby offering a means to estimate policy effects even in scenarios with serious positivity problems. We apply the approach to define and estimate the longitudinal effects of Naloxone Access Laws on opioid overdose rates.
PMCID:9373236
PMID: 35944151
ISSN: 1531-5487
CID: 5310592

Hospital Standards of Care for People with Substance Use Disorder

Englander, Honora; Davis, Corey S
PMID: 35984354
ISSN: 1533-4406
CID: 5300292

A modified Delphi process to identify experts' perceptions of the most beneficial and harmful laws to reduce opioid-related harm

Hamilton, Leah K; Wheeler-Martin, Katherine; Davis, Corey S; Martins, Silvia S; Samples, Hillary; Cerdá, Magdalena
BACKGROUND:States have enacted multiple types of laws, with a variety of constituent provisions, in response to the opioid epidemic, often simultaneously. This temporal proximity and variation in state-to-state operationalization has resulted in significant challenges for empirical research on their effects. Thus, expert consensus can be helpful to classify laws and their provisions by their degree of helpfulness and impact. METHODS:We conducted a four-stage modified policy Delphi process to identify the top 10 most helpful and 5 most harmful provisions from eight opioid-related laws. This iterative consultation with six types of opioid experts included a preliminary focus group (n=12), two consecutive surveys (n=56 and n=40, respectively), and a final focus group feedback session (n=5). RESULTS:On a scale of very harmful (0) to very helpful (4), overdose Good Samaritan laws received the highest average helpfulness rating (3.62, 95% CI: 3.48-3.75), followed by naloxone access laws (3.37, 95% CI: 3.22-3.51), and pain management clinic laws (3.08, 95% CI: 2.89-3.26). Drug-induced homicide (DIH) laws were rated the most harmful (0.88, 95% CI: 0.66-1.11). Impact ratings aligned similarly, although Medicaid laws received the second highest overall impact rating (3.71, 95% CI: 3.45, 3.97). The two most helpful provisions were naloxone standing orders (3.94, 95% CI: 3.86-4.02) and Medicaid coverage of medications for opioid use disorder (MOUD) (3.89, 95% CI: 3.82). Mandatory minimum DIH laws were the most harmful provision (0.73, 95% CI 0.53-0.93); followed by requiring prior authorization for Medicaid coverage of MOUD (1.00 95% CI: 0.72-1.27). CONCLUSION/CONCLUSIONS:Overall, experts rated laws and provisions that facilitated harm reduction efforts and access to MOUD as most helpful. Laws and provisions rated as most harmful criminalized substance use and placed restrictions on access to MOUD. These ratings provide a foundation for evaluating the overall overdose policy environment for each state.
PMID: 35908313
ISSN: 1873-4758
CID: 5287742

The Importance of Federal Action Supporting Overdose-Prevention Centers

Naeem, Aneeqah H; Davis, Corey S; Samuels, Elizabeth A
PMID: 35593724
ISSN: 1533-4406
CID: 5283702