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Effects of a Collaborative Problem-Solving Approach on an Inpatient Adolescent Psychiatric Unit

Ercole-Fricke, Eugenia; Fritz, Paul; Hill, Linda E; Snelders, Jill
OBJECTIVE:Effects of collaborative problem-solving (CPS) approaches on an inpatient adolescent psychiatric unit were investigated during this study, modeling Dr. Ross Greene's CPS theory, which considers that cognitive deficits are associated with adolescent behavioral dysfunction; his research, treatment, and subsequent results on similar units were notably successful. PROBLEM:The staff viewed prestudy, negative behavior modification and resultant punitive consequences as culturally acceptable. New York State's Office of Mental Health (OMH) disapproved these strategies, necessitating cultural transformation and alteration of routine responses to patients' maladaptive behaviors. METHOD:The study incorporates quantitative, comparative, quasi-experimental design, utilizing retrospective staff surveys and hospital medical records to compare behavioral outcomes and staff perceptions during pre- and post-training phases of this 5-year study. RESULTS:A significant decrease in punitive strategies and techniques (p = .001), reduction in behaviors related to the need for restraints, and significant decline in self-inflicted injury (p = .005), length of stay (p = .001), and need for security staff involvement (p = .001) were noted.
PMID: 27580658
ISSN: 1744-6171
CID: 4065292

Clozapine-associated cardiac dysfunction during a gastroenteritis outbreak [Case Report]

Szema, Anthony M; Marboe, Charles; Fritz, Paul; Nguyen, Tram N B
We report that two young adult patients who were initiated with clozapine for severe psychosis during a hospital-wide gastroenteritis outbreak went into severe shock. Neither patient had troponin elevation. Each required left ventricular assist device support for myocarditis. Endomyocardial biopsy revealed lymphocytic myocarditis in one patient and eosinophilic myocarditis in the other. The former patient expired. Polymerase chain reaction testing was negative for Coxsackie virus. These two patients illustrate that myocarditis can occur at usual incipient doses and that there may be an epidemiologic risk associated with gastroenteritis. Although the white blood cell (WBC) count is expected to decrease with clozapine, these patients had persistently elevated WBC counts. In conclusion, physicians should exercise caution when prescribing clozapine, especially for those with diarrhea.
PMID: 27987278
ISSN: 2000-9666
CID: 4065302

Developmental risk factors in postpartum women with urine tests positive for cocaine

Fritz P; Galanter M; Lifshutz H; Egelko S
The aim of the study was to ascertain whether there was a difference in developmental experiences between two groups of inner city postpartum patients, those who used cocaine during pregnancy and those who did not. A retrospective structured interview was administered to 80 postpartum women examining demographic characteristics, adaptive function, drug use patterns, and selected risk factors for adult substance abuse encountered before age 16. The sample was divided into two cohorts of women: 40 women identified by urine tests of their babies as using cocaine shortly before delivery and a comparison group of 40 women not identified by positive urines. Comparisons between the two cohorts revealed that the cocaine identified women had significantly higher overall past and present use of a broad range of drugs, particularly crack and other forms of cocaine, as well as lower levels of general adaptive functioning despite the fact that they were demographically comparable. When compared to the nonusers, they displayed markedly elevated scores on measures of developmental risk factors for adult substance use. This study highlights the importance of early developmental risk factors on later drug use during pregnancy and general adult adaptive functioning. Further study and intervention targeted at persons with these risk factors are warranted
PMID: 7683450
ISSN: 0095-2990
CID: 13337

Lack of efficacy of d-propranolol in neuroleptic-induced akathisia

Adler LA; Angrist B; Fritz P; Rotrosen J; Mallya G; Lipinski JF Jr
d-Propranolol lacks clinically significant beta-adrenergic receptor blocking properties, but has the same membrane stabilizing effects as racemic (d,l) propranolol. To assess the role of beta-blockade versus membrane stabilization or other shared nonspecific effects in the therapeutic action of propranolol in neuroleptic-induced akathisia (NIA) we treated 11 patients with NIA in a crossover, double-blind study of d-propranolol versus placebo. Akathisia scores were unchanged after both d-propranolol and placebo. Eight patients were subsequently treated in a nonblind manner with racemic propranolol, with a significant reduction in akathisia scores. These findings suggest that beta-blockade, not membrane stabilization or other shared nonspecific effects, contributes to the efficacy of propranolol in NIA
PMID: 1673844
ISSN: 0893-133x
CID: 23587