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Invited Commentary: Mitral Annular Disease: An Underrecognized and Forgotten Entity

Stojanovska, Jadranka; Fujikura, Kana
PMID: 38870046
ISSN: 1527-1323
CID: 5669322

CMR provides comparable measurements of diastolic function as echocardiography

Fujikura, Kana; Sathya, Bharath; Acharya, Tushar; Benovoy, Mitchel; Jacobs, Matthew; Sachdev, Vandana; Hsu, Li-Yueh; Arai, Andrew E
Clinical application of cardiac magnetic resonance (CMR) is expanding but CMR assessment of LV diastolic function is still being validated. The purpose of this study was to validate assessments of left ventricular (LV) diastolic dysfunction (DD) using CMR by comparing with transthoracic echocardiography (TTE) performed on the same day. Patients with suspected or diagnosed cardiomyopathy (n = 63) and healthy volunteers (n = 24) were prospectively recruited and included in the study. CMR diastolic parameters were measured on cine images and velocity-encoded phase contrast cine images and compared with corresponding parameters measured on TTE. A contextual correlation feature tracking method was developed to calculate the mitral annular velocity curve. LV DD was classified by CMR and TTE following 2016 guidelines. Overall DD classification was 78.1% concordant between CMR and TTE (p < 0.0001). The trans-mitral inflow parameters correlated well between the two modalities (E, r = 0.78; A, r = 0.90; E/A, r = 0.82; all p < 0.0001) while the remaining diastolic parameters showed moderate correlation (e', r = 0.64; E/e', r = 0.54; left atrial volume index (LAVi), r = 0.61; all p < 0.0001). Classification of LV diastolic function by CMR showed good concordance with standardized grades established for TTE. CMR-based LV diastolic function may be integrated in routine clinical practice.Name of the registry: Technical Development of Cardiovascular Magnetic Resonance Imaging. Trial registration number: NCT00027170. Date of registration: November 26, 2001. URL of trial registry record:
PMID: 38778036
ISSN: 2045-2322
CID: 5654792

Transcatheter Closure of Left Ventricular Outflow Tract Pseudoaneurysm Compressing the Left Anterior Descending Artery

Fahim, Mirette A; Wang, Lin; Petrossian, George; Khalique, Omar; Robinson, Newell; Khan, Jaffar; Fujikura, Kana
PMID: 38244005
ISSN: 1876-7605
CID: 5635492

Inversion recovery and saturation recovery pulmonary vein MR angiography using an image based navigator fluoro trigger and variable-density 3D cartesian sampling with spiral-like order

Craft, Jason; Weber, Jonathan; Li, Yulee; Cheng, Joshua Y.; Diaz, Nancy; Kunze, Karl P.; Schmidt, Michaela; Grgas, Marie; Weber, Suzanne; Tang, John; Parikh, Roosha; Onuegbu, Afiachukwu; Yamashita, Ann Marie; Haag, Elizabeth; Fuentes, Daniel; Czipo, Michael; Neji, Radhouene; Espada, Cristian B.; Figueroa, Leana; Rothbaum, Jonathan A.; Fujikura, Kana; Bano, Ruqiyya; Khalique, Omar K.; Prieto, Claudia; Botnar, Rene M.
Contrast enhanced pulmonary vein magnetic resonance angiography (PV CE-MRA) has value in atrial ablation pre-procedural planning. We aimed to provide high fidelity, ECG gated PV CE-MRA accelerated by variable density Cartesian sampling (VD-CASPR) with image navigator (iNAV) respiratory motion correction acquired in under 4 min. We describe its use in part during the global iodinated contrast shortage. VD-CASPR/iNAV framework was applied to ECG-gated inversion and saturation recovery gradient recalled echo PV CE-MRA in 65 patients (66 exams) using.15 mmol/kg Gadobutrol. Image quality was assessed by three physicians, and anatomical segmentation quality by two technologists. Left atrial SNR and left atrial/myocardial CNR were measured. 12 patients had CTA within 6 months of MRA. Two readers assessed PV ostial measurements versus CTA for intermodality/interobserver agreement. Inter-rater/intermodality reliability, reproducibility of ostial measurements, SNR/CNR, image, and anatomical segmentation quality was compared. The mean acquisition time was 3.58 ± 0.60 min. Of 35 PV pre-ablation datasets (34 patients), mean anatomical segmentation quality score was 3.66 ± 0.54 and 3.63 ± 0.55 as rated by technologists 1 and 2, respectively (p = 0.7113). Good/excellent anatomical segmentation quality (grade 3/4) was seen in 97% of exams. Each rated one exam as moderate quality (grade 2). 95% received a majority image quality score of good/excellent by three physicians. Ostial PV measurements correlated moderate to excellently with CTA (ICCs range 0.52"“0.86). No difference in SNR was observed between IR and SR. High quality PV CE-MRA is possible in under 4 min using iNAV bolus timing/motion correction and VD-CASPR. Graphical Abstract: (Figure presented.)
ISSN: 1569-5794
CID: 5662112

Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease [Letter]

Fujikura, Kana; Cheng, Andrew L; Suriany, Silvie; Detterich, Jon; Arai, Andrew E; Wood, John C
PMID: 35926908
ISSN: 1876-7591
CID: 5421732

Decreased Left Atrial Reservoir Strain Is Associated with Adverse Outcomes in Restrictive Cardiomyopathy

Stojanovska, Jadranka; Topaloglu, Nevriye; Fujikura, Kana; Khazai, Behnaz; Ibrahim, El-Sayed; Tsodikov, Alex; Bhave, Nicole M; Kolias, Theodore J
BACKGROUND:Restrictive cardiomyopathy (RCM) places patients at high risk for adverse events. In this study, we aim to evaluate the association between left atrial function and time to adverse events such as all-cause mortality and cardiovascular hospitalizations related to RCM. MATERIAL AND METHODS/METHODS:In this single-center study, ninety-eight patients with a clinical diagnosis of RCM were recruited from our registry: 30 women (31%); age (mean ± standard deviation) 61 ± 13 years. These patients underwent cardiac magnetic resonance (CMR) imaging from May 2007 to September 2015. Left atrial (LA) function (reservoir, contractile, and conduit strain), LA diameter and area, and left ventricular function (global longitudinal strain, ejection fraction), and volume were quantified, and the presence of late gadolinium enhancement was visually assessed. The cutoff value of the LA reservoir strain was selected based on tertile. An adjusted Cox proportional regression analysis was used to assess time to adverse outcomes with a median follow up of 49 months. RESULTS:= 0.008). CONCLUSIONS:The decreased LA reservoir strain is independently associated with time to adverse events in patients with RCM.
PMID: 35887884
ISSN: 2077-0383
CID: 5276502

Society for Cardiovascular Magnetic Resonance 2021 cases of SCMR and COVID-19 case collection series

Johnson, Jason N; Loriaux, Daniel B; Jenista, Elizabeth; Kim, Han W; Baritussio, Anna; De Garate Iparraguirre, Estefania; Bucciarelli-Ducci, Chiara; Denny, Vanessa; O'Connor, Brian; Siddiqui, Saira; Fujikura, Kana; Benton, Charles W; Weinsaft, Jonathan W; Kochav, Jonathan; Kim, Jiwon; Madamanchi, Chaitanya; Steigner, Michael; Kwong, Raymond; Chango-Azanza, Diego; Chapa, Mónica; Rosales-Uvera, Sandra; Sitwala, Puja; Filev, Peter; Sahu, Anurag; Craft, Jason; Punnakudiyil, George J; Jayam, Viraj; Shams, Farah; Hughes, Sean G; Lee, Jonan C Y; Hulten, Edward A; Steel, Kevin E; Chen, Sylvia S M
The Society for Cardiovascular Magnetic Resonance (SCMR) is an international society focused on the research, education, and clinical application of cardiovascular magnetic resonance (CMR). "Cases of SCMR" is a case series hosted on the SCMR website ( ) that demonstrates the utility and importance of CMR in the clinical diagnosis and management of cardiovascular disease. The COVID-19 Case Collection highlights the impact of coronavirus disease 2019 (COVID-19) on the heart as demonstrated on CMR. Each case in series consists of the clinical presentation and the role of CMR in diagnosis and guiding clinical management. The cases are all instructive and helpful in the approach to patient management. We present a digital archive of the 2021 Cases of SCMR and the 2020 and 2021 COVID-19 Case Collection series of nine cases as a means of further enhancing the education of those interested in CMR and as a means of more readily identifying these cases using a PubMed or similar literature search engine.
PMID: 35787291
ISSN: 1532-429x
CID: 5428172

Pericardial Effusion on MRI in Autosomal Dominant Polycystic Kidney Disease

Liu, Jin; Fujikura, Kana; Dev, Hreedi; Riyahi, Sadjad; Blumenfeld, Jon; Kim, Jiwon; Rennert, Hanna; Prince, Martin R
Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiac abnormalities including mitral valve prolapse and aneurysmal dilatation of the aortic root. Herein, we investigated the potential association of pericardial effusion with ADPKD. Subjects with ADPKD (n = 117) and control subjects without ADPKD matched for age, gender and renal function (n = 117) undergoing MRI including ECG-gated cine MRI of the aorta and heart were evaluated for pericardial effusion independently by three observers measuring the maximum pericardial effusion thickness in diastole using electronic calipers. Pericardial effusion thickness was larger in ADPKD subjects compared to matched controls (Mann-Whitney p = 0.001) with pericardial effusion thickness >5 mm observed in 24 of 117 (21%) ADPKD subjects compared to 4 of 117 (3%) controls (p = 0.00006). Pericardial effusion thickness in ADPKD was associated with female gender patients (1.2 mm greater than in males, p = 0.03) and pleural effusion thickness (p < 0.001) in multivariate analyses. No subjects exhibited symptoms related to pericardial effusion or required pericardiocentesis. In conclusion, pericardial effusion appears to be more prevalent in ADPKD compared to controls. Although in this retrospective cross-sectional study we did not identify clinical significance, future investigations of pericardial effusion in ADPKD subjects may help to more fully understand its role in this disease.
PMID: 35207400
ISSN: 2077-0383
CID: 5421712

Correlation Between Cardiovascular Magnetic Resonance and Echocardiography in Assessment of Diastolic Function [Comment]

Fujikura, Kana; Arai, Andrew E
PMID: 34503693
ISSN: 1876-7591
CID: 5421702

Reply to "the impact of mechanical properties on aortic dilation in patients with COPD and emphysema" [Comment]

Fujikura, Kana; Hiura, Grant T; Barr, R Graham; Prince, Martin R
PMID: 33933509
ISSN: 1874-1754
CID: 5421672