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Haemophilus influenzae serotype f endocarditis and septic arthritis

Oikonomou, Katerina; Alhaddad, Basel; Kelly, Kayla; Rajmane, Ravindra; Apergis, George
Haemophilus influenzae represents gram-negative coccobacilli which can cause endocarditis, meningitis, septicemia, pneumonia, septic arthritis. H.influenzae exists as encapsulated and unencapsulated (non-typeable) strains. Non-typeable H.influenzae are emerging pathogens especially in elderly population. We report a case of a 73 year old woman with bacteremia, endocarditis and septic arthritis due to H.influenzae serotype f. This case emphasizes the clinical features and the key elements of diagnosis and management of infections caused by non-typeable strains of H.influenzae.
PMID: 28725560
ISSN: 2214-2509
CID: 2640092

Do Cardiovascular Risk Factors and Severity and Complexity of Coronary Atherosclerosis Predict Aortic Pulse Pressure during Cardiac Catheterization?

Bhatt, Hemal; Sanghani, Dharmesh; Apergis, George; Fernaine, George
Pulse pressure (PP), estimated from the peripheral blood pressure measurements, has been linked with adverse cardiovascular events. But, the association of PP and coronary artery disease is not well studied. There is a lack of data on the association of invasively measured aortic PP and cardiovascular risk factors and severity of coronary atherosclerosis. We determined the predictive factors of aortic PP during cardiac catheterization. Electronic medical records from 2010 to 2013 were retrospectively reviewed. A total of 368 patients were eligible. The data on demographics, cardiovascular risk factors, coronary lesion characteristics, and medication use was collected. On multivariable regression analysis, aging (β = 0.34, p = 0.001, 95% confidence interval [CI] 0.14-0.53) and prior aspirin use (β = 5.09, p = 0.015, 95% CI 0.99-9.18) were associated with higher aortic PP. Increasing estimated glomerular filtration rate (β = - 0.52, p = 0.040, 95% CI -0.90 to -0.23) was associated with lower aortic PP. Severity and complexity of coronary lesions, SYNTAX score, and number of obstructed vessels were not associated with aortic PP. Aging, prior aspirin use, and declining renal function were associated with an increase in aortic PP. Aortic PP may not predict the severity and complexity of coronary atherosclerosis. Therefore, the risk of adverse cardiovascular events associated with an elevated aortic PP may not be mediated by the severity of coronary atherosclerosis.
PMID: 27231423
ISSN: 1061-1711
CID: 3104142

Pulmonary Vein Varix: A Rare Incidental Finding [Meeting Abstract]

Eslaamizaad, Y; Kalatoudis, H; Kaiser, I; Apergis, G
ISSN: 1535-4970
CID: 2414692

Intimal (spindle cell) sarcoma of the left atrium presenting with abnormal neurological examination

Saith, Sunil Evan; Duzenli, Anthony; Zavaro, Doris; Apergis, George
A 43-year-old man with an unremarkable medical history presented to our hospital with 2 weeks of headaches, ataxia and confusion. CT of the head revealed a large haemorrhagic cystic lesion. A subsequent chest CT revealed a large left atrial mass. The mass was subsequently biopsied with positive immunohistochemistry staining for MDM2, FLI1 and vimentin. Real-time PCR revealed MDM2 amplification, confirming the diagnosis of intimal sarcoma. The patient underwent surgical resection and reconstruction of the atrium with subsequent discharge to short-term rehabilitation, but his symptoms continued to progress. A repeat CT of the head revealed a new cerebellar mass. He underwent a second resection, but continued to experience worsening symptoms. He was diagnosed with stage IV intimal sarcoma and referred to hospice. The patient died 5 months after initial presentation. Autopsy was performed and revealed the cause of death as pneumonia. There was no involvement of the pulmonic or aortic vessels.
PMID: 26483389
ISSN: 1757-790x
CID: 1893762

Methylprednisolone-induced transient ventricular dysfunction [Letter]

Bhatt, Hemal; Apergis, George; Saxena, Archana
PMID: 25873813
ISSN: 1526-6702
CID: 1740322

Saddle pulmonary embolism as the initial manifestation of pancreatic cancer [Case Report]

Vlachostergios, Panagiotis J; Oikonomou, Katerina G; Cheema, Muhammad A; Apergis, George
PMID: 25786468
ISSN: 1349-7235
CID: 1893782

Elevated lactic acid is a negative prognostic factor in metastatic lung cancer

Vlachostergios, Panagiotis J; Oikonomou, Katerina G; Gibilaro, Eugene; Apergis, George
BACKGROUND: Hyperlactatemia with or without type B lactic acidosis is a rare complication of cancer, previously observed most often in hematological malignancies. The aim of this study was to assess the prognostic value of lactic acid (LA) in patients with metastatic lung cancer. METHODS: Patients diagnosed with stage IV non-small cell lung cancer (NSCLC) and extensive stage small cell lung cancer (SCLC), were included in this single center retrospective study. Arterial and venous LA level, anion gap (AG), serum LDH and presence of urine ketones were recorded for each patient and their associations with demographic and clinical data and overall survival (OS) were examined. RESULTS: Eighty-five patients (43 males, median age 74, range 45-96 years) were studied. The maximal levels of arterial or venous LA were significantly associated with presence of >/= 2 metastatic sites (p= 0.001), ICU admission or transfer (p= 0.016), intubation (p= 0.029), elevated serum anion gap (p< 0.001) and LDH levels (p< 0.001). Hyperlactatemia (>/= 1.4 mmol/L) was associated with shorter OS (log-rank p< 0.001). In a multivariate model including LA, ICU, intubation, AG as well as other known prognostic factors of NSCLC and SCLC, including age, sex, smoking status, number and location of metastases, histologic type, performance status (PS), chemotherapy and LDH, LA retained its prognostic value (OR: 1.3; 95%CI: 1.082-1.561; p= 0.005), along with PS (p= 0.039) and chemotherapy (p= 0.039). CONCLUSIONS: The results of the study suggest that a high lactic acid level (>/= 1.4 mmol/L) is associated with significantly shorter overall survival in patients with metastatic non-small cell lung cancer and extensive stage small cell lung cancer. Hyperlactatemia is an independent predictor of poor survival in metastatic lung cancer patients.
PMID: 26406401
ISSN: 1875-8592
CID: 1893772

Angiomyolipomas, renal cell carcinomas and pulmonary lymphangioleiomyomatosis

Vlachostergios, Panagiotis J; Rad, Bahareh Soroori; Karimi, Kamran; Apergis, George
PMID: 25478388
ISSN: 2249-782x
CID: 1893792

Common hepatic duct stricture: are lithiasis and negative brush cytology enough to rule out Klatskin tumor?

Vlachostergios, Panagiotis J; Apergis, George
In this case report, the experience of treating a patient with clinical suspicion of hilar cholangiocarcinoma is shared and key points in differentiating from coexistent lithiasis are discussed.
PMID: 25083310
ISSN: 2078-6891
CID: 1893802

Vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy

Fotiou, Pandelis; Raptis, Athanasios; Apergis, George; Dimitriadis, George; Vergados, Ioannis; Theodossiadis, Panagiotis
We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hyperhomocysteinemia (P < 0.001), lower serum folic acid (P < 0.001), and vitamin B12 (P = 0.014) levels than those without diabetic retinopathy. Regression analysis revealed that homocysteine was an independent risk factor for diabetic retinopathy and there was a threshold in its serum level (13.7 mu mol/L), above which the risk of diabetic retinopathy greatly increases (OR = 1.66, P = 0.001). Folic acid was associated with decreased odds for diabetic retinopathy (OR = 0.73, P < 0.001). There was a threshold in serum vitamin B12 level (248.4 pg/mL), below which serum homocysteine concentration significantly increases with decreasing serum vitamin B12 (P = 0.003). Our findings suggest that hyperhomocysteinemia is an independent risk factor for the development and progression of diabetic retinopathy. Decreased serum levels of folic acid and vitamin B12, through raising serum homocysteine concentrations, may also affect the diabetic retinopathy risk.
PMID: 25006590
ISSN: 2314-6753
CID: 1893812