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Tramadol in Knee Osteoarthritis: Does Preoperative Use Affect Patient-Reported Outcomes After Total Knee Arthroplasty?

Driesman, Adam; Kaplan, Daniel; Feng, James E; Waren, Daniel P; Vigdorchik, Jonathan; Meere, Patrick; Fernandez-Madrid, Ivan; Slover, James; Macaulay, William
BACKGROUND:The 2013 American Academy of Orthopedic Surgeons evidence-based guidelines recommend against the use of preoperative narcotics in the management of symptomatic osteoarthritic knees; however, the guidelines strongly recommend tramadol in this patient population. To our knowledge, no study to date has evaluated outcomes in patients who use tramadol exclusively as compared with narcotics naive patients. METHODS:This is a retrospective study of prospectively collected data for patients who underwent unilateral primary total knee arthroplasty between January 2017 and March 2018. PRO scores were obtained using a novel electronic patient rehabilitation application, which pushed PRO surveys via email and mobile devices within 1 month prior to surgery and 3 months postoperatively. RESULTS:One hundred and thirty-six patients were opiate naïve, while 63 had obtained narcotics before the index operation. Of those, 21 patients received tramadol. The average preoperative Knee Disability and Osteoarthritis Outcome Scores were 50.4, 49.95, and 48.01 for the naïve, tramadol, and narcotic populations, respectively, (P = .60). The tramadol cohort had the least gain in 3 months postoperative Knee Disability and Osteoarthritis Outcome Scores, improving on average 12.5 points in comparison to the 19.1 and 20.1 improvements seen in the narcotic and naïve cohorts, respectively (P = .09). This difference was statistically significant when comparing the naïve and tramadol populations alone in post hoc analysis (P = .016). CONCLUSIONS:When comparing patients who took tramadol preoperatively to patients who were opiate naïve, patients that used tramadol trended toward significantly less improvement in functional outcomes in the short-term postoperative period.
PMID: 31076193
ISSN: 1532-8406
CID: 4002032

Are Patients More Satisfied With a Balanced Total Knee Arthroplasty?

Golladay, Gregory J; Bradbury, Thomas L; Gordon, Alexander C; Fernandez-Madrid, Ivan J; Krebs, Viktor E; Patel, Preetesh D; Suarez, Juan C; Higuera Rueda, Carlos A; Barsoum, Wael K
BACKGROUND:Patient-reported outcome measures are increasingly recognized as an important tool in quantifying the clinical success of arthroplasty surgery. The aim of this study is to measure post-operative joint awareness and satisfaction in patients with and without a quantitatively balanced knee following primary total knee arthroplasty (TKA). METHODS:In this multi-center study, a total of 318 eligible patients were assigned to one of the 2 patient groups: sensor-guided TKA or surgeon-guided TKA. In the sensor-guided group, quantitative balancing was performed according to intercompartmental tibiofemoral load measurements measured by an instrumented tibial trial component. In contrast, for the surgeon-guided group, the knees were balanced according to the surgeons' standard manual techniques while blinding the surgeon to the sensor measurements. Patients were blinded to their allocation and filled out the validated Forgotten Joint Score and 2011 Knee Society Satisfaction questionnaires at 6 weeks and 6 months. For the purposes of this study, the subjects were pooled and stratified by their state of soft tissue balance, based on the mediolateral load differential through the range of motion. RESULTS:In the surgeon-guided group, approximately 50% of the cases yielded a quantitatively balanced knee. Significantly more balanced knees were observed in the sensor-guided group (84.0%). More importantly, for both outcome measures, the balanced group of patients reported significantly better outcomes scores. CONCLUSION/CONCLUSIONS:This demonstrates that using sensor feedback during knee arthroplasty surgery results in a more reproducible procedure, resulting in a higher percentage of balanced patients who in turn demonstrate superior clinical outcomes compared to unbalanced patients.
PMID: 31079993
ISSN: 1532-8406
CID: 3908932

A Meta-Analysis and Systematic Review Evaluating Skin Closure After Total Knee Arthroplasty-What Is the Best Method?

Kim, Kelvin Y; Anoushiravani, Afshin A; Long, William J; Vigdorchik, Jonathan M; Fernandez-Madrid, Ivan; Schwarzkopf, Ran
BACKGROUND: Many cost drivers of total knee arthroplasty (TKA) have been critically evaluated to meet the heightened quality-associated expectations of performance-based care. However, assessing the efficacy of the different modalities of skin closure has been an underappreciated topic. The present study aims to provide further insight by conducting a meta-analysis and systematic review evaluating the rates of common complications and perioperative quality outcomes associated with different suture and staple skin closure techniques after TKA. METHODS: The present study was conducted in accordance with both the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement and the Cochrane Handbook for meta-analyses and systematic reviews. Primary outcome measures evaluated rates of common complications associated with primary TKA. Secondary outcome measures evaluated wound closure time, direct surgical costs, and cosmetic and knee function outcomes. RESULTS: Our meta-analysis demonstrated that skin sutures had a higher likelihood of superficial and deep infections, abscess formation, and wound dehiscence. Conversely, staples had a higher tendency for prolonged wound discharge. A systematic review of wound closure times and overall resource utilization demonstrated that wound closure was faster and more cost-effective with skin staples than sutures. CONCLUSION: Primary skin incision closure with staples demonstrated lower wound complications, decreased wound closure times, and an overall reduction in resource utilization. Given these outcomes, the use of staples after TKA may have several subtle clinical advantages over sutures.
PMID: 28487090
ISSN: 1532-8406
CID: 2548992

Comparison of robot surgery modular and total knee arthroplasty kinematics

Yildirim, Gokce; Fernandez-Madrid, Ivan; Schwarzkopf, Ran; Walker, Peter S; Karia, Raj
The kinematics of seven knee specimens were measured from 0 to 120 degrees flexion using an up-and-down crouching machine. Motion was characterized by the positions of the centers of the lateral and medial femoral condyles in the anterior-posterior direction relative to a fixed tibia. A modular unicompartmental knee, trochlea flange, and patella resurfacing (multicompartmental knee [MCK] system) were implanted using a surgeon-interactive robot system that provided accurate surface matching. The MCK was tested, followed by standard cruciate retaining (CR) and posterior stabilized (PS) knees. The motion of the MCK was close to anatomic, especially on the medial side, in contrast to the CR and PS knees that showed abnormal motion features. Such a modular knee system, accurately inserted, has the potential for close to normal function in clinical application.
PMID: 24227400
ISSN: 1538-8506
CID: 836032

Sequencing of the Alzheimer's APP gene Dutch variant (APP-D) [Letter]

Vidal RG; Fernandez-Madrid I; Frangione B; Levy E
PMID: 8111419
ISSN: 1059-7794
CID: 9530

Sequencing of the Alzheimer's APP gene Dutch variant (APP.D)

Vidal, RG; FernandezMadrid, I; Frangione, B; Levy, E
SCOPUS:84991124617
ISSN: 1059-7794
CID: 2293362

Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay

Haltia M; Levy E; Meretoja J; Fernandez-Madrid I; Koivunen O; Frangione B
Familial amyloidosis, Finnish (FAF), is an autosomal dominant form of systemic amyloidosis with lattice corneal dystrophy and progressive cranial neuropathy as principal clinical manifestations. We have shown that the novel amyloid fibril protein found in these patients is an internal degradation fragment of gelsolin, an actin-binding protein, and that it contains an amino acid substitution, asparagine for aspartic acid at position 15, that is due to a guanine-to-adenine transversion corresponding to codon 187 of human plasma gelsolin cDNA. To test that this mutation cosegregates with the disease high-molecular-weight genomic DNA was isolated from autopsied tissues or lymphocytes of 23 patients, 6 healthy relatives and 20 unrelated healthy control persons. Specific fragments were amplified with the polymerase chain reaction for oligonucleotide hybridization analysis using the slot-blot technique. The guanine-to-adenine transversion was found in all FAF patients tested, but in none of the control subjects. Our results show that the mutation (G to A) cosegregates with the disease phenotype, and that the slot-blot analysis can be used as a diagnostic assay, including prenatal evaluation
PMID: 1311149
ISSN: 0148-7299
CID: 9539

Codon 618 variant of Alzheimer amyloid gene associated with inherited cerebral hemorrhage [Case Report]

Fernandez-Madrid I; Levy E; Marder K; Frangione B
Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) is an autosomal dominant form of severe cerebrovascular amyloid angiopathy causing recurrent strokes during the fifth and sixth decades of life. The major constituent of the amyloid deposits in HCHWA-D is the amyloid beta-protein (A beta), also found in Alzheimer's disease. A point mutation in the DNA sequence encoding A beta has been found in 2 unrelated patients with HCHWA-D, and an assay detecting the single base change was developed for diagnostic purposes. We describe the detection of the point mutation in a patient living in the United States, suffering from recurring cerebral hemorrhages, who only recently was diagnosed with HCHWA-D. In addition, we tested a number of family members, and found the mutation in 2 additional individuals, one of them too young to exhibit clinical manifestations. This study combined with the study of two other families in Holland indicates that the codon 618 variant in the amyloid precursor protein gene segregates with HCHWA-D
PMID: 1763898
ISSN: 0364-5134
CID: 57029

Mutation in gelsolin gene in Finnish hereditary amyloidosis

Levy E; Haltia M; Fernandez-Madrid I; Koivunen O; Ghiso J; Prelli F; Frangione B
Familial amyloidosis, Finnish type (FAF), is an autosomal dominant form of familial amyloid polyneuropathy. The novel amyloid fibril protein found in these patients is a degradation fragment of gelsolin, an actin-binding protein. We found a mutation (adenine for guanine) at nucleotide 654 of the gelsolin gene in genomic DNA isolated from five FAF patients. This site is polymorphic since the normal allele was also present in all the patients tested. This mutation was not found in two unaffected family members and 11 normal controls. The A for G transition causes an amino acid substitution (asparagine for aspartic acid) that was found at position 15 of the amyloid protein. The mutation and consequent amino acid substitution may lead to the development of FAF
PMCID:2188742
PMID: 2175344
ISSN: 0022-1007
CID: 9427

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

Levy E; Carman MD; Fernandez-Madrid IJ; Power MD; Lieberburg I; van Duinen SG; Bots GT; Luyendijk W; Frangione B
An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy. Cloning and sequencing of the two exons that encode the amyloid protein from two patients with this amyloidosis revealed a cytosine-to-guanine transversion, a mutation that caused a single amino acid substitution (glutamine instead of glutamic acid) at position 22 of the amyloid protein. The mutation may account for the deposition of this amyloid protein in the cerebral vessel walls of these patients, leading to cerebral hemorrhages and premature death
PMID: 2111584
ISSN: 0036-8075
CID: 8382